Very little is known about the neural circuitry guiding anger, angry rumination, and aggressive personality. In the present fMRI experiment, participants were insulted and induced to ruminate. ...Activity in the dorsal anterior cingulate cortex was positively related to self-reported feelings of anger and individual differences in general aggression. Activity in the medial prefrontal cortex was related to self-reported rumination and individual differences in displaced aggression. Increased activation in the hippocampus, insula, and cingulate cortex following the provocation predicted subsequent self-reported rumination. These findings increase our understanding of the neural processes associated with the risk for aggressive behavior by specifying neural regions that mediate the subjective experience of anger and angry rumination as well as the neural pathways linked to different types of aggressive behavior.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Aim: The Sibutramine Cardiovascular OUTcomes trial showed that sibutramine produced greater mean weight loss than placebo but increased cardiovascular morbidity but not mortality. The relationship ...between 12‐month weight loss and subsequent cardiovascular outcomes is explored.
Methods: Overweight/obese subjects (N = 10 744), ≥55 years with cardiovascular disease and/or type 2 diabetes mellitus, received sibutramine plus weight management during a 6‐week Lead‐in Period before randomization to continue sibutramine (N = 4906) or to receive placebo (N = 4898). The primary endpoint was the time from randomization to first occurrence of a primary outcome event (non‐fatal myocardial infarction, non‐fatal stroke, resuscitated cardiac arrest or cardiovascular death).
Results: For the total population, mean weight change during Lead‐in Period (sibutramine) was −2.54 kg. Post‐randomization, mean total weight change to Month 12 was −4.18 kg (sibutramine) or −1.87 kg (placebo). Degree of weight loss during Lead‐in Period or through Month 12 was associated with a progressive reduction in risk for the total population in primary outcome events and cardiovascular mortality over the 5‐year assessment. Although more events occurred in the randomized sibutramine group, on an average, a modest weight loss of approximately 3 kg achieved in the Lead‐in Period appeared to offset this increased event rate. Moderate weight loss (3–10 kg) reduced cardiovascular deaths in those with severe, moderate or mild cardiovascular disease.
Conclusions: Modest weight loss over short‐term (6 weeks) and longer‐term (6–12 months) periods is associated with reduction in subsequent cardiovascular mortality for the following 4–5 years even in those with pre‐existing cardiovascular disease. While the sibutramine group experienced more primary outcome events than the placebo group, greater weight loss reduced overall risk of these occurring in both groups.
Researchers wishing to conduct studies in Nunavut are asked by potential funders and licensing agencies to incorporate Inuit Qaujimajatuqangit (IQ) and meaningfully engage Inuit communities, but they ...must usually interpret for themselves what this means and how to do it in practice. As a group of Inuit youth from four Nunavut communities, we have developed a concept we call ScIQ (pronounced sigh-cue) to describe how science and IQ can be combined for more meaningful engagement to benefit both Inuit communities and scientific researchers. ScIQ is based on the understanding that IQ is not only knowledge that Inuit have gained over many generations; it is more holistic and includes Inuit values, customs and principles for living our lives. Incorporating IQ into research then, should be as much about how research is conducted as it is about data collected from Inuit and local knowledge used to conduct the research. Over a five-day Ikaarvik Youth ScIQ Summit in Cambridge Bay, Nunavut, we developed 45 recommendations for specific things researchers can do before, during, and after their research that, from our perspective, are examples of truly incorporating IQ and result in more meaningful engagement of Inuit communities. This paper presents the Ikaarvik ScIQ recommendations.
