The CHIME/FRB experiment has detected thousands of Fast Radio Bursts (FRBs) due to its sensitivity and wide field of view; however, its low angular resolution prevents it from localizing events to ...their host galaxies. Very Long Baseline Interferometry (VLBI), triggered by FRB detections from CHIME/FRB will solve the challenge of localization for non-repeating events. Using a refurbished 10-m radio dish at the Algonquin Radio Observatory located in Ontario Canada, we developed a testbed for a VLBI experiment with a theoretical ~<30 masec precision. We provide an overview of the 10-m system and describe its refurbishment, the data acquisition, and a procedure for fringe fitting that simultaneously estimates the geometric delay used for localization and the dispersive delay from the ionosphere. Using single pulses from the Crab pulsar, we validate the system and localization procedure, and analyze the clock stability between sites, which is critical for phase-referencing an FRB event. We find a localization of 50 masec is possible with the performance of the current system. Furthermore, for sources with insufficient signal or restricted wideband to simultaneously measure both geometric and ionospheric delays, we show that the differential ionospheric contribution between the two sites must be measured to a precision of 1e-8 pc/cc to provide a reasonable localization from a detection in the 400--800 MHz band. Finally we show detection of an FRB observed simultaneously in the CHIME and the Algonquin 10-m telescope, the first FRB cross-correlated in this very long baseline. This project serves as a testbed for the forthcoming CHIME/FRB Outriggers project.
We present a synthesis of fast radio burst (FRB) morphology (the change in flux as a function of time and frequency) as detected in the 400-800 MHz octave by the FRB project on the Canadian Hydrogen ...Intensity Mapping Experiment (CHIME/FRB), using events from the first CHIME/FRB catalog. The catalog consists of 61 bursts from 18 repeating sources, plus 474 one-off FRBs, detected between 2018 July 25 and 2019 July 2. We identify four observed archetypes of burst morphology ("simple broadband," "simple narrowband," "temporally complex" and "downward drifting") and describe relevant instrumental biases that are essential for interpreting the observed morphologies. Using the catalog properties of the FRBs, we confirm that bursts from repeating sources, on average, have larger widths and we show, for the first time, that bursts from repeating sources, on average, are narrower in bandwidth. This difference could be due to a beaming or propagation effects, or it could be intrinsic to the populations. We discuss potential implications of these morphological differences for using FRBs as astrophysical tools.
The CHIME/FRB Project has recently released its first catalog of fast radio bursts (FRBs), containing 492 unique sources. We present results from angular cross-correlations of CHIME/FRB sources with ...galaxy catalogs. We find a statistically significant (\(p\)-value \(\sim 10^{-4}\), accounting for look-elsewhere factors) cross-correlation between CHIME FRBs and galaxies in the redshift range \(0.3 \lesssim z \lesssim 0.5\), in three photometric galaxy surveys: WISE\(\times\)SCOS, DESI-BGS, and DESI-LRG. The level of cross-correlation is consistent with an order-one fraction of the CHIME FRBs being in the same dark matter halos as survey galaxies in this redshift range. We find statistical evidence for a population of FRBs with large host dispersion measure (\(\sim 400\) pc cm\(^{-3}\)), and show that this can plausibly arise from gas in large halos (\(M \sim 10^{14} M_\odot\)), for FRBs near the halo center (\(r \lesssim 100\) kpc). These results will improve in future CHIME/FRB catalogs, with more FRBs and better angular resolution.
