We use the United Kingdom Infrared Telescope Deep Sky Survey (UKIDSS) Ultra Deep Survey (UDS), the deepest degree-scale near-infrared survey to date, to investigate the clustering of star-forming and ...passive galaxies to z ∼ 3.5. Our new measurements include the first determination of the clustering for passive galaxies at z > 2, which we achieve using a cross-correlation technique. We find that passive galaxies are the most strongly clustered, typically hosted by massive dark matter haloes with M
halo > 5 × 1012 M irrespective of redshift or stellar mass. Our findings are consistent with models in which a critical halo mass determines the transition from star-forming to passive galaxies. Star-forming galaxies show no strong correlation between stellar mass and halo mass, but passive galaxies show evidence for an anticorrelation; low-mass passive galaxies appear, on average, to be located in the most massive haloes. These results can be understood if the termination of star formation is most efficient for galaxies of low stellar mass in very dense environments.
We report the results of a comprehensive study of the relationship between galaxy size, stellar mass and specific star formation rate (sSFR) at redshifts 1.3 < z < 1.5. Based on a mass-complete (M
≥ ...6 × 1010 M), spectroscopic sample from the UK Infrared Deep Sky Survey (UKIDSS) Ultradeep Survey, with accurate stellar-mass measurements derived from spectro-photometric fitting, we find that at z 1.4 the location of massive galaxies on the size-mass plane is determined primarily by their sSFR. At this epoch, we find that massive galaxies which are passive (sSFR ≤ 0.1 Gyr−1) follow a tight size-mass relation, with half-light radii a factor of f
g = 2.4 ± 0.2 smaller than their local counterparts. Moreover, amongst the passive sub-sample we find no evidence that the off-set from the local size-mass relation is a function of stellar population age. In contrast, we find that massive star-forming galaxies at this epoch lie closer to the local late-type size-mass relation and are only a factor of f
g = 1.6 ± 0.2 smaller than observed locally. Based on a sub-sample with dynamical-mass estimates, which consists of both passive and star-forming objects, we also derive an independent estimate of f
g = 2.3 ± 0.3 for the typical growth in half-light radius between z 1.4 and the present day. Focusing on the passive sub-sample, we conclude that to produce the necessary evolution predominantly via major mergers would require an unfeasible number of merger events and overpopulate the high-mass end of the local stellar-mass function. In contrast, we find that a scenario in which mass accretion is dominated by minor mergers can comfortably produce the necessary evolution, whereby an increase in stellar mass of only a factor of 2, accompanied by size growth of a factor of 3.5, is required to reconcile the size-mass relation at z 1.4 with that observed locally. Finally, we note that a significant fraction (44 ± 12 per cent) of the passive galaxies in our sample have a disc-like morphology, providing additional evidence that separate physical processes are responsible for the quenching of star formation and morphological transformation in massive galaxies.
Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to condition dendritic cells (DCs) to prime ...Th2 responses. However, the molecular mechanisms underlying this effect remain unknown. We show in this study by site-directed mutagenesis of omega-1 that both the glycosylation and the RNase activity are essential to condition DCs for Th2 polarization. Mechanistically, we demonstrate that omega-1 is bound and internalized via its glycans by the mannose receptor (MR) and subsequently impairs protein synthesis by degrading both ribosomal and messenger RNA. These experiments reveal an unrecognized pathway involving MR and interference with protein synthesis that conditions DCs for Th2 priming.
Context: Both genetic and environmental factors contribute to susceptibility to Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), as well as disease manifestations.
Objective: The objective of ...the study was to define how endogenous/environmental factors contribute to variation in phenotype.
Design/Setting: This was a multicenter cohort study.
Patients/Outcome Measures: We prospectively collected clinical/biochemical data as part of the protocol for a United Kingdom DNA collection for GD and HT. We investigated, in 2805 Caucasian subjects, whether age at diagnosis, gender, family history (FH), smoking history, and presence of goiter influenced disease manifestations.
Results: For 2405 subjects with GD, the presence of goiter was independently associated with disease severity (serum free T4 at diagnosis) (P < 0.001). Free T4 (P < 0.05) and current smoking (P < 0.001) were both independent predictors of the presence of ophthalmopathy. Approximately half of those with GD (47.4% of females, 40.0% of males) and HT (n = 400) (56.4% of females, 51.7% of males) reported a FH of thyroid dysfunction. In GD, a FH of hyperthyroidism in any relative was more frequent than hypothyroidism (30.1 vs. 24.4% in affected females, P < 0.001). In HT, a FH of hypothyroidism was more common than hyperthyroidism (42.1 vs. 22.8% in affected females, P < 0.001). For GD (P < 0.001) and HT (P < 0.05), a FH was more common in maternal than paternal relatives. The reporting of a parent with thyroid dysfunction (hyper or hypo) was associated with lower median age at diagnosis of both GD (mother with hyperthyroidism, P < 0.001) and HT (father with hypothyroidism, P < 0.05). In GD and HT, there was an inverse relationship between the number of relatives with thyroid dysfunction and age at diagnosis (P < 0.01).
