A hybrid filler system, which combines hexagonal boron nitride (hBN) and copper particles, was applied on the surface of continuous carbon fiber tapes by utilizing electrophoretic deposition to ...maximize the thermal conductivity of carbon fiber-reinforced polymer (CFRP) composite in this study. The results show that as the deposition time increased, the thermal conductivity increased. The annealing treatment made the copper particles connect with adjacent particles, which highly enhanced the thermal conductivity. The CFRP made of annealed carbon fiber tapes with hBN/Cu coating performed the best thermal conductivity and largest enhancement efficiency in this work for as high as 2.16 W/m·K and 217% in through-plane direction, and 6.14 W/m·K, and 47% in in-plane direction.
2,3-Butanediol (2,3-BD) has great potential for diverse industries, including chemical, cosmetics, agriculture, and pharmaceutical areas. However, its industrial production and usage are limited by ...the fairly high cost of its petro-based production. Several bio-based 2,3-BD production processes have been developed and their economic advantages over petro-based production process have been reported. In particular, many 2,3-BD-producing microorganisms including bacteria and yeast have been isolated and metabolically engineered for efficient production of 2,3-BD. In addition, several fermentation processes have been tested using feedstocks such as starch, sugar, glycerol, and even lignocellulose as raw materials. Since separation and purification of 2,3-BD from fermentation broth account for the majority of its production cost, cost-effective processes have been simultaneously developed. The construction of a demonstration plant that can annually produce around 300 tons of 2,3-BD is scheduled to be mechanically completed in Korea in 2019. In this paper, core technologies for bio-based 2,3-BD production are reviewed and their potentials for use in the commercial sector are discussed.
The demand for wearable, stretchable soft electronics for human–machine interface applications continues to grow given the potential of these devices in humanoid robotics, prosthetics, and ...health-monitoring devices. We demonstrate fabrication of multifunctional sensors with simultaneous temperature-, pressure-, proximity-, and strain (or bending)-sensing capabilities, combined with heating and UV-protection features. These multifunctional sensors are flexible, light, and transparent and are thus body-attachable. Silver nanowires are supersonically sprayed on a large-scale transparent and flexible roll-to-roll substrate. The junctions between nanowires are physically fused by a strong impact resulting from supersonic spraying, which promotes adhesion and efficient deposition of the nanowire network. Accordingly, nanowires are strongly interconnected, facilitating efficient propagation of electric signals through the fused nanowire network, which allows simultaneous operation of such sensors while maintaining significant transparency. These multifunctional sensors are mechanically durable and retain long-term stability. A theoretical discussion is provided to explain the respective mechanisms of heating and proximity, pressure, and strain sensing.
Sound rendering is the process of determining the sound propagation path from an audio source to a listener and generating 3D sound based on it. This task demands complex calculations, including ...trigonometric functions. This paper presents hardware-based inverse cosine function calculations using the table method and linear approximation. This approach maintains a high accuracy while limiting hardware size for suitability in sound rendering applications. Consequently, our proposed hardware-based inverse cosine calculation method is a valuable tool for achieving high efficiency and accuracy in 3D sound rendering.
Early detection and classification of bone tumors in the proximal femur is crucial for their successful treatment. This study aimed to develop an artificial intelligence (AI) model to classify bone ...tumors in the proximal femur on plain radiographs.
Standard anteroposterior hip radiographs were obtained from a single tertiary referral center. A total of 538 femoral images were set for the AI model training, including 94 with malignant, 120 with benign, and 324 without tumors. The image data were pre-processed to be optimized for training of the deep learning model. The state-of-the-art convolutional neural network (CNN) algorithms were applied to pre-processed images to perform three-label classification (benign, malignant, or no tumor) on each femur. The performance of the CNN model was verified using fivefold cross-validation and was compared against that of four human doctors.
The area under the receiver operating characteristic (AUROC) of the best performing CNN model for the three-label classification was 0.953 (95% confidence interval, 0.926-0.980). The diagnostic accuracy of the model (0.853) was significantly higher than that of the four doctors (0.794) (P = 0.001) and also that of each doctor individually (0.811, 0.796, 0.757, and 0.814, respectively) (P<0.05). The mean sensitivity, specificity, precision, and F1 score of the CNN models were 0.822, 0.912, 0.829, and 0.822, respectively, whereas the mean values of four doctors were 0.751, 0.889, 0.762, and 0.797, respectively.
The AI-based model demonstrated high performance in classifying the presence of bone tumors in the proximal femur on plain radiographs. Our findings suggest that AI-based technology can potentially reduce the misdiagnosis of doctors who are not specialists in musculoskeletal oncology.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The ability to image pressure distribution over complex three-dimensional surfaces would significantly augment the potential applications of electronic skin. However, existing methods show poor ...spatial and temporal fidelity due to their limited pixel density, low sensitivity, or low conformability. Here, we report an ultraflexible and transparent electroluminescent skin that autonomously displays super-resolution images of pressure distribution in real time. The device comprises a transparent pressure-sensing film with a solution-processable cellulose/nanowire nanohybrid network featuring ultrahigh sensor sensitivity (>5000 kPa
) and a fast response time (<1 ms), and a quantum dot-based electroluminescent film. The two ultrathin films conform to each contact object and transduce spatial pressure into conductivity distribution in a continuous domain, resulting in super-resolution (>1000 dpi) pressure imaging without the need for pixel structures. Our approach provides a new framework for visualizing accurate stimulus distribution with potential applications in skin prosthesis, robotics, and advanced human-machine interfaces.
