The New Horizons spacecraft's encounter with the cold classical Kuiper Belt object (486958) Arrokoth (provisional designation 2014 MU
) revealed a contact-binary planetesimal. We investigated how ...Arrokoth formed and found that it is the product of a gentle, low-speed merger in the early Solar System. Its two lenticular lobes suggest low-velocity accumulation of numerous smaller planetesimals within a gravitationally collapsing cloud of solid particles. The geometric alignment of the lobes indicates that they were a co-orbiting binary that experienced angular momentum loss and subsequent merger, possibly because of dynamical friction and collisions within the cloud or later gas drag. Arrokoth's contact-binary shape was preserved by the benign dynamical and collisional environment of the cold classical Kuiper Belt and therefore informs the accretion processes that operated in the early Solar System.
The New Horizons spacecraft flew past the Kuiper Belt object (486958) Arrokoth (also known as 2014 MU69) in January 2019. Because of the great distance to the outer Solar System and limited ...bandwidth, it will take until late 2020 to downlink all the spacecraft's observations back to Earth. Three papers in this issue analyze recently downlinked data, including the highest-resolution images taken during the encounter (see the Perspective by Jewitt). Spencer et al. examined Arrokoth's geology and geophysics using stereo imaging, dated the surface using impact craters, and produced a geomorphological map. Grundy et al. investigated the composition of the surface using color imaging and spectroscopic data and assessed Arrokoth's thermal emission using microwave radiometry. McKinnon et al. used simulations to determine how Arrokoth formed: Two gravitationally bound objects gently spiraled together during the formation of the Solar System. Together, these papers determine the age, composition, and formation process of the most pristine object yet visited by a spacecraft.
We report new constraints on the local escape speed of our Galaxy. Our analysis is based on a sample of high-velocity stars from the RAVE survey and two previously published data sets. We use ...cosmological simulations of disc galaxy formation to motivate our assumptions on the shape of the velocity distribution, allowing for a significantly more precise measurement of the escape velocity compared to previous studies. We find that the escape velocity lies within the range 498 < vesc < 608 km s−1 (90 per cent confidence), with a median likelihood of 544 km s−1. The fact that v2esc is significantly greater than 2v2circ (where vcirc= 220 km s−1 is the local circular velocity) implies that there must be a significant amount of mass exterior to the solar circle, that is, this convincingly demonstrates the presence of a dark halo in the Galaxy. We use our constraints on vesc to determine the mass of the Milky Way halo for three halo profiles. For example, an adiabatically contracted NFW halo model results in a virial mass of 1.42+1.14−0.54× 1012 M⊙ and virial radius of (90 per cent confidence). For this model the circular velocity at the virial radius is 142+31−21 km s−1. Although our halo masses are model dependent, we find that they are in good agreement with each other.
Microfluidics has emerged rapidly over the past 20 years and has been investigated for a variety of applications from life sciences to environmental monitoring. Although continuous-flow microfluidics ...is ubiquitous, segmented-flow or droplet microfluidics offers several attractive features. Droplets can be independently manipulated and analyzed with very high throughput. Typically, microfluidics is carried out within planar networks of microchannels, namely, microfluidic chips. We propose that fibers offer an interesting alternative format with key advantages for enhanced optical coupling. Herein, we demonstrate the generation of monodisperse droplets within a uniaxial optofluidic Lab-in-a-Fiber scheme. We combine droplet microfluidics with laser-induced fluorescence (LIF) detection achieved through the development of an optical side-coupling fiber, which we term a periscope fiber. This arrangement provides stable and compact alignment. Laser-induced fluorescence offers high sensitivity and low detection limits with a rapid response time making it an attractive detection method for in situ real-time measurements. We use the well-established fluorophore, fluorescein, to characterize the Lab-in-a-Fiber device and determine the generation of Formula: see text 0.9 nL droplets. We present characterization data of a range of fluorescein concentrations, establishing a limit of detection (LOD) of 10 nM fluorescein. Finally, we show that the device operates within a realistic and relevant fluorescence regime by detecting reverse-transcription loop-mediated isothermal amplification (RT-LAMP) products in the context of COVID-19 diagnostics. The device represents a step towards the development of a point-of-care droplet digital RT-LAMP platform.