Conclusions: Marked associations among age at diagnosis, disease severity, goiter, ophthalmopathy, smoking, and FH provide evidence for interactions between genetic and environmental/endogenous factors; understanding these may allow preventive measures or better tailoring of therapies.
Genetic parameters were estimated for a range of meat quality traits recorded on Australian lamb meat. Data were collected from Merino and crossbred progeny of Merino, terminal and maternal meat ...breed sires of the Information Nucleus programme. Lambs born between 2007 and 2010 (n=8968) were slaughtered, these being the progeny of 372 sires and 5309 dams. Meat quality traits were found generally to be of moderate heritability (estimates between 0.15 and 0.30 for measures of meat tenderness, meat colour, polyunsaturated fat content, mineral content and muscle oxidative capacity), with notable exceptions of intramuscular fat (0.48), ultimate pH (0.08) and fresh meat colour a* (0.08) and b* (0.10) values. Genetic correlations between hot carcass weight and the meat quality traits were low. The genetic correlation between intramuscular fat and shear force was high (−0.62). Several measures of meat quality (fresh meat redness, retail meat redness, retail oxy/met value and iron content) appear to have potential for inclusion in meat sheep breeding objectives.
•Genetic parameters were estimated among a range of meat quality traits in lamb meat.•Moderate heritability of many traits showed that they can be altered via selection.•Selection to improve IMF or tenderness associated with reduced meat colour stability•Meat redness and iron content could possibly be included in sheep breeding programmes.
Helicoverpa armigera and Helicoverpa zea are major caterpillar pests of Old and New World agriculture, respectively. Both, particularly H. armigera, are extremely polyphagous, and H. armigera has ...developed resistance to many insecticides. Here we use comparative genomics, transcriptomics and resequencing to elucidate the genetic basis for their properties as pests.
We find that, prior to their divergence about 1.5 Mya, the H. armigera/H. zea lineage had accumulated up to more than 100 more members of specific detoxification and digestion gene families and more than 100 extra gustatory receptor genes, compared to other lepidopterans with narrower host ranges. The two genomes remain very similar in gene content and order, but H. armigera is more polymorphic overall, and H. zea has lost several detoxification genes, as well as about 50 gustatory receptor genes. It also lacks certain genes and alleles conferring insecticide resistance found in H. armigera. Non-synonymous sites in the expanded gene families above are rapidly diverging, both between paralogues and between orthologues in the two species. Whole genome transcriptomic analyses of H. armigera larvae show widely divergent responses to different host plants, including responses among many of the duplicated detoxification and digestion genes.
The extreme polyphagy of the two heliothines is associated with extensive amplification and neofunctionalisation of genes involved in host finding and use, coupled with versatile transcriptional responses on different hosts. H. armigera's invasion of the Americas in recent years means that hybridisation could generate populations that are both locally adapted and insecticide resistant.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We present spectroscopic confirmation of 10 highly luminous (L≥ 2L
★) Lyα emitters (LAEs) in the redshift range 6.01 < z < 6.49 (nine galaxies and one active galactic nucleus), initially drawn from a ...sample of 14 z
phot≥ 6 Lyman-break galaxies (LBGs) selected from an area of 0.25 deg2 within the UK Infrared Deep Sky Survey (UKIDSS) Ultra-Deep Survey (UDS). Overall, our high rate of spectroscopic confirmation (≥71 per cent) and low rate of contamination provides a strong vindication of the photometric redshift analysis used to define the original sample. By considering star formation rate estimates based on the Lyα and ultraviolet continuum luminosity we conclude that our sample is consistent with a Lyα escape fraction of ≃25 per cent. Moreover, after careful consideration of the potential uncertainties and biases, we find that 40-50 per cent of our sample of L≥ 2L
★ galaxies at 6.0 < z < 6.5 display strong Lyα emission (rest-frame equivalent width ≥25 Å), a fraction which is a factor of ≃2 higher than previously reported for L≤L
★ galaxies at z≃ 6. Our results suggest that, as the epoch of reionization is approached, it is plausible that the LAE fraction amongst luminous (L≥ 2L
★) LBGs shows a similarly sharp increase to that observed in their lower luminosity (L≤L
★) counterparts.
