In this study, researchers describe the clinical characteristics of coronavirus disease 2019 in a selected cohort of 1099 patients with laboratory-confirmed disease throughout mainland China during ...the first 2 months of the current outbreak.
Abstract
The multicomponent reactions of quinoxalin‐2(1
H
)‐ones has attracted considerable interest due to their significant biological and chemical activities. The very recent advances (from 2021 ...to the beginning of 2023) on the radical three‐component cascade reaction of quinoxalin‐2(1
H
)‐one derivatives at the C3 position were summarized in this mini‐review. According to the kind of radical types involved, some representative examples and detailed reaction mechanism have been categorized and discussed.
The red front was covered by Figure 1.
Current X-ray imaging technologies involving flat-panel detectors have difficulty in imaging three-dimensional objects because fabrication of large-area, flexible, silicon-based photodetectors on ...highly curved surfaces remains a challenge
. Here we demonstrate ultralong-lived X-ray trapping for flat-panel-free, high-resolution, three-dimensional imaging using a series of solution-processable, lanthanide-doped nanoscintillators. Corroborated by quantum mechanical simulations of defect formation and electronic structures, our experimental characterizations reveal that slow hopping of trapped electrons due to radiation-triggered anionic migration in host lattices can induce more than 30 days of persistent radioluminescence. We further demonstrate X-ray luminescence extension imaging with resolution greater than 20 line pairs per millimetre and optical memory longer than 15 days. These findings provide insight into mechanisms underlying X-ray energy conversion through enduring electron trapping and offer a paradigm to motivate future research in wearable X-ray detectors for patient-centred radiography and mammography, imaging-guided therapeutics, high-energy physics and deep learning in radiology.
A new, simple and sensitive fluorescence strategy was developed for the trypsin assay based on copper nanoparticles (CuNPs) and its different fluorescence response toward trypsin-catalyzed hydrolysis ...of cytochrome c (Cyt c). Polythymine (poly T)-templated CuNPs served as effective fluorescent probes. Cyt c is well-known to act as a quencher. However, herein, a low concentration of Cyt c was designed specially to act as the substrate of trypsin to avoid the quenching effects by electron transfer from Cyt c to CuNPs. In the presence of trypsin, Cyt c hydrolyzes to small peptides, releasing free cysteine residues. Nonfluorescent coordination complexes were formed upon exposure to free cysteine residues by a metal-ligand bond between Cu atoms and sulfur atoms, leading to a decreased fluorescence response to CuNPs. This novel method for the quantitative determination of trypsin has a linear detection range from 0.25 μg mL
−1
to 1000 μg mL
−1
and a relatively low detection limit of 42 ng mL
−1
. To the best of our knowledge, this is the first application of the trypsin-catalyzed hydrolysis reaction of Cyt c to produce quenching effect in bioanalysis, which provided a novel approach for the biochemical sensing strategy.
A novel fluorescence assay for trypsin was developed based on trypsin-catalyzed hydrolysis of cytochrome c-induced fluorescence quenching of CuNPs.
With both ferrocene and air as the redox catalysts, for the first time, the low-cost natural ilmenite (FeTiO3) was successfully used for photocatalytic bond formations. Under the assistance of a ...traceless H-bond, and HCHO as the methylene reagent, a variety of imidazo1,5-aquinoxalinones were semi-heterogeneously photosynthesized in high yields with good functional group compatibility.
Aptamer-based rolling circle amplification (aptamer-RCA) was developed as a novel versatile electrochemical platform for ultrasensitive detection of protein. This method utilized antibodies ...immobilized on the electrode surface to capture the protein target, and the surface-captured protein was then sandwiched by an aptamer−primer complex. The aptamer−primer sequence mediated an in situ RCA reaction that generated hundreds of copies of a circular DNA template. Detection of the amplified copies via enzymatic silver deposition then allowed enormous sensitivity enhancement in the assay of target protein. This novel aptamer−primer design circumvented time-consuming preparation of the antibody−DNA conjugate for the common immuno-RCA assay. Moreover, the detection strategy based on enzymatic silver deposition enabled a highly efficient readout of the RCA product as compared to a redox-labeled probe based procedure that might exhibit low detection efficiency due to RCA product distance from the electrode. With the platelet-derived growth factor B-chain (PDGF-BB) as a model target, it was demonstrated that the presented method was highly sensitive and specific with a wide detection range of 4 orders of magnitude and a detection limit as low as 10 fM. Because of the wide availability of aptamers for numerous proteins, this platform holds great promise in ultrasensitive immunoassay.
