The activity towards superoxide anion radical (O
2
·−
) generated in an enzymatic model system upon reduction of nitro blue tetrazolium (NBT test), as well as during non-enzymatic oxidation of ...adrenaline in an alkaline media, was revealed for water-soluble quaternary ammonium salts bearing 2,6-di-
tert
-butylphenol and pyridine moiety. An increased activity of superoxide dismutase of the Russian sturgeon liver homogenate in the presence of these salts was found. A moderate Fe
2+
-chelating activity relative to the EDTA standard is characteristic of these salts. Their inhibitory effect was demonstrated in model systems of non-enzymatic oxidation of
cis
-octadec-9-enoic acid and lipids of the Russian sturgeon liver homogenate. The highest gross antioxidant activity was found for a water-soluble quaternary ammonium salt containing the
ortho
-pyridinyl moiety.
The antioxidant and cryoprotective efficiencies of a 3,5-di-tert-butyl-4-hydroxyphenyl)methylenediphosphonic acid (MDPA) differ significantly for sperm cells of various species of sturgeon fish ...(Russian sturgeon, beluga and Stellate sturgeon). The ability of phosphorus-containing phenol MDPA to decrease the level of lipid peroxidation of sperm, beneficial effect on the activity indicators of the sperm of native sturgeon and of the defrosted one after deep freezing as well as on the fertility of sperm cells was shown.
Baikal-GVD: status and prospects Avrorin, A.D.; Avrorin, A.V.; Aynutdinov, V.M. ...
EPJ Web of Conferences,
01/2018, Letnik:
191
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
Baikal-GVD is a next generation, kilometer-scale neutrino telescope under construction in Lake Baikal. It is designed to detect astrophysical neutrino fluxes at energies from a few TeV up to 100 PeV. ...GVD is formed by multi-megaton subarrays (clusters). The array construction started in 2015 by deployment of a reduced-size demonstration cluster named "Dubna" . The first cluster in it’s baseline configuration was deployed in 2016, the second in 2017 and the third in 2018. The full-scale GVD will be an array of ~10.000 light sensors with an instrumented volume about of 2 cubic km. The first phase (GVD-1) is planned to be completed by 2020-2021. It will comprise 8 clusters with 2304 light sensors in total. We describe the design of Baikal-GVD and present selected results obtained in 2015 - 2017.
A series of organotin complexes with Sn-S bonds of formulae Me2Sn(SR)2 (1); Et2Sn(SR)2 (2); (n-Bu)2Sn(SR)2 (3); Ph2Sn(SR)2 (4); R2Sn(SR)2 (5); Me3SnSR (6); Ph3SnSR (7) (R = ...3,5-di-tert-butyl-4-hydroxyphenyl) were synthesized and characterized by elemental analysis, (1)H, (13)C NMR, and IR. The crystal structures of compounds 1, 4, 5, and 7 were determined by X-ray diffraction analysis. The tetrahedral geometry around the Sn center in the monocrystals of 1, 4, 5, and 7 was confirmed by X-ray crystallography. The high radical scavenging activity of the complexes was confirmed spectrophotometrically in a DPPH-test. The binding affinity of 1-7 and the starting R2SnCl2 (8) towards tubulin through their interaction with SH groups of proteins was studied. It was found that the hindered organotin complexes could interact with the colchicine site of tubulin, which makes them promising antimitotic drugs. Compounds 1-8 were tested for their in vitro cytotoxicity against human breast (MCF-7) and human cervix (HeLa) adenocarcinoma cells. Complexes 1-8 were also tested against normal human fetal lung fibroblast cells (MRC-5). Complexes 2-4 and 8 exhibit significantly lower cytostatic activity against the normal MRC-5 cell line compared to the tumor cell lines MCF-7 and HeLa used. A high activity against both cell lines 250 nM (MCF-7) and 160 nM (HeLa) was determined for the triphenyltin complex 7 while the introduction of hindered phenol groups decreases the cytotoxicity of the complexes against normal cells.
