Surface tension measurements are a central task in the study of surfaces and interfaces. For liquid metals, they are complicated by the high temperatures and the consequently high reactivity ...characterising these melts. In particular, oxidation of the liquid surface in combination with evaporation phenomena requires a stringent control of the experimental conditions, and an appropriate theoretical treatment. Recently, much progress has been made on both sides. In addition to improving the conventional sessile drop technique, new containerless methods have been developed for surface tension measurements. This paper reviews the experimental progress made in the last few years, and the theoretical framework required for modelling and understanding the relevant physico-chemical surface phenomena.
We report, for the first time, the long-awaited detection of diffuse gamma rays with energies between 100 TeV and 1 PeV in the Galactic disk. Particularly, all gamma rays above 398 TeV are observed ...apart from known TeV gamma-ray sources and compatible with expectations from the hadronic emission scenario in which gamma rays originate from the decay of π^{0}'s produced through the interaction of protons with the interstellar medium in the Galaxy. This is strong evidence that cosmic rays are accelerated beyond PeV energies in our Galaxy and spread over the Galactic disk.
While complex physiological mechanisms exist to regulate and optimize tissue oxygenation under various conditions, clinical and experimental evidence indicates that anaemia, unchecked, is associated ...with organ injury and unfavourable outcomes. More data (especially from human studies) are needed to answer questions regarding the optimal approaches to the treatment of acute and chronic anaemia. Meantime, allogeneic blood transfusions remain the most common treatment, particularly in surgical/trauma patients and those with moderate-to-severe anaemia. Clinical studies emphasize the paradox that both anaemia and transfusion are associated with organ injury and increased morbidity and mortality across a wide span of disease states and surgical interventions. Further characterization of the mechanisms of injury is needed to appropriately balance these risks and to develop novel treatment strategies that will improve patient outcomes. Here, we present the current understanding of the physiological mechanisms of tissue oxygen delivery, utilization, adaptation, and survival in the face of anaemia and current evidence on the independent (and often, synergistic) deleterious impact of anaemia and transfusion on patient outcomes. The risks of anaemia and transfusion in the light of substantial variations in transfusion practices, increasing costs, shrinking pool of donated resources, and ambiguity about actual clinical benefits of banked allogeneic blood demand better management strategies targeted at improving patient outcomes.
Background and objectives
Fresh frozen plasma (FFP) usage has significantly increased over the last decade leading to elevated healthcare costs. Although FFP is used in several clinical settings, it ...is often inappropriately transfused and evidence for its clinical efficacy is poor. Here, we describe plasma usage and transfusion costs in a real‐world US inpatient setting to determine the cost‐effectiveness of FFP transfusion and for comparison to various patient blood management (PBM) options to treat coagulopathies.
Materials and methods
All activities related to plasma transfusion recorded at a single US hospital over one calendar year were collected in a stepwise manner using an activity‐based costing (ABC) methodology. This model maps all technical, administrative and clinical processes inherent to the cost of plasma.
Results
Of 18 200 inpatients recorded, 849 were charged for blood products. In total, 136 medical and surgical inpatients were charged for 577 units of FFP, receiving a total of 534 units; 43 units were charged but not transfused. The total cost per unit of FFP transfused was $409·62 and $1,608·37 per patient transfused with FFP. Wasted products, in‐hospital processes and overhead costs were found to account for 89·8% of the total cost of FFP transfusions.
Conclusion
This study is the first to use ABC methodology to determine the full cost of plasma transfusion in a US inpatient setting. These data reveal the true cost of plasma, providing a useful reference point to compare with the cost of other PBM options to manage coagulation disorders.
