Direct beam patterning on metal/protein/organic material coated ITO substrates is investigated using laser light for submicron scale lithography. A laser writing lithography method is developed using ...the 400nm Ti:Sapphire laser. Using a microscope objective lens, a laser beam is focused onto a glass slide coated with metal/protein/organic material film. Localized laser absorption results in partial melting and ablation of film. Spatially moving the laser spot, a stable etched pattern is obtained at submicron resolution. This result opens many possibilities for microfabrication of bioelectronic devices.
The formation of molecular hetero-film consisting of green fluorescence protein (GFP) and viologen LB film using the electrophoretic sedimentation technique (EPS) is investigated. The fabrication ...condition by EPS such as the exposure voltage affects the topology and photoresponse of GFP films. Based on the surface topology measured by atomic force microscopy (AFM), the optimal electric field for the fabrication of GFP film was found as 4.5V.
Two ITO-coated glass wafers (Corning #7740, #0080) are successfully bonded by the typical Si-Pyrex electrostatic bonding mechanism. Both Si-#7740 and Ti-(Li-doped SiO2) interlayer systems can be ...employed for the electrostatic bonding of #7059-#7059 and #0080-#0080 glass wafer pairs. This glass-to-glass electrostatic bonding process can be applied to the clean and tubeless packaging of field emission display panels.
Perchlorate interferes with iodide accumulation in the thyroid resulting in reduced thyroidal hormone synthesis. The objective of this project was to conduct a series of experiments to investigate ...the role of perchlorate on the uptake of iodide in the thyroid and its effects on the synthesis of thyroid hormones. A time course study with perchlorate (single iv dose) was performed to investigate its kinetic behavior in the adult male rat. Rats were injected with 0, 0.01, 0.11 and 3 mg perchlorate/kg via tail vein, challenged with 1251 with carrier at 2 h post dosing, and euthanized at predetermined time points. Three groups (n=6 per group) of 1-, 5-, and 14-day drinking water studies were performed at different levels of perchlorate (0, 1, 3 and 10 mg/kg). At the end of exposure, rats were challenged once by tail vein injection with 1251 with carrier. Dose-related inhibition of thyroid iodide uptake after a single iv dose of perchlorate, and both dose- and time- dependent changes in inhibition of thyroid iodide uptake were observed in drinking water studies. In both the single dose and drinking water studies, TSH and free T4 levels were elevated with T4 levels decreased. Serum T3 levels in drinking water studies remained unchanged in all dosing groups.
An 18-year-old male was admitted to Seoul National University Hospital for the evaluation of fever and chill on February 3, 1988.
On physical examination, his face showed a characteristic “elfin” ...facial appearance. His face was characterized by abnormalities of dental development, a broad overhanging upper lip, high arched palate and gum hypertrophy. He also showed mental retardation.
Cardiac catheterization with selective cineangiocardiography demonstrated a supravalvular aortic narrowing, grade 2 aortic insufficiency, and moderately dilated proximal coronary arteries with normal distribution without an intraluminal narrowing. There was a systolic pressure gradient (55mmHg) between the aortic root and ascending aorta distal to a stenotic segment.
MRI showed a supravalvular aortic stenosis.
Vegetation was not found on echocardiograpghy. Unidentified G(−) rods were isolated in 3 out of 9 bottles in blood culture test.
He was treated with Na-penicillin and gentamicin for 28 days.
Superconducting MgB2 thin films were prepared on Al2O3(0001) and MgO(100)
substrates. Boron thin films were deposited by the electron-beam evaporation
followed by post-annealing process with ...magnesium. Proper post annealing
conditions were investigated to grow good superconducting MgB2 thin films. The
X-ray diffraction patterns showed randomly orientated growth of MgB2 phase in
our thin films. The surface morphology was examined by scanning electron
microscope (SEM) and atomic force microscope (AFM). Critical current density
(Jc) measured by transport method was about 10^7 A/cm^2 at 15 K, and
superconducting transition temperature (Tc) was ~ 39 K in the MgB2 thin films
on Al2O3.
A 56-year-old male patient who had a history of syncopal attack was diagnosed as having cardiac amyloidosis. His ECG finding showed a pattern of inferior and anteroseptal wall infarction with ...Wenckebach AV block.
Echocardiographic examination revealed that the LV posterior wall and interventricular septum were markedly thickened with granular sparkling.
We demonstrated the amyloid deposit in the myocardium by endomyocardial biopsy.
Pathology showed a green white birefringence by polarizing illumination and amyloid fibril in electron microscopic study.
Samultang has been traditionally used for treatment of ischemic heart and brain diseases in oriental medicine. However, little is known about the mechanism by which Samultang rescues the myocardial ...and neuronal cells from ischemic damage. This study was designed to evaluate whether the water extract of Samultang may modulate the production of nitric oxide (NO) in LPS and PMA treated-C6 glial cells to protect the cells from NO-induced cytotoxicity. C6 glial cells treated with both LPS and PMA significantly produced a large amount of NO compared to untreated, PMA, or LPS-treated cells. In parallel with NO production, cotreatment of LPS and PMA induced the severe apoptotic death of C6 glial cells. However, Samultang significantly reduced both cell death and NO production by LPS/PMA in a dose-dependent manner. In addition, the modulatory effects of Samultang on LPS/PMA-induced cytotoxicity and NO production could be mimicked by exogenous treatments of N
GMMA, a nitric oxide synthase (NOS) inhibitor, and pyrrolidine dithiocarbamate (PDTC), a strong NF-κB inhibitor. Treatment of C6-glial cells with LPS/PMA induced the transcriptional activation of NF-κB, which was markedly inhibited by Samultang. Taken together, we suggest that the protective effects of Samultang against LPS/PMA-induced cytotoxicity may be mediated by the suppression of NO synthesis via down-regulation of NF-κB activation.
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