Purpose
Pheochromocytoma crisis is a life-threatening endocrine emergency that requires prompt diagnosis and treatment. Because of its rarity, sudden onset, and lack of internationally uniform and ...validated diagnostic criteria, pheochromocytoma crisis remains to be fully clarified. Therefore, we aimed to describe the clinical characteristics and outcomes of pheochromocytoma crisis through a literature review.
Methods
We performed a systematic literature search of PubMed/MEDLINE database, Igaku-Chuo-Zasshi (Japanese database), and Google Scholar to identify case reports of pheochromocytoma crisis published until February 5, 2021. Information was extracted and analyzed from the literature that reported adequate individual patient data of pheochromocytoma crisis in English or Japanese. Cases were also termed as pheochromocytoma multisystem crisis (PMC) if patients had signs of hyperthermia, multiple organ failure, encephalopathy, and labile blood pressure.
Results
In the 200 cases of pheochromocytoma crisis identified from 187 articles, the mean patient age was 43.8 ± 15.5 years. The most common symptom was headache (39.5%). The heart was the most commonly damaged organ resulting from a complication of a pheochromocytoma crisis (99.0%), followed by the lungs (44.0%) and the kidney (21.5%). PMC accounted for 19.0% of all pheochromocytoma crisis cases. After excluding 12 cases with unknown survival statuses, the mortality rate was 13.8% (26/188 cases). Multivariable logistic regression analysis revealed that nausea and vomiting were significantly associated with a higher mortality rate.
Conclusion
Pheochromocytoma can present with different symptomatology, affecting different organ systems. Clinicians should be aware that patients with nausea or vomiting are at a higher risk of death because of pheochromocytoma crisis.
Calpains, a family of Ca(2+)-dependent cytosolic cysteine proteases, can modulate their substrates' structure and function through limited proteolytic activity. In the human genome, there are 15 ...calpain genes. The most-studied calpains, referred to as conventional calpains, are ubiquitous. While genetic studies in mice have improved our understanding about the conventional calpains' physiological functions, especially those essential for mammalian life as in embryogenesis, many reports have pointed to overactivated conventional calpains as an exacerbating factor in pathophysiological conditions such as cardiovascular diseases and muscular dystrophies. For treatment of these diseases, calpain inhibitors have always been considered as drug targets. Recent studies have introduced another aspect of calpains that calpain activity is required to protect the heart and skeletal muscle against stress. This review summarizes the functions and regulation of calpains, focusing on the relevance of calpains to cardiovascular disease.
We present a new determination of the ultraviolet (UV) galaxy luminosity function (LF) at redshift z 7 and 8, and a first estimate at z 9. An accurate determination of the form and evolution of the ...galaxy LF during this era is of key importance for improving our knowledge of the earliest phases of galaxy evolution and the process of cosmic reionization. Our analysis exploits to the full the new, deepest Wide Field Camera 3/infrared imaging from our Hubble Space Telescope (HST) Ultra-Deep Field 2012 (UDF12) campaign, with dynamic range provided by including a new and consistent analysis of all appropriate, shallower/wider area HST survey data. Our new measurement of the evolving LF at z 7 to 8 is based on a final catalogue of 600 galaxies, and involves a step-wise maximum-likelihood determination based on the photometric redshift probability distribution for each object; this approach makes full use of the 11-band imaging now available in the Hubble Ultra-Deep Field (HUDF), including the new UDF12 F140W data, and the latest Spitzer IRAC imaging. The final result is a determination of the z 7 LF extending down to UV absolute magnitudes M
1500 = −16.75 (AB mag) and the z 8 LF down to M
1500 = −17.00. Fitting a Schechter function, we find M1500
* = −19.90+0.23
−0.28, log φ* = −2.96+0.18
−0.23 and a faint-end slope α = −1.90+0.14
−0.15 at z 7, and M1500* = −20.12+0.37
−0.48, log φ* = −3.35+0.28
−0.47 and α = −2.02+0.22
+0.23 at z 8. These results strengthen previous suggestions that the evolution at z > 7 appears more akin to 'density evolution' than the apparent 'luminosity evolution' seen at z 5 − 7. We also provide the first meaningful information on the LF at z 9, explore alternative extrapolations to higher redshifts, and consider the implications for the early evolution of UV luminosity density. Finally, we provide catalogues (including derived z
phot, M
1500 and photometry) for the most robust z ∼ 6.5-11.9 galaxies used in this analysis. We briefly discuss our results in the context of earlier work and the results derived from an independent analysis of the UDF12 data based on colour-colour selection.
