En el oeste de Rajasthan, India, la Arenisca de Jodhpur (Supergrupo de Marwar) ha librado un nuevo conjunto fósil ediacárico que comprende especímenes macroscópicos bien conservados de Aspidella, ...Hiemalora, grandes discos ediacáricos, Tirasiana disciformis, asteroides de Medusinites, fósiles de cuerpo blando ediacáricos similares a Anfesta y estructuras de tapices microbianas (Arumberia banksi, estructuras microbianas de tipo Kinneyia, estructuras microbianas arrugadas y otras estructuras microbianas). El registro fósil permite sugerir una amplia correlación con la Formación de Fermuse, Terranova, Australia meridional, el Mar Blanco de Rusia y Noruega, y la correlación regional con el Grupo de Bhander (Supergroup de Vindhyan) y el Grupo de Krol del Himalaya Interior.
The present paper describes the abundant and very well preserved ichnotaxon complex
Hillichnus agrioensis
, as established by four different morphological levels of exposures. Associated ...trace-fossils such as
Jamesonichnites heinbergi
and
Ancorichnus ancorichnus
are also being reported from the Hettangian to Bajocian Thaiat Member of Lathi Formation of Jaisalmer basin, western Rajasthan, India. The ichnospeices
Hillichnus agrioensis
is being documented for the first time in India. Morphologically,
Hillichnus agrioensis
includes straight to gently curved, branched or feather-like (almost flat) structures with a central tube. It is interpreted as a deep-burrowing bi-siphonate or tellinaceans bivalves. The ichnotaxon
Jamesonichnites heinbergi
is interpreted as a burrow made by an infaunal deposit-feeder (fodinichnion), while
Ancorichnus ancorichnus
is domichnion and may also solely be the result of locomotion (repichnion). This study suggests the presence of shallow or marginal-marine environment for the above-mentioned trace-fossil bearing horizons as trace-fossils characterized by such features have also been found from other parts of the world.
Infliximab, a monoclonal antibody directed against tumour necrosis factor, is an effective therapy for moderate-to-severe ulcerative colitis and Crohn’s disease. Uncommonly, serious opportunistic ...infections have occurred in patients after infliximab administration. Here, we describe meningitis caused by
Listeria monocytogenes
developing in a 37-year-old man with ulcerative colitis refractory to intravenous corticosteroids 10 days after receiving his first infusion of infliximab. With the increasing use of tumour necrosis factor-α-neutralizing agents, clinicians should be aware of the risk of opportunistic infections caused by
L. monocytogenes
in patients with inflammatory bowel disease following infliximab treatment. The half-life of infliximab is 9.5 days; therefore, patients tend to be more susceptible in the immediate period following infusion. Patients receiving anti-TNF therapy should be advised to avoid foods such as soft cheeses and unpasteurized dairy products.
The incidence of
Listeria species in the seafood of markets in Goa, India was studied. One hundred and fifteen raw/fresh seafoods bought at the fish markets were sampled and tested for presence of
...Listeria spp. using a two step enrichment procedure, followed by plating on two selective agars. The confirmation of the isolates was based on biochemical identification. Twenty eight seafood samples were positive for
Listeria spp. and in 10 samples
L. monocytogenes was detected.
L. innocua was the most common
Listeria species recovered and was detected in 18 samples.
L. monocytogenes in raw seafood may pose a health risk in kitchen if contaminating ready-to-eat food.
The differential diagnosis of a mediastinal mass is a common challenge in clinical practice, with a wide range of differential diagnosis to be considered. One of the rarer causes is tuberculosis. ...Atypical presentations of tuberculosis are well documented in immunocompromised patients, but should also be considered in the immunocompetent.
This case outlines a previously healthy 22 year-old immunocompetent male presenting with worsening chest pain, positional dyspnea, dry cough and dysphagia. Chest x-ray showed evidence of an isolated anterior mediastinal mass, which was confirmed on computed tomography. A mediastinoscopy was diagnostic as histology revealed necrotizing granulomatous inflammation and the presence of acid-fast bacilli, indicating mediastinal tuberculosis.
Typically the underlying presentation of mediastinal tuberculosis is mediastinal lymphadenitis. This case was unusual in that we detected an isolated large anterior mediastinal mass accompanied by a relatively small burden of mediastinal lymphadenitis. Cases similar to this have been documented in immunosuppressed patients however in our case no evidence of immunosuppression was found. This case report emphasizes the importance that a detailed and logical pathway of investigation is pursued when encountering a mediastinal mass.
Background
The effects of thiopurines on white cell count are well documented.
Objective
We compared the effects of infliximab 5 mg/kg monotherapy and combination of infliximab with thiopurines on ...the total and differential white cell count (WBC).
Methods
13 IBD patients treated with infliximab monotherapy and 18 IBD patients treated with a combination of infliximab and thiopurines were included in the study. Using retrospective data, cell counts were examined prior to induction of infliximab, and at 6 weeks and 1 year post-induction.
Results
The patients on combination therapy had an absolute WBC at 52 weeks of 5.7 whereas that of patients on Infliximab monotherapy at the same time point was 8.3 with comparable neutrophil count of 3.4 and 5.4. The results showed a significant reduction in white cell count and neutrophils at 6 weeks which persisted at 52 weeks in both groups (
p
< 0.05) with a greater drop in patients on combination infliximab and thiopurine (
p
< 0.05) as compared to Infliximab monotherapy. There was no significant change in the lymphocyte count.
Conclusion
Full blood counts should be closely monitored in all patients starting infliximab therapy, in particular patients receiving concomitant thiopurines.
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