Qaujisaqtiit qaujisarniqarumajut Nunavummi apirijauvut kiinaujaqaqtiutuinnarialingni amma laisansitaaqtittijiujuni ilaliujjinirmut Inuit Qaujimajatuqanginni (IQ) amma tukiqattiaqtumi ilautittinirmi Inungni nunaliujuni, kisiani tukiliurijariaqaqput immingnut qanuq tukiqarningani ammalu qanuq pilirianguvangningani atuqtauninganut. Katinnganiulutik Inungni makkuktuni tisamani Nunavummi nunaliujuni, pivalliatittisimavugut isumagijautuinnarniujumi taijavut ScIQ (taijausuuq sigh-cue) unikkaarinirmi qanuq qaujisarniq amma Inuit Qaujimajatuqangit katitirijaujunnarningani tukiqattiarniqsaujumi ilautittiniujumi pivaallirutiqarniaqtumut tamakkini inungni nunaliujuni amma qaujisarnirmut qaujisaqtiujuni. ScIQ tunngaviqaqpuq tukisiumaniujumi Inuit Qaujimajatuqangit qaujimanituinnaunnginningani Inuit pisimajanginni arraagugasaalungnut, iluittuuniuvuq amma ilaqaqpuq Inuit pinnarijanginni, atuqpaktanginni amma tunngaviujuni inuunirmi inuusittinni. Ilaliujjiniq Inuit Qaujimajatuqanginni qaujisarnirmut asuilaak, ilaqalluaqpuq qanuq qaujisaqtauninga pilirianguvangningani ammalu qaujisaqtaunikuni titiraqsimajuni katiqsuqtaujuni Inungni amma nunalingni qaujimaniujunut atuqtauvaktuni pilirinirmut qaujisarniujumi. Tallimanut−ullunut, Ikaarvik Makkuktuni ScIQ Katimaniujumi Iqaluktuuttiaq, Nunavummi, pivalliatittilauqpugut 45-ni atuliqujaujuni nalunaiqtausimajunut kisutuinnanut qaujisaqtiit pilirijariaqaqtanginni sivuniani, taikani amma kinguniagut qaujisarninginni, isumagijattinni, uuktuutiuvut ilaliujjillaringningani Inuit Qaujimajatuqanginni amma pitittilluni tukiqarniqsaujumi ilautittiniujumi Inungni nunaliujunit. Una paippaaq tunisivuq Ikaarvik ScIQ atuqunajaqtanginni.
Mid-infrared (MIR) imaging has emerged as a valuable tool to investigate biological samples, such as tissue histological sections and cell cultures, by providing non-destructive chemical specificity ...without recourse to labels. While feasibility studies have shown the capabilities of MIR imaging approaches to address key biological and clinical questions, these techniques are still far from being deployable by non-expert users. In this review, we discuss the current state of the art of MIR technologies and give an overview on technical innovations and developments with the potential to make MIR imaging systems more readily available to a larger community. The most promising developments over the last few years are discussed here. They include improvements in MIR light sources with the availability of quantum cascade lasers and supercontinuum IR sources as well as the recently developed upconversion scheme to improve the detection of MIR radiation. These technical advances can substantially speed up data acquisition of multispectral or hyperspectral datasets thus providing the end user with vast amounts of data when imaging whole tissue areas of many mm2. Therefore, effective data analysis is of tremendous importance, and progress in method development is discussed with respect to the specific biomedical context.
Background: Oral anticoagulation (OAC) in patients with atrial fibrillation (AF) is a double‐edged sword, because it decreases the risk of stroke at the cost of an increased risk of bleeding. We ...compared the performance of a new bleeding prediction scheme, HAS‐BLED, with an older bleeding prediction scheme, HEMORR2HAGES, in a cohort of ‘real‐world’ AF patients. Methods: By individual‐level‐linkage of nationwide registers, we identified all patients (n = 118 584) discharged with non‐valvular AF in Denmark during the period 1997–2006, with and without OAC. Major bleeding rates during 1 year of follow‐up were determined, and the predictive capabilities of the two schemes were compared by c‐statistics. The risk of bleeding associated with individual risk factors composing HAS‐BLED was estimated using Cox proportional‐hazard analyses. Results: Of AF patients receiving OAC (n = 44 771), 34.8% and 47.3% were categorized as ‘low bleeding risk’ by HAS‐BLED and HEMORR2HAGES, respectively, and the bleeding rates per 100 person‐years were 2.66 (95% confidence interval CI, 2.40–2.94) and 3.06 (2.83–3.32), respectively. C‐statistics for the two schemes were 0.795 (0.759–0.829) and 0.771 (0.733–0.806), respectively. The risk factors composing HAS‐BLED were associated with varying risks, with a history of bleeding (hazard ratio HR 2.98; 95% CI 2.68–3.31) and being elderly (HR 1.93; 95% CI 1.71–2.18) being associated with the highest risks. Comparable results were found in AF patients not receiving OAC (n = 77 813). Conclusions: In an unselected nationwide cohort of hospitalized patients with atrial fibrillation, the HAS‐BLED score performs similarly to HEMORR2HAGES in predicting bleeding risk but HAS‐BLED is much simpler and easier to use in everyday clinical practise.
