This synthesis discusses the emissions of carbon dioxide from fossil-fuel combustion and cement production. While much is known about these emissions, there is still much that is unknown about the ...details surrounding these emissions. This synthesis explores our knowledge of these emissions in terms of why there is concern about them; how they are calculated; the major global efforts on inventorying them; their global, regional, and national totals at different spatial and temporal scales; how they are distributed on global grids (i.e., maps); how they are transported in models; and the uncertainties associated with these different aspects of the emissions. The magnitude of emissions from the combustion of fossil fuels has been almost continuously increasing with time since fossil fuels were first used by humans. Despite events in some nations specifically designed to reduce emissions, or which have had emissions reduction as a byproduct of other events, global total emissions continue their general increase with time. Global total fossil-fuel carbon dioxide emissions are known to within 10 % uncertainty (95 % confidence interval). Uncertainty on individual national total fossil-fuel carbon dioxide emissions range from a few percent to more than 50 %. This manuscript concludes that carbon dioxide emissions from fossil-fuel combustion continue to increase with time and that while much is known about the overall characteristics of these emissions, much is still to be learned about the detailed characteristics of these emissions.
We present atmospheric sulfur hexafluoride (SF6 ) mole fractions and emissions estimates from the 1970s to 2008. Measurements were made of archived air samples starting from 1973 in the Northern ...Hemisphere and from 1978 in the Southern Hemisphere, using the Advanced Global Atmospheric Gases Experiment (AGAGE) gas chromatographic-mass spectrometric (GC-MS) systems. These measurements were combined with modern high-frequency GC-MS and GC-electron capture detection (ECD) data from AGAGE monitoring sites, to produce a unique 35-year atmospheric record of this potent greenhouse gas. Atmospheric mole fractions were found to have increased by more than an order of magnitude between 1973 and 2008. The 2008 growth rate was the highest recorded, at 0.29 ± 0.02 pmolmol-1 yr-1 . A three-dimensional chemical transport model and a minimum variance Bayesian inverse method was used to estimate annual emission rates using the measurements, with a priori estimates from the Emissions Database for Global Atmospheric Research (EDGAR, version 4). Consistent with the mole fraction growth rate maximum, global emissions during 2008 were also the highest in the 1973-2008 period, reaching 7.4 ± 0.6 Gg yr-1 (1-σ uncertainties) and surpassing the previous maximum in 1995. The 2008 values follow an increase in emissions of 48 ± 20% since 2001. A second global inversion which also incorporated National Oceanic and Atmospheric Administration (NOAA) flask measurements and in situ monitoring site data agreed well with the emissions derived using AGAGE measurements alone. By estimating continent-scale emissions using all available AGAGE and NOAA surface measurements covering the period 2004-2008, with no pollution filtering, we find that it is likely that much of the global emissions rise during this five-year period originated primarily from Asian developing countries that do not report detailed, annual emissions to the United Nations Framework Convention on Climate Change (UNFCCC). We also find it likely that SF6 emissions reported to the UNFCCC were underestimated between at least 2004 and 2005.
In the context of recent discussions at the UN climate negotiations we compared several ways of calculating historical greenhouse gas (GHG) emissions, and assessed the effect of these different ...approaches on countries’ relative contributions to cumulative global emissions. Elements not covered before are: (i) including recent historical emissions (2000–2010), (ii) discounting historical emissions to account for technological progress; (iii) deducting emissions for ‘basic needs’; (iv) including projected emissions up to 2020, based on countries’ unconditional reduction proposals for 2020. Our analysis shows that countries’ contributions vary significantly based on the choices made in the calculation: e.g. the relative contribution of developed countries as a group can be as high as 80 % when excluding recent emissions, non-CO
2
GHGs, and land-use change and forestry CO
2
; or about 48 % when including all these emissions and discounting historical emissions for technological progress. Excluding non-CO
2
GHGs and land-use change and forestry CO
2
significantly changes relative historical contributions for many countries, altering countries’ relative contributions by multiplicative factors ranging from 0.15 to 1.5 compared to reference values (i.e. reference contribution calculations cover the period 1850-2010 and all GHG emissions). Excluding 2000–2010 emissions decreases the contributions of most emerging economies (factor of up to 0.8). Discounting historical emissions for technological progress reduces the relative contributions of some developed countries (factor of 0.8) and increases those of some developing countries (factor of 1.2–1.5). Deducting emissions for ‘basic needs’ results in smaller contributions for countries with low per capita emissions (factor of 0.3–0.5). Finally, including projected emissions up to 2020 further increases the relative contributions of emerging economies by a factor of 1.2, or 1.5 when discounting pre-2020 emissions for technological progress.
