The study was based on the data of a sample of 400 epileptic patients
(200 idiopathic and 200 symptomatic) and 100 normal healthy individuals
serving as controls. The PTC threshold distribution was ...bimodal. The
number of non-tasters among idiopathic epileptics (35.5%) and
symptomatic epileptics (32.5%) was significantly higher than controls
(20%). The relative incidence of non-tasters in idiopathic and
symptomatic epilepsies was 2.20 and 1.93 respectively. There is
evidence that non-tasters tend to ingest a greater quantity of bitter
tasting goitrogenic substances present naturally in edible plants which
in turn exert greater thyroid stress in non-tasters or less sensitive
tasters. Such a stress during intrauterine or early childhood growth
and development might have affected neurological maturation which in
turn made them more susceptible to epilepsy than tasters, who faced
lesser stress.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Present work deals with prediction of flank wear of drill bit using back propagation neural network (BPNN). Drilling operations have been performed in mild steel work-piece by high-speed steel (HSS) ...drill bits over a wide range of cutting conditions. Important process parameters have been used as input for BPNN and drill wear has been used as output of the network. Inclusion of chip thickness as an input in addition to conventional parameters leads to better training of the network. Performance of the neural network has been found to be satisfactory while validated with experimental result.
A methodology is described for evolving a Rough-fuzzy multi layer perceptron with modular concept using a genetic algorithm to obtain a structured network suitable for both classification and rule ...extraction. The modular concept, based on "divide and conquer" strategy, provides accelerated training and a compact network suitable for generating a minimum number of rules with high certainty values. The concept of variable mutation operator is introduced for preserving the localized structure of the constituting knowledge-based subnetworks, while they are integrated and evolved. Rough set dependency rules are generated directly from the real valued attribute table containing fuzzy membership values. Two new indices viz., "certainty" and "confusion" in a decision are defined for evaluating quantitatively the quality of rules. The effectiveness of the model and the rule extraction algorithm is extensively demonstrated through experiments alongwith comparisons.
Water molecules in the DNA grooves are critical for maintaining structural integrity, conformational changes, and molecular recognition. Here we report studies of site- and sequence-specific ...hydration dynamics, using 2-aminopurine (Ap) as the intrinsic fluorescence probe and with femtosecond resolution. The dodecamer dCGCA(Ap)ATTTGCG2was investigated, and we also examined the effect of a specific minor groove-binding drug, pentamidine, on hydration dynamics. Two time scales were observed: ≈1 ps (bulk-like) and 10-12 ps (weakly bound type), consistent with layer hydration observed in proteins and DNA. However, for denatured DNA, the cosolvent condition of 40% formamide hydration is very different: it becomes that of bulk (in the presence of formamide). Well known electron transfer between Ap and nearby bases in stacked assemblies becomes inefficient in the single-stranded state. The rigidity of Ap in the single strands is significantly higher than that in bulk water and that attached to deoxyribose, suggesting a unique role for the dynamics of the phosphate-sugarbase in helix formation. The disparity in minor and major groove hydration is evident because of the site selection of Ap and in the time scale observed here (in the presence and absence of the drug), which is different by a factor of 2 from that observed in the minor groove-drug recognition.
We report studies of hydration dynamics at the surface of the enzyme protein bovine pancreatic α-chymotrypsin. The probe is the well known 1-anilinonaphthalene-8-sulfonate, which binds selectively in ...the native state of the protein, not the molten globule, as shown by x-ray crystallography. With femtosecond time resolution, we examined the hydration dynamics at two pHs, when the protein is physiologically in the inactive state (pH 3.6) or the active state (pH 6.7); the global structure and the binding site remain the same. The hydration correlation function, C(t), whose decay is governed by the rotational and translational motions of water molecules at the site, shows the behavior observed in this laboratory for other proteins, Subtilisin Carlsberg and Monellin, using the intrinsic amino acid tryptophan as a probe for surface hydration. However, the time scales and amplitudes vary drastically at the two pHs. For the inactive protein state, C(t) decays with an ultrafast component, close to bulk-type behavior, but 50% of the C(t) decays at a much slower rate, τ = 43 ps. In contrast, for the active state, the ultrafast component becomes dominant (90%) and the slow component changes to a faster decay, τ = 28 ps. These results indicate that in the active state water molecules in the hydration layer around the site have a high degree of mobility, whereas in the inactive state the water is more rigidly structured. For the substrate-enzyme complex, the function and dynamics at the probe site are correlated, and the relevance to the enzymatic action is clear.
