Colloidal crystal engineering with nucleic acid-modified nanoparticles is a powerful way for preparing 3D superlattices, which may be useful in many areas, including catalysis, sensing, and ...photonics. To date, the building blocks studied have been primarily based upon metals, metal oxides, chalcogenide semiconductors, and proteins. Here, we show that metal-organic framework nanoparticles (MOF NPs) densely functionalized with oligonucleotides can be programmed to crystallize into a diverse set of superlattices with well-defined crystal symmetries and compositions. Electron microscopy and small-angle X-ray scattering characterization confirm the formation of single-component MOF superlattices, binary MOF-Au single crystals, and two-dimensional MOF nanorod assemblies. Importantly, DNA-modified porphyrinic MOF nanorods (PCN-222) were assembled into 2D superlattices and found to be catalytically active for the photooxidation of 2-chloroethyl ethyl sulfide (CEES, a chemical warfare simulant of mustard gas). Taken together, these new materials and methods provide access to colloidal crystals that incorporate particles with the well-established designer properties of MOFs and, therefore, increase the scope of possibilities for colloidal crystal engineering with DNA.
The formation of ultradiffuse galaxies in clusters Sales, Laura V; Navarro, Julio F; Peñafiel, Louis ...
Monthly notices of the Royal Astronomical Society,
05/2020, Letnik:
494, Številka:
2
Journal Article
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ABSTRACT
We use the IllustrisTNG cosmological hydrodynamical simulation to study the formation of ultradiffuse galaxies (UDGs) in galaxy clusters. We supplement the simulations with a realistic ...mass–size relation for galaxies at the time of infall into the cluster, as well as an analytical model to describe the tidally induced evolution of their stellar mass, velocity dispersion, and size. The model assumes ‘cuspy’ NFW haloes and, contrary to recent claims, has no difficulty reproducing the observed number of UDGs in clusters. Our results further suggest that the UDG population consists of a mixture of ‘normal’ low surface brightness galaxies such as those found in the field (‘born’ UDGs, or B-UDGs), as well as a distinct population that owe their large size and low surface brightness to the effects of cluster tides (‘tidal’, or T-UDGs). The simulations indicate that T-UDGs entered the cluster earlier and should be more prevalent than B-UDGs near the cluster centres. T-UDGs should also have, at given stellar mass, lower velocity dispersion, higher metallicities, and lower dark matter content than B-UDGs. Our results suggest that systems like DF-44 are consistent with having been born as UDGs, while others such as DF2, DF4, and VLSB-D are possibly extreme T-UDG examples.
The solid electrolyte interphase (SEI) forms during the initial cycles in lithium ion batteries and evolves throughout the battery life. By protecting the electrode and passing lithium ions, the SEI ...plays an important role in the performance and degradation of lithium ion batteries. Identifying how the SEI forms and evolves during battery cycling helps us understand and mitigate battery degradation. In this work, we address the SEI chemical and electrochemical evolution during its formation process and provide a correlation between these properties. It is found that the SEI chemistry, not just its thickness, has a distinct influence on its impedance, which may ultimately impact the battery performance.
Chronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress-induced epinephrine promoted breast ...cancer stem-like properties via lactate dehydrogenase A-dependent (LDHA-dependent) metabolic rewiring. Chronic stress-induced epinephrine activated LDHA to generate lactate, and the adjusted pH directed USP28-mediated deubiquitination and stabilization of MYC. The SLUG promoter was then activated by MYC, which promoted development of breast cancer stem-like traits. Using a drug screen that targeted LDHA, we found that a chronic stress-induced cancer stem-like phenotype could be reversed by vitamin C. These findings demonstrated the critical importance of psychological factors in promoting stem-like properties in breast cancer cells. Thus, the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.
ABSTRACT We report the discovery of three large ( 1′) extremely low surface brightness (LSB; ) galaxies identified using our deep, wide-field imaging of the Virgo Cluster from the Burrell Schmidt ...telescope. Complementary data from the Next Generation Virgo Cluster Survey do not resolve red giant branch stars in these objects down to i = 24, yielding a lower distance limit of 2.5 Mpc. At the Virgo distance, these objects have half-light radii 3-10 kpc and luminosities = 2-9 × 107 . These galaxies are comparable in size but lower in surface brightness than the large ultradiffuse LSB galaxies recently identified in the Coma cluster, and are located well within Virgo's virial radius; two are projected directly on the cluster core. One object appears to be a nucleated LSB in the process of being tidally stripped to form a new Virgo ultracompact dwarf galaxy. The others show no sign of tidal disruption, despite the fact that such objects should be most vulnerable to tidal destruction in the cluster environment. The relative proximity of Virgo makes these objects amenable to detailed studies of their structural properties and resolved stellar populations. They thus provide an important new window onto the connection between cluster environment and galaxy evolution at the extremes.
Abstract
We present Keck/DEIMOS spectroscopy of the first complete sample of ultradiffuse galaxies (UDGs) in the Virgo cluster. We select all UDGs in Virgo that contain at least 10 globular cluster ...(GC) candidates and are more than 2.5
σ
outliers in scaling relations of size, surface brightness, and luminosity (a total of 10 UDGs). We use the radial velocity of their GC satellites to measure the velocity dispersion of each UDG. We find a mixed bag of galaxies, from one UDG that shows no signs of dark matter, to UDGs that follow the luminosity–dispersion relation of early-type galaxies, to the most extreme examples of heavily dark matter–dominated galaxies that break well-known scaling relations such as the luminosity–dispersion or U-shaped total mass-to-light ratio relations. This is indicative of a number of mechanisms at play forming these peculiar galaxies. Some of them may be the most extended version of dwarf galaxies, while others are so extreme that they seem to populate dark matter halos consistent with that of the Milky Way or even larger. Even though Milky Way stars and other GC interlopers contaminating our sample of GCs cannot be fully ruled out, our assessment of this potential problem and simulations indicate that the probability is low and, if present, unlikely to be enough to explain the extreme dispersions measured. Further confirmation from stellar kinematics studies in these UDGs would be desirable. The lack of such extreme objects in any of the state-of-the-art simulations opens an exciting avenue of new physics shaping these galaxies.
