Epilepsy is a common neurological disease that negatively affects all areas of life, with a need to take antiepileptic drugs (AEDs) for a long time and with a high incidence of side effects.
...Objective
: to determine the main directions of studies dealing with the problem of pregnancy in epilepsy, by analyzing their results.
Material and methods
. Over past 10-year publications on pregnancy in epilepsy, their prospects for and prognostic significance for solving scientific and practical problems underwent an analytical review.
Results and discussion
. It was found that the risk for higher frequency of seizures was 15 times lower if the latter were controlled within 9–12 months before pregnancy. AED therapy noncompliance during pregnancy is the cause of relapses, increased seizure frequency, and status epilepticus. Changes in the blood concentrations of AED during pregnancy require therapeutic drug monitoring and correction of daily dosages of these drugs. The indication for caesarean section in epilepsy is a high perinatal and maternal risk. Breastfeeding in maternal epilepsy is indicated applying a personalized approach. Studying the predictors of changes in the frequency of seizures and improving pregravid preparation are promising areas for optimizing pregnancy outcomes in epilepsy.
Abstract
Recently, increased attention has been paid to issues of information and analytical support for the Russian Arctic security. However, risk management problems are especially acute for lower ...levels of management hierarchy. Therefore, it is relevant to consider issues of managing technogenic-ecological industrial-natural complexes safety of the Arctic. In this article, these features are considered on the example of a heat power plant. Accidents related to oil and oil products spills are considered as a typical example. In first part of the work, main goals and objectives of prevention, forecasting and elimination of accidents consequences are given, the features of operational management in event of an emergency are revealed. It is shown that Arctic industrial-natural complexes safety management is a complex interdisciplinary area of fundamental and applied research. The structure of information-analytical complex for risk management has been formed. The second section presents some research and developments in field of information-analytical support of industrial-natural safety. Directions for further research are outlined.
The turning of Caprolon with a machining fluid is considered. If an aqueous water-repellent emulsion is supplied to the cutting zone in machining, the Caprolon absorbs less water, and the final ...surface quality is improved.
The relationships of the stone charr
Salvelinus malma kuznetzovi,
an endemic taxon to the Kamchatka River basin, were inferred from analysis of the nucleotide sequences of the mitochondrial DNA ...control region (
CR
) and cytochrome
b
(
Cytb
) and cytochrome oxidase-1 (
COI
) genes, as well as the nuclear lactate dehydrogenase gene (
LDH-C1
). Genealogical analysis of mtDNA haplotypes confirmed the phylogenetic closeness of
S. m. kuznetzovi, S. albus,
and
S. m. malma
and showed that the above taxa represent the Beringian phylogenetic group of charr. The level of mtDNA divergence between
S. m. kuznetzovi, S. albus,
and
S. m. malma
did not exceed the intraspecific variation in Northern Dolly Varden populations. The existence of a cryptic Pleistocene refugium in the Kamchatka River basin has been substantiated; nevertheless, extensive and complex studies of charr of the Beringian group are needed.
The results of microplankton (Protista) investigations in the Barents Sea (standard "Kola Meridian Transect", ~70–78° N, 33° 30′ E) in November / December have been presented. Samples for the ...determination of the taxonomical composition and abundance have been fixed with buffered formalin and examined with light microscopy using Nageotte counting chambers. A list of species recorded in the Barents Sea on transect, abundance and vertical distribution of microplankton has been given: a) the seasonal composition of species (Ceratium fusus, Dicroerisma psilonereiella, Dinophysis rotundata, Lessardia elongata aff., Oxytoxum caudatum, Pronoctiluca pelagica, Protoperidinium brevipes, Prorocentrum balticum (Dinophyta), Corethron criophilum (Bacillariophyta), Coccolithus pelagicus (Haptophyta), Halosphaera viridis (Prasinophyta)); b) mean values of the total biomass of microplankton and its distribution in the water column (1.14 mkg/l in the layer of 50–0 m, 0.97 mkg/l – 100–50 m, 0.75 mkg/l – 200–100 m, 0.53 mkg/l – 300–200 m). Such parameter as dominant species in the structure of the total number is less constant (the ordinary dominant O. caudatum, subdominants – L. elongata aff., P. balticum, C. pelagicus, C. criophilum); in some years, at selected sites of the Barents Sea most of the total number has been formed to unusual species (Emiliania huxleyi, Mesoporos perforatus). The less stable characteristics of microplancton are dominant species composition in the biomass structure, total number of cells and their distribution in the water column.
