A
bstract
We study lepton flavor violation (LFV) within the Littlest Higgs Model with T parity (LHT) realizing an inverse seesaw (ISS) mechanism of type I. With respect to the traditional LHT, there ...appear new 𝒪(10 TeV) Majorana neutrinos, driving LFV. For
τ →
ℓℓ
′
ℓ
¯
″
(including wrong-sign,
ℓ
=
e, μ
) decays and
μ → e
conversion in Ti, we get typical rates only one order of magnitude below present bounds (
ℓ → ℓ′γ
can reach the current upper limit) and for
Z →
τ
¯
ℓ
,
μ →
ee
e
¯
and conversion in Au, results are within two orders of magnitude from present limits. Correlations among modes are drastically different to the traditional LHT and other models, which would ease the confrontation of this scenario to eventual measurements of LFV processes involving charged leptons.
A
bstract
We first study the hadronic lepton flavor violating tau decays within the littlest Higgs model with T-parity (including one or two pseudoscalars, or a vector resonance). We consider the ...case where only T-odd particles and partner fermions contribute, and also its extension including Majorana neutrinos coming from an inverse seesaw. In both cases our mean values lie mostly only one order of magnitude below current upper limits, strengthening the case of searching for these decays in the quest for new physics.
How are professors paid? Can the "best and brightest" be attracted to the academic profession? With universities facing international competition, which countries compensate their academics best, and ...which ones lag behind? "Paying the Professoriate" examines these questions and provides key insights and recommendations into the current state of the academic profession worldwide. "Paying the Professoriate" is the first comparative analysis of global faculty salaries, remuneration, and terms of employment. Offering an in-depth international comparison of academic salaries in 28 countries across public, private, research, and non-research universities, chapter authors shed light on the conditions and expectations that shape the modern academic profession. The top researchers on the academic profession worldwide analyze common themes, trends, and the impact of these matters on academic quality and research productivity. In a world where higher education capacity is a key driver of national innovation and prosperity, and nations seek to fast-track their economic growth through expansion of higher education systems, policy makers and administrators increasingly seek answers about what actions they should be taking. "Paying the Professoriate" provides a much needed resource, illuminating the key issues and offering recommendations. Contents of this book include: (1) Academic Remuneration and Contracts: Global Trends and Realities (Philip G. Altbach, Liz Reisberg, and Ivan F. Pacheco); (2) Quantitative Analysis: Looking for Commonalities in a Sea of Differences (Gregory Androushchak and Maria Yudkevich); (3) Labor Contracts and Economic Incentives for Argentine University Faculty (Ana Garcia de Fanelli); (4) The Academic Career in a Transition Economy: Case Study of the Republic of Armenia (Arevik Ohanyan); (5) Academic Salaries, Massification, and the Rise of an Underclass in Australia (Anthony Welch); (6) Brazil: The Widening Gap (Simon Schwartzman); (7) The Organization of Academic Work and Faculty Remuneration at Canadian Universities (Glen A. Jones and Julian Weinrib); (8) A Study on Academic Salary and Remunerations in China (Wanhua Ma and Jianbo Wen); (9) Academic Salaries in Colombia: The Data Tell Only a Small Part of the Story (Ivan F. Pacheco); (10) The Czech Republic: High Estimation for the Academic Profession (Helena Sebkova); (11) Salary and Incentive Structure in Ethiopian Higher Education (Elizabeth Ayalew); (12) Changing the Rules of the French Academic Market (Gaele Goastellec); (13) The Income Situation in the German System of Higher Education: A Rag Rug (Marius Herzog and Barbara M. Kehm); (14) Academic Salaries and Career Advancement: Tuning the Professoriate for a Knowledge Economy in India (Narayana Jayaram); (15) Israel: Academic Salaries and Remuneration (Sara Guri-Rosenblit); (16) Italy: From Bureaucratic Legacy to Reform of the Profession (Giliberto Capano and Gianfranco Rebora); (17) Working Conditions and Salaries of the Academic Profession in Japan (vKazunori Shima); (18) Academic Salaries in Kazakhstan: Current Status and Perspectives (Sholpan Kalanova); (19) The Academic Salary System: Conditions and Trends in Latvia (Tatjana Volkova); (20) Attractiveness of Salaries and Remunerations of Malaysian Academics (Muhamad Jantan); (21) Mexican Faculty Salaries Today: Once a Bagger, Always a Beggar? (Alma Maldonado-Maldonado); (22) Introducing Market Forces in Academic Remuneration: