Summary Objective Cam hip shape morphology is a recognised cause of femoroacetabular impingement (FAI) and is associated with hip osteoarthritis. Our aim was to systematically review the available ...epidemiological evidence assessing the prevalence of cam hip shape morphology in the general population and any studied subgroups including subjects with and without hip pain. Design All studies that reported the prevalence of cam morphology, measured by alpha angles, in subjects aged 18 and over, irrespective of study population or presence of hip symptoms were considered for inclusion. We searched AMED, MEDLINE, EMBASE, CINAHL and CENTRAL in October 2015. Two authors independently identified eligible studies and assessed risk of bias. We planned to pool data of studies considered clinically homogenous. Results Thirty studies met inclusion criteria. None of the included studies were truly population-based: three included non-representative subgroups of the general population, 19 included differing clinical populations, while eight included professional athletes. All studies were judged to be at high risk of bias. Due to substantial clinical heterogeneity meta analysis was not possible. Across all studies, the prevalence estimates of cam morphology ranged from 5 to 75% of participants affected. We were unable to demonstrate a higher prevalence in selected subgroups such as athletes or those with hip pain. Conclusions There is currently insufficient high quality data to determine the true prevalence of cam morphology in the general population or selected subgroups. Well-designed population-based epidemiological studies that use homogenous case definitions are required to determine the prevalence of cam morphology and its relationship to hip pain.
Most past studies of river dune dynamics have concentrated on two‐dimensional (2‐D) bed forms, with constant heights and straight crest lines transverse to the flow, and their associated turbulent ...flow structure. This morphological simplification imposes inherent limitations on the interpretation and understanding of dune form and flow dynamics in natural channels, where dune form is predominantly three‐dimensional. For example, studies over 2‐D forms neglect the significant influence that lateral flows and secondary circulation may have on the flow structure and thus dune morphology. This paper details a field study of a swath of 3‐D dunes in the Rio Paraná, Argentina. A large (0.35 km wide, 1.2 km long) area of dunes was surveyed using a multibeam echo sounder (MBES) that provided high‐resolution 3‐D detail of the river bed. Simultaneous with the MBES survey, 3‐D flow information was obtained with an acoustic Doppler current profiler (ADCP), revealing a complicated pattern of dune morphology and associated flow structure within the swath. Dune three‐dimensionality appears intimately connected to the morphology of the upstream dune, with changes in crest line curvature and crest line bifurcations/junctions significantly influencing the downstream dune form. Dunes with lobe or saddle‐shaped crest lines were found to have larger, more structured regions of vertical velocity with smaller separation zones than more 2‐D straight‐crested dunes. These results represent the first integrated study of 3‐D dune form and mean flow structure from the field and show several similarities to recent laboratory models of flow over 3‐D dunes.
Submarine channels are key features for the transport of flow and nutrients into deep water. Previous studies of their morphology and channel evolution have treated these systems as abiotic, and ...therefore assume that physical processes are solely responsible for morphological development. Here, a unique dataset is utilised that includes spatial measurements around a channel bend that hosts active sediment gravity flows. The data include flow velocity and density, alongside bed grain size and channel‐floor benthic macrofauna. Analysis of these parameters demonstrate that while physical processes control the broadest scale variations in sedimentation around and across the channel, benthic biology plays a critical role in stabilising sediment and trapping fines. This leads to much broader mixed grain sizes than would be expected from purely abiotic sedimentation, and the maintenance of sediment beds in positions where all the sediment should be actively migrating. Given that previous work has also shown that submarine channels can be biological hotspots, then the present study suggests that benthic biology probably plays a key role in channel morphology and evolution, and that these need to be considered both in the modern and when considering examples preserved in the rock record.
This work first integrates flow data, sediment and biota for a subaqueous channel showing clear feedbacks between them. We suggest that biota can play a major role in sedimentation within submarine channels. Therefore, the assumption that submarine channels are abiotic should be discarded, which directly impacts on palaeoflow characteristics in ancient sediments.