We demonstrate the blind interferometric detection and localization of two fast radio bursts (FRBs) with 2- and 25-arcsecond precision on the 400-m baseline between the Canadian Hydrogen Intensity ...Mapping Experiment (CHIME) and the CHIME Pathfinder. In the same spirit as very long baseline interferometry (VLBI), the telescopes were synchronized to separate clocks, and the channelized voltage (herein referred to as "baseband") data were saved to disk with correlation performed offline. The simultaneous wide field of view and high sensitivity required for blind FRB searches implies a high data rate -- 6.5 terabits per second (Tb/s) for CHIME and 0.8 Tb/s for the Pathfinder. Since such high data rates cannot be continuously saved, we buffer data from both telescopes locally in memory for \(\approx 40\) s, and write to disk upon receipt of a low-latency trigger from the CHIME Fast Radio Burst Instrument (CHIME/FRB). The \(\approx200\) deg\(^2\) field of view of the two telescopes allows us to use in-field calibrators to synchronize the two telescopes without needing either separate calibrator observations or an atomic timing standard. In addition to our FRB observations, we analyze bright single pulses from the pulsars B0329+54 and B0355+54 to characterize systematic localization errors. Our results demonstrate the successful implementation of key software, triggering, and calibration challenges for CHIME/FRB Outriggers: cylindrical VLBI outrigger telescopes which, along with the CHIME telescope, will localize thousands of single FRB events to 50 milliarcsecond precision.
The origin of fast radio bursts (FRBs), millisecond-duration flashes of radio waves that are visible at distances of billions of light-years, remains an open astrophysical question. Here we report ...the detection of the multi-component FRB 20191221A with the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst Project (CHIME/FRB), and the identification of a periodic separation of 216.8(1) ms between its components with a significance of 6.5 sigmas. The long (~ 3 s) duration and nine or more components forming the pulse profile make this source an outlier in the FRB population. We also report two additional FRBs, 20210206A and 20210213A, whose multi-component pulse profiles show some indication of periodic separations of 2.8(1) and 10.7(1) ms, respectively, suggesting the possible existence of a group of FRBs with complex and periodic pulse profiles. Such short periodicities provide strong evidence for a neutron-star origin of these events. Moreover, our detections favour emission arising from the neutron-star magnetosphere, as opposed to emission regions located further away from the star, as predicted by some models. Possible explanations for the observed periodicity include super-giant pulses from a neutron star that are possibly related to a magnetar outburst and interacting neutron stars in a binary system.
Fast radio bursts (FRBs) are highly dispersed millisecond-duration radio flashes likely arriving from far outside the Milky Way galaxy. This phenomenon was discovered at radio frequencies near 1.4 ...GHz and to date has been observed in one case at as high as 8 GHz, but not below 700 MHz in spite of significant searches at low frequencies. Here we report detections of FRBs at radio frequencies as low as 400 MHz, on the Canadian Hydrogen Intensity Mapping Experiment (CHIME) using the CHIME/FRB instrument. We present 13 FRBs detected during a telescope pre-commissioning phase, when our sensitivity and field-of-view were not yet at design specifications. Emission in multiple events is seen down to 400 MHz, the lowest radio frequency to which we are sensitive. The FRBs show a variety of temporal scattering behaviours, with the majority significantly scattered, and some apparently unscattered to within measurement uncertainty even at our lowest frequencies. Of the 13 reported here, one event has the lowest dispersion measure yet reported, implying it is among the closest yet known, and another has shown multiple repeat bursts, as described in a companion paper. Our low-scattering events suggest that efforts to detect FRBs at radio frequencies below 400 MHz will eventually be successful. The overall scattering properties of our sample suggest that FRBs as a class are preferentially located in environments that scatter radio waves more strongly than the diffuse interstellar medium (ISM) in the Milky Way.
