The landscape of union formation has been shifting; Americans are now marrying at the highest ages on record and the majority of young adults have cohabited. Yet little attention has been paid to the ...timing of cohabitation relative to marriage. Using the National Survey of Families and Households and 4 cycles of the National Survey of Family Growth, the authors examined the timing of marriage, cohabitation, and unions over 20years. As the median age at first marriage has climbed, the age at cohabitation has remained stable for men and women. The changes in the timing of union formation have been similar according to race/ethnicity. The marked delay in marriage among women and men with low educational attainment has resulted in a near-convergence in the age at first marriage according to education. The authors conclude that the rise in cohabitation has offset changes in the levels and timing of marriage
Using data from the nationally representative 2010 Married and Cohabiting Couples Survey of different-sex cohabiting and married couples, we compared the relationship quality of today’s cohabitors ...and marrieds. Consistent with diffusion theory and recent conceptual work on the deinstitutionalization of marriage, we found that the relationship between union type and relationship quality is now bifurcated with direct marrieds reporting the highest relationship quality and cohabitors without marriage plans reporting the lowest marital quality. In the middle were the two largest groups: marrieds who premaritally cohabited and cohabitors with plans to marry. These two groups did not differ in terms of relationship quality. This study adds to the growing literature indicating that the role of cohabitation in the family life course is changing in the contemporary context.
Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs vaccine policy for booster doses and future vaccine ...designs. Existing studies demonstrate humoral correlates of protection, but the role of T cells in protection is still unclear. In this study, we explore antibody and T cell immune responses associated with protection against Delta variant vaccine breakthrough infection in a well-characterized cohort of UK Healthcare Workers (HCWs). We demonstrate evidence to support a role for CD4+ and CD8+ T cells as well as antibodies against Delta vaccine breakthrough infection. In addition, our results suggest a potential role for cross-reactive T cells in vaccine breakthrough.
Children in America today are at an unacceptably high risk of developing neurodevelopmental disorders that affect the brain and nervous system including autism, attention deficit hyperactivity ...disorder, intellectual disabilities, and other learning and behavioral disabilities. These are complex disorders with multiple causes--genetic, social, and environmental. The contribution of toxic chemicals to these disorders can be prevented. APPROACH: Leading scientific and medical experts, along with children's health advocates, came together in 2015 under the auspices of Project TENDR: Targeting Environmental Neuro-Developmental Risks to issue a call to action to reduce widespread exposures to chemicals that interfere with fetal and children's brain development. Based on the available scientific evidence, the TENDR authors have identified prime examples of toxic chemicals and pollutants that increase children's risks for neurodevelopmental disorders. These include chemicals that are used extensively in consumer products and that have become widespread in the environment. Some are chemicals to which children and pregnant women are regularly exposed, and they are detected in the bodies of virtually all Americans in national surveys conducted by the U.S. Centers for Disease Control and Prevention. The vast majority of chemicals in industrial and consumer products undergo almost no testing for developmental neurotoxicity or other health effects. CONCLUSION: Based on these findings, we assert that the current system in the United States for evaluating scientific evidence and making health-based decisions about environmental chemicals is fundamentally broken. To help reduce the unacceptably high prevalence of neurodevelopmental disorders in our children, we must eliminate or significantly reduce exposures to chemicals that contribute to these conditions. We must adopt a new framework for assessing chemicals that have the potential to disrupt brain development and prevent the use of those that may pose a risk. This consensus statement lays the foundation for developing recommendations to monitor, assess, and reduce exposures to neurotoxic chemicals. These measures are urgently needed if we are to protect healthy brain development so that current and future generations can reach their fullest potential.
Celotno besedilo
Dostopno za:
CEKLJ, DOBA, IZUM, KILJ, NUK, OILJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
'Viruses: From Understanding to Investigation' provides students with a map for lifetime learning by presenting the definition and unique characteristics of viruses, including major topics, such as ...the virus lifecycle, structure, taxonomy, evolution, history, host-virus interactions and methods to study viruses. In addition, the book assesses the connections between, and among, the aforementioned topics, providing an integrated approach and in-depth understanding of how viruses work.
Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many individuals possessing hybrid immunity, generated through a combination of vaccination and infection. Concerns have ...been raised that omicron breakthrough infections in triple-vaccinated individuals result in poor induction of omicron-specific immunity, and that prior SARS-CoV-2 infection is associated with immune dampening. Taking a broad and comprehensive approach, we characterize mucosal and blood immunity to spike and non-spike antigens following BA.1/BA.2 infections in triple mRNA-vaccinated individuals, with and without prior SARS-CoV-2 infection. We find that most individuals increase BA.1/BA.2/BA.5-specific neutralizing antibodies following infection, but confirm that the magnitude of increase and post-omicron titres are higher in the infection-naive. In contrast, significant increases in nasal responses, including neutralizing activity against BA.5 spike, are seen regardless of infection history. Spike-specific T cells increase only in infection-naive vaccinees; however, post-omicron T cell responses are significantly higher in the previously-infected, who display a maximally induced response with a highly cytotoxic CD8+ phenotype following their 3
mRNA vaccine dose. Responses to non-spike antigens increase significantly regardless of prior infection status. These findings suggest that hybrid immunity induced by omicron breakthrough infections is characterized by significant immune enhancement that can help protect against future omicron variants.
We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early ...analogues were poorly soluble and had a propensity to inhibit the hERG channel. Remarkably, both of these challenges were overcome by incorporation of a single carboxylate moiety. Structural modification of carboxylate-containing lead R -4g with a wide range of substituents at each position of the pyrazoline ring resulted in R -12o, which shows excellent activity against MR and reasonable pharmacokinetic profile. Introduction of conformational restriction led to a novel series characterized by exquisite potency and favorable steroid receptor selectivity and pharmacokinetic profile. Oral dosing of 3 S ,3a R -27d (PF-3882845) in the Dahl salt sensitive preclinical model of salt-induced hypertension and nephropathy showed blood pressure attenuation significantly greater than that with eplerenone, reduction in urinary albumin, and renal protection. As a result of these findings, 3 S ,3a R -27d was advanced to clinical studies.
Visualizing Children’s Family Structure Juteau, Gabrielle; Westrick-Payne, Krista K.; Brown, Susan L. ...
Socius : sociological research for a dynamic world,
01/2023, Letnik:
9
Journal Article
Recenzirano
Odprti dostop
This visualization illustrates the multidimensionality of family life among U.S. children. The authors used the 2022 Current Population Survey Annual Social and Economic Supplements from the ...Integrated Public Use Microdata Series to examine the intersection of three family structure domains: number of parents, relationship of child to parent(s), and parental union type. Even as 74 percent of children live with two parents, only 60 percent lived with their two biological or adoptive married parents, and substantial variation was evident in children’s family configurations. By focusing on child’s relationship to parent, the authors revealed that a minority of children lived with only their stepparent(s). A consideration of parents’ parental union status shows that parents within stepfamilies are almost nearly as likely to cohabit than marry. Children not residing with their parents were mostly living with other family members, mainly their grandparents, and these relatives were largely married or single. The results suggest that limiting family structure to one domain conceals its complexity by providing a narrow lens on families.
Birds and bornaviruses Payne, Susan L; Delnatte, Pauline; Guo, Jianhua ...
Animal health research reviews
13, Številka:
2
Journal Article
Recenzirano
In 2008, avian bornaviruses (ABV) were identified as the cause of proventricular dilatation disease (PDD). PDD is a significant condition of captive parrots first identified in the late 1970s. ABV ...infection has subsequently been shown to be widespread in wild waterfowl across the United States and Canada where the virus infects 10-20% of some populations of ducks, geese and swans. In most cases birds appear to be healthy and unaffected by the presence of the virus; however, infection can also result in severe non-suppurative encephalitis and lesions similar to those seen in parrots with PDD. ABVs are genetically diverse with seven identified genotypes in parrots and one in canaries. A unique goose genotype (ABV-CG) predominates in waterfowl in Canada and the northern United States. ABV appears to be endemic in North American waterfowl, in comparison to what appears to be an emerging disease in parrots. It is not known whether ABV can spread between waterfowl and parrots. The discovery of ABV infection in North American waterfowl suggests that European waterfowl should be evaluated for the presence of ABV, and also as a possible reservoir species for Borna disease virus (BDV), a related neurotropic virus affecting horses and sheep in central Europe. Although investigations have suggested that BDV is likely derived from a wildlife reservoir, for which the shrew and water vole are currently prime candidates, we suggest that the existence of other mammalian and avian reservoirs should not be discounted.
The 2020 decennial census provides a unique opportunity to directly count same-sex couples using a revised household roster, and its recently released Demographic and Housing Characteristics File ...offers county-level data on the concentration of same-sex couples. As county-level data can unveil more nuanced geographic patterns than state-level data, the authors examine within-state variation using two maps of county-level quartiles to compare the percentages of individuals in unions among the population and same-sex unions among all unions. The findings reveal that concentrations of same-sex couples are not necessarily driven by the percentages of individuals in unions. These patterns suggest that the social location of same-sex couples is not determined solely by the area’s couple configuration but by other factors. To help illuminate these factors, future research should explore whether the counties with high shares of couples but low shares of same-sex couples are also areas where inclusivity tends to be lagging.
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