The Case of the Netherlands (Ben Jongbloed); (23) Nigeria: Toward an Open Market (Olufemi A. Bamiro); (24) Academic Salaries in Norway: Increasing Emphasis on Research Achievement (Svein Kyvik); (25) Russian Higher Education: Salaries and Contracts (Gregory Androushchak and Maria Yudkevich); (26) Faculty Salary and Remuneration in the Kingdom of Saudi Arabia (Mohammad Al-Ohali and Hamad Al-Mehrej); (27) The Unequal Playing Field: Academic Remuneration in South Africa (Chika Trevor Sehoole); (28) Remuneration of Academic Staff in Turkish Universities (Kemal Guruz); (29) Academic Salary in the United Kingdom: Marketization and National Policy Development (Fumi Kitagawa); (30) The Power of Institutional and Disciplinary Markets: Academic Salaries in the United States (Martin J. Finkelstein); and (31) Academic Community and Contracts: Modern Challenges and Responses (Yaroslav Kuzminov).
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal). Tick bites are recognized as the most important cause ...of anti-α-Gal IgE antibody increase in humans. Several risk factors have been associated with the development of AGS, but their integration into a standardized disease diagnosis has proven challenging.
Herein we discuss the current AGS diagnosis based on anti-α-Gal IgE titers and propose an algorithm that considers all co-factors in the clinical history of α-Gal-sensitized patients to be incorporated into the AGS diagnosis. The need for identification of host-derived gene markers and tick-derived proteins for the diagnosis of the AGS is also discussed.
The current AGS diagnosis based on anti-α-Gal IgE titers has limitations because not all patients sensitized to α-Gal and with anti-α-Gal IgE antibodies higher than the cutoff (0.35 IU/ml) develop anaphylaxis to mammalian meat and AGS. The basophil activation test proposed to differentiate between patients with AGS and asymptomatic α-Gal sensitization cannot be easily implemented as a generalized clinical test. In coming years, the algorithm proposed here could be used in a mobile application for easier AGS diagnosis in the clinical practice.
Symptomatic Acromioclavicular (AC) dislocations have historically been surgically treated with Coracoclavicular (CC) ligament reconstruction with transfer of the Coracoacromial (CA) ligament. ...Tensioning the CA ligament is the key to success.
Seventeen patients with chronic, symptomatic Type III AC joint or acute Type IV and V injuries were treated surgically. The distal clavicle was resected and stabilized with CC ligament reconstruction using the CA ligament. The CA ligament was passed into the medullary canal and tensioned, using a modified 'docking' technique. Average follow-up was 29 months (range 12-57).
Postoperative ASES and pain significantly improved in all patients (p = 0.001). Radiographically, 16 (94%) maintained reduction, and only 1 (6%) had a recurrent dislocation when he returned to karate 3 months postoperatively. His ultimate clinical outcome was excellent.
The docking procedure allows for tensioning of the transferred CA ligament and healing of the ligament in an intramedullary bone tunnel. Excellent clinical results were achieved, decreasing the risk of recurrent distal clavicle instability.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Ticks are arthropod ectoparasite vectors of pathogens and the cause of allergic reactions affecting human health worldwide. In humans, tick bites can induce high levels of immunoglobulin E antibodies ...against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) present in glycoproteins and glycolipids from tick saliva that mediate anaphylactic reactions known as the alpha-Gal syndrome (AGS) or red meat allergy. In this study, a new animal model was developed using zebrafish for the study of allergic reactions and the immune mechanisms in response to tick salivary biogenic substances and red meat consumption. The results showed allergic hemorrhagic anaphylactic-type reactions and abnormal behavior patterns likely in response to tick salivary toxic and anticoagulant biogenic compounds different from α-Gal. However, the results showed that only zebrafish previously exposed to tick saliva developed allergic reactions to red meat consumption with rapid desensitization and tolerance. These allergic reactions were associated with tissue-specific Toll-like receptor-mediated responses in types 1 and 2 T helper cells (T
1 and T
2) with a possible role for basophils in response to tick saliva. These results support previously proposed immune mechanisms triggering the AGS and provided evidence for new mechanisms also potentially involved in the AGS. These results support the use of the zebrafish animal model for the study of the AGS and other tick-borne allergies.
Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (α-Gal) present in glycoproteins and glycolipids from mammalian meat. ...To advance in the diagnosis and treatment of AGS, further research is needed to unravel the molecular and immune mechanisms underlying this syndrome. The objective of this study is the characterization of tick salivary components and proteins with and without α-Gal modifications involved in modulating human immune response against this carbohydrate.
Protein and α-Gal content were determined in tick saliva components, and proteins were identified by proteomics analysis of tick saliva fractions. Pathophysiological changes were recorded in the zebrafish (Danio rerio) model after exposure to distinct Ixodes ricinus tick salivary components. Serum samples were collected from zebrafish at day 8 of exposure to determine anti-α-Gal, anti-glycan, and anti-tick saliva protein IgM antibody titers by enzyme-linked immunosorbent assay (ELISA).
Zebrafish treated with tick saliva and saliva protein fractions combined with non-protein fractions demonstrated significantly higher incidence of hemorrhagic type allergic reactions, abnormal behavioral patterns, or mortality when compared to the phosphate-buffered saline (PBS)-treated control group. The main tick salivary proteins identified in these fractions with possible functional implication in AGS were the secreted protein B7P208-salivary antigen p23 and metalloproteases. Anti-α-Gal and anti-tick salivary gland IgM antibody titers were significantly higher in distinct saliva protein fractions and deglycosylated saliva group when compared with PBS-treated controls. Anti-glycan antibodies showed group-related profiles.
Results support the hypothesis that tick salivary biomolecules with and without α-Gal modifications are involved in modulating immune response against this carbohydrate.
Ticks are obligate hematophagous arthropods that synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) associated with the alpha-gal syndrome (AGS) or allergy to mammalian meat consumption.
In this ...study, we used a proteomics approach to characterize tick proteins in salivary glands (sialome SG), secreted saliva (sialome SA) and with α-Gal modification (alphagalactome SG and SA) in model tick species associated with the AGS in the United States (Amblyomma americanum) and Australia (Ixodes holocyclus). Selected proteins reactive to sera (IgE) from patients with AGS were identified to advance in the identification of possible proteins associated with the AGS. For comparative analysis, the α-Gal content was measured in various tick species.
The results confirmed that ticks produce proteins with α-Gal modifications and secreted into saliva during feeding. Proteins identified in tick alphagalactome SA by sera from patients with severe AGS symptomatology may constitute candidate disease biomarkers.
The results support the presence of tick-derived proteins with α-Gal modifications in the saliva with potential implications in AGS and other disorders and protective capacity against tick infestations and pathogen infection. Future research should focus on the characterization of the function of tick glycoproteins with α-Gal in tick biology and AGS.
To interpret the motives of pregnancy in girls and the re-signification of their life's course.
In the cities of Bogota, Cali, Cartagena and Medellin, 18 life stories of adolescents under 15 years ...old with experience of pregnancy were made during 2012 and 2013. A phenomenological analytical framework was used to reveal the motives and meanings.
The "because motives" and "in order to motives" of adolescents life course, are redefined by the moral control of families, couples, education and health professionals based on common sense and professional habitus.
In the real "because motives" it is found that common sense assigns blame and responsibility to teens for their pregnancy. In the educational context there is a device that excludes them and promotes dropouts. In the field of health, human rights abuses are used as a control and punishment mechanism.
PDF