•Sodium alginate beads containing chemically bound PB beads were prepared.•The beads showed improved adsorption of Cs ions compared to conventional sodium alginate beads containing PB.•The beads ...showed efficient adsorption in a fixed bed column as well as in a batch with good stability.•The beads exhibited high removal efficiency toward radioactive 137Cs.
A new approach for efficient removal of radioactive 137Cs was developed using a sodium alginate hydrogel beads-based adsorbent containing chemically bound Prussian blue (PB). Sodium alginate was crosslinked with Fe (III) ions to form hydrogel beads, in which Fe (III) had a dual function; it served as a crosslinking agent and also led to PB formation via reaction with hexacyanoferrate. Fe (III) ions, an unusual crosslinking agent for sodium alginate gel, led to stable, homogeneous distribution of PB inside the beads. The amount of embedded PB in the composite beads was more than two times larger than in the conventional sodium alginate-PB composite beads, resulting in an adsorption capacity for Cs ions that was two to five times higher, mainly because of a higher PB contents and because of the microporosity of the sodium alginate hydrogel.
The purpose of this study is to investigate imaging characteristics of young age breast cancer (YABC) focusing on correlation with pathologic factors and association with disease recurrence. From ...January 2017 to December 2019, patients under 40 years old who were diagnosed as breast cancer were enrolled in this study. Morphologic analysis of tumor and multiple quantitative parameters were obtained from pre-treatment dynamic contrast enhanced breast magnetic resonance imaging (DCE-MRI). Tumor-stroma ratio (TSR), microvessel density (MVD) and endothelial Notch 1 (EC Notch 1) were investigated for correlation with imaging parameters. In addition, recurrence associated factors were assessed using both clinico-pathologic factors and imaging parameters. A total of 53 patients were enrolled. Several imaging parameters derived from apparent diffusion coefficient (ADC) histogram showed negative correlation with TSR; and there was negative correlation between MVD and Ve in perfusion analysis. There were nine cases of recurrences with median interval of 16 months. Triple negative subtype and low CD34 MVD positivity in Notch 1 hotspots showed significant association with tumor recurrence. Texture parameters reflecting tumor sphericity and homogeneity were also associated with disease recurrence. In conclusion, several quantitative MRI parameters can be used as imaging biomarkers for tumor microenvironment and can predict disease recurrence in YABC.
Human serum albumin (HSA) has been widely used as a pharmaceutical excipient in Botulinum toxin serotype A (BoNT/A) products that are indicated for use in therapeutics and cosmetics. However, HSA as ...a human-derived material has some concerns, such as the potential risk of transmission of infectious agents, an insufficient supply, and difficulty in maintaining a certain quality. For those reasons, newly developed BoNT/A products (CORETOX®, Medytox, Inc., Republic of Korea) contained polysorbate 20, a non-human-derived excipient, to replace the HSA. However, most safety studies of polysorbate 20 have been conducted with non-invasive routes of administration, and thus there are a few studies on the safety of polysorbate 20 when administered intramuscularly. To secure the in vivo safety profile of polysorbate 20, a four-week repeated intramuscular dose toxicity study (0.02, 0.1, and 0.4 mg/kg, one injection every two weeks for a total of three injections) was conducted in 66 Sprague-Dawley (SD) rats. An intradermal irritation study was further conducted with 18 New Zealand White (NZW) rabbits. The toxicological evaluation of HSA (0.06 and 0.12 mg/kg) was also carried out as a comparative substance. Systemic and local toxicities were not observed in any of the SD rats or NZW rabbits based on clinical signs, body weight, hematology, clinical biochemistry, macroscopic findings on necropsy, histopathology of the injection site, and allergic reactions. The current study suggested that intramuscular administration of polysorbate 20 was considered to be safe at a level similar to that of HSA, which has an in vivo safety profile accumulated over the years. This provided the basis for the in vivo safety profile of polysorbate 20 administered intramuscularly and the scientific reliability of the use of polysorbate 20 as an alternative to HSA, which is used as an excipient for various pharmaceuticals in terms of its safety.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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•Self-propelled micromotor adsorbent was developed for selective adsorption of radioactive Cs.•The random movement of the micromotor adsorbent significantly reduced the Cs cleanup ...time.•The micromotor adsorbent was remotely steerable and collectable using a magnetic field.•More than 98% of the radioactive 137Cs ions were removed from solution containing competing ions.
We report the development of magnetically steerable self-propelled micromotors that selectively remove radioactive Cs from contaminated water. Mesoporous silica microspheres were functionalized with the highly Cs-selective copper ferrocyanide, and half of the adsorptive particle surface was then coated with ferromagnetic Ni and catalytic Pt layers to fabricate Janus micromotors. The micromotor adsorbent displayed random propulsion in an H2O2 solution via catalytic bubble evolution from the Pt surface, and the micromotor adsorbent self-propulsion resulted in an 8-fold higher Cs removal compared to the stationary adsorbent within one hour. The ferromagnetism of the Ni layer allowed the micromotor adsorbent to be magnetically and remotely steerable, and the propulsion speed under a magnetic field was ˜11-fold greater than it was in the absence of the magnetophoretic force. The adsorption of Cs by the self-propelling micromotor adsorbent and the subsequent magnetic recovery of the adsorbent enabled the successful removal of radioactive 137Cs from aqueous solutions. More than 98% of the radioactive 137Cs ions were removed from solution, even in the presence of competing ions, such as Na+ (1000 ppm).
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