Objective To clarify associations of fish consumption and long chain omega 3 fatty acids with risk of cerebrovascular disease for primary and secondary prevention.Design Systematic review and ...meta-analysis.Data sources Studies published before September 2012 identified through electronic searches using Medline, Embase, BIOSIS, and Science Citation Index databases.Eligibility criteria Prospective cohort studies and randomised controlled trials reporting on associations of fish consumption and long chain omega 3 fatty acids (based on dietary self report), omega 3 fatty acids biomarkers, or supplementations with cerebrovascular disease (defined as any fatal or non-fatal ischaemic stroke, haemorrhagic stroke, cerebrovascular accident, or transient ischaemic attack). Both primary and secondary prevention studies (comprising participants with or without cardiovascular disease at baseline) were eligible.Results 26 prospective cohort studies and 12 randomised controlled trials with aggregate data on 794 000 non-overlapping people and 34 817 cerebrovascular outcomes were included. In cohort studies comparing categories of fish intake the pooled relative risk for cerebrovascular disease for 2-4 servings a week versus ≤1 servings a week was 0.94 (95% confidence intervals 0.90 to 0.98) and for ≥5 servings a week versus 1 serving a week was 0.88 (0.81 to 0.96). The relative risk for cerebrovascular disease comparing the top thirds of baseline long chain omega 3 fatty acids with the bottom thirds for circulating biomarkers was 1.04 (0.90 to 1.20) and for dietary exposures was 0.90 (0.80 to 1.01). In the randomised controlled trials the relative risk for cerebrovascular disease in the long chain omega 3 supplement compared with the control group in primary prevention trials was 0.98 (0.89 to 1.08) and in secondary prevention trials was 1.17 (0.99 to 1.38). For fish or omega 3 fatty acids the estimates for ischaemic and haemorrhagic cerebrovascular events were broadly similar. Evidence was lacking of heterogeneity and publication bias across studies or within subgroups.Conclusions Available observational data indicate moderate, inverse associations of fish consumption and long chain omega 3 fatty acids with cerebrovascular risk. Long chain omega 3 fatty acids measured as circulating biomarkers in observational studies or supplements in primary and secondary prevention trials were not associated with cerebrovascular disease. The beneficial effect of fish intake on cerebrovascular risk is likely to be mediated through the interplay of a wide range of nutrients abundant in fish.
Leggett–Garg inequalities (LGIs) test the incompatibility between the notion of macrorealism and quantum theory. For unitary dynamics, the optimal quantum violation of a Leggett–Garg inequality is ...constrained by the Lüders bound. However, the LGIs do not provide the necessary and sufficient condition of macrorealism. A suitably formulated set of no‐signaling in time conditions along with the arrow‐of‐time condition provides the same. In this paper, two formulations in the three‐time Leggett–Garg scenario, are studied namely, the standard LGIs and the recently formulated variant of LGIs when the system evolves under PT‐symmetric Hamiltonian. It is first demonstrated that the quantum violations of both forms of LGIs exceed their respective Lüders bounds and can even reach their algebraic maximum. It is further shown that for the case of standard Leggett–Garg inequality, the violation of Lüders bound can be obtained when both no‐signaling in time and arrow‐of‐time conditions are violated. Interestingly, for the case of a variant of LGIs, for suitable choices of relevant parameters, the quantum violation can even be obtained when only the arrow‐of‐time is violated. However, all no‐signaling in time conditions are satisfied. Such a feature is hitherto unexplored.
The Lüders bounds of the standard and variant of Leggett‐Garg inequalities in unitary quantum mechanics requires the violation of no‐signaling in time conditions. In PT‐symmetric quantum mechanics the quantum violation of both form of Leggett‐Garg inequalities exceeds their Lüders bound and reach their algebraic maxima. PT‐symmetric evolution results in violation of arrow‐of‐time along with no‐signaling in time.
