A new set of pyrazolone based Cu(II) complexes has been reported with single crystal structures. DNA/protein binding and anti-cancer activity against A549 lung cancer cells suggested strong influence ...of ligand substitution on pharmacological activities.
A new series of 4-acyl pyrazolone based ternary Cu(II) complexes Cu(TPMP)(Phen)NCS (1), Cu(TPMP)(Bipy)NCS (2) and binary Cu(II) complex Cu(TPMP-BA)2 (3) has been synthesized and characterized by structural, analytical and spectral methods, in order to investigate the influence of ligand substitution on structure and pharmacological properties. In all of the complexes, the pyrazolone based ligand is coordinated to the Cu(II) ion in a neutral fashion as bidentate ligand. The single-crystal X-ray study of binary complex (3) exhibits a square planar structure, while ternary complexes (1) and (2) revealed slightly distorted square-pyramidal structures. The interaction of the compounds with calf thymus DNA (CT-DNA) has been explored by absorption and emission titration methods, which revealed that compounds 1–3 could interact with CT-DNA through intercalation. The interaction of the compounds with bovine serum albumin (BSA) was also investigated using fluorescence spectroscopic method. The results indicated that all of the compounds could quench the intrinsic fluorescence of BSA in a static quenching process. Further, the cytotoxic effect of the compounds 1–3 examined on human lung cancerous cell line (A549) and noncancerous rat cardiomyoblasts (H9C2) cell lines showed that all three complexes exhibited substantial cytotoxic activity. All the pharmacological investigations support the fact that there exists a strong influence of ligand substitution on pharmacological activities.
Objective: To assess the effects of routine intraoperative transesophageal echocardiography (TEE) on surgical management of patients undergoing all types of cardiac surgery. Design: Prospective, ...observational. Setting: A single-institution, clinical investigation, university-affiliated hospital. Participants: Two hundred eighty-three consecutive patients undergoing cardiac surgery. Interventions: A comprehensive TEE examination was performed in every patient after the induction of anesthesia. An appropriate surgical plan was then developed. A focused TEE examination was also performed at the conclusion of surgery. Whether or not TEE findings represented new information and whether or not this new information altered surgical management was documented. Measurements and Main Results: There were 106 new TEE findings in 87 patients (31%). Half of the new findings involved the mitral valve, and a quarter involved the tricuspid valve. The new TEE information altered surgical management 77 ways in 71 patients (25%). Half of the altered surgical managements involved the mitral valve, and a third involved the tricuspid valve. In 8 patients (3%), TEE information influenced decisions regarding use/nonuse of cardiopulmonary bypass (CPB). In 2 patients, TEE examination after the separation from CPB prompted reinitiation of CPB. In 1 patient, TEE examination after the induction of general anesthesia prompted cancellation of surgery. Conclusions: The routine use of TEE during cardiac surgery revealed new cardiac pathology in 1 of every 3 patients and led to altered surgical management in 1 of every 4 patients. TEE information also influenced decisions regarding use/nonuse of CPB in 3% of patients. Thus, the authors suggest that intraoperative TEE should be used routinely in all patients undergoing cardiac surgery.
Syphilitic myelitis, also known as tabes dorsalis, is a disease affecting the posterior columns of the spinal cord and dorsal roots and presents as sensory ataxia and neuropathic pain and less ...commonly as paresthesia and gastrointestinal disturbance. Tabes dorsalis is the clinical manifestation of a previous infection with syphilis, and the average latency period from initial infection to presentation of symptoms is approximately 25 years. This is a rarely encountered manifestation of syphilis since the widespread usage of antibiotics. Penicillin G is the mainstay therapy of neurosyphilis and has been shown to improve and resolve spinal cord lesions associated with tertiary syphilis. We present a case of tabes dorsalis in a 56-year-old female with a history of extensive autoimmune disease who initially presented with neck pain and numbness of the right lower extremity. The unique nature of this case lies in the patient's clinical course, as her symptoms were initially attributed to her history of autoimmune disease. A reactive CSF-VDRL (cerebrospinal fluid Venereal Disease Research Laboratory) test and MRI findings led clinicians to suspect neurosyphilis and begin penicillin G. The patient began to show significant clinical improvement after penicillin G therapy was begun and was discharged to a rehabilitation facility to continue antibiotics and begin aggressive physical therapy.
Case 3—2007 Patel, Komal, MD; Chaney, Mark A., MD; Scott, Nick B., FRCA, FRCS(Ed) ...
Journal of cardiothoracic and vascular anesthesia,
June 2007, Letnik:
21, Številka:
3
Journal Article
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