Abstract
Global greenhouse gas (GHG) emissions can be traced to five economic sectors: energy, industry, buildings, transport and AFOLU (agriculture, forestry and other land uses). In this topical ...review, we synthesise the literature to explain recent trends in global and regional emissions in each of these sectors. To contextualise our review, we present estimates of GHG emissions trends by sector from 1990 to 2018, describing the major sources of emissions growth, stability and decline across ten global regions. Overall, the literature and data emphasise that progress towards reducing GHG emissions has been limited. The prominent global pattern is a continuation of underlying drivers with few signs of emerging limits to demand, nor of a deep shift towards the delivery of low and zero carbon services across sectors. We observe a moderate decarbonisation of energy systems in Europe and North America, driven by fuel switching and the increasing penetration of renewables. By contrast, in rapidly industrialising regions, fossil-based energy systems have continuously expanded, only very recently slowing down in their growth. Strong demand for materials, floor area, energy services and travel have driven emissions growth in the industry, buildings and transport sectors, particularly in Eastern Asia, Southern Asia and South-East Asia. An expansion of agriculture into carbon-dense tropical forest areas has driven recent increases in AFOLU emissions in Latin America, South-East Asia and Africa. Identifying, understanding, and tackling the most persistent and climate-damaging trends across sectors is a fundamental concern for research and policy as humanity treads deeper into the Anthropocene.
In June 2015, China announced its post-2020 reduction targets, its central element being the intention to peak CO2 emissions by 2030 or earlier. China has implemented several policies to reduce its ...greenhouse gas (GHG) emissions. This study provides emission projections for China up to 2030 given current policies and a selected set of enhanced policies, and compares the results with projected CO2 emission trajectories that are consistent with the announced target for 2030. The projections are based on existing scenarios and energy system and land use model calculations. We project that the 2030 CO2 emission level consistent with a peak in CO2 emissions by 2030 ranges from 11.3 to 11.8 GtCO2. The corresponding total GHG emission level ranges from 13.5 to 14.0 GtCO2e in 2030. Current policies are likely not to be sufficient to achieve the 2030 targets, as our projected total GHG emission level under current policies ranges from 14.7 to 15.4 GtCO2e by 2030. However, an illustrative set of enhancement policy measures, all of which are related to national priorities, leads to projected GHG emission levels from 13.1 to 13.7 GtCO2e by 2030 – and thus below the levels necessary for peaking CO2 emissions before 2030.
•China has announced its intention to peak CO2 emissions by 2030 or earlier.•The peak in greenhouse gas emissions would reach 35–40% above 2010 levels.•Current policies are likely not to be sufficient to meet the announced 2030 target.•The expected emission levels reach about 50% above 2010 levels.•Our selected enhancement policy measures lead to peaking CO2 emissions before 2030.
Purpose
Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response ...to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urology met on February 21, 2020, in Amsterdam, The Netherlands, to formulate criteria for PSMA PET/CT-based response in patients treated for metastatic PCa and optimal timing to use it.
Methods
Panelists received thematic topics and relevant literature prior to the meeting. Statements on how to interpret response and progression on therapy in PCa with PSMA PET/CT and when to use it were developed. Panelists voted anonymously on a nine-point scale, ranging from strongly disagree (1) to strongly agree (9). Median scores described agreement and consensus.
Results
PSMA PET/CT consensus statements concerned utility, best timing for performing, criteria for evaluation of response, patients who could benefit, and handling of radiolabeled PSMA PET tracers. Consensus was reached on all statements. PSMA PET/CT can be used before and after any local and systemic treatment in patients with metastatic disease to evaluate response to treatment. Ideally, PSMA PET/CT imaging criteria should categorize patients as responders, patients with stable disease, partial response, and complete response, or as non-responders. Specific clinical scenarios such as oligometastatic or polymetastatic disease deserve special consideration.
Conclusions
Adoption of PSMA PET/CT should be supported by indication for appropriate use and precise criteria for interpretation. PSMA PET/CT criteria should categorize patients as responders or non-responders. Specific clinical scenarios deserve special consideration.
Abstract
Pseudomonas aeruginosa is a Gram-negative bacterium belonging to the γ-proteobacteria. Like other members of the Pseudomonas genus, it is known for its metabolic versatility and its ability ...to colonize a wide range of ecological niches, such as rhizosphere, water environments and animal hosts, including humans where it can cause severe infections. Another particularity of P. aeruginosa is its high intrinsic resistance to antiseptics and antibiotics, which is partly due to its low outer membrane permeability. In contrast to Enterobacteria, pseudomonads do not possess general diffusion porins in their outer membrane, but rather express specific channel proteins for the uptake of different nutrients. The major outer membrane ‘porin’, OprF, has been extensively investigated, and displays structural, adhesion and signaling functions while its role in the diffusion of nutrients is still under discussion. Other porins include OprB and OprB2 for the diffusion of glucose, the two small outer membrane proteins OprG and OprH, and the two porins involved in phosphate/pyrophosphate uptake, OprP and OprO. The remaining nineteen porins belong to the so-called OprD (Occ) family, which is further split into two subfamilies termed OccD (8 members) and OccK (11 members). In the past years, a large amount of information concerning the structure, function and regulation of these porins has been published, justifying why an updated review is timely.
