The Research Domain Criteria (RDoC) and the Hierarchical Taxonomy of Psychopathology (HiTOP) represent major dimensional frameworks proposing two alternative approaches to accelerate progress in the ...way psychopathology is studied, classified, and treated. RDoC is a research framework rooted in neuroscience aiming to further the understanding of transdiagnostic biobehavioral systems underlying psychopathology and ultimately inform future classifications. HiTOP is a dimensional classification system, derived from the observed covariation among symptoms of psychopathology and maladaptive traits, which seeks to provide more informative research and treatment targets (i.e., dimensional constructs and clinical assessments) than traditional diagnostic categories. This article argues that the complementary strengths of RDoC and HiTOP can be leveraged in order to achieve their respective goals. RDoC's biobehavioral framework may help elucidate the underpinnings of the clinical dimensions included in HiTOP, whereas HiTOP may provide psychometrically robust clinical targets for RDoC-informed research. We present a comprehensive mapping between dimensions included in RDoC (constructs and subconstructs) and HiTOP (spectra and subfactors) based on narrative review of the empirical literature. The resulting RDoC-HiTOP interface sheds light on the biobehavioral correlates of clinical dimensions and provides a broad set of dimensional clinical targets for etiological and neuroscientific research. We conclude with future directions and practical recommendations for using this interface to advance clinical neuroscience and psychiatric nosology. Ultimately, we envision that this RDoC-HiTOP interface has the potential to inform the development of a unified, dimensional, and biobehaviorally-grounded psychiatric nosology.
•This article provides a narrative review outlining an interface connecting RDoC and HiTOP dimensions.•RDoC provides a solid transdiagnostic framework for elucidating the underpinnings of HiTOP dimensions.•HiTOP may aid RDoC-informed research by providing psychometrically robust clinical targets.•Leveraging the complementary strengths of RDoC and HiTOP may advance clinical neuroscience and psychopathology research.•This interface may facilitate the development of future biobehaviorally-grounded classifications of psychopathology.
The Personality Inventory for DSM-5 (PID-5) is the primary tool for assessing maladaptive personality traits within the DSM-5 alternative model for personality disorders. Evidence has begun to ...accumulate on the replicability and measurement invariance of its five-domain factor structure across countries, clinical and community populations, and sex, but its equivalency across racial groups within a given country is largely unstudied. Attempting to replicate the evidence of noninvariance demonstrated by Bagby et al. (2022), we examined the factor structure of the PID-5 across White Americans (n = 612) and Black Americans (n = 613) within the United States. The five-domain structure emerged across both samples with reasonably congruent factor loadings. Therefore, we tested for measurement invariance using the 13-step framework advocated by Marsh et al. (2009) for personality data. We found support for the PID-5's comparability across racial groups, offering some preliminary backing for its use with Black Americans, though additional evidence is needed to clarify the conflicting results and further validate the instrument.
Public Significance Statement
The Personality Inventory for DSM-5 is increasingly being used to assess personality disorders, though it is unclear if it measures the same constructs in White and Black American samples. Previous evidence suggests some inconsistencies, but the evidence presented here suggests it is an applicable tool across groups. More data from diverse samples are needed to further clarify its measurement properties.
Current literature on the relationship between dispositional fear (or threat sensitivity) and amygdala gray matter volume (GMV) is heterogeneous, with findings including positive, negative, and null ...correlations. A clearer understanding of this relationship would help to determine the potential utility of amygdala volume as a biomarker of anxious/depressive (internalizing) disorders and contribute to understanding of neural mechanisms for variations in fearfulness. The study reported here used voxel-based morphometry to quantify amygdala GMV scores from structural neuroimaging data in a sample of 44 monozygotic twins (i.e., 22 pairs). Dispositional threat sensitivity (THT) was quantified using a biobehavioral cross-domain score that combined neurophysiological indicators with a psychological scale measure. Analyses revealed expected high concordance for amygdala GMV between co-twins. With respect to the major question of the study, a negative correlation was found between biobehavioral THT scores and amygdala volume – with individuals higher in THT showing smaller amygdala GMV scores. More modest associations of amygdala GMV with symptoms of social phobia, and fear disorder symptomology more broadly, were mediated by THT. These results provide insight into prior mixed findings and support the combined use of biological and behavioral measures to quantify characteristics relevant to mental health problems.
•Higher threat sensitivity correlates with lower amygdala gray matter volume.•Both threat sensitivity and amygdala volume correlate between twins.•Threat sensitivity of one twin predicts amygdala volume of the other.•Amygdala volume also relates to fear disorder symptomatology.•This latter relationship is due to variance in common with threat sensitivity.