We present high-speed ULTRACAM photometry of the eclipsing post-common-envelope binaries DE CVn, GK Vir, NN Ser, QS Vir, RR Cae, RX J2130.6+4710, SDSS 0110+1326 and SDSS 0303+0054 and use these data ...to measure precise mid-eclipse times in order to detect any period variations. We detect a large (∼250 s) departure from linearity in the eclipse times of QS Vir which Applegate's mechanism fails to reproduce by an order of magnitude. The only mechanism able to drive this period change is a third body in a highly elliptical orbit. However, the planetary/sub-stellar companion previously suggested to exist in this system is ruled out by our data. Our eclipse times show that the period decrease detected in NN Ser is continuing, with magnetic braking or a third body the only mechanisms able to explain this change. The planetary/sub-stellar companion previously suggested to exist in NN Ser is also ruled out by our data. Our precise eclipse times also lead to improved ephemerides for DE CVn and GK Vir. The width of a primary eclipse is directly related to the size of the secondary star and variations in the size of this star could be an indication of Applegate's mechanism or Wilson (starspot) depressions which can cause jitter in the O−C curves. We measure the width of primary eclipses for the systems NN Ser and GK Vir over several years but find no definitive variations in the radii of the secondary stars. However, our data are precise enough (ΔRsec/Rsec < 10−5) to show the effects of Applegate's mechanism in the future. We find no evidence of Wilson depressions in either system. We also find tentative indications that flaring rates of the secondary stars depend on their mass rather than rotation rates.
Abstract
Marine microplastics (MPs) accumulate in sediments but impacts on ecosystem functions are poorly understood. MPs interactions with stabilizing benthic flora/fauna or biostabilization ...processes, have not been fully investigated, yet this is critical for unraveling MPs effects on ecosystem-scale processes and functions. This is also vital for understanding feedback processes that may moderate the stock and flow of MPs as they are transported through estuaries. The relationships between sedimentary MPs, biota, environmental properties and sediment stability from field sediments, were examined using variance partitioning (VP) and correlation analyses. VP was used to identify common and unique contributions of different groups of variables (environmental, fauna and microplastic variables) to sediment stability. The influence of microplastic presence (fragment/fiber abundances and microplastic diversity) on sediment stability (defined using erosion thresholds and erosion rates) was demonstrated. Furthermore, MPs appeared to mediate the biostabilizing effects of environmental properties (including microorganisms) and fauna. Environmental properties and sediment stability could also explain the variation in MPs across sites suggesting biostabilizing properties may mediate the abundance, type and diversity of MPs that accumulate in the bed. The potential for MPs to influence biota and biostabilization processes and mediate microplastic resuspension dynamics within estuaries is discussed.
The heart receives high radiation doses during radiation therapy of advanced-stage lung cancer. We have explored associations between overall survival, cardiac radiation doses, and ...electrocardiographic (ECG) changes in patients treated in IDEAL-CRT, a trial of isotoxically escalated concurrent chemoradiation delivering tumor doses of 63 to 73 Gy.
Dosimetric and survival data were analyzed for 78 patients. The whole heart, pericardium, AV node, and walls of left and right atria (LA/RA-Wall) and ventricles (LV/RV-Wall) were outlined on radiation therapy planning scans, and differential dose-volume histograms (dDVHs) were calculated. For each structure, dDVHs were approximated using the average dDVH and the 10 highest-ranked structure-specific principal components (PCs). ECGs at baseline and 6 months after radiation therapy were analyzed for 53 patients, dichotomizing patients according to presence or absence of “any ECG change” (conduction or ischemic/pericarditis-like change). All-cause death rate (DR) was analyzed from the start of treatment using Cox regression.
38% of patients had ECG changes at 6 months. On univariable analysis, higher scores for LA-Wall-PC6, Heart-PC6, “any ECG change,” and larger planning target volume (PTV) were significantly associated with higher DR (P=.003, .009, .029, and .037, respectively). Heart-PC6 and LA-Wall-PC6 represent larger volumes of whole heart and left atrial wall receiving 63 to 69 Gy. Cardiac doses ≥63 Gy were concentrated in the LA-Wall, and consequently Heart-PC6 was highly correlated with LA-Wall-PC6. “Any ECG change,” LA-Wall-PC6 scores, and PTV size were retained in the multivariable model.