In this article, the author describes a 61 years old male patient who presented himself at our clinic with advanced inoperable gastric carcinoma. The option of chemotherapy was discussed with the ...patient and his care givers. In view of the nature of the disease and the little likelihood of response, the patient did not consent for the same. The patient opted for an alternative homeopathic therapy to treat his cancer. The patient again visited the clinic after one year for checkup. On examination, it was found that, though there was no significant change in the gastric mass, there was no evidence of ascites or lymphadenopathy. Liver, gall bladder, spleen, pancreas, both kidneys and adrenal appeared normal. There was a significant clinical improvement in the patient and he was able to lead a normal life. The author followed the patient for the next one year and found that there was no remarkable deterioration in his clinical condition.
The nature of single-walled carbon nanotube (SWNT)−solvent interaction that is responsible for the stabilization of ultrasonicated dispersions was investigated using various techniques. It was found ...that the sonochemical decomposition and polymerization of o-dichlorobenzene (ODCB) is necessary for the stabilization of SWNTs in ODCB. The rate of decomposition of ODCB was shown to be dependent on the shape of the sonication vessel. The decomposition products of sonicated ODCB interact irreversibly with SWNTs. Under similar sonication conditions, N,N-dimethylformamide (DMF) did not induce discernible modification of the near-infrared spectrum of the dispersed SWNTs.
Intramolecular charge transfer (ICT) processes of the neutral fluorescence probe, nile red, I, confined in the water pool of aerosol-OT (AOT) reverse micelle in n-heptane, is studied using picosecond ...emission spectroscopy. Utilizing the solvatochromism of nile red, only those probe molecules inside the reverse micelle are selectively excited. It is observed that while in aqueous solutions the lifetime (τf) of nile red is 650 ps, inside the reverse micelles τf increases to 3.73 ns in reverse micelle and to 2.06 ns at the highest water content of the microemulsion (w o = 32). With increase in the water-to-surfactant ratio, w o, as the water pool swells in size, the lifetime and quantum yield of emission decrease and the rate of the ICT process of nile red increases. However, the magnitude of the change (at most 8 times) in the rate of the ICT process of nile red compared to that of ordinary water is much smaller than the several thousandfold decrease observed in the solvation dynamics of water in the water pool relative to bulk water. It is proposed that while the solvation dynamics in the water pool is governed by the dielectric relaxation time, dynamics of the ICT process is controlled by the static polarity of the medium.
Tarapur Atomic Power Station-3 is 540 MWe pressurized heavy water reactor in India, it achieved first criticality on May 5, 2006 and then operated at full power. The control of dose rates and ...collective dose of radiation worker is most important for the best performance of reactor. This article discusses the sudden rise in radiation levels on primary heat transport (PHT) pipelines and equipment. The radionuclide contributed to high radiation levels was Ag-110 m. Finding obtained during the route cause analysis used for the station operation and removal of Ag-110 m from PHT system using special type of resin (macroporous). The purification of the system using special type of resin has been enhanced. Ag-110 m activity in the PHT fluid has been controlled. PHT pipelines and equipment shielded for exposure control. The postirradiation examination of steam generator (SG) manhole gasket showed the presence of sulfur. The PHT fluid sample analysis revealed the presence of oil content in PHT fluid which was ingressed from buffer tank and FT D2O tank in PHT system. Oil containing sulfur was responsible for erosion of silver from SG manhole gasket in the form of silver sulfide and its ultimate transport to reactor core and neutron activation of silver.
We report studies of the enzymatic activity of α-chymotrypsin (CHT) in aqueous buffer and AOT reverse micelle with various degrees of hydration using the substrate ...Ala–Ala–Phe–7-amido-4-methylcoumarin (AMC). From Michaelis–Menten kinetics, we determined equilibrium and rate constants for catalytic activity in aqueous buffer. In the reverse micelle we found that the activity of CHT to be
retarded by two orders of magnitude compared to that in aqueous buffer. The activity is also found to be nearly
insensitive to the degree of hydration of reverse micelle. From these studies, we attempt to elucidate the influence of hydration on enzyme activity.
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