Abstract
The hippocampus is functionally heterogeneous between the dorsal and ventral subfields with left–right asymmetry. To determine the possible location of contextual memory, we performed an ...inhibitory avoidance task to analyze synaptic plasticity using slice patch-clamp technique. The training bilaterally increased the AMPA/NMDA ratio at dorsal CA3–CA1 synapses, whereas the training did not affect the ratio at ventral CA3–CA1 synapses regardless of the hemisphere. Moreover, sequential recording of miniature excitatory postsynaptic currents and miniature inhibitory postsynaptic currents from the same CA1 neuron clearly showed learning-induced synaptic plasticity. In dorsal CA1 neurons, the training dramatically strengthened both excitatory and inhibitory postsynaptic responses in both hemispheres, whereas the training did not promote the plasticity in either hemisphere in ventral CA1 neurons. Nonstationary fluctuation analysis further revealed that the training bilaterally increased the number of AMPA or GABAA receptor channels at dorsal CA1 synapses, but not at ventral CA1 synapses, suggesting functional heterogeneity of learning-induced receptor mobility. Finally, the performance clearly impaired by the bilateral microinjection of plasticity blockers in dorsal, but not ventral CA1 subfields, suggesting a crucial role for contextual learning. The quantification of synaptic diversity in specified CA1 subfields may help us to diagnose and evaluate cognitive disorders at the information level.
•215 hyperscanning publications were found from 2000-2022 computing inter-brain coupling.•Throughout these 27 different methods used to compute IBC.•fNIRS and Wavelet coherence were the most commonly ...neuroimaging modality and method.
Hyperscanning is a form of neuroimaging experiment where the brains of two or more participants are imaged simultaneously whilst they interact. Within the domain of social neuroscience, hyperscanning is increasingly used to measure inter-brain coupling (IBC) and explore how brain responses change in tandem during social interaction. In addition to cognitive research, some have suggested that quantification of the interplay between interacting participants can be used as a biomarker for a variety of cognitive mechanisms aswell as to investigate mental health and developmental conditions including schizophrenia, social anxiety and autism. However, many different methods have been used to quantify brain coupling and this can lead to questions about comparability across studies and reduce research reproducibility. Here, we review methods for quantifying IBC, and suggest some ways moving forward. Following the PRISMA guidelines, we reviewed 215 hyperscanning studies, across four different brain imaging modalities: functional near-infrared spectroscopy (fNIRS), functional magnetic resonance (fMRI), electroencephalography (EEG) and magnetoencephalography (MEG). Overall, the review identified a total of 27 different methods used to compute IBC. The most common hyperscanning modality is fNIRS, used by 119 studies, 89 of which adopted wavelet coherence. Based on the results of this literature survey, we first report summary statistics of the hyperscanning field, followed by a brief overview of each signal that is obtained from each neuroimaging modality used in hyperscanning. We then discuss the rationale, assumptions and suitability of each method to different modalities which can be used to investigate IBC. Finally, we discuss issues surrounding the interpretation of each method.