The broad dimension of empathy has been shown to underlie various forms of psychopathology, most extensively studied for the externalizing spectrum of psychopathology. However, associations between ...subdimensions of empathy and functions of aggression remain unclear. The current study (
= 409) aimed to investigate common and specific associations between a higher-order model of aggression, comprising reactive aggression (RA) and proactive aggression (PA) factors with an overarching general aggression factor, and item-level factor analytically derived dimensions of empathy:
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Results demonstrated specific and opposing associations between dimensions of empathy and the general aggression factor, such that affective/self-oriented empathy was positively associated, and cognitive/other-oriented empathy was negatively associated with general aggression. Affective/self-oriented empathy was positively associated with RA, whereas cognitive/other-oriented empathy was negatively associated with RA and PA. Results confirm the importance of considering the multidimensionality of empathy and aggression and suggest both common and distinct pathways from empathy to aggression.
Given growing evidence for a joint hierarchical framework of clinical and personality symptomatology, situating triarchic traits within this model would acknowledge transdiagnostic trait-related ...variance and provide a basis for linking the
Alternative Model of Personality Disorders (AMPD) domains to established indicators of these neurobehavioral traits. The current study (
= 2,041 Italian adults) sought to replicate and extend recent evidence regarding the locations of triarchic traits within the AMPD and to examine relations with criterion measures at different levels of the hierarchy. "Bass-ackwards" analyses revealed a hierarchical structure of personality pathology in which triarchic traits aligned with broad dispositional domains of the AMPD. Boldness, meanness, and disinhibition were clearly situated within the Externalizing branch of the hierarchy and helped to differentiate the Negative Affect, Antagonism, Detachment, and Disinhibition domains at lower levels. The current findings support the view of psychopathy as multidimensional and encompassing developmentally meaningful and neurobehaviorally relevant traits.
Recent initiatives emphasize the need to consider developmental and transdiagnostic contributions of temperamental variation to psychopathological expression. Triarchic neurobehavioral trait ...dimensions (boldness, meanness, disinhibition), which demonstrate compatibility with established temperament models and can be quantified using items from different existing inventories, are well-suited to pursuing these goals. We undertook to develop item-based scales for indexing these traits in 285 children (ages 5-10) tested in the Child Mind Institute's Healthy Brain Network (HBN) study, and evaluated their psychometric properties in two separate samples of similar-aged children: 519 others from the HBN study and 261 for whom parental-informant ratings were obtained through MTurk. Associations with psychopathology measures provided evidence for a) transdiagnostic utility of the triarchic scales, b) (reversed) boldness as the strongest predictor of internalizing problems, c) meanness as related to both internalizing and externalizing problems, d) disinhibition as the strongest predictor of externalizing problems, and e)a moderating effect of meanness level on disinhibition's relationship with externalizing problems. This research demonstrates that the triarchic traits can be effectively represented in young children and show expected relations with clinical outcome measures. As such, this work provides a foundation for developmental research clarifying the role that core neurobehavioral dispositions play in mental health.
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Dostopno za:
BFBNIB, DOBA, FSPLJ, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Quantitative extraction of imaging features from medical scans (‘radiomics’) has attracted a lot of research attention in the last few years. The literature has consistently emphasized the potential ...use of radiomics for computer-assisted diagnosis, as well as for predicting survival and response to treatment. Radiomics is appealing in that it enables full-field analysis of the lesion, provides nearly real-time results, and is non-invasive. Still, a lot of studies suffer from a series of drawbacks such as lack of standardization and repeatability. Such limitations, along with the unmet demand for large enough image datasets for training the algorithms, are major hurdles that still limit the application of radiomics on a large scale. In this paper, we review the current developments, potential applications, limitations, and perspectives of PET/CT radiomics with specific focus on the management of patients with lung cancer.
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•PBI is valid alternative to WBI in patients at low-risk of local relapse.•PBI is delivered by means of various techniques, one of which is IOeRT.•After IOeRT, an unexpectedly high LR ...rate was observed in the only phase III RCT.•Patient selection impacts on LR rates after IOeRT.•With appropriate patient selection IOeRT outcomes overlap with other RT techniques.
Methodological and conceptual differences across studies have impeded our understanding of the relationship between psychopathy and internalizing psychopathology. To shed further light on this ...question, we undertook correlational and structural-modeling analyses of data from two samples to characterize how facets of psychopathy relate to internalizing psychopathology when assessed using multidimensional measures of each construct (i.e., Triarchic Psychopathy Measure, Inventory of Depression and Anxiety Symptoms). Participants for Study 1 were 470 undergraduates and community-dwelling adults who completed these measures in self-report form; participants for Study 2 were 301 community-dwelling adults who completed informant-rating versions of these measures (as applied to a known-other). Across samples, analyses revealed sharply contrasting associations for the three triarchic-model facets with internalizing psychopathology and its subdomains, with boldness relating negatively in most cases, disinhibition relating positively in most cases, and meanness exhibiting mostly null associations. Results provide a nuanced picture of associations between psychopathic symptomatology and internalizing problems.
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