A survey of intrusion detection techniques in Cloud Modi, Chirag; Patel, Dhiren; Borisaniya, Bhavesh ...
Journal of network and computer applications,
January 2013, 2013, 2013-1-00, Letnik:
36, Številka:
1
Journal Article
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Odprti dostop
In this paper, we survey different intrusions affecting availability, confidentiality and integrity of Cloud resources and services. Proposals incorporating Intrusion Detection Systems (IDS) and ...Intrusion Prevention Systems (IPS) in Cloud are examined. We recommend IDS/IPS positioning in Cloud environment to achieve desired security in the next generation networks.
Cloud computing offers scalable on-demand services to consumers with greater flexibility and lesser infrastructure investment. Since Cloud services are delivered using classical network protocols and ...formats over the Internet, implicit vulnerabilities existing in these protocols as well as threats introduced by newer architectures raise many security and privacy concerns. In this paper, we survey the factors affecting Cloud computing adoption, vulnerabilities and attacks, and identify relevant solution directives to strengthen security and privacy in the Cloud environment.
Biodegradable Piezoelectric Force Sensor Curry, Eli J.; Ke, Kai; Chorsi, Meysam T. ...
Proceedings of the National Academy of Sciences,
01/2018, Letnik:
115, Številka:
5
Journal Article
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Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using ...mechanical stimulation for tissue regeneration. Pressure sensors are often required to be implanted and directly integrated with native soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery that can damage directly interfaced tissues. Despite recent achievements in degradable electronic devices, there is still a tremendous need to develop a force sensor which only relies on safe medical materials and requires no complex fabrication process to provide accurate information on important biophysiological forces. Here, we present a strategy for material processing, electromechanical analysis, device fabrication, and assessment of a piezoelectric Poly-L-lactide (PLLA) polymer to create a biodegradable, biocompatible piezoelectric force sensor, which only employs medical materials used commonly in Food and Drug Administration-approved implants, for the monitoring of biological forces. We show the sensor can precisely measure pressures in a wide range of 0–18 kPa and sustain a reliable performance for a period of 4 d in an aqueous environment. We also demonstrate this PLLA piezoelectric sensor can be implanted inside the abdominal cavity of a mouse to monitor the pressure of diaphragmatic contraction. This piezoelectric sensor offers an appealing alternative to present biodegradable electronic devices for the monitoring of intraorgan pressures. The sensor can be integrated with tissues and organs, forming self-sensing bionic systems to enable many exciting applications in regenerative medicine, drug delivery, and medical devices.
Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic ...stability. Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), had higher affinity at opioid receptors than at adrenergic receptors while the vice versa was observed for corynantheidine. The observed polypharmacology of kratom alkaloids may support its utilization to treat opioid use disorder and withdrawal.
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in vivo ...activity of kratom alkaloids at serotonin receptors (5-HTRs). Paynantheine and speciogynine exhibited high affinity for 5-HT1ARs and 5-HT2BRs, unlike the principal kratom alkaloid mitragynine. Both alkaloids produced antinociceptive properties in rats via an opioid receptor-independent mechanism, and neither activated 5-HT2BRs in vitro. Paynantheine, speciogynine, and mitragynine induced lower lip retraction and antinociception in rats, effects blocked by a selective 5-HT1AR antagonist. In vitro functional assays revealed that the in vivo 5-HT1AR agonistic effects may be due to the metabolites 9-O-desmethylspeciogynine and 9-O-desmethylpaynantheine and not the parent compounds. Both metabolites did not activate 5-HT2BR, suggesting low inherent risk of causing valvulopathy. The 5-HT1AR agonism by kratom alkaloids may contribute to the mood-enhancing effects associated with kratom use.
Background
Over 50% of US adults do not take their prescriptions as prescribed, which is responsible for 33%–69% of hospital admissions and 125,000 deaths annually. Given the higher prevalence of ...prescription drug use among middle-aged and older adult populations, promoting medication adherence is of particular importance with these age groups. Two speculated facilitators of medication adherence are home medication storage location and the use of digital health devices.
Objective
Our objective was to use survey data to investigate the associations between medication storage location and medication adherence among adults 40 years and older. Additionally, we aimed to report preliminary findings about the associations between use of devices and medication adherence in this same population.
Methods
We conducted primary analysis of data sampled from a home medication management survey deployed in November 2021 (
n
= 580). We conducted exploratory analyses by way of chi
2
tests and creation of bivariate logistic regression models.
Results
The most commonly used storage locations by our sample were nightstand drawers (27%), kitchen cabinets (25%), and atop bedroom nightstands (23%). Several medication storage locations were significantly associated with decreased odds of having ever forgotten to take a medication, including kitchen drawers, in refrigerators, atop bedroom nightstands, in nightstand drawers, and backpacks, purses, or bags. Two home medication storage locations were significantly associated with increased odds of having ever forgotten to take a medication: kitchen cabinets and bathroom vanities. Further, most (94%) survey respondents indicated they would be receptive to guidance about where to store their medications.
Conclusions
Given that some home medication storage locations are associated with adherence, an intervention to guide storage location selection may support increased adherence, especially with high receptivity expressed for such guidance. Increased adherence may also accrue from device usage paired with optimized home medication storage location. We plan to investigate that further, as well as how new device designs can incorporate contextual cues related to location to promote medication adherence more effectively in middle aged and older adults.
Abstract We present the first integrated-light, TESS-based light curves for star clusters in the Milky Way, Small Magellanic Cloud, and Large Magellanic Cloud. We explore the information encoded in ...these light curves, with particular emphasis on variability. We describe our publicly available package elk , which is designed to extract the light curves by applying principal component analysis to perform background light correction and incorporating corrections for TESS systematics, allowing us to detect variability on timescales shorter than ∼10 days. We perform a series of checks to ensure the quality of our light curves, removing observations where systematics are identified as dominant features, and deliver light curves for 348 previously cataloged open and globular clusters. Where TESS has observed a cluster in more than one observing sector, we provide separate light curves for each sector (for a total of 2204 light curves). We explore in detail the light curves of star clusters known to contain high-amplitude Cepheid and RR Lyrae variable stars, and we confirm that the variability of these known variables is still detectable when summed together with the light from thousands of other stars. We also demonstrate that even some low-amplitude stellar variability is preserved when integrating over a stellar population.
Filth flies, cockroaches, and dung beetles have been close neighbors with humans and animals throughout our joint histories. However, these insects can also serve as vectors for many zoonotic enteric ...parasites (ZEPs). Zoonoses by ZEPs remain a paramount public health threat due to our close contact with animals, combined with poor water, sanitation, and hygiene access, services, and behaviors in many global regions. Our objective in this systematic review was to determine which ZEPs have been documented in these vectors, to identify risk factors associated with their transmission, and to provide effectual One Health recommendations for curbing their spread. Using PRISMA guidelines, a total of 85 articles published from 1926 to 2021 were reviewed and included in this study. Qualitative analysis revealed that the most common parasites associated with these insects included, but were not limited to:
spp.,
spp.,
spp., and
spp. Additionally, prominent risk factors discovered in the review, such as poor household and community WASH services, unsafe food handling, and exposure to domestic animals and wildlife, significantly increase parasitic transmission and zoonoses. The risk of insect vector transmission in our shared environments makes it critically important to implement a One Health approach in reducing ZEP transmission.
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