La Linguistica Cognitiva:un’applicazione didattica perl’insegnamento dello spagnolo come lingua stranieradi Valentina PaleariRELATORE: prof.ssa Elena LandoneCORRELATORE: prof.ssa Emilia PerassiCORSO ...DI LAUREA: Laurea Magistrale in Lingue e Letterature Europee ed ExtraeuropeeUNIVERSITA’: Università degli Studi di MilanoANNO ACCADEMICO: 2014-2015
KRAS mutations characterize pancreatic cell transformation from the earliest stages of carcinogenesis, and are present in >95% of pancreatic ductal adenocarcinoma (PDAC) cases. In search of novel ...biomarkers for the early diagnosis of PDAC, we identified the proteins secreted by the normal human pancreatic cell line (HPDE) recently transformed by inducing the overexpression of the KRASG12V oncogene. We report a proteomic signature of KRAS-induced secreted proteins, which was confirmed in surgical tumor samples from resected PDAC patients. The putative diagnostic performance of three candidates, Laminin-C2 (LAMC2), Tenascin-C (TNC) and Pentraxin-3 (PTX3), was investigated by ELISA quantification in two cohorts of PDAC patients (n = 200) eligible for surgery. Circulating levels of LAMC2, TNC and PTX3 were significantly higher in PDAC patients compared to the healthy individuals (p < 0.0001). The Receiver Operating Characteristics (ROC) curve showed good sensitivity (1) and specificity (0.63 and 0.85) for LAMC2 and PTX3, respectively, but not for TNC, and patients with high levels of LAMC2 had significantly shorter overall survival (p = 0.0007). High levels of LAMC2 and PTX3 were detected at early stages (I−IIB) and in CA19-9-low PDAC patients. In conclusion, pancreatic tumors release LAMC2 and PTX3, which can be quantified in the systemic circulation, and may be useful in selecting patients for further diagnostic imaging.
The prevalence of ANA and anti-ENA in the general population is not well established, especially their clinical significance in healthy subjects. We herein determined the prevalence and predictive ...value of serum ANA and anti-ENA for connective tissue diseases (CTD), cancer, and mortality. We took advantage of a randomly selected sample of the 1998 general population (Isola I) consisting of 2828 subjects (53% women, age 43±13 years) from a well-defined Northern Italian area. Serum ANA and anti-ENA were tested on the 2690 samples available in 2012 (Isola II, 50% women, age 58±13 years). Administrative databases were searched for CTD, cancer diagnosis, and death cases occurring between enrollment and December 31, 2013. The hazard ratio (HR) was calculated for incident cases. Serum ANA is positive in 18.1% for any titer and 6.1% for titers ≥1:160, 23% in subjects over 50 years and 13.1% and 6.1% for any titer and titers ≥1:160, respectively, in women. The HR for CTD development was significantly high for all ANA titers, with the highest for ANA ≥1:160 (HR 14.19, 95% CI 3.07–65.68). ANA positivity was not associated with cancer (HR 1.03; 95% CI 0.75–1.43), or with mortality (HR adjusted for age and sex 1.40; 95% CI 0.94–2.09). Serum anti-ENA is positive in a minority of subjects with highest figures for anti-nucleosome (1.9%), -histone (1.6%) and -PM/Scl (1.5%). In conclusion, serum ANA prevalence in the general population is highest in senior subjects and in women, while the female predominance is significantly lower compared to overt CTD. Serum ANA is associated with an increased probability of CTD development over time, but does not influence survival or cancer risk.
•Serum ANA is detected in 18.1% of the general population and the prevalence increases with age.•Serum ANA is associated with an increased risk of connective tissue disease over 15 years.•Serum ANA is not related to an increased risk of cancer over 15 years.•Serum ANA positivity is not associated with increased mortality over 15 years.
N. Strejilevich, Una sola morte numerosa Valentina Paleari
Nuovi autoritarismi e democrazie : diritto, instituzioni, società : NAD,
05/2019, Letnik:
1, Številka:
1
Journal Article
Recenzirano
Odprti dostop
In the book Una sola morte numerosa Nora Strejilevich shares with the reader her personal commitment to convey a painful memory, as direct witness of one of the darkest moments of the history of ...Argentina.
La violación de las más elementales reglas de la democracia y del estado de derecho, la tortura, la desaparición, el asesinato y las violaciones de género fueron prácticas corrientes de la historia ...de América Latina que vivió dictaduras cívico-militares en los años 70. Las transiciones políticas de los años 80-90 promovieron reformas institucionales para reforzar la democracia recuperada y procesos de justicia transicional en nombre de la verdad, memoria, justicia y reparación, las cuales se han tomado como modelo para el reciente proceso de paz en Colombia. El presente volumen recoge ensayos de estudiosos italianos y extranjeros que reconstruyen desde perpectivas socio-jurídicas estos procesos.
Las formas de testimonio que se perfilan son obras diferentes de las de âÂliteratura testimonial' en el sentido estricto del término, porque surgen de las aulas judiciales y de los informes de las comisiones de verdad, y se imponen como verdades respaldadas por la actuación de la jurisprudencia, que las defiende de los asaltos del olvido y de la impunidad. Texto de la editorial.
Maria Vittoria Calvi, Irina Bajini e Milin Bonomi (a cura di), Lingue migranti e nuovi paesaggi (Milano, LED, 2015, 240 pp. ISBN 978-88-7916-700-0) di Valentina Paleari
The violation of the most elementary rules of democracy and the rule of law, torture, disappearance, murder and gender violations were common practices in the history of Latin America that lived ...civic-military dictatorships in the 1970s. Political transitions of the 80-90s promoted institutional reforms to reinforce recovered democracy and transitional justice processes in the name of truth, memory, justice and reparation, which have been taken as a model for the recent peace process in Colombia. This volume includes essays by Italian and foreign scholars who reconstruct these processes from socio-legal perspectives. The forms of testimony that are outlined are works different from those of 'testimonial literature' in the strict sense of the term, because they arise from the judicial classrooms and the reports of the truth commissions, and are imposed as truths backed by the performance of jurisprudence, which defends them from the assaults of oblivion and impunity.