Porins of Pseudomonas aeruginosa play numerous important functions and their expression seems to be highly regulated, reflecting their involvement in the bacterial adaptability to evolving environmental conditions.
CKD: A Call for an Age-Adapted Definition Delanaye, Pierre; Jager, Kitty J; Bökenkamp, Arend ...
Journal of the American Society of Nephrology,
10/2019, Letnik:
30, Številka:
10
Journal Article
Recenzirano
Odprti dostop
Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m
...This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that GFR declines with healthy aging without any overt signs of compensation (such as elevated single-nephron GFR) or kidney damage. Older living kidney donors, who are carefully selected based on good health, have a lower predonation GFR compared with younger donors. Furthermore, the results from the large meta-analyses conducted by the CKD Prognosis Consortium and from numerous other studies indicate that the GFR threshold above which the risk of mortality is increased is not consistent across all ages. Among younger persons, mortality is increased at GFR <75 ml/min per 1.73 m
, whereas in elderly people it is increased at levels <45 ml/min per 1.73 m
Therefore, we suggest that amending the CKD definition to include age-specific thresholds for GFR. The implications of an updated definition are far reaching. Having fewer healthy elderly individuals diagnosed with CKD could help reduce inappropriate care and its associated adverse effects. Global prevalence estimates for CKD would be substantially reduced. Also, using an age-specific threshold for younger persons might lead to earlier identification of CKD onset for such individuals, at a point when progressive kidney damage may still be preventable.
The rise and fall of novel renal magnesium transporters Schäffers, Olivier J M; Hoenderop, Joost G J; Bindels, René J M ...
American journal of physiology. Renal physiology,
06/2018, Letnik:
314, Številka:
6
Journal Article
Recenzirano
Odprti dostop
Body Mg
balance is finely regulated in the distal convoluted tubule (DCT), where a tight interplay among transcellular reabsorption, mitochondrial exchange, and basolateral extrusion takes place. In ...the last decades, several research groups have aimed to identify the molecular players in these processes. A multitude of proteins have been proposed to function as Mg
transporter in eukaryotes based on phylogenetic analysis, differential gene expression, and overexpression studies. However, functional evidence for many of these proteins is lacking. The aim of this review is, therefore, to critically reconsider all putative Mg
transporters and put their presumed function in context of the renal handling of Mg
. Sufficient experimental evidence exists to acknowledge transient receptor potential melastatin (TRPM) 6 and TRPM7, solute carrier family 41 (SLC41) A1 and SLC41A3, and mitochondrial RNA splicing 2 (MRS2) as Mg
transporters. TRPM6/7 facilitate Mg
influx, SLC41A1 mediates Mg
extrusion, and MRS2 and SLC41A3 are implicated in mitochondrial Mg
homeostasis. These proteins are highly expressed in the DCT. The function of cyclin M (CNNM) proteins is still under debate. For the other proposed Mg
transporters including Mg
transporter subtype 1 (MagT1), nonimprinted in Prader-Willi/Angelman syndrome (NIPA), membrane Mg
transport (MMgT), Huntingtin-interacting protein 14 (HIP14), and ATP13A4, functional evidence is limited, or functions alternative to Mg
transport have been suggested. Additional characterization of their Mg
transport proficiency should be provided before further claims about their role as Mg
transporter can be made.
Published data on the natural history of low-grade dysplasia (LGD) in Barrett's esophagus (BE) are inconsistent and difficult to interpret. We investigated the natural history of LGD in a large ...community-based cohort of BE patients after reviewing the original histological diagnosis by an expert panel of pathologists.
Histopathology reports of all patients diagnosed with LGD between 2000 and 2006 in six non-university hospitals were reviewed by two expert pathologists. This panel diagnosis was subsequently compared with the histological outcome during prospective endoscopic follow-up.
A diagnosis of LGD was made in 147 patients. After pathology review, 85% of the patients were downstaged to non-dysplastic BE (NDBE) or to indefinite for dysplasia. In only 15% of the patients was the initial diagnosis LGD. Endoscopic follow-up was carried out in 83.6% of patients, with a mean follow-up of 51.1 months. For patients with a consensus diagnosis of LGD, the cumulative risk of progressing to high-grade dysplasia or carcinoma (HGD or Ca) was 85.0% in 109.1 months compared with 4.6% in 107.4 months for patients downstaged to NDBE (P<0.0001). The incidence rate of HGD or Ca was 13.4% per patient per year for patients in whom the diagnosis of LGD was confirmed. For patients downstaged to NDBE, the corresponding incidence rate was 0.49%.
LGD in BE is an overdiagnosed and yet underestimated entity in general practice. Patients diagnosed with LGD should undergo an expert pathology review to purify this group. In case the diagnosis of LGD is confirmed, patients should undergo strict endoscopic follow-up or should be considered for endoscopic ablation therapy.
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