Chondroma of the bladder PAUWELS, C. F; VAN DEN BROECKE, C; DEMEYER, J. M ...
Virchows Archiv : an international journal of pathology,
03/1998, Letnik:
432, Številka:
3
Journal Article
Recenzirano
This case report describes a chondroma of the bladder in a 63-year-old woman with clinical complaints of pain in the left fossa iliaca. The lesion was a tumour with a lobulated growth pattern ...composed of chondrocytes embedded in a chondroid matrix. Neither mitotic figures nor increased cellularity were present. Nuclei were inconspicuous. Immunohistochemical examination showed reactivity for S100 and vimentin.
The WTO and the Audiovisual Sector Pauwels, Caroline; Loisen, Jan
European journal of communication (London),
09/2003, Letnik:
18, Številka:
3
Journal Article
Recenzirano
In this article the authors raise historical and legal status questions concerning the audiovisual dossier as discussed within the framework of the World Trade Organization. This implies an overview, ...first, of the rules applying directly to the audiovisual sector; second, of the liberalization agreements concerning telecommunications; and third, of the rules concerning copyright (TRIPs). In anticipation of the discussions in the new multilateral negotiation round - launched at the end of last year - the main argument of the article is that the interference of the WTO in the audiovisual and related sectors is irreversible, but also partly unpredictable.
The expression of the neu oncogene product was investigated in invasive and non-invasive ductal carcinomas of the breast, non-neoplastic lesions of the breast, fragments of normal adult and fetal ...breasts and in several other normal and fetal tissues at different weeks of pregnancy by means of an immunohistochemical study with monoclonal antibodies. The staining pattern along the cytoplasmic membrane was specific for malignancy and occurred in 29% of the breast carcinomas. It was observed in invasive carcinomas as well as in ductal carcinoma in situ and it showed a significantly higher expression in premenopausal women than in postmenopausal women. This higher expression was also present in oestrogen receptor-negative tumours. The tubules of the fetal and adult kidney, the absorption cells of the fetal and adult small and large intestine, the sebaceous glands of the fetal and adult small and large intestine, the sebaceous glands of the fetal and adult skin, the adult endocervix, the endometrium, the C-cells of the thyroid, hepatocytes and all ductal cells of the fetal breast showed a constant diffuse intracytoplasmic granular staining. staining. The same granular intracytoplasmic staining pattern was focally observed in rare cases of normal breast tissue in adults and in some cases of epitheliosis, aprocrine metaplasia and some breast carcinoma cells, which did not express neu oncogene product on their membrane. Western blot experiments showed that the cytoplasmic protein had a molecular weight of 155 kD (kilodaltons); the membrane protein is the known 185 kD neu protein.
Abstract
P
aecilomyces lilacinus
is an emerging pathogen in immunocompromised patients. We report here a case of cutaneous hyphomycosis in a 63‐year‐old heart transplant recipient caused by the ...simultaneous presence of 2 molds:
P
aecilomyces lilacinus
and
A
lternaria alternata
. The infection was successfully treated with local voriconazole followed by oral terbinafine.
OBJECTIVE To identify prognostic factors for relapse in the first year after cessation of therapy in bullous pemphigoid (BP). DESIGN Prospective, multicenter, cohort study (January 1, 2000, through ...December 31, 2006). SETTING Fifteen French dermatology departments. PATIENTS Patients with BP in remission under low doses of topical or systemic corticosteroids. INTERVENTIONS Cessation of corticosteroid treatment (day 0) followed by a systematic clinical and immunologic follow-up. MAIN OUTCOME MEASURES The end point was clinical relapse within the first year after cessation of therapy. Associations of clinical, biological, and immunologic (including direct immunofluorescence, serum anti–basement membrane zone autoantibodies, and serum BP180 autoantibodies by enzyme-linked immunosorbent assay ELISA on day 0) variables with clinical relapse were assessed by means of univariate and multivariate analyses. RESULTS On day 0, 30 of 114 patients (26.3%) still had a positive result of direct immunofluorescence, 63 of 112 (56.3%) had circulating anti–basement membrane zone autoantibodies, and 34 of 57 (60%) had anti-BP180 antibodies by ELISA. At month 12, 22 patients were dead (n = 11) or lost to follow-up (n = 11), 51 were in remission, and 45 had had relapses (mean interval to relapse, 3.2 months). Factors predictive of relapse within 12 months after cessation of therapy were a positive result of direct immunofluorescence microscopy (P = .02), a greater age (P = .01), and high-titer ELISA scores (P = .02) on day 0. In multivariate analysis, the only factor independently predictive of relapse was a high-titer ELISA score on day 0 (odds ratio, 11.00; 95% confidence interval, 1.29-93.76). CONCLUSIONS High-titer anti-BP180 ELISA score and, to a lesser degree, a positive direct immunofluorescence finding are good indicators of further relapse of BP. At least 1 of these tests should be performed before therapy is discontinued.Arch Dermatol. 2009;145(5):537-542-->
Introduction. –
La nécrose cutanée au cours de traitements par l'interféron est un effet indésirable rare et de mécanisme physiopathologique non élucidé. L'hypothèse d'une activité thrombogène locale ...a été émise pour expliquer sa survenue.
Exégèse. –
Un homme de 64 ans atteint d'une maladie de Kaposi cutanée, liée au virus de l'immunodéficience humaine, a présenté une nécrose cutanée après 9 mois de traitement par 'interféron alpha, alors qu'il s'avérait avoir une résistance à la protéine C activée. Il s'agit du premier cas à notre connaissance, décrivant l'association de nécrose cutanée sous interféron et résistance à la protéine C activée.
Conclusion. –
Cette observation suggère l'intérêt de la recherche systématique d'anomalies de la coagulation en cas de nécrose cutanée sous interféron et pose la question d'un « profil procoagulant particulier » favorisant cet effet indésirable.
Introduction. –
Cutaneous necrosis occurring in the course of treatment by alpha interferon is an uncommon side-effect. Its physiopathologic mechanism remains obscure. A local thrombotic action of interferon has been suggested to explain its occurrence.
Exegesis. –
A 64-year-old male patient with human immunodeficiency virus-related cutaneous Kaposi's sarcoma presented cutaneous necrosis after a 9-month treatment by interferon alpha, while his resistance to activated protein C had already been demonstrated. To our knowledge, this is the first case ever described regarding the association of interferon-induced cutaneous necrosis with activated protein C resistance.
Conclusion. –
This suggests that in case of interferon treatment-induced cutaneous necrosis coagulation disorders should be investigated and questions the existence of a particular «pro-coagulant profile» facilitating this side effect.
A clinical picture of hypodermitis in the lumbar region may reveal an abscess arising from infection due to pyonephrosis. We report a case below.
A 58 year-old woman consulted for an area of ...inflammation in the left lumbar region that had been present for two months. The area of inflammation appeared two days after physiotherapy sessions prescribed for lower back pain. Laboratory examinations revealed inflammation associated with moderate renal failure. A skin biopsy sample taken from around the inflamed area showed septal hypodermitis. Ultrasound examination revealed a pocket of liquid measuring 7 x 2 x 2 cm; Proteus mirabilis was isolated following ultrasound-guided needle aspiration,. Magnetic resonance imaging (MRI) and uroscan revealed pyonephrosis with suffusion into the hypodermis and left lumbar fossa.
This was a case of bacterial hypodermitis with abscesses secondary to pyonephrosis. Pyonephrosis may be transferred to the skin, causing fistulas and subcutaneous pus collection. In such rare and potentially misleading clinical settings, the diagnosis can be established by imaging.
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