We use data from the Radial Velocity Experiment (RAVE) and the Tycho-Gaia astrometric solution (TGAS) catalogue to compute the velocity fields yielded by the radial (V-R), azimuthal (V-phi), and ...vertical (V-z) components of associated Galactocentric velocity. We search in particular for variation in all three velocity components with distance above and below the disc midplane, as well as how each component of V-z (line-of-sight and tangential velocity projections) modifies the obtained vertical structure. To study the dependence of velocity on proper motion and distance, we use two main samples: a RAVE sample including proper motions from the Tycho-2, PPMXL, and UCAC4 catalogues, and a RAVE-TGAS sample with inferred distances and proper motions from the TGAS and UCAC5 catalogues. In both samples, we identify asymmetries in V-R and V-z. Below the plane, we find the largest radial gradient to be partial derivative V-R/partial derivative R = -7.01 +/- 0.61 km s(-1) kpc(-1), in agreement with recent studies. Above the plane, we find a similar gradient with partial derivative V-R/partial derivative R = -9.42 +/- 1.77 km s(-1) kpc(-1). By comparing our results with previous studies, we find that the structure in V-z is strongly dependent on the adopted proper motions. Using the Galaxia Milky Way model, we demonstrate that distance uncertainties can create artificial wave-like patterns. In contrast to previous suggestions of a breathing mode seen in RAVE data, our results support a combination of bending and breathing modes, likely generated by a combination of external or internal and external mechanisms.
The RAdial Velocity Experiment survey, combined with proper motions and distance estimates, can be used to study in detail stellar kinematics in the extended solar neighbourhood (solar suburb). Using ...72 365 red-clump stars, we examine the mean velocity components in 3D between 6 < R < 10 kpc and −2 < Z < 2 kpc, concentrating on north-south differences. Simple parametric fits to the (R, Z) trends for V
φ and the velocity dispersions are presented. We confirm the recently discovered gradient in mean Galactocentric radial velocity, V
R, finding that the gradient is marked below the plane (δ〈V
R〉/δR = −8 km s−1 kpc−1 for Z < 0, vanishing to zero above the plane), with a Z gradient thus also present. The vertical velocity, V
Z
, also shows clear, large-amplitude (|V
Z
| = 17 km s−1) structure, with indications of a rarefaction-compression pattern, suggestive of wave-like behaviour. We perform a rigorous error analysis, tracing sources of both systematic and random errors. We confirm the north-south differences in V
R and V
Z
along the line of sight, with the V
R estimated independent of the proper motions. The complex three-dimensional structure of velocity space presents challenges for future modelling of the Galactic disc, with the Galactic bar, spiral arms and excitation of wave-like structures all probably playing a role.
We present chemical elemental abundances for 36,561 stars observed by the RAdial Velocity Experiment (RAVE), an ambitious spectroscopic survey of our Galaxy at Galactic latitudes |b| > 25? and with ...magnitudes in the range 9 DENIS <13. RAVE spectra cover the Ca-triplet region at 8410-8795 A with resolving power R ~ 7500. This first data release of the RAVE chemical catalog is complementary to the third RAVE data release of radial velocities and stellar parameters, and it contains chemical abundances for the elements Mg, Al, Si, Ca, Ti, Fe, and Ni, with a mean error of ~0.2 dex, as judged from accuracy tests performed on synthetic and real spectra. Abundances are estimated through a dedicated processing pipeline in which the curve of growth of individual lines is obtained from a library of absorption line equivalent widths to construct a model spectrum that is then matched to the observed spectrum via a Delta *y2 minimization technique. We plan to extend this pipeline to include estimates for other elements, such as oxygen and sulfur, in future data releases.