The prototyping/early construction phase of the BAIKAL-GVD project Avrorin, A.D.; Avrorin, A.V.; Aynutdinov, V.M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2014, Letnik:
742
Journal Article
Recenzirano
Odprti dostop
The prototyping phase of the BAIKAL-GVD project has been started in April 2011 with the deployment of a three string engineering array which comprises all basic elements and systems of the Gigaton ...Volume Detector (GVD) in Lake Baikal. In April 2012 the version of engineering array which comprises the first full-scale string of the GVD demonstration cluster had been deployed and operated during 2012. The first stage of the GVD-cluster which consists of three strings was deployed in April 2013. We review the prototyping phase of the BAIKAL-GVD project and describe the configuration and design of the 2013 engineering array.
The Advanced Laser Interferometer Gravitational-Wave Observatory and Advanced Virgo observatories recently discovered gravitational waves from a binary neutron star inspiral. A short gamma-ray burst ...that followed the merger of this binary was also recorded by Fermi gamma-ray burst monitor and International Gamma-Ray Astrophysics Laboratory, indicating particle acceleration by the source. The precise location of the event was determined by optical detections of emission following the merger. We searched for high-energy neutrinos from the merger in the energy range of 1 TeV–100 PeV using the Baikal Gigaton Volume Detector. No neutrinos directionally coincident with the source were detected within ±500 s around the merger time, as well as during a 14-day period after the gravitational wave detection. We derived 90% C.L. upper limits on the neutrino fluence from GW170817 during a ±500 s window centered on the gravitational wave trigger time, and a 14-day window following the gravitational wave signal under the assumption of an
E
−2
neutrino energy spectrum.
A cryoprotective effect of an addition of a new synthetic antioxidant – a representative of phosphorus-containing sterically hindered phenols is presented. The efficiency of the compound was shown to ...exceed the effect of lipid-soluble antioxidants butylated hydroxytoluene (BHT) and trolox in the conditions of cryopreservation of beluga sperm in the presence of the modified Stein’s medium. It was shown that the level of carbonyl oxidation by-products, which can react with thiobarbituric acid (TBARS), in beluga sperm was inversely proportional to the motility time of sperm cells. The fertility of beluga sperm increased 2 times upon the addition of phosphorus-containing phenol to a modified Stein’s medium. The prospects of the new antioxidant application to improve cryoresistance of beluga sperm in the conditions of cryopreservation for its efficient protection from the peroxidation processes are discussed.
This consensus reviewed the main current issues of clinical application and integration into everyday practice of a new targeted preventive therapy for migraine using monoclonal antibodies (mAbs) to ...the calcitonin gene related peptide (CGRP) ligand or receptor. These recommendations are based on current scientific and clinical studies and an analysis of the results of several years of clinical use. The main purpose of the consensus is to assist practitioners in prescribing effective prophylactic treatment of migraine using anti-CGRP mAbs and to improve care for patients with various forms of the disease.
Recommendations for the diagnosis and treatment of migraine based on the principles of evidence-based medicine are presented. The latest edition of the International Classification of Migraine is ...provided. Diagnostic methods and criteria are oriented to discriminating different types of migraine. Recommendations are given on the basis of data on the epidemiology and pathophysiological mechanisms of migraine. The most effective medication-based and non-medication-based approaches to the management of migraine patients are discussed.
1-(3,5-Di-
tert
-butyl-4-hydroxyphenyl)propane-1,2-dione dioxime and 3,5-di-
tert
-butyl-4-hydroxybenzohydrazide showed a high antioxidant efficiency in comparison to the known inhibitors ...2,6-di-tertbutylphenol, 2,6-di-
tert
-butyl-4-mercaptophenol, and 2,6-di-tert-butyl-4-methylphenol (BHT), in model nonenzymatic human erythrocyte membrane lipid peroxidation.
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