Feline infectious peritonitis (FIP) is caused by a mutant biotype of the feline enteric coronavirus. The resulting FIP virus (FIPV) commonly causes central nervous system (CNS) and ocular pathology ...in cases of noneffusive disease. Over 95% of cats with FIP will succumb to disease in days to months after diagnosis despite a variety of historically used treatments. Recently developed antiviral drugs have shown promise in treatment of nonneurological FIP, but data from neurological FIP cases are limited. Four cases of naturally occurring FIP with CNS involvement were treated with the antiviral nucleoside analogue GS‐441524 (5‐10 mg/kg) for at least 12 weeks. Cats were monitored serially with physical, neurologic, and ophthalmic examinations. One cat had serial magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis (including feline coronavirus FCoV) titers and FCoV reverse transcriptase RT‐PCR) and serial ocular imaging using Fourier‐domain optical coherence tomography (FD‐OCT) and in vivo confocal microscopy (IVCM). All cats had a positive response to treatment. Three cats are alive off treatment (528, 516, and 354 days after treatment initiation) with normal physical and neurologic examinations. One cat was euthanized 216 days after treatment initiation following relapses after primary and secondary treatment. In 1 case, resolution of disease was defined based on normalization of MRI and CSF findings and resolution of cranial and caudal segment disease with ocular imaging. Treatment with GS‐441524 shows clinical efficacy and may result in clearance and long‐term resolution of neurological FIP. Dosages required for CNS disease may be higher than those used for nonneurological FIP.
Abstract Subchronic phencyclidine (subPCP) treatment induces schizophrenic-like behavior in rodents, including cognitive deficits and increased locomotor sensitivity towards acute administration of ...PCP. Evidence is accumulating that the gut microbiota (GM) influences behavior through modulation of the microbiota–gut–brain axis, and hence, part of the variation within this animal model may derive from variation in the GM. The aims of this study was to investigate first, the duration of subPCP-induced cognitive impairment in the novel object recognition test, and second, the possible effect of subchronic PCP-treatment on the GM, and the association between the GM and the behavioral parameters. The association was further investigated by antibiotic reduction of the GM. Male Lister Hooded rats were dosed twice daily i.p. with either 5 mg/kg PCP or sterile isotonic saline for seven days followed by a seven-day washout period. Rats were tested in the novel object recognition and the locomotor activity assays immediately after, three weeks after, or six weeks after washout, and the fecal GM was analyzed by high throughput sequencing. Antibiotic- and control-treated rats were tested in the same manner following washout. In conclusion, subPCP-treatment impaired novel object recognition up to three weeks after washout, whereas locomotor sensitivity was increased for at least six weeks after washout. Differences in the core gut microbiome immediately after washout suggested subPCP treatment to alter the GM. GM profiles correlated to memory performance. Administration of ampicillin abolished the subPCP-induced memory deficit. It thus seems reasonable to speculate that the GM influences memory performance, contributing to variation within the model.
The hemagglutination-inhibition (HI) assay is a classical laboratory procedure for the classification or subtyping of hemagglutinating viruses. For the avian influenza (AI) virus, the HI assay is ...used to identify the hemagglutinin (H) subtype of an unknown AI virus isolate or the HA subtype specificity of antibodies to AI virus. Since the HI assay is quantitative, it is frequently applied to evaluate the antigenic relationships between different AI virus isolates of the same subtype. The basis of the HI test is inhibition of hemagglutination with subtype-specific antibodies. The HI assay is a relatively inexpensive procedure utilizing standard laboratory equipment, is less technical than molecular tests, and is easily completed within several hours. However, when working with uncharacterized viruses or antibody subtypes, the library of reference reagents required for identifying antigentically distinct AI viruses and/or antibody specificities from multiple lineages of a single hemagglutinin subtype requires extensive laboratory support for the production and optimization of reagents.
