This paper introduces a robust network admission control (NAC) solution tailored specifically for 6LoWPAN Wireless Sensor Networks (WSN), aiming to enhance the overall security infrastructure. By ...implementing stringent measures, this solution not only safeguards legitimate nodes but also fortifies the network against potential security threats originating from unauthorized nodes attempting to communicate with both legitimate nodes and the Internet. The solution enhances security through innovative features for administrative nodes, including node presence detection and robust authentication. It incorporates data filtering to swiftly identify and discard unauthorized frames, strengthening network resilience. Established protocols like Neighbor Discovery and DSDV facilitate seamless integration. This strategic utilization minimizes the reliance on additional control messages, thereby optimizing the network's efficiency and resource utilization. The solution utilizes cryptographic methods, particularly the XOR algorithm, to enhance data security in wireless sensor networks. This algorithm ensures authenticity, integrity, and freshness of transmitted data frames, providing robust protection against manipulation and bolstering network security. The proposed network admission control solution addresses security risks in 6LoWPAN WSN and integrates advanced features for a strong and efficient overall security infrastructure in wireless sensor networks.
Pentavalent vaccines (DTP-HepB-Hib) have been introduced in many countries in their routine public immunization programmes to protect against diphtheria (D), tetanus (T), pertussis (P), hepatitis B ...(Hep B) and Hemophilus influenzae type b (Hib) diseases. This study compared the safety and immunogenicity of a new formulation of a whole-cell Bordetella pertussis (wP) based pentavalent vaccine (DTwP-HepB-Hib). The new formulation was developed using well-characterized hepatitis B and pertussis whole cell vaccine components. This was a phase III, observer-blind, randomized, non-inferiority, multi-center study conducted in India among 460 infants who were followed up for safety and immunogenicity for 28 days after administration of three doses of either investigational or licensed comparator formulations at 6-8, 10-12 and 14-16 weeks of age. The investigational formulation of DTwP-HepB-Hib vaccine was non-inferior to the licensed formulation in terms of hepatitis B seroprotection rate (% of subjects with HepB antibodies greater than or equal to10mIU/mL were 99.1% versus 99.0%, respectively, corresponding to a difference of 0.1% (95% CI, -2.47 to 2.68)) and pertussis immune responses (adjusted geometric mean concentrations of antibodies for anti-PT were 76.7 EU/mL versus 63.3 EU/mL, with a ratio of aGMTs of 1.21 (95% CI, 0.89-1.64), and for anti-FIM were 1079 EU/mL versus 1129 EU/mL, with a ratio of aGMTs of 0.95 (95% CI, 0.73-1.24), respectively). The immune responses to other valences (D, T, and Hib) in the two formulations were also similar. The safety profile of both formulations was found to be similar and were well tolerated. The investigational DTwP-HepB-Hib vaccine formulation was immunogenic and well-tolerated when administered as three dose primary series in infants.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The current study evaluates the results of acrysof toric intraocular lens implantation to correct pre-existing corneal astigmatism in patients undergoing cataract surgery.
This study was done on ...Prospective interventional at Osmania Medical College, Sarojini Devi Eye Hospital, Hyderabad. The sample of the study is included 40 eyes of 38 consecutive patients with 1.5 D or more of pre-existing astigmatism consists of cataract surgery with toric open-loop IOL implantation (Alcon, Fort Worth, TX, USA). The pre-operative markings for the position of incisions and IOL placement were being done under the slit lamp. The visual acuity, residual keratometric and refractive cylinders, and toric IOL axis were being measured.
54.71 years was the mean age of the patients. All the 40 eyes at the final check-up had post-operative unaided visual acuity of 6/12 or better. 10 patients (25 %) had an unaided visual acuity of 6/6.37 eyes (92.5%) had best corrected post-operative visual acuity of 6/9 or better. The mean pre-operative refractive astigmatism in 40 eyes was 2.34D. 22 eyes had the Refractive astigmatism of >2D. No eyes had refractive astigmatism of <1.5D. The mean axial length was 24.22mm
Out of 40 eyes in which Toric IOL was implanted, the post-operative residual refractive sphere was seen in 4 eyes. Out of 40 eyes in whom Toric IOL was implanted, a post-operative residual refractive cylinder was seen in 30 eyes. 10 patients had No post-operative refractive cylinder. The mean post-operative residual refractive cylinder was 0.58D. The mean Post-operative Keratometric cylinder was 2.24D. The mean post-operative Keratometric cylinder was 2.34D. In comparison, both pre-operative and post-operative keratometric astigmatism, it was found that there was no statistically significant difference between them.
The misalignment of Toric IOL was 10 degrees or less in 36 patients (94.73%) and less than 5 degrees in 22 patients (57.89%). Misalignment of >10 degrees (11 degrees and 13 degrees) was seen in 2 patients. The mean IOL rotation among 38 patients was 4.55 degrees (Range 0-13 degrees, SD 3.43). None of the eyes required repositioning.
The results of this study show that implantation of AcrysofTor ic IOL is a good surgical method to evaluate pre-existing corneal astigmatism in cataract surgery. Acrysoftoric IOL has shown good rotational stability.