The complex physical, kinematic, and chemical properties of galaxy centres make them interesting environments to examine with molecular line emission. We present new 2 − 4″ (∼75 − 150 pc at 7.7 Mpc) ...observations at 2 and 3 mm covering the central 50″ (∼1.9 kpc) of the nearby double-barred spiral galaxy NGC 6946 obtained with the IRAM Plateau de Bure Interferometer. We detect spectral lines from ten molecules: CO, HCN, HCO
+
, HNC, CS, HC
3
N, N
2
H
+
, C
2
H, CH
3
OH, and H
2
CO. We complemented these with published 1 mm CO observations and 33 GHz continuum observations to explore the star formation rate surface density Σ
SFR
on 150 pc scales. In this paper, we analyse regions associated with the inner bar of NGC 6946 – the nuclear region (NUC), the northern (NBE), and southern inner bar end (SBE) and we focus on short-spacing corrected bulk (CO) and dense gas tracers (HCN, HCO
+
, and HNC). We find that HCO
+
correlates best with Σ
SFR
, but the dense gas fraction (
f
dense
) and star formation efficiency of the dense gas (SFE
dense
) fits show different behaviours than expected from large-scale disc observations. The SBE has a higher Σ
SFR
,
f
dense
, and shocked gas fraction than the NBE. We examine line ratio diagnostics and find a higher CO(2−1)/CO(1−0) ratio towards NBE than for the NUC. Moreover, comparison with existing extragalactic datasets suggests that using the HCN/HNC ratio to probe kinetic temperatures is not suitable on kiloparsec and sub-kiloparsec scales in extragalactic regions. Lastly, our study shows that the HCO
+
/HCN ratio might not be a unique indicator to diagnose AGN activity in galaxies.
Introduction
Non-suicidal Self-Injury (NSSI) refers to causing damage on body tissue without attending to death. It is mostly presented among the youths and not approved by the society. Studies ...nowadays have explored the perspectives, feelings or experience of the youths or healthcare professionals. However, negative feelings and misunderstandings toward each other remain from both sides.
Objectives
The aim was to explore the encountering experience of the youths with NSSI and the healthcare professionals during the same hospitalization in a psychiatric acute ward.
Methods
Qualitative study was employed by using narrative approach. In-depth interview was conducted for the youths with NSSI and their primary nurse and resident from a medical center in southern Taiwan.
Results
Narratives from the patients and healthcare professionals showed that the youths seemed to be comfortable as encountering with the healthcare professionals’ caring. In contrast, the healthcare professionals’ struggles had been hidden inside and remained uneasy and unsolved. Two extreme experiences have been reported by the youths with NSSI: felt satisfied and understood about being cared vs. felt numbness and not been understood. Four kinds of experience were identified as: struggling on caring them, feeling confused and helpless, keeping a safe distance, and having contradicted values.
Conclusions
This study found that the healthcare professionals suffer from varied aspects when encountering the youths with NSSI, which they often hid inside without expressing. Future improvement such as care guideline or staff’s support system should be built to decrease the negative effects inside the healthcare professionals’ mind.
Disclosure
No significant relationships.
To examine the long-term relationship between changes in water and beverage intake and weight change.
Prospective cohort studies of 50013 women aged 40-64 years in the Nurses' Health Study (NHS, ...1986-2006), 52987 women aged 27-44 years in the NHS II (1991-2007) and 21988 men aged 40-64 years in the Health Professionals Follow-up Study (1986-2006) without obesity and chronic diseases at baseline.
We assessed the association of weight change within each 4-year interval, with changes in beverage intakes and other lifestyle behaviors during the same period. Multivariate linear regression with robust variance and accounting for within-person repeated measures were used to evaluate the association. Results across the three cohorts were pooled by an inverse-variance-weighted meta-analysis.
Participants gained an average of 1.45 kg (5th to 95th percentile: -1.87 to 5.46) within each 4-year period. After controlling for age, baseline body mass index and changes in other lifestyle behaviors (diet, smoking habits, exercise, alcohol, sleep duration, TV watching), each 1 cup per day increment of water intake was inversely associated with weight gain within each 4-year period (-0.13 kg; 95% confidence interval (CI): -0.17 to -0.08). The associations for other beverages were: sugar-sweetened beverages (SSBs) (0.36 kg; 95% CI: 0.24-0.48), fruit juice (0.22 kg; 95% CI: 0.15-0.28), coffee (-0.14 kg; 95% CI: -0.19 to -0.09), tea (-0.03 kg; 95% CI: -0.05 to -0.01), diet beverages (-0.10 kg; 95% CI: -0.14 to -0.06), low-fat milk (0.02 kg; 95% CI: -0.04 to 0.09) and whole milk (0.02 kg; 95% CI: -0.06 to 0.10). We estimated that replacement of 1 serving per day of SSBs by 1 cup per day of water was associated with 0.49 kg (95% CI: 0.32-0.65) less weight gain over each 4-year period, and the replacement estimate of fruit juices by water was 0.35 kg (95% CI: 0.23-0.46). Substitution of SSBs or fruit juices by other beverages (coffee, tea, diet beverages, low-fat and whole milk) were all significantly and inversely associated with weight gain.
Our results suggest that increasing water intake in place of SSBs or fruit juices is associated with lower long-term weight gain.