Rhesus monkeys are a non-rodent species employed in the preclinical safety evaluation of pharmaceuticals and biologics. These nonhuman primate species have been increasingly used in biomedical ...research because of the similarity in their ionic mechanisms of repolarization with humans. Heart rate and QT interval are two primary endpoints in determining the pro-arrhythmic risk of drugs. As heart rate and QT interval have an inverse relationship, any change in heart rate causes a subsequent change in QT interval. This warrants for calculation of a corrected QT interval. This study aimed to identify an appropriate formula that best corrected QT for change in heart rate. We employed seven formulas based on source-species type, clinical relevance, and requirements of various international regulatory guidelines. Data showed that corrected QT interval values varied drastically for different correction formulas. Equations were compared on their slope values based on QTc versus RR plots. The rank order of the slope for different formulas was (closest to farthest from zero) QTcNAK, QTcHAS, QTcBZT, QTcFRD, QTcVDW, QTcHDG, and QTcFRM. QTcNAK emerged to be the best correcting formula in this study. It showed the least correlation with the RR interval (r = −0.01) and displayed no significant difference amongst the sexes. As there is no universally recognized formula for preclinical use, the authors recommend developing a best-case scenario model for specific study designs and individual organizations. The data from this research will be helpful in deciding an appropriate QT correction formula for the safety assessment of new pharmaceuticals and biologics.
Electrocardiographic evaluation is performed in rhesus monkeys to establish the cardiovascular safety of candidate molecules before progressing to clinical trials. These animals are usually ...immobilized chemically by ketamine (KTM) and tiletamine-zolazepam (TZ) to obtain a steady-state heart rate and to ensure adequate human safety. The present study aimed to evaluate the effect of these anesthetic regimens on different electrocardiographic parameters. Statistically significant lower HR and higher P-wave duration, RR, QRS, and QT intervals were observed in the KTM-anesthetized group in comparison to TZ-anesthetized animals. No significant changes were noticed in the PR interval and p-wave amplitude. Sex-based significance amongst these parameters was observed in male and female animals of TZ- and KTM-anesthetized groups. Regression analysis of four QTc formulas in TZ-anesthetized rhesus monkeys revealed that QTcNAK (Nakayama) better corrected the QT interval than QTcHAS (Hassimoto), QTcBZT (Bazett), and QTcFRD (Fridericia) formulas. QTcNAK exhibited the least correlation with the RR interval (slope closest to zero and r = .01) and displayed no statistical significance between male and female animals. These data will prove useful in the selection of anesthetic regimens for chemical restraint of rhesus monkeys in nonclinical safety evaluation studies.
Occupational immunization is an integral part of institutional occupational safety and health (OSH) programs. Laboratory animal workers (LAWs) are personnel working with various small and large ...vertebrate animals. LAWs are at the risk of contracting a myriad of zoonotic infections as they are occupationally exposed to animals and their biological products. Immunizing employees against such zoonotic pathogens is the best way to prevent disease transmission. This review provides information on various zoonotic diseases, vaccines available to protect against such infections, and vaccination schedules. Certain sections of institutional occupational immunization programs such as risk evaluation, immunizing special categories of personnel and exemption from immunization among others are also described. Additionally, the authors have discussed various probable modes of impact through which occupational immunization of laboratory animal workers fulfills different United Nations Sustainable Development Goals.
These toxicity studies aimed to assess the safety and tolerability of a novel intravenous diclofenac sodium (37.5 mg/mL) formulation containing povidone K12 (80 mg/mL) as the key excipient in Wistar ...rats. This formulation was tested at doses of 3, 7, and 15 mg/kg/day and was administered daily for 28 days by intravenous route. Toxicokinetic estimation revealed a dose-proportional increase in plasma exposure to diclofenac. The formulation was well tolerated in males; however, mortality was observed in females (2/15) at the highest dose (15 mg/kg/day). Adverse gastrointestinal events related to NSAIDS and a few other treatment-related effects on clinical and anatomic pathology were noted at the 15 mg/kg/day dose, which normalized at the end of the 2-week recovery period. In addition, the excipient povidone K12 was present in a higher amount than the approved Inactive Ingredient Database (IID) limit in the proposed novel formulation. It was qualified through a separate 28-day repeated dose toxicity study by intravenous route in Wistar rats. Povidone K12 was found to be well tolerated and safe up to a dose of 165 mg/kg/day. No treatment-related adverse effects were observed in this study. In conclusion, repeated administration of a novel intravenous formulation containing diclofenac sodium was found to be safe up to the dose of 7 mg/kg/day in female rats and 15 mg/kg/day in male rats.