Abstract Ceramsite was made from sludge, phosphogypsum, and red mud and then modified with different concentrations of hydrochloric, nitric, or citric acid. The resulting composite ceramsite was ...subsequently utilized for the adsorption of Pb(II). The maximum adsorption capacities of hydrochloric acid– and nitric acid–modified ceramsites were 90.38 and 88.57 mg/g, respectively, which were much higher than those of unmodified ceramsite (66.86 mg/g) and citric acid–modified ceramsite (57.85 mg/g). The variation of isoelectric point, acidic and basic groups, and Fourier transform infrared spectra of ceramsite were compared before and after adsorption. A decrease of isoelectric point implied weakening of electrostatic repulsion between Pb(II) and the modified ceramsite. Functional groups, such as O─H, C═O (or C═C), and Si─O─Si (or Al─O─Al), were involved in the adsorption. In addition, phenol hydroxyl, which exhibited a significant increase in modified ceramsite and a noticeable decrease after adsorption, was the most important group. Besides, the modified ceramsite had larger specific surface areas and pores (30.66 g/m 2 , .11256 cm 3 /g), more functional groups, and lower isoelectric points (8.57), which were favorable for adsorption. The adsorption processes described by pseudo‐second‐order kinetics were controlled by chemical adsorptions. Isothermal studies indicated that monolayer adsorption occurred on hydrochloric acid–modified ceramsite and multiple processes occurred on nitric acid– and citric acid–modified ceramsites. Thermodynamic analysis confirmed Pb(II) adsorption on modified ceramsite was spontaneous and endothermic.
Abstract Dense outflowing gas, traced by transitions of molecules with large dipole moment, is important for understanding mass loss and feedback of massive star formation. HCN 3-2 and HCO + 3-2 are ...good tracers of dense outflowing molecular gas, which are closely related to active star formation. In this study, we present on-the-fly mapping observations of HCN 3-2 and HCO + 3-2 toward a sample of 33 massive star-forming regions using the 10-m Submillimeter Telescope. With the spatial distribution of line wings of HCO + 3-2 and HCN 3-2, outflows are detected in 25 sources, resulting in a detection rate of 76%. The optically thin H 13 CN and H 13 CO + 3-2 lines are used to identify line wings as outflows and estimate core mass. The mass M out , momentum P out , kinetic energy E K , force F out , and mass-loss rate M ̇ out of outflow and core mass, are obtained for each source. A sublinear tight correlation is found between the mass of dense molecular outflow and core mass, with an index of ∼0.8 and a correlation coefficient of 0.88.
Reaction of silver nitrate with 2‐aminobenzothiazole (abbreviated as Habt) in methanol at 45°C gave mononuclear complex of formula Ag (Habt)2NO3•CH3OH. The structure of the complex was characterized ...by infrared (IR) spectra, single crystal X‐ray diffraction, and elemental analysis. X‐ray diffraction analysis indicated that the title complex was crystallized in the triclinic crystal system with space group P–1, in which silver(I) ion was coordinated to two 2‐aminobenzothiazole ligands through the benzothiazol nitrogen atom. Theoretical study of the complex was carried out by density functional theory (DFT) B3LYP method. The antimicrobial effects of the ligand and its silver(I) complex were evaluated by bio‐microcalorimetry on the growth of Schizosaccharomyces pombe (S. pombe). Some quantitative metabolic parameters, such as growth rate constant (k), maximum heat power (Pmax), inhibition ratio (I), and half inhibition concentration (IC50), were derived from the metabolic power–time curves of S. pombe growth. The half inhibition concentration (IC50) of the ligand was calculated to be 2.58 × 10−3 mol L−1. The complex could strongly influence the lag phase of S. pombe.
A silver(I) 2‐aminobenzothiazole complex was prepared and characterized by single crystal X‐ray diffraction. Highest Occupied Molecular Orbital–Lowest Unoccupied Molecular Orbital (HOMO–LUMO) energy gap of the complex is 5.57 eV, which is little larger than that of the ligand (5.43 eV). The inhibitory concentration of the complex is much lower than that of the ligand, and the complex can strongly influence the lag phase of bacteria.
Aim
To explore and improve nursing care for infants after enterostomy.
Methods
A total of 483 infants who underwent enterostomy from January 2014 to January 2019 were enrolled in this study.
Results
...During hospitalization and follow‐up, there were 30 infants with peripheral skin complications, including 15 cases of allergic dermatitis, 13 cases of faecal dermatitis and two cases of avulsion injury.
Conclusion
Without proper and effective nursing care, the peripheral skin complications of enterostomy‐related can easily develop. Therefore, careful postoperative care and effective family follow‐up and guidance are essential after discharge, and using WeChat to follow‐up can provide timely and effective follow‐up and guidance to patients.
Implications for Nursing Management
This study summarizes the experience of nursing care for infants over a 5‐year period. Nurses must provide sound care for infants after enterostomy, timely and effectively address complications, guide nursing care performed by family members and strengthen follow‐up through the WeChat online support group to reduce the occurrence of complications.
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