Most conventional biped robots process leg movements and information from each sensor by numerical calculation using a CPU. However, to cope with diverse environments, the numerical calculations are ...enormous, so they must be processed at high speed using a high-performance CPU and high power consumption. On the other hand, focusing on human motor control, it is believed that basic motor patterns such as walking and running are generated by a neural network called the central pattern generator (CPG), which is localized in the spinal cord and is independent of calculation. We previously focused on pulse-type hardware neural networks (P-HNNs), in which the neural network was composed of analog electronic circuits, and developed a hardware CPG model for controlling a single leg of a musculoskeletal humanoid robot. However, to actually move a biped robot, a CPG model that takes into account both legs and sensory information is required. Therefore, this study aims to develop a hardware CPG model for controlling both legs of a musculoskeletal humanoid robot whose gait changes according to the higher center and sensory information. We report on a hardware CPG model configured by circuit simulation confirmed the generation of walking and running patterns.
Purpose
Previous studies reported that the long-acting erythropoiesis-stimulating agent (ESA) significantly suppresses the expression of hepcidin, which regulates iron availability. In this study, we ...compared the iron availability for erythropoiesis between short and long-acting ESA over a long period.
Methods
We enrolled 69 hemodialysis patients in this study. All patients were treated with short-acting ESA (epoetin-α or epoetin-β) for the first 30 months. Then, all patients switched to long-acting ESA (continuous erythropoietin receptor activator-methoxy polyethylene glycol-epoetin beta) for the next 30 months. We measured their blood levels of Hb, ferritin, iron, total iron-binding capacity, intact-parathyroid hormone, calcium, phosphate, albumin, and highly sensitive CRP level.
Results
There was no significant change in the dose of short or long-acting ESA during the study period. Compared with the short-acting ESA period, the mean hemoglobin (Hb) and transferrin saturation levels were significantly increased in the long-acting ESA period (from 10.3 ± 0.2 to 10.6 ± 0.3 g/dL). On the other hand, the mean serum ferritin level (from 72 ± 22.2 to 56.3 ± 14 ng/mL) and the dose of IV iron (from 108 ± 63 to 53 ± 27 mg/month) were significantly decreased in the long-acting ESA period.
Conclusion
In this study, we found that anemia treatment with long-acting ESA attenuated the iron utilization for erythropoiesis and maintained target Hb levels without requiring a higher dose of IV iron or ESA.
We present a case of a congenital retinal macrovessel (CRM) with spontaneous resolution of cystoid macular edema. A 39-year-old woman with sudden decreased vision in her right eye was referred to our ...clinic and found to have a CRM with macular edema. Her visual acuity was 20/25. A week later, the macular edema disappeared without any treatment, and her visual acuity was 20/15. We performed optical coherence tomography angiography and fluorescein angiography (FA), which revealed no obstruction of retinal flow but a slight disturbance of retinal flow near the central fovea on FA. We encountered a case of spontaneous resolution of macular edema with abnormal vessel crossing near the central macula by a CRM, and multimodal imaging was useful for investigating the pathology of the disease.
We study the geometry and the internal structure of the outflowing wind from the accretion disk of a quasar by observing multiple sightlines with the aid of strong gravitational lensing. Using ...Subaru/High Dispersion Spectrograph, we performed high-resolution (R ~ 36,000) spectroscopic observations of images A and B of the gravitationally lensed quasar SDSS J1029+2623 (at z sub(em) ~ 2.197) whose image separation angle, straighttheta ~ 22".5, is the largest among those discovered so far. We confirm that the difference in absorption profiles in images A and B discovered by Misawa et al. has remained unchanged since 2010, implying the difference is not due to time variability of the absorption profiles over the delay between the images. Deltat ~ 744 days, but rather due to differences along the sightlines. We also discovered a time variation of C IV absorption strength in both images A and B due to a change in the ionization condition. If a typical absorber's size is smaller than its distance from the flux source by more than five orders of magnitude, it should be possible to detect sightline variations among images of other smaller separation, galaxy-scale gravitationally lensed quasars.
Kiso Supernova Survey (KISS): Survey strategy Morokuma, Tomoki; Tominaga, Nozomu; Tanaka, Masaomi ...