We found associations between higher DR and conduction or ischemic/pericarditis-like changes on ECG at 6 months, and between higher DR and higher Heart-PC6 or LA-Wall-PC6 scores, which are closely related to heart or left atrial wall volumes receiving 63 to 69 Gy in this small cohort of patients.
Abstract
The Large Array Survey Telescope (LAST) is a wide-field visible-light telescope array designed to explore the variable and transient sky with a high cadence. LAST will be composed of 48, 28 ...cm f/2.2 telescopes (32 already installed) equipped with full-frame backside-illuminated cooled CMOS detectors. Each telescope provides a field of view (FoV) of 7.4 deg
2
with 1.″25 pix
−1
, while the system FoV is 355 deg
2
in 2.9 Gpix. The total collecting area of LAST, with 48 telescopes, is equivalent to a 1.9 m telescope. The cost-effectiveness of the system (i.e., probed volume of space per unit time per unit cost) is about an order of magnitude higher than most existing and under-construction sky surveys. The telescopes are mounted on 12 separate mounts, each carrying four telescopes. This provides significant flexibility in operating the system. The first LAST system is under construction in the Israeli Negev Desert, with 32 telescopes already deployed. We present the system overview and performances based on the system commissioning data. The
B
p
5
σ
limiting magnitude of a single 28 cm telescope is about 19.6 (21.0), in 20 s (20 × 20 s). Astrometric two-axes precision (rms) at the bright-end is about 60 (30) mas in 20 s (20 × 20 s), while absolute photometric calibration, relative to GAIA, provides ∼10 millimag accuracy. Relative photometric precision, in a single 20 s (320 s) image, at the bright-end measured over a timescale of about 60 minutes is about 3 (1) millimag. We discuss the system science goals, data pipelines, and the observatory control system in companion publications.
Purpose
Heat stress exacerbates post-exercise hypotension (PEH) and cardiovascular disturbances from elevated body temperature may contribute to exertion-related incapacity. Mast cell degranulation ...and muscle mass are possible modifiers, though these hypotheses lack practical evidence. This study had three aims: (1) to characterise pre–post-responses in histamine and mast cell tryptase (MCT), (2) to investigate relationships between whole body muscle mass (WBMM) and changes in blood pressure post-marathon, (3) to identify any differences in incapacitated runners.
Methods
24 recreational runners were recruited and successfully completed the 2019 Brighton Marathon (COMPLETION). WBMM was measured at baseline. A further eight participants were recruited from incapacitated runners (COLLAPSE). Histamine, MCT, blood pressure, heart rate, body temperature and echocardiographic measures were taken before and after exercise (COMPLETION) and upon incapacitation (COLLAPSE).
Results
In completion, MCT increased by nearly 50% from baseline (
p
= 0.0049), whereas histamine and body temperature did not vary (
p
> 0.946). Systolic (SBP), diastolic (DBP) and mean (MAP) arterial blood pressures and systemic vascular resistance (SVR) declined (
p
< 0.019). WBMM negatively correlated with
Δ
SBP (
r
= − 0.43,
p
= 0.046). For collapse versus completion, there were significant elevations in MCT (1.77 ± 0.25 μg/L vs 1.18 ± 0.43 μg/L,
p
= 0.001) and body temperature (39.8 ± 1.3 °C vs 36.2 ± 0.8 °C,
p
< 0.0001) with a non-significant rise in histamine (9.6 ± 17.9 μg/L vs 13.7 ± 33.9 μg/L,
p
= 0.107) and significantly lower MAP, DBP and SVR (
p
< 0.033).
Conclusion
These data support the hypothesis that mast cell degranulation is a vasodilatory mechanism underlying PEH and exercise associated collapse. The magnitude of PEH is inversely proportional to the muscle mass and enhanced by concomitant body heating.
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