•Examines the complex inter-actor communications in a service ecosystem using SDL.•Identifies how digital information flows impact service innovation adoption.•Cocreated information flows directly ...and indirectly impact telemedicine adoption.•Cocreated information flows help reduce value perception information asymmetry.•Cocreated provider/consumer information has more influence on the service adoption.
Value co-creation for service innovations involves integrating inputs from multiple actors within service ecosystems. Traditionally, value co-creation has been considered in light of business-to-consumer (B2C) interactions. The emergence of digital information platforms allowing consumer-to-consumer (C2C) communications is changing how service ecosystems establish and create value for service innovations. In this paper, we develop a Digital Information Flow Continuum that includes B2C, external provider and consumer co-created (B2C/C2C combined) and C2C digital communications. Using Service-Dominant Logic (SDL), we assess the impact digital information flow elements have on the perceptions and usage likelihood for telemedicine (TM) services. We use structural equation modeling to analyze online survey results from 827 health consumers collected as part of a healthcare organization’s TM launch. The results demonstrate that the Digital Information Flow Continuum impacts the acceptance of the TM innovation directly, and indirectly through value perceptions of comparable service quality relative to alternatives and ease of access to care.
Purpose
In “Social media’s slippery slope: challenges, opportunities and future research directions”, Schultz and Peltier (2013) asked “whether or how social media can be used to leverage consumer ...engagement into highly profitable relationships for both parties”. The purpose of this article is to continue this discussion by reviewing recent literature on consumer engagement and proposing a framework for future research.
Design/methodology/approach
The paper reviews the marketing literature on social media, paying particular attention to consumer engagement, which was identified as a primary area of concern in Schultz and Peltier (2013).
Findings
A significant amount of research has been conducted on consumer engagement since 2010. Lack of consensus on the definition of the construct has led to fragmentation in the discipline, however. As a result, research related to consumer engagement is often not identified as such, making it difficult for academics and practitioners to stay abreast of developments in this area.
Originality/value
This critical review provides marketing academics and practitioners insights into the antecedents and consequences of consumer engagement and offers a conceptual framework for future research.
The health service ecosystem traditionally has focused on unidirectional information flow from the health provider to consumer. However, this model fails to adequately engage consumers in their ...health decision-making to improve consumers' wellness. Consumers' health information seeking in today's omni-channel information environment is a critical value co-creation activity that increases consumers' engagement. Yet little is known about how consumers' health information seeking is evolving the information flow pattern and resulting consequences on consumers' health self-awareness. Our study closes this gap by empirically exploring the effects of consumers' health information seeking in an omni-channel environment and its influences on consumers' health self-awareness. We used structural equation modeling to analyze survey results from 310 health consumers collected as part of a healthcare organization's annual door-to-door wellness study. The results demonstrate the importance of helping consumers integrate informational inputs outside the service encounter to increase consumers' engagement and conscious reflection on their well-being.
•Identifies necessary paradigm shift in healthcare services to maximize well-being•Encouraging digital information seeking enhances consumers' health self-awareness•Consumers are more mindful when motivated to seek external digital health resources.
PDL1 Regulation by p53 via miR-34 Cortez, Maria Angelica; Ivan, Cristina; Valdecanas, David ...
JNCI : Journal of the National Cancer Institute,
01/2016, Letnik:
108, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non-small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that PDL1 is ...regulated by p53 via miR-34.
p53 wild-type and p53-deficient cell lines (p53(-/-) and p53(+/+) HCT116, p53-inducible H1299, and p53-knockdown H460) were used to determine if p53 regulates PDL1 via miR-34. PDL1 and miR-34a expression were analyzed in samples from patients with NSCLC and mutated p53 vs wild-type p53 tumors from The Cancer Genome Atlas for Lung Adenocarcinoma (TCGA LUAD). We confirmed that PDL1 is a direct target of miR-34 with western blotting and luciferase assays and used a p53(R172HΔ)g/+K-ras(LA1/+) syngeneic mouse model (n = 12) to deliver miR-34a-loaded liposomes (MRX34) plus radiotherapy (XRT) and assessed PDL1 expression and tumor-infiltrating lymphocytes (TILs). A two-sided t test was applied to compare the mean between different treatments.
We found that p53 regulates PDL1 via miR-34, which directly binds to the PDL1 3' untranslated region in models of NSCLC (fold-change luciferase activity to control group, mean for miR-34a = 0.50, SD = 0.2, P < .001; mean for miR-34b = 0.52, SD = 0.2, P = .006; and mean for miR-34c = 0.59, SD = 0.14, and P = .006). Therapeutic delivery of MRX34, currently the subject of a phase I clinical trial, promoted TILs (mean of CD8 expression percentage of control group = 22.5%, SD = 1.9%; mean of CD8 expression percentage of MRX34 = 30.1%, SD = 3.7%, P = .016, n = 4) and reduced CD8(+)PD1(+) cells in vivo (mean of CD8/PD1 expression percentage of control group = 40.2%, SD = 6.2%; mean of CD8/PD1 expression percentage of MRX34 = 20.3%, SD = 5.1%, P = .001, n = 4). Further, MRX34 plus XRT increased CD8(+) cell numbers more than either therapy alone (mean of CD8 expression percentage of MRX34 plus XRT to control group = 44.2%, SD = 8.7%, P = .004, n = 4). Finally, miR-34a delivery reduced the numbers of radiation-induced macrophages (mean of F4-80 expression percentage of control group = 52.4%, SD = 1.7%; mean of F4-80 expression percentage of MRX34 = 40.1%, SD = 3.5%, P = .008, n = 4) and T-regulatory cells.