Acute heat stress (HS) and heat stroke can be detrimental to the health, well-being, and performance of mammals such as swine. Therefore, our objective was to chronologically characterize how a ...growing pig perceives and initially copes with a severe heat load. Crossbred gilts (n = 32; 63.8 ± 2.9 kg) were subjected to HS conditions (37°C and 40% humidity) with ad libitum intake for 0, 2, 4, or 6 h (n = 8/time point). Rectal temperature (Tr), respiration rates (RR), and feed intake were determined every 2 h. Pigs were euthanized at each time point and fresh ileum and colon samples were mounted into modified Ussing chambers to assess ex vivo intestinal integrity and function. Transepithelial electrical resistance (TER) and fluorescein isothiocyanate-labeled dextran (FD4) permeability were assessed. As expected, Tr increased linearly over time (P < 0.001) with the highest temperature observed at 6 h of HS. Compared to the 0-h thermal-neutral (TN) pigs, RR increased (230%; P < 0.001) in the first 2 h and remained elevated over the 6 h of HS (P < 0.05). Feed intake was dramatically reduced due to HS and this corresponded with significant changes in plasma glucose, ghrelin, and glucose-dependent insulinotropic peptide (P < 0.050). At as early as 2 h of HS, ileum TER linearly decreased (P < 0.01), while FD4 linearly increased with time (P < 0.05). Colon TER and FD4 changed due to HS in quadratic responses over time (P = 0.050) similar to the ileum but were less pronounced. In response to HS, ileum and colon heat shock protein (HSP) 70 mRNA and protein abundance increased linearly over time (P < 0.050). Altogether, these data indicated that a short duration of HS (2-6 h) compromised feed intake and intestinal integrity in growing pigs.
In common with several other autoimmune diseases, autoimmune Addison's disease (AAD) is thought to be caused by a combination of deleterious susceptibility polymorphisms in several genes, together ...with undefined environmental factors and stochastic events. To date, the strongest genomic association with AAD has been with alleles at the HLA locus, DR3-DQ2 and DR4. The contribution of other genetic variants has been inconsistent. We have studied the association of 16 single-nucleotide polymorphisms (SNPs) within the CD28-CTLA-4-ICOS genomic locus, in a cohort comprising 691 AAD patients of Norwegian and UK origin with matched controls. We have also performed a meta-analysis including 1002 patients from European countries. The G-allele of SNP rs231775 in CTLA-4 is associated with AAD in Norwegian patients (odds ratio (OR)=1.35 (confidence interval (CI) 1.10-1.66), P=0.004), but not in UK patients. The same allele is associated with AAD in the total European population (OR=1.37 (CI 1.13-1.66), P=0.002). A three-marker haplotype, comprising PROMOTER_1661, rs231726 and rs1896286 was found to be associated with AAD in the Norwegian cohort only (OR 2.43 (CI 1.68-3.51), P=0.00013). This study points to the CTLA-4 gene as a susceptibility locus for the development of AAD, and refines its mapping within the wider genomic locus.
Acute heat stress (HS) and heat stroke can be detrimental to the health, well-being, and performance of mammals such as swine. Therefore, our objective was to chronologically characterize how a ...growing pig perceives and initially copes with a severe heat load. Crossbred gilts (n=32; 63.8±2.9 kg) were subjected to HS conditions (37°C and 40% humidity) with ad libitum intake for 0, 2, 4, or 6 h (n=8/time point). Rectal temperature (Tr), respiration rates (RR), and feed intake were determined every 2 h. Pigs were euthanized at each time point and fresh ileum and colon samples were mounted into modified Ussing chambers to assess ex vivo intestinal integrity and function. Transepithelial electrical resistance (TER) and fluorescein isothiocyanate-labeled dextran (FD4) permeability were assessed. As expected, Tr increased linearly over time (P<0.001) with the highest temperature observed at 6 h of HS. Compared to the 0-h thermal-neutral (TN) pigs, RR increased (230%; P<0.001) in the first 2 h and remained elevated over the 6 h of HS (P<0.05). Feed intake was dramatically reduced due to HS and this corresponded with significant changes in plasma glucose, ghrelin, and glucose-dependent insulinotropic peptide (P<0.050). At as early as 2 h of HS, ileum TER linearly decreased (P<0.01), while FD4 linearly increased with time (P<0.05). Colon TER and FD4 changed due to HS in quadratic responses over time (P=0.050) similar to the ileum but were less pronounced. In response to HS, ileum and colon heat shock protein (HSP) 70 mRNA and protein abundance increased linearly over time (P<0.050). Altogether, these data indicated that a short duration of HS (2-6 h) compromised feed intake and intestinal integrity in growing pigs.
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