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1
zadetkov: 9
1.
  • MET Alterations Are a Recur... MET Alterations Are a Recurring and Actionable Resistance Mechanism in ALK-Positive Lung Cancer
    Dagogo-Jack, Ibiayi; Yoda, Satoshi; Lennerz, Jochen K ... Clinical cancer research, 06/2020, Letnik: 26, Številka: 11
    Journal Article
    Recenzirano
    Odprti dostop

    Most -positive lung cancers will develop ALK-independent resistance after treatment with next-generation ALK inhibitors. amplification has been described in patients progressing on ALK inhibitors, ...
Celotno besedilo
Dostopno za: CMK, NUK, UL, UM, UPUK

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2.
  • BRG1 Loss Predisposes Lung ... BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency
    Gupta, Manav; Concepcion, Carla P; Fahey, Caroline G ... Cancer research (Chicago, Ill.), 09/2020, Letnik: 80, Številka: 18
    Journal Article
    Recenzirano
    Odprti dostop

    Inactivation of SMARCA4/BRG1, the core ATPase subunit of mammalian SWI/SNF complexes, occurs at very high frequencies in non-small cell lung cancers (NSCLC). There are no targeted therapies for this ...
Celotno besedilo
Dostopno za: CMK, UL

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3.
  • Small cell transformation o... Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition
    Lin, Jessica J; Langenbucher, Adam; Gupta, Pranav ... NPJ precision oncology, 08/2020, Letnik: 4, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in -mutant and fusion-positive lung cancers. Whether small cell ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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4.
  • Abstract 2049: LKB1 regulat... Abstract 2049: LKB1 regulates BH3-mimetics vulnerability of KRAS mutant non-small cell lung cancer by alternating mitochondrial apoptotic protein interactions
    Li, Chendi; Oh, Audris; Nangia, Varuna ... Cancer research (Chicago, Ill.), 07/2019, Letnik: 79, Številka: 13_Supplement
    Journal Article
    Recenzirano

    Abstract Over 30% of lung adenocarcinomas harbor KRAS mutation. Despite progress in targeted therapies for specific genetic subsets of lung cancer (e.g. EGFR or ALK), there are no clinically ...
Celotno besedilo
Dostopno za: CMK, UL
5.
  • Abstract 982: LKB1 loss rew... Abstract 982: LKB1 loss rewires stress signaling-induced apoptotic protein dynamics and sensitizes KRAS -mutant non-small cell lung cancers to combined MAPK + MCL-1 blockade
    Li, Chendi; Shen, Yi; Syed, Mohammed Usman ... Cancer research (Chicago, Ill.), 07/2021, Letnik: 81, Številka: 13_Supplement
    Journal Article
    Recenzirano

    Abstract Background: There are currently no approved targeted therapies for KRAS-mutant non-small cell lung cancers (NSCLC), which represent 25-30% of lung adenocarcinomas. The development of ...
Celotno besedilo
Dostopno za: CMK, UL
6.
  • Abstract 2150: LKB1 loss re... Abstract 2150: LKB1 loss rewires JNK-induced apoptotic protein dynamics through NUAKs and sensitizes KRAS-mutant non-small cell lung cancers to combined KRAS G12C + MCL-1 blockade
    Li, Chendi; Syed, Mohammed Usman; Shen, Yi ... Cancer research (Chicago, Ill.), 06/2022, Letnik: 82, Številka: 12_Supplement
    Journal Article
    Recenzirano

    Abstract The recent approval of the KRAS G12C inhibitor sotorasib (AMG 510) for non-small cell lung cancer (NSCLC) marked a milestone in the development of targeted therapies for KRAS mutant cancers. ...
Celotno besedilo
Dostopno za: CMK, UL
7.
  • Small cell transformation o... Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition
    Lin, Jessica J; Langenbucher, Adam; Gupta, Pranav ... NPJ precision oncology, 2020-Aug-03, Letnik: 4, Številka: 1
    Journal Article
    Recenzirano

    Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR-mutant and ALK fusion-positive lung cancers. Whether ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
8.
Celotno besedilo
9.
  • Small cell transformation o... Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition
    Lin, Jessica J; Langenbucher, Adam; Gupta, Pranav ... NPJ precision oncology, 01/2020, Letnik: 4
    Report

    Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR-mutant and ALK fusion-positive lung cancers. Whether ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

PDF
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zadetkov: 9

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