We use the kinematics of ∼200 000 giant stars that lie within ∼1.5 kpc of the plane to measure the vertical profile of mass density near the Sun. We find that the dark mass contained within the ...isodensity surface of the dark halo that passes through the Sun ((6 ± 0.9) × 1010 M⊙), and the surface density within 0.9 kpc of the plane ((69 ± 10) M⊙ pc−2) are almost independent of the (oblate) halo's axis ratio q. If the halo is spherical, 46 per cent of the radial force on the Sun is provided by baryons, and only 4.3 per cent of the Galaxy's mass is baryonic. If the halo is flattened, the baryons contribute even less strongly to the local radial force and to the Galaxy's mass. The dark matter density at the location of the Sun is 0.0126 q
−0.89 M⊙ pc−3 = 0.48 q
−0.89 GeV cm−3. When combined with other literature results we find hints for a mildly oblate dark halo with q ≃ 0.8. Our value for the dark mass within the solar radius is larger than that predicted by cosmological dark-matter-only simulations but in good agreement with simulations once the effects of baryonic infall are taken into account. Our mass models consist of three double-exponential discs, an oblate bulge and a Navarro–Frenk–White dark matter halo, and we model the dynamics of the RAVE (RAdial Velocity Experiment) stars in the corresponding gravitational fields by finding distribution functions f J
that depend on three action integrals. Statistical errors are completely swamped by systematic uncertainties, the most important of which are the distance to the stars in the photometric and spectroscopic samples and the solar distance to the Galactic Centre. Systematics other than the flattening of the dark halo yield overall uncertainties ∼15 per cent.
We analyse a sample of 82 850 stars from the RAdial Velocity Experiment (RAVE) survey, with well-determined velocities and stellar parameters, to isolate a sample of 18 026 high-probability thin-disc ...dwarfs within 600 pc of the Sun. We derive space motions for these stars, and deduce the solar space velocity with respect to the local standard of rest. The peculiar solar motion we derive is in excellent agreement in radial U⊙ and vertical W⊙ peculiar motions with other recent determinations. Our derived tangential peculiar velocity, V⊙, agrees with very recent determinations, which favour values near 13 km s−1, in disagreement with earlier studies. The derived values are not significantly dependent on the comparison sample chosen, or on the method of analysis. The local Galaxy seems very well dynamically relaxed, in a near symmetric potential.
Summary
Background
The validity of the eosinophilic oesophagitis (EoE) histologic scoring system (EoEHSS) has been demonstrated, but only preliminary reliability data exist.
Aim
Formally assess the ...reliability of the EoEHSS and additional histologic features.
Methods
Four expert gastrointestinal pathologists independently reviewed slides from adult patients with EoE (N = 45) twice, in random order, using standardised training materials and scoring conventions for the EoEHSS and additional histologic features agreed upon during a modified Delphi process. Intra‐ and inter‐rater reliability for scoring the EoEHSS, a visual analogue scale (VAS) of overall histopathologic disease severity, and additional histologic features were assessed using intra‐class correlation coefficients (ICCs).
Results
Almost perfect intra‐rater reliability was observed for the composite EoEHSS scores and the VAS. Inter‐rater reliability was also almost perfect for the composite EoEHSS scores and substantial for the VAS. Of the EoEHSS items, eosinophilic inflammation was associated with the highest ICC estimates and consistent with almost perfect intra‐ and inter‐rater reliability. With the exception of dyskeratotic epithelial cells and surface epithelial alteration, ICC estimates for the remaining EoEHSS items were above the benchmarks for substantial intra‐rater, and moderate inter‐rater reliability. Estimation of peak eosinophil count and number of lamina propria eosinophils were associated with the highest ICC estimates among the exploratory items.
Conclusion
The composite EoEHSS and most component items are associated with substantial reliability when assessed by central pathologists. Future studies should assess responsiveness of the score to change after a therapeutic intervention to facilitate its use in clinical trials.
Linked ContentThis article is linked to Conner and Kirsch and Pai et al papers. To view these articles visit https://doi.org/10.1111/apt.14633 and https://doi.org/10.1111/apt.14658.
PDF
