► 16-channel, GSa/s digitizer chip TARGET. ► Designed for imaging atmospheric Cherenkov telescopes for very-high-energy gamma-ray astronomy. ► Measured chip performance details. ► A prototype camera ...module is described. ► The next-generation chip, TARGET 2, is described.
The next-generation very-high-energy (VHE) gamma-ray observatory, the Cherenkov Telescope Array, will feature dozens of imaging atmospheric Cherenkov telescopes (IACTs), each with thousands of pixels of photo-sensors. To be affordable and reliable, reading out such an array of up to a million channels requires event recording technology that is highly integrated and modular, with a low cost per channel. We present the design and performance of a chip targeted to this application: the TeV Array Readout with GSa/s sampling and Event Trigger (TARGET). This application-specific integrated circuit (ASIC) has 16 parallel input channels, a 4096-sample buffer for each channel, adjustable input termination, self-trigger functionality, and tight window-selected readout. We report the performance of the first-generation version of this chip (TARGET 1) in terms of sampling frequency, power consumption, dynamic range, current-mode gain, analog bandwidth, and cross talk. The large number of channels per chip allows a low cost per channel ($10 to $20 including front-end and back-end electronics but not including photosensors) to be achieved with a TARGET-based IACT readout system. In addition to basic performance parameters of the TARGET 1 chip, we present a camera module prototype as well as a second-generation chip (TARGET 2), both of which have now been produced.
Background: The cerebral metabolism of patients in the chronic stage of traumatic diffuse brain injury (TDBI) has not been fully investigated. Aim: To study the relationship between regional cerebral ...metabolism (rCM) and consciousness disturbance in patients with TDBI. Methods: 52 patients with TDBI in the chronic stage without large focal lesions were enrolled, and rCM was evaluated by fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) with statistical parametric mapping (SPM). All the patients were found to have disturbed consciousness or cognitive function and were divided into the following three groups: group A (n = 22), patients in a state with higher brain dysfunction; group B (n = 13), patients in a minimally conscious state; and group C (n = 17), patients in a vegetative state. rCM patterns on FDG-PET among these groups were evaluated and compared with those of normal control subjects on statistical parametric maps. Results: Hypometabolism was consistently indicated bilaterally in the medial prefrontal regions, the medial frontobasal regions, the cingulate gyrus and the thalamus. Hypometabolism in these regions was the most widespread and prominent in group C, and that in group B was more widespread and prominent than that in group A. Conclusions: Bilateral hypometabolism in the medial prefrontal regions, the medial frontobasal regions, the cingulate gyrus and the thalamus may reflect the clinical deterioration of TDBI, which is due to functional and structural disconnections of neural networks rather than due to direct cerebral focal contusion.
In current practice of clinical genetics, molecular diagnosis has become more widely used than ever before. DNA diagnosis is important for appropriate medical care of the patient, and proper genetic ...counseling to the family. However, genetic testing of orphan disease cannot always be performed easily. In multiple congenital anomalies (MCA) syndromes by monogenic cause, the broad mutational spectrum and large size of responsible genes often make molecular diagnosis expensive and cumbersome. We solve this problem with on‐demand genetic testing by CHIPS (CEL nuclease mediated heteroduplex incision with polyacrylamide gel electrophoresis and silver staining) technology, which is the ultimately conventional and economical mutation screening system. In this article, we show eight patients with MCA syndromes who were recently treated at our hospital, and demonstrate that CHIPS successfully offers efficient and inexpensive genetic testing and facilitates clinical genetic service in our local region.
•A novel adenovirus outbreak occurred in a colony of African pygmy hedgehogs (APHs).•An African pygmy hedgehog adenovirus 1 (AhAdV-1) infection was confirmed in 13 APHs.•AhAdV-1 was isolated from one ...APH.•Five APHs died during the outbreak and AhAdV-1 can cause fatal pneumonia in a case.•AhAdV-1 should be monitored as a potential cause of emerging infections in APHs.
An African pygmy hedgehog adenovirus 1 (AhAdV-1) outbreak in a colony of 24 African pygmy hedgehogs (APHs) with a case of fatal pneumonia occurred in Japan. Thirteen out of a colony of 15 APHs with respiratory symptoms were diagnosed with AhAdV-1 infection based on the detection of AhAdV-1 genome in throat/nasal swabs and further one APH was diagnosed on isolation of the virus. Five infected APHs died during the outbreak and AhAdV-1 caused severe pneumonia and death in one case. After the outbreak, persistent AhAdV-1 infection was suggested in one surviving APH. AhAdV-1 is a novel adenovirus and is suspected to be an emerging pathogen.
Near UltraViolet High Density (NUV-HD) SiPMs produced by Fondazione Bruno Kessler in collaboration with INFN have been tested and characterized in INFN laboratories. The third generation of these ...devices (HD3) has proven to be suitable to equip the focal plane of the prototype Schwarzschild–Couder Medium Size Telescope (pSCT) proposed for the Cherenkov Telescope Array Observatory. Photosensors have been assembled in 4 16-pixel optical units coupled with TARGET–7 ASIC front-end electronics for amplification and digitization of the signal. At present, 9 modules have been successfully integrated on the pSCT camera and are currently taking data. In this contribution we report on the performances of the HD3 technology as single sensor and as assembled optical units, showing their performance and homogeneity in terms of gain and dark count rate.
We have developed a prototype hexagonal light concentrator for the Large-Sized Telescopes of the Cherenkov Telescope Array. To maximize the photodetection efficiency of the focal-plane camera pixels ...for atmospheric Cherenkov photons and to lower the energy threshold, a specular film with a very high reflectance of 92–99% has been developed to cover the inner surfaces of the light concentrators. The prototype has a relative anode sensitivity (which can be roughly regarded as collection efficiency) of about 95 to 105% at the most important angles of incidence. The design, simulation, production procedure, and performance measurements of the light-concentrator prototype are reported.
Nonspecific manifestations and a varied distribution of brain lesions can delay the diagnosis of herpes simplex encephalitis (HSE) in neonates. The aim of this study was to report predominant brain ...lesions in neonatal HSE, and then to investigate the association between pattern of predominant brain lesions, clinical variables and neurodevelopmental outcome.
A multicenter retrospective study was performed in neonates diagnosed with HSE between 2009 and 2014. Magnetic resonance (MR) images, including diffusion-weighted images, were obtained in the acute and chronic phase.
Three predominant areas of brain injury could be defined based on characteristic MRI findings in 10 of the 13 infants (77%). The inferior frontal/temporal pole area was involved in five (38%) patients. The watershed distribution was present in six (46%) patients. Four (31%) infants involved the corticospinal tract area. No significant association was found between any predominant distribution of brain lesion pattern and sex, country, viral type or viral load. However, the corticospinal tract involvement was significantly associated with motor impairment (P=0.045).
Three predominant areas of brain lesion could be recognized in neonatal HSE. Recognition of those areas can improve prediction of neurodevelopmental outcome.
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