The Telescope Array (TA) observatory utilizes fluorescence detectors and surface detectors (SDs) to observe air showers produced by ultra high energy cosmic rays in Earth's atmosphere. Cosmic-ray ...events observed in this way are termed hybrid data. The depth of air shower maximum is related to the mass of the primary particle that generates the shower. This paper reports on shower maxima data collected over 8.5 yr using the Black Rock Mesa and Long Ridge fluorescence detectors in conjunction with the array of SDs. We compare the means and standard deviations of the observed X max distributions with Monte Carlo X max distributions of unmixed protons, helium, nitrogen, and iron, all generated using the QGSJet II-04 hadronic model. We also perform an unbinned maximum likelihood test of the observed data, which is subjected to variable systematic shifting of the data X max distributions to allow us to test the full distributions, and compare them to the Monte Carlo to see which elements are not compatible with the observed data. For all energy bins, QGSJet II-04 protons are found to be compatible with TA hybrid data at the 95% confidence level after some systematic X max shifting of the data. Three other QGSJet II-04 elements are found to be compatible using the same test procedure in an energy range limited to the highest energies where data statistics are sparse.
Shergottites and Chassignites practiced major deformation effects whose nature, magnitude and relevance were controversially evaluated and disputatively debated. Our studies of many shocked ...shergottites present, contrary to numerous previous reports, ample evidence for pervasive shock-induced melting amounting of at least 23vol.% of the shergottite consisting of maskelynite and pyrrhotite, partial melting of pyroxene, titanomagnetite, ilmenite and finding of several high-pressure polymorphs and pressure-induced dissociation reactions. Our results cast considerable doubt on using the refractive index (RI) or cathodoluminescence (CL) spectra of maskelynite, in estimating the magnitudes of peak-shock pressure in both shergottites and ordinary chondrites. RI of maskelynite was set after quenching of the feldspar liquid before decompression to maskelynite glass followed by glass relaxation after decompression at the closure temperature of relaxation. The RI procedure widely practiced in the past 38years revealed unrealistic very high-pressure estimates discrepant with the high-pressure mineral inventory in shocked shergottites and ordinary chondrites and with results obtained by robust laboratory static experiments. Shergottites contain the silica high-pressure polymorphs: the scrutinyite-structured polymorph seifertite, a monoclinic ultra dense polymorph of silica with ZrO2-structure, stishovite, a dense liquidus assemblage consisting of stishovite+Na-hexa-aluminosilicate (Na-CAS) and both K-lingunite and Ca-lingunite. Applying individual high-pressure silica polymorphs alone like stishovite, to estimate the equilibrium shock pressure, is inadequate due to the considerable shift of their nominal upper pressure bounds intrinsically induced by spatially variable absorptions of minor oxides like Al2O3, Na2O, FeO, MgO and TiO2. This practice revealed variable pressure estimates even within the same shergottite subjected to the same peak-shock pressure. Occurrence of Na-CAS+stishovite, lack of the NaAlSiO4 Ca-ferrite structured polymorph or jadeite indicates that the peak-shock pressures barely exceeded 22GPa. We present convincing and ample evidence refuting the claim that the shock-induced high-pressure inventory in shergottites and ordinary chondrites are disequilibrium assemblages resulted from local pressure spikes in excess of 80GPa and during the decompression stage. Such scenario calls for a series of incomplete and quenched retrograde reactions starting with the crystallization of Mg–silicate perovskite+magnesiowüstite, if the claimed peak-shock pressure was in excess of 80GPa. This would be followed by replacement of this pair by majorite-pyropess+magnesiowüstite or akimotoite+magnesiowüstite below 23GPa and 2000°C, polycrystalline ringwoodite above 16GPa, respectively and finally replacement by polycrystalline olivine below 16GPa. Such incomplete retrograde reactions were never encountered in any shergottite, chassignite or shocked ordinary chondrite so far. Olivine–ringwoodite phase transformation in the L6 Y-791384 commences with the coherent mechanism producing ringwoodite lamellae with their (111) planes parallel to the (100) of olivine followed by the incoherent mechanism due to build up of strain in the parental olivine. This is in accord with the olivine–ringwoodite settings produced in static laboratory experiments in a multi-anvil device. Olivine–ringwoodite phase transitions were also encountered in comparable settings in the shergottite NWA 1068. Application of experimentally obtained kinetic parameters of the olivine–ringwoodite phase transitions reveals possible duration of the natural dynamic events up to few seconds thus unambiguously refuting the claimed disequilibrium decompression mechanism.