Publications of the Astronomical Society of Japan,
12/2014, Letnik:
66, Številka:
6
Journal Article
Recenzirano
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Abstract
The Kiso Supernova Survey (KISS) is a high-cadence optical wide-field supernova (SN) survey. The primary goal of the survey is to catch the very early light of a SN, during the shock ...breakout phase. Detection of SN shock breakouts combined with multi-band photometry obtained with other facilities would provide detailed physical information on the progenitor stars of SNe. The survey is performed using a 2 $_{.}^{\circ}$2 × 2 $_{.}^{\circ}$2 field-of-view instrument on the 1.05-m Kiso Schmidt telescope, the Kiso Wide Field Camera (KWFC). We take a 3-min exposure in g-band once every hour in our survey, reaching magnitude g ∼ 20–21. About 100 nights of telescope time per year have been spent on the survey since 2012 April. The number of the shock breakout detections is estimated to be of the order of 1 during our three-year project. This paper summarizes the KISS project including the KWFC observing setup, the survey strategy, the data reduction system, and CBET-reported SNe discovered so far by KISS.
We study the geometry and the internal structure of the outflowing wind from the accretion disk of a quasar by observing multiple sightlines with the aid of strong gravitational lensing. Using ...Subaru/HDS, we performed high-resolution (\(R\) \(\sim\) 36,000) spectroscopic observations of images A and B of the gravitationally lensed quasar SDSS J1029+2623 (at \(z_{em}\) \(\sim\) 2.197) whose image separation angle, \(\theta\) \(\sim\) 22\(^{\prime\prime}\!\!\).5, is the largest among those discovered so far. We confirm that the difference in absorption profiles in the images A and B discovered by Misawa et al. (2013) remains unchanged since 2010, implying the difference is not due to time variability of the absorption profiles over the delay between the images, \(\Delta t\) \(\sim\) 744 days, but rather due to differences along the sightlines. We also discovered time variation of C IV absorption strength in both images A and B, due to change of ionization condition. If a typical absorber's size is smaller than its distance from the flux source by more than five orders of magnitude, it should be possible to detect sightline variations among images of other smaller separation, galaxy-scale gravitationally lensed quasars.
The Kiso Supernova Survey (KISS) is a high-cadence optical wide-field supernova (SN) survey. The primary goal of the survey is to catch the very early light of a SN, during the shock breakout phase. ...Detection of SN shock breakouts combined with multi-band photometry obtained with other facilities would provide detailed physical information on the progenitor stars of SNe. The survey is performed using a 2.2x2.2 deg field-of-view instrument on the 1.05-m Kiso Schmidt telescope, the Kiso Wide Field Camera (KWFC). We take a three-minute exposure in g-band once every hour in our survey, reaching magnitude g~20-21. About 100 nights of telescope time per year have been spent on the survey since April 2012. The number of the shock breakout detections is estimated to be of order of 1 during our 3-year project. This paper summarizes the KISS project including the KWFC observing setup, the survey strategy, the data reduction system, and CBET-reported SNe discovered so far by KISS.
Objective
This study aimed to investigate the role of the programmed cell death protein 1 (PD-1) pathway and T peripheral helper (Tph) cells in the pathogenesis of lupus nephritis using lupus-prone ...BXSB-Yaa mice.
Methods
Male BXSB-Yaa mice and age-matched male C57BL/6 mice were used. The expression of PD-1 and its ligands (programmed cell death 1 ligand-1, PD-L1 and programmed cell death 1 ligand-2, PD-L2) and the phenotypes of kidney-derived cells and splenocytes expressing these molecules were analyzed by immunofluorescence and flow cytometry.
Results
Nephritis spontaneously developed in 16-week-old but not in 8-week-old BXSB-Yaa or C57BL/6 mice. PD-1 was expressed on CD4+ mononuclear cells (MNCs) that infiltrated the glomeruli of 16-week-old BXSB-Yaa mice. The frequency of CD4+PD-1+CXCR5−ICOS+ kidney-derived Tph cells was higher in 16-week-old than in 8-week-old BXSB-Yaa and C57BL/6 mice, whereas the frequency of CD4+PD-1+CXCR5+ICOS+ kidney-derived T follicular helper (Tfh) cells was not significantly different between the mice. PD-L1 was constitutively expressed in the renal tubules. PD-L2 was expressed in the glomeruli of 16-week-old BXSB-Yaa mice. The frequency of PD-L1highCD11c+CD3−CD19- and PD-L2+CD11c+CD3−CD19- kidney-derived MNCs in 16-week-old BXSB-Yaa mice was significantly higher than that of the control mice. The percentage of kidney-derived Tph cells but not Tfh cells was correlated with the urinary protein levels in the nephritic mice.
Conclusion
The results of this study suggest that kidney-infiltrating PD-1+ Tph cells expanded concomitantly with the upregulation of PD-L1 and PD-L2 in the kidneys and the progression of lupus nephritis.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, OILJ, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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