We identified a novel mechanism by which tumor immune evasion is regulated by p53/miR-34/PDL1 axis. Our results suggest that delivery of miRNAs with standard therapies, such as XRT, may represent a novel therapeutic approach for lung cancer.
Purpose
– This paper aims to develop an omni-channel framework in the context of sales and sales management related to six areas: sales contexts, impact of technology, stages in the sales process, ...impact on relationships, impact on firm performance and the role of various communication tools and platforms. The paper also offers future reach needs in each of these areas.
Design/methodology/approach
– Literature review and research needs development.
Findings
– Research in omni-channel marketing in the context of sales and sales management is virtually silent. The authors identify key research gaps and offer recommended future research opportunities.
Originality/value
– To date, little research in sales and sales management has studied multi-channel marketing. The omni-channel research framework reported here is unique and will help guide research in this area.
The microRNA (miR)-200s and their negative regulator ZEB1 have been extensively studied in the context of the epithelial–mesenchymal transition. Loss of miR-200s has been shown to enhance cancer ...aggressiveness and metastasis, whereas replacement of miR-200 miRNAs has been shown to inhibit cell growth in several types of tumors, including lung cancer. Here, we reveal a novel function of miR-200c, a member of the miR-200 family, in regulating intracellular reactive oxygen species signaling and explore a potential application for its use in combination with therapies known to increase oxidative stress such as radiation. We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2, GAPB/Nrf2, and SESN1 in ways that inhibits DNA double-strand breaks repair, increase levels of reactive oxygen species, and upregulate p21. We used a lung cancer xenograft model to further demonstrate the therapeutic potential of systemic delivery of miR-200c to enhance radiosensitivity in lung cancer. Our findings suggest that the antitumor effects of miR-200c result partially from its regulation of the oxidative stress response; they further suggest that miR-200c, in combination with radiation, could represent a therapeutic strategy in the future.
PurposeArtificial intelligence (AI) is transforming consumers' experiences and how firms identify, create, nurture and manage interactive marketing relationships. However, most marketers do not have ...a clear understanding of what AI is and how it may mutually benefit consumers and firms. In this paper, the authors conduct an extensive review of the marketing literature, develop an AI framework for understanding value co-creation in interactive buyer–seller marketing relationships, identify research gaps and offer a future research agenda.Design/methodology/approachThe authors first conduct an extensive literature review in 16 top marketing journals on AI. Based on this review, an AI framework for understanding value co-creation in interactive buyer–seller marketing relationships was conceptualized.FindingsThe literature review led to a number of key research findings and summary areas: (1) an historical perspective, (2) definitions and boundaries of AI, (3) AI and interactive marketing, (4) relevant theories in the domain of interactive marketing and (5) synthesizing AI research based on antecedents to AI usage, interactive AI usage contexts and AI-enabled value co-creation outcomes.Originality/valueThis is one of the most extensive reviews of AI literature in marketing, including an evaluation of in excess or 300 conceptual and empirical research. Based on the findings, the authors offer a future research agenda, including a visual titled “What is AI in Interactive Marketing? AI design factors, AI core elements & interactive marketing AI usage contexts.”
In response to the Journal of Marketing Education special issue on teaching turmoil and triumphs in times of crisis, we develop and test a student anxiety, preparation and learning framework for ...responding to external crises. We use structural equation modeling to assess how COVID-19 anxiety impacts classrelated anxiety, class preparation, and class learning, and how these then affect class satisfaction and intent to pursue a sales career. Using three sequential virtual sales competitions, we test our model in the immediate aftermath of the transition from live in-class learning to virtual learning brought on by COVID-19, offering an ideal setting for investigating marketing education in a time of crisis. The findings are unique, and show that how crises are managed impacts the deleterious effects of anxiety on education and learning. While anxiety had the greatest influence on class preparation, class preparation in turn was not related to class learning, class satisfaction, nor intent to pursue a sales career. However, when digital self-efficacy was considered as a moderator, the expected effects of class preparation emerged. Our findings contribute to multiple theoretical contexts, including anxiety, crisis management, self-efficacy, marketing education, and virtual sales role-plays.
Businesses face a challenge recruiting and maintaining a high-quality salesforce. Increasingly, recruiting focus for entry-level sales positions has turned to university business students and sales ...centers. Unfortunately, research shows that most students have persistent negative misconceptions about professional sales careers and there is little research examining comprehensive and structured decision-making frameworks used by students when evaluating a sales career. This paper develops and tests an integrative framework that maps students' decision-making process to their intention to pursue a sales career. Specifically, we examine how perceived sales knowledge, perceptions of selling ethics, perceptions of salespeople, and perceptions of the selling profession impact their intent to pursue a sales career both pre- and post-exposure to sales professionals in the classroom. Utilizing structural equation modeling, we investigate the interactive relationships of these four areas (sales knowledge, selling ethics, salespeople, and the selling profession) on intent to pursue. Results show empirical evidence of how sales professionals affect the structural orientation of students' intent to pursue a sales career and constructs hypothesized to impact this intent after only one interaction. The findings offer an opportunity for how businesses may increase student interest in both sales and their organization.
This article develops information continua for (1) the perceived sensitivity of data and (2) consumers' willingness to disclose information that can be used to evaluate information attitudes of U.S. ...and Brazilian consumers. Using a cross-national survey between U.S. and Brazilian consumers, this research examines how consumers' perceived sensitivity and willingness to provide information are affected by country of origin, age, perceived privacy control, consumer data relationship (with a friend, marketer, trusted marketer, or unknown marketer), and type of information (whether it is personally identifiable information or linkable). The findings provide public policy insights into potential market solutions and regulatory approaches that bridge the gap between marketers' need for personalizing customer relationships and consumers' preferences for information privacy.
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