Acute respiratory distress syndrome is the most severe form of acute lung injury (ALI) and is associated with significant mortality. Lipopolysaccharide (LPS)-induced injury is a valuable murine model ...of ALI but there is a paucity of data on lung regeneration and the role of angiogenic signaling involving vascular endothelial growth factor (VEGF). Eight-week-old male C57BL/6J mice were randomized to receive intratracheal instillation of either LPS or isovolumetric phosphate buffered saline as a vehicle control. Mice were observed at a single follow-up time-point that was either short-term (24 h or 4 days) or long-term (7 days or 4 weeks). On pulmonary function testing, LPS-treated mice had increased compliance at 4 weeks post-instillation, which correlated with decreased vascularization and with time-dependent, progressive decrease in alveolarization. Treadmill exercise tolerance testing demonstrated impaired performance at 24 h, 4 days and 4 weeks following LPS exposure. On lung protein analysis, LPS instillation decreased VEGF expression at up to 4 weeks, and decreased activation of its key receptor, VEGFR2 at 7 days and 4 weeks post-instillation. Together, these data provide insight on long-term pulmonary functional outcomes 4 weeks after ALI and identify angiogenic proteins as possible therapeutic targets following lung injury.
We study various formulations of Leggett-Garg inequality (LGI), specifically, the Wigner and Clauser-Horne forms of LGI, in the context of subatomic systems, in particular, three flavor neutrino as ...well as meson systems. The optimal forms of various LGIs for either neutrinos or mesons are seen to depend on measurement settings. For the neutrinos, some of these inequalities can be written completely in terms of experimentally measurable probabilities. Hence, the Wigner and Clauser-Horne forms of LGI are found to be more suitable as compared to the standard LGI from the experimental point of view for the neutrino system. Further, these inequalities exhibit maximum quantum violation around the energies roughly corresponding to the maximum neutrino flux. The Leggett-Garg type inequality is seen to be more suited for the meson dynamics. The meson system being inherently a decaying system allows one to see the effect of decoherence on the extent of violation of various inequalities. Decoherence is observed to reduce the degree of violation, and hence the nonclassical nature of the system.
Abstract The ‘default mode network’ (DMN), a collection of brain regions including the posterior cingulate cortex (PCC), shows reliable inter-regional functional connectivity at rest. It has been ...implicated in rumination and other negative affective states, but its role in suicidal ideation is not well understood. We employed seed based functional connectivity methods to analyze resting state fMRI data in 34 suicidal ideators and 40 healthy control participants. Whole-brain connectivity with dorsal PCC or ventral PCC was broadly intact between the two groups, but while the control participants showed greater coupling between the dorsal anterior cingulate cortex (dACC) and dorsal PCC, compared to the dACC and ventral PCC, this difference was reversed in the ideators. Furthermore, ongoing low frequency BOLD signal in these three regions (dorsal, ventral PCC, dACC) was reduced in the ideators. The structural integrity of the cingulum bundle, as measured using diffusion tensor imaging (DTI), also explained variation in the functional connectivity measures but did not abolish the group differences. Together, these findings provide evidence of abnormalities in the DMN underlying the tendency towards suicidal ideation.
In this work we propose a definite theoretical implementation of the three-box paradox-a scheme in which a single quantum particle appears to be present with certainty in two separate boxes-with ...spin-1 atoms. We further show how our setup can give rise to a 'Cheshire cat grin' type of situation, in which an atom can apparently be found with certainty in one of the boxes while one of its properties (the angular momentum projection along a specifically chosen axis) appears to be in a different box. The significance of our findings is discussed relative to the status of the properties of a system obtained from weak measurements.
In Budroni and Emary (Phys. Rev. Lett.
113
, 050401,
2014
) the authors have shown that instead of L
ü
der rule, if degeneracy breaking von Neumann projection rule is adopted for state reduction, the ...quantum value of three-time Leggett-Garg inequality can exceed it’s L
ü
ders bound. Such violation of L
ü
ders bound may even approach algebraic maximum of the inequality in the asymptotic limit of system size. They also claim that for Clauser-Horne-Shimony-Holt (CHSH) inequality such violation of L
ü
ders bound (known as Cirelson’s bound) cannot be obtained even when the measurement is performed sequentially first by Alice followed by Bob. In this paper, we have shown that if von Neumann projection rule is used, quantum bound of CHSH inequality exceeds it’s Cirelson’s bound and may also reach its algebraic maximum four. This thus provide a strong objection regarding the viability of von Neumann rule as a valid state reduction rule. Further, we pointed out that the violation of Cirelson’s bound occurs due to the injection of additional quantum non-locality by the act of implementing von Neumann rule.
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