The shock-induced pervasive melting of labradorite, pyrrhotite, titanomagnetite, ilmenite and partial melting of clinopyroxene strongly suggests shock-induced partial to complete resetting of the Ar–Ar, Rb–Sr, Sm–Nd, Re–Os, U–Pb and Lu–Hf radiometric systems. This also casts considerable doubt on the radiometric ages shorter than 575Ma reported in the past 38years to allegedly be the igneous crystallization ages. These short ages probably resulted from partial or total shock-induced age resetting.
In this paper, we present the measurement of the energy spectra of carbon and oxygen in cosmic rays based on observations with the Calorimetric Electron Telescope on the International Space Station ...from October 2015 to October 2019. Analysis, including the detailed assessment of systematic uncertainties, and results are reported. The energy spectra are measured in kinetic energy per nucleon from 10 GeV/n to 2.2 TeV/n with an all-calorimetric instrument with a total thickness corresponding to 1.3 nuclear interaction length. The observed carbon and oxygen fluxes show a spectral index change of ∼0.15 around 200 GeV/n established with a significance > 3σ. They have the same energy dependence with a constant C/O flux ratio 0.911 ± 0.006 above 25 GeV/n. The spectral hardening is consistent with that measured by AMS-02, but the absolute normalization of the flux is about 27% lower, though in agreement with observations from previous experiments including the PAMELA spectrometer and the calorimetric balloon-borne experiment CREAM.
Flaxseed lignan secoisolariciresinol diglucoside (SDG) has been reported to prevent and alleviate lifestyle-related diseases including diabetes and hypercholesterolaemic atherosclerosis. This study ...assesses the effect of SDG on the development of diet-induced obesity in mice and the effect of the SDG metabolite enterodiol (END) on adipogenesis in 3T3-L1 adipocytes. We compared body weight, visceral fat weight, liver fat content, serum parameters, mRNA levels of lipid metabolism-related enzymes and adiponectin in mice fed either a low-fat diet (5 % TAG), high-fat diet (30 % TAG) or high-fat diet containing 0·5 and 1·0 % (w/w) SDG for 4 weeks. Administration of SDG to mice significantly reduced high-fat diet-induced visceral and liver fat accumulation, hyperlipaemia, hypercholesterolaemia, hyperinsulinaemia and hyperleptinaemia. SDG also suppressed sterol regulatory element binding protein 1c mRNA level in the liver and induced increases in the adiponectin mRNA level in the white adipose tissue and carnitine palmitoyltransferase I mRNA level in the skeletal muscle. Differentiated 3T3-L1 adipocytes were treated with 0, 5, 10 and 20 μmol/l END and then assayed for mRNA expression of adipogenesis-related genes and DNA binding activity of PPARγ to the PPAR response element consensus sequence. END induced adipogenesis-related gene mRNA expression including adiponectin, leptin, glucose transporter 4 and PPARγ, and induced PPARγ DNA binding activity in 3T3-L1 adipocytes. In conclusion, SDG induced adiponectin mRNA expression and showed beneficial effects on lipid metabolism in diet-induced obesity in mice. Flaxseed lignans are suggested to regulate adipogenesis-related gene expressions through an increase in PPARγ DNA binding activity.
Bilateral control systems are strongly required to apply to endoscopic surgeries. It is necessary that the system has enough degrees of freedom for applying various operation procedures including ...endoscopic surgery. When the degrees of freedom of the system are increased, the amount of control calculation is also increased, and it is hard to keep sampling periods short. The bilateral control systems, however, require comparatively shorter sampling periods, particularly the control system based on an acceleration control system. Hence, it is a difficult issue to increase the degrees of freedom of the bilateral control system. In this paper, the sampling period is kept short in the multidegree of freedom system by using field programmable gate arrays as processors. The bilateral control system based on the acceleration control system is implemented in a robot system, which has 12 DOF, and some experimental results are shown, and the errors between the response of the master and slave robots are discussed.
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