The concentration of apparent elemental carbon (ECa, based on a thermal‐optical method) in the snow was investigated in Svalbard (European Arctic) during spring 2007. The median ECa concentration of ...81 samples was 4.1 μg l−1 and the values ranged from 0 to 80.8 μg l−1 of melt water. The median concentration is nearly an order of magnitude lower than the previously published data of equivalent black carbon (BCe, based on an optical method), obtained from Svalbard snow in the 1980s. A systematic regional difference was evident: ECa concentrations were higher in east Svalbard compared to west Svalbard. The observations of snow ECa cover spatial scales up to several hundred kilometers, which is comparable to the resolution of many climate models. Measurements of atmospheric carbonaceous aerosol (2002–2008) at Zeppelin station in Ny‐Ålesund, Svalbard, were divided to air mass sectors based on calculated back trajectories. The results show that air originating from the eastern sector contains more than two and half times higher levels of soot than air arriving from south to west. The observed east–west gradient of ECa concentrations in snow may be because of a combination of the atmospheric concentration gradient, the orographic effect of the archipelago, and the efficient scavenging of the carbonaceous particles through precipitation.
Abstract
Background
Cardiac troponin T (cTnT) and I (cTnI) are the gold standard biomarkers of myocardial infarction (MI). Studies have shown that the concentration of cTn increases with age among ...healthy individuals, but the clinical impact of this is unclear. Further, there seem to be a difference in the increases in cTnI and in cTnT - the latter being more sensitive to increasing age.
Purpose
To investigate the impact of age on the diagnostic ability of cTnT and cTnI for myocardial infarction.
Methods
This nationwide cohort study includes patients admitted with cTn measurements from 2009-2022 using one of five cTn assays: Roche high-sensitivity cTnT (hs-cTnT), Abbott Alinity high sensitivity cTnI (hs-cTnI), Siemens Vista Hs-cTnI, Siemens Atellica hs-cTnI and Beckman-Coulter hs-cTnI. We selected the peak concentration of cTn on admission and grouped patients into those who had cTnI and those who had cTnT measured which were divided into age groups of <40 years, 40-50 years, 50-60 years, 60-70 years, 70-80 years, 80-90 years and >90 years. The primary outcome was a diagnosis of MI during admission. Receiver operating characteristics (ROC) were used for the concentration of cTn normalized to the assays 99th percentile, and we explored the specificity of elevations of each assay above the 99th percentile.
Results
A total of 350,428 patients were included in this study with a median age of 67 years (IQR 52-77); 188,382 (54%) were males and 48,262 (14%) had a history of ischemic heart disease prior to the admission. When grouping for type of cTn used, more patients were treated when hs-cTnT (240,660, 69%) was used compared with hs-cTnI (109,768, 31%). The patient treated using hs-cTnT were slightly older than patients treated with hs-cTnI, 67 years (IQR 53-77) vs 65 years (53-77) p<0.001.
During the admission 29,023 patients (8.3%) had a MI. Figure 1 panel A shows the ROC curve of hs-cTnT and hs-cTnI for each age group. Both biomarkers showed a decline in the area under the curve (AUC) with increasing age. Figure 1 panel B shows the AUC for each age group. Hs-cTnI had a higher AUC for all age groups and seemed to decrease less with age. Figure 2 shows the specificity for the 99th percentile of each assay for the age groups. There were substantial differences in the specificity at the 99th percentile between cTn assays, with the cTnT assay being the least specific for all age groups, while the two Siemens assays had the highest specificity. An elevation above the 99th percentile of the cTnT assay had a specificity of 3% in the group of patients >90 years old.
Conclusion
The specificity of elevation of cTn for MI declined with increasing age for all assays. This decline seemed to be largest for the cTnT assay were an elevation above the 99th percentile among patients >90 years old had a specificity of 3% for MI.Figure 1Figure 2
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