We describe a program to measure surface brightness fluctuation (SBF) distances to galaxies observed in the Next Generation Virgo Cluster Survey (NGVS), a photometric imaging survey covering 104 deg2 ...of the Virgo cluster in the u*, g, i, and z bandpasses with the Canada-France-Hawaii Telescope. We describe the selection of the sample galaxies, the procedures for measuring the apparent i-band SBF magnitude , and the calibration of the absolute as a function of observed stellar population properties. The multiband NGVS data set provides multiple options for calibrating the SBF distances, and we explore various calibrations involving individual color indices as well as combinations of two different colors. Within the color range of the present sample, the two-color calibrations do not significantly improve the scatter with respect to wide-baseline, single-color calibrations involving u*. We adopt the calibration as a reference for the present galaxy sample, with an observed scatter of 0.11 mag. For a few cases that lack good u* photometry, we use an alternative relation based on a combination of and colors, with only a slightly larger observed scatter of 0.12 mag. The agreement of our measurements with the best existing distance estimates provides confidence that our measurements are accurate. We present a preliminary catalog of distances for 89 galaxies brighter than BT 13.0 mag within the survey footprint, including members of the background M and W Clouds at roughly twice the distance of the main body of the Virgo cluster. The extension of the present work to fainter and bluer galaxies is in progress.
The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis, whereas Aurora‐C executes ...unique roles in meiosis. Overexpression or gene amplification of Aurora kinases has been reported in a broad range of human malignancies, pointing to their role as potent oncogenes in tumorigenesis. Aurora kinases therefore represent promising targets for anticancer therapeutics. A number of Aurora kinase inhibitors (AKIs) have been generated; some of which are currently undergoing clinical evaluation. Recent studies have unveiled novel unexpected functions of Aurora kinases during cancer development and the mechanisms underlying the anticancer actions of AKIs. In this review, we discuss the most recent advances in Aurora‐A kinase research and targeted cancer therapy, focusing on the oncogenic roles and signaling pathways of Aurora‐A kinases in promoting tumorigenesis, the recent preclinical and clinical AKI data, and potential alternative routes for Aurora‐A kinase inhibition.
Observations of nearby galaxy clusters at low surface brightness have identified galaxies with low luminosities, but sizes as large as Llow * galaxies, leading them to be dubbed "ultra-diffuse ...galaxies" (UDGs). The survival of UDGs in dense environments like the Coma cluster suggests that UDGs could reside in much more massive dark halos. We report the detection of a substantial population of globular clusters (GCs) around a Coma UDG, Dragonfly 17 (DF17). We find that DF17 has a high GC specific frequency of S sub(N)= 26 + or - 13. The GC system is extended, with an effective radius of 12" + or - 2", or 5.6 + or - 0.9 kpc at Coma distance, 70% larger than the galaxy itself. We also estimate the mean of the GC luminosity function to infer a distance of (ProQuest: Formulae and/or non-USASCII text omitted) Mpc, providing redshift-independent confirmation that one of these UDGs is in the Coma cluster. The presence of a rich GC system in DF17 indicates that, despite its low stellar density, star formation was intense enough to form many massive star clusters. If DF17's ratio of total GC mass to total halo mass is similar to those in other galaxies, then DF17 has an inferred total mass of ~10 super(11)M sub(middo t in circle), only ~10% the mass of the Milky Way, but extremely dominated by dark matter, with M/L sub(V)approximate 1000. We suggest that UDGs like DF17 may be "pure stellar halos," i.e., galaxies that formed their stellar halo components, but then suffered an early cessation in star formation that prevented the formation of any substantial central disk or bulge.
The Advanced Camera for Surveys (ACS) Fornax Cluster Survey is a Hubble Space Telescope program to image 43 early-type galaxies in the Fornax cluster, using the F475W and F850LP bandpasses of the ...ACS. We employ both one-dimensional and two-dimensional techniques to characterize the properties of the stellar nuclei in these galaxies, defined as the central "luminosity excesses", relative to a Sersic model fitted to the underlying host. We find 72% + or - 13% of our sample (31 galaxies) to be nucleated, with only three of the nuclei offset by more than 0".5 from their galaxy photocenter, and with the majority of nuclei having colors bluer than their hosts. The nuclei are observed to be larger, and brighter, than typical Fornax globular clusters and to follow different structural scaling relations. A comparison of our results to those from the ACS Virgo Cluster Survey reveals striking similarities in the properties of the nuclei belonging to these different environments. We briefly review a variety of proposed formation models and conclude that, for the low-mass galaxies in our sample, the most important mechanism for nucleus growth is probably infall of star clusters through dynamical friction, while for higher mass galaxies, gas accretion triggered by mergers, accretions, and tidal torques is likely to dominate, with the relative importance of these two processes varying smoothly as a function of galaxy mass. Some intermediate-mass galaxies in our sample show a complexity in their inner structure that may be the signature of the "hybrid nuclei" that arose through parallel formation channels.
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