A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles (
10–13) and isoxazoles (
14, 15) were prepared from the synthetically vulnerable intermediate
E-styrylsulfonylacetic acid methyl ester (
1) ...and studied their antioxidant activity.
A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles (
10–13) and isoxazoles (
14, 15) were prepared from the synthetically vulnerable intermediate
E-styrylsulfonylacetic acid methyl ester (
1) and studied their antioxidant activity.
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► A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles were prepared. ► The compound isoxazole in combination with oxazoline exhibited greater antioxidant activity. ► Presence of electron donating substituents on the aromatic ring enhances the activity.
Bax and Bid are pro-apoptotic members of the Bcl-2 protein family. Upon cleavage by caspase-8, Bid activates Bax. Activated Bax inserts into the mitochondrial outer membrane forming oligomers which ...lead to membrane poration, release of cytochrome c, and apoptosis. The detailed mechanism of Bax activation and the topology and composition of the oligomers are still under debate. Here molecular details of Bax activation and oligomerization were obtained by application of several biophysical techniques, including atomic force microscopy, cryoelectron microscopy, and particularly electron paramagnetic resonance (EPR) spectroscopy performed on spin-labeled Bax. Incubation with detergents, reconstitution, and Bid-triggered insertion into liposomes were found to be effective in inducing Bax oligomerization. Bid was shown to activate Bax independently of the stoichiometric ratio, suggesting that Bid has a catalytic function and that the interaction with Bax is transient. The formation of a stable dimerization interface involving two Bcl-2 homology 3 (BH3) domains was found to be the nucleation event for Bax homo-oligomerization. Based on intermolecular distance determined by EPR, a model of six adjacent Bax molecules in the oligomer is presented where the hydrophobic hairpins (helices α5 and α6) are equally spaced in the membrane and the two BH3 domains are in close vicinity in the dimer interface, separated by >5 nm from the next BH3 pairs.
A new class of methylthio linked pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles were prepared under conventional and ultrasound irradiation methods. All the compounds were ...obtained in higher yields and in shorter reaction times in ultrasound irradiation method when compared with the conventional method. The title compounds were tested for antimicrobial activity. The compounds 12c and 12f exhibited promising antibacterial activity against P. aeruginosa whereas the compounds 13c and 13f showed pronounced antifungal activity against A. niger.
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•A new class of pyrimidinyl oxadiazoles, thiadiazoles and triazoles were prepared.•Ultrasonication offers high yields in shorter reaction times than conventional method.•Electron withdrawing substituents on the aromatic ring enhanced the activity.•12c and 12f exhibited promising antibacterial activity against P. aeruginosa.•13c and 13f showed pronounced antifungal activity against A. niger.
A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to ...thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds
7a–
d to
12a–
d were tested. Compounds
10d and
12d showed pronounced antimicrobial activity. Further, compound
10d exhibited maximum cytotoxicity.
A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds
7a–
d to
12a–
d were tested. Compounds
10d and
12d showed pronounced antimicrobial activity. Further compound
10d exhibited maximum cytotoxicity.
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A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts, 2-(1,2-diaroylethyl)malononitrile and ...2-(1,2-diarylsulfonylethyl)malononitrile by cyclocondensation with appropriate nucleophiles. The lead compounds were screened for the antimicrobial and antioxidant activities.
A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts, 2-(1,2-diaroylethyl)malononitrile and 2-(1,2-diarylsulfonylethyl)malononitrile by cyclocondensation with appropriate nucleophiles. The lead compounds were screened for the antimicrobial and antioxidant activities.
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Every now and then, there has been natural or man‐made calamities. Such adversities instigate various institutions to find solutions for them. The current study attempts to explore the disaster ...caused by the micro enemy called coronavirus for the past few months and aims at finding the solution for the system of nonlinear ordinary differential equations to which q−homotopy analysis transform method (q−HATM) has been applied to arrive at effective results. In this paper, there are eight nonlinear ordinary differential equations considered and to solve them the advanced fractional operator Atangana‐Baleanu (AB) fractional derivative has been applied to produce better understanding. The outcomes have been presented in terms of plots. Ultimately, the present study assists in examining the real‐world models and aids in predicting their behavior corresponding to the parameters considered in the models.
A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio, methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic activities. The ...compound pyrimidinyl bis methylthio benzimidazole 22 was a potent antimicrobial agent particularly against Staphylococcus aureus (29 mm, MIC 12.5 μg/mL) and Penicillium chrysogenum (38 mm, MIC 12.5 μg/mL). The amino linked pyrimidinyl bis benzothiazole 24 exhibited cytotoxic activity on A549 cells with IC50 value of 10.5 μM.
A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio, methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic activities. The compound 22 was a potent antimicrobial agent and compound 24 exhibited cytotoxic activity on A549 cells with IC50 value of 10.5 μM. Display omitted
•We have synthesized a new class of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles.•The pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles compounds show antimicrobial and cytotoxic activity.•The pyrimidinyl bis methylthio benzimidazole showed greater antimicrobial activity than benzoxazole and benzothiazole.
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