The effect of graft-versus-host disease (GVHD) on transplant outcomes after unrelated cord blood transplantation (UCBT) has not been fully elucidated. We analyzed the impact of acute and chronic GVHD ...on outcomes in adult patients with acute leukemia or myelodysplastic syndrome who underwent their first UCBT (n=2558). The effect of GVHD on outcomes was analyzed after adjusting for other significant variables. The occurrence of GVHD was treated as a time-dependent covariate. The occurrence of grade 1-2 or 3-4 acute GVHD was significantly associated with a lower relapse rate. Grade 3-4 acute GVHD was associated with a higher risk of non-relapse and overall mortality than no acute GVHD, whereas grade 1-2 acute GVHD was associated with a lower risk of non-relapse and overall mortality than no acute GVHD. Limited or extensive chronic GVHD was significantly associated with a lower relapse rate. Limited chronic GVHD was associated with a lower overall and non-relapse mortality than no chronic GVHD. In conclusion, mild acute or chronic GVHD was associated not only with a low risk of relapse but also with a low risk of non-relapse mortality, and provides a survival benefit in UCBT.
Abstract
Using stacks of Lyα images of 2128 Lyα emitters (LAEs) and 24 proto-cluster UV-selected galaxies (LBGs) at z = 3.1, we examine the surface brightness profiles of Lyα haloes around high-z ...galaxies as a function of environment and UV luminosity. We find that the slopes of the Lyα radial profiles become flatter as the Mpc-scale LAE surface density increases, but that they are almost independent of the central UV luminosity. The characteristic exponential scalelength of the Lyα haloes appears to be proportional to the square of the LAE surface density (). Including the diffuse, extended Lyα haloes, the rest-frame Lyα equivalent width of the LAEs in the densest regions approaches EW
0 ∼ 200 Å, the maximum value expected for young (<107 yr) galaxies. This suggests that Lyα photons formed via shock compression by gas outflows or cooling radiation by gravitational gas inflows may partly contribute to the illumination of Lyα haloes; however, most of their Lyα luminosity can be explained by photoionization by or by scattering of Lyα photons produced from H ii regions in and around the central galaxies. Regardless of the source of Lyα photons, if the Lyα haloes trace the overall gaseous structure, following the dark matter distribution, it is not surprising that the Lyα spatial extent depends more strongly on the surrounding Mpc-scale environment than on the activity of the central galaxies.
We use the new ultra-deep, near-infrared imaging of the Hubble Ultra-Deep Field (HUDF) provided by our UDF12 Hubble Space Telescope (HST) Wide Field Camera 3/IR campaign to explore the rest-frame ...ultraviolet (UV) properties of galaxies at redshifts z > 6.5. We present the first unbiased measurement of the average UV power-law index, 〈β〉, (f
λ ∝ λβ) for faint galaxies at z 7, the first meaningful measurements of 〈β〉 at z 8, and tentative estimates for a new sample of galaxies at z 9. Utilizing galaxy selection in the new F140W (J
140) imaging to minimize colour bias, and applying both colour and power-law estimators of β, we find 〈β〉 = −2.1 ± 0.2 at z 7 for galaxies with M
UV −18. This means that the faintest galaxies uncovered at this epoch have, on average, UV colours no more extreme than those displayed by the bluest star-forming galaxies at low redshift. At z 8 we find a similar value, 〈β〉 = −1.9 ± 0.3. At z 9, we find 〈β〉 = −1.8 ± 0.6, essentially unchanged from z 6 to 7 (albeit highly uncertain). Finally, we show that there is as yet no evidence for a significant intrinsic scatter in β within our new, robust z 7 galaxy sample. Our results are most easily explained by a population of steadily star-forming galaxies with either solar metallicity and zero dust, or moderately sub-solar ( 10-20 per cent) metallicity with modest dust obscuration (A
V
0.1-0.2). This latter interpretation is consistent with the predictions of a state-of-the-art galaxy-formation simulation, which also suggests that a significant population of very-low metallicity, dust-free galaxies with β −2.5 may not emerge until M
UV > −16, a regime likely to remain inaccessible until the James Webb Space Telescope.
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