Smart Production Systems: A New Approach Chervyakov, L. M.; Oleinik, A. V.; Bychkova, N. A.
Russian engineering research,
2019/12, Letnik:
39, Številka:
12
Journal Article
Recenzirano
Modification of the design method for smart production systems is considered. A new classification of decision-making systems is proposed, by morphological analysis of the system’s environment. The ...primary levels of intellectual capacity of these systems are determined.
On the basis of recent information regarding conduction, analysis of heat transfer by the response function method is proposed. Comparison with the finite-element method confirms the high accuracy of ...the proposed approach.
Stable Turning of Fluoroplastic Workpieces Erenkov, O. Yu; Ivakhnenko, A. G.; Anikeeva, O. V. ...
Russian engineering research,
02/2020, Letnik:
40, Številka:
2
Journal Article
Recenzirano
Instability of the system in the machining of fluoroplastic is investigated. The influence of the cutting conditions and preliminary workpiece preparation on the roughness of the machined surface is ...determined. Turning conditions leading to instability of the system and sharp increase in roughness of the machined surface are identified.
We tested the locus of the nuclear lactate dehydrogenase gene (
LDH-C1
) as a phylogenetic marker in specimens of 11 salmonid genera (
Thymallus, Coregonus, Hucho, Brachymystax, Salmo, Salmothymus, ...Acantholingua, Parahucho, Salvelinus, Parasalmo
, and
Oncorhynchus
). All the sequences were veraciously clustered according to their taxonomic affiliation at the species and genus levels. It is shown that used complex of characters contains a phylogenetic signal that represents specific information about the phylogenesis process. This allows us to recommend the
LDH-C1
locus to specify the phylogeny of salmonids in the combined analysis of several independent nuclear genes and mitochondrial DNA.
Lake Kronotskoye (the Kronotsky Biosphere State Reserve, south-eastern Kamchatka Peninsula) contains three closely related resident morphotypes charrs, which are considered to be either independent ...species (white charr Salvelinus albus, longhead charr Salvelinus kronocius, Schmidt's charr Salvelinus schmidti) or a united lacustrine-riverine charrs, represented by several phenotypes. Salvelinus malma malma is isolated from the lake charr populations by an upstream migration barrier in the Kronotskaya River, which flows out of the lake. We examined the level of genetic variability and divergence of mtDNA both between charrs from Kronotsky Lake and between resident lacustrine charrs and the hypothetical ancestor species S. m. malma. The RFLP-PCR analysis was used to examine six regions (ND1/ND2, ND3/ND4L/ND4, ND5/ND6, COI/COII/A8, A8/A6/COIII/ND3, and Cytb/D-loop), comprising ~80% of the mtDNA. Significantly different levels of diversity were found among the populations of lacustrine charrs. S. albus and S. schmidti had the highest indices of mtDNA diversity among the investigated populations from the different habitats. Heterogeneity tests revealed highly significant differentiation among lake populations and among riverine (Kronotskaya River) and lake (Lake Kronotskoye) populations of charrs, indicating their reproductive isolation. Hierarchical analysis of molecular variance revealed the following regularities of diversity distribution: the high proportion of interpopulation variation (93.25%) and low but statistically significant subdivision between charr populations (6.75%, P < 0.001). Results of the present study suggest that the populations of S. albus, S. kronocius, S. schmidti belong to the S. m. malma phylogenetic group. The divergence value of mtDNA of resident charrs (0.0357-0.0010%) does not exceed the intraspecific variability of S. m. malma. The analysis of the mtDNA haplotypes genealogy of charrs showed that the low values of nucleotide divergence reflect a short period from the beginning of divergence from the ancestral lineages and are due to ancestral polymorphism, as well as to haplotype exchange between the diverged phylogenetic groups as a result of introgressive hybridization.
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