Less research has been conducted on the association between camellia oil's (CO) phenolic composition and antioxidant capability. In this study, the phenolic profile of CO and its connection to ...antioxidant capacity were examined utilizing a combination of widely-targeted phenolic metabolomics and multivariate statistical analysis. A total of 751 phenolics were discovered. The WGCNA was used to link phenols to antioxidants, yielding 161 antioxidant-related phenols from the blue module. In response to several antioxidant assays, 59 (FRAP), 59 (DPPH), and 53 (ABTS) phenolics were identified as differential phenolic markers (DPMs). Further stepwise multiple linear regression revealed six DPMs that substantially influenced the antioxidant capacities. Nine metabolic pathways and their associated network mechanisms for the most significant phenolics were developed. This study sheds light on the phenolic content of CO, elucidates their role in antioxidant activity, and lays the groundwork for improving extraction techniques and generating improved product.Less research has been conducted on the association between camellia oil's (CO) phenolic composition and antioxidant capability. In this study, the phenolic profile of CO and its connection to antioxidant capacity were examined utilizing a combination of widely-targeted phenolic metabolomics and multivariate statistical analysis. A total of 751 phenolics were discovered. The WGCNA was used to link phenols to antioxidants, yielding 161 antioxidant-related phenols from the blue module. In response to several antioxidant assays, 59 (FRAP), 59 (DPPH), and 53 (ABTS) phenolics were identified as differential phenolic markers (DPMs). Further stepwise multiple linear regression revealed six DPMs that substantially influenced the antioxidant capacities. Nine metabolic pathways and their associated network mechanisms for the most significant phenolics were developed. This study sheds light on the phenolic content of CO, elucidates their role in antioxidant activity, and lays the groundwork for improving extraction techniques and generating improved product.
Hepatic veno-occlusive disease (VOD) is a potentially fatal complication of hematopoietic stem cell transplantation (HSCT). We conducted this study to investigate the incidence and risk factors of ...hepatic VOD for patients receiving HSCT in Taiwan. We retrospectively analyzed the data from a nationwide registry for patients receiving HSCT, which was collected by the Taiwan Society of Blood and Marrow Transplantation. The data collection period was from 2009 to 2014. A total 2345 patients were reviewed and 39 patients among them were diagnosed as having hepatic VOD. The cumulative incidence of hepatic VOD in the whole cohort of 2345 patients was 1.66%. In multivariate analysis, disease diagnosis of myelodysplastic syndrome, chronic HCV infection, condition regimens of bulsulfan intravenously administered, and antithymocyte immunoglobulin were independent factors to predict higher risk of hepatic VOD. The overall mortality rate for patients with hepatic VOD was 79%. Patients with hepatic VOD had significant worse survival outcomes when compared with those without hepatic VOD (
P
= 0.00063). In conclusion, although the incidence is low, hepatic VOD remains a serious complication after HSCT in Taiwan. The findings of this study could be the basis for developing prophylactic or early treatment strategies for hepatic VOD.
Aim
To explore the energy expenditure (EE) in a group of preterm infants during the periods of environmental stress, and to explore the relationship between EE and physiological stress signals of ...preterm infants.
Methods
Research design was an explorative secondary analysis of 4164 research data from 37 preterm infants which included physiological signals and environmental stressors in neonatal intensive care units. The current study investigated the data of EE calculated using heart‐rate‐based EE estimate.
Results
A significantly positive relationship between EE and different levels of nursing intervention was found (P < 0.005). In addition, there was a significantly negative relationship between EE and oxygen saturation (P < 0.001).
Conclusion
These research results confirmed that environmental stressors may impact the growth and developmental outcomes in preterm infants by increasing their EE. Neonatal clinicians should minimize excessive stimulations in order to conserve energy for the growth and developmental needs of preterm infants. Research found a significant relationship between an increase in EE and a decrease in oxygen saturation in preterm infants. The authors further hypothesized that EE of preterm infants may be predicted by estimating the oxygen saturation. Further study using different research methods and an enlarged sample size is needed.
Colorectal cancer is a common malignancy with the third highest incidence and second highest mortality rate among all cancers in the world. Chemotherapy resistance in colorectal cancer is an ...essential factor leading to the high mortality rate. The ATP-binding cassette (ABC) superfamily G member 2 (ABCG2) confers multidrug resistance (MDR) to a range of chemotherapeutic agents by decreasing their intracellular content. The development of novel ABCG2 inhibitors has emerged as a tractable strategy to circumvent drug resistance. In this study, an ABCG2-knockout colorectal cancer cell line was established to assist inhibitor screening. Additionally, we found that ataxia-telangiectasia mutated (ATM) kinase inhibitor AZ32 could sensitize ABCG2-overexpressing colorectal cancer cells to ABCG2 substrate chemotherapeutic drugs mitoxantrone and doxorubicin by retaining them inside cells. Western blot assay showed that AZ32 did not alter the expression of ABCG2. Moreover, molecule docking analysis predicted that AZ32 stably located in the transmembrane domain of ABCG2. In conclusion, our result demonstrated that AZ32 could potently reverse ABCG2-mediated MDR in colorectal cancer.
Titanium alloys with special macro-micro composite structures of directional hydrophobicity are difficult to prepare due to poor thermal conductivity and good corrosion resistance, inhibiting the ...wide engineering applications for aerospace, marine engineering, and biomedicine. To prepare macro-micro composite structures on the surface of titanium alloys and achieve directional hydrophobicity, the sub-millimeter structures with an edge width of 150 μm, a groove width of 250 μm, and a depth of 250 μm were fabricated on the titanium alloy by wire electrical discharge machining (WEDM) technology, and high voltage-induced weak electric arc machining (HV-μEAM) was used to fabricate micro-scale feature size micro-structures on the processed macro-structure edges. The influence of process parameters on the morphology of microstructures was studied experimentally. The smooth surface of the titanium alloy is isotropically hydrophilic, and its contact angle is 68°. After processing the macrostructure on the titanium alloy surface, it shows directional hydrophobicity after being modified by low surface energy materials. The macro-micro composite structure formed by HV-μEAM realizes a directional hydrophobic surface with contact angles (CA) of 140° (parallel direction) and 130° (perpendicular direction), respectively. This surface has been modified with low surface energy to achieve contact angles of 154° and 143°. The results of the abrasion resistance test show that under the load of 100 g, it retains directional hydrophobicity at a friction distance of 700 mm with 600# sandpaper. The existence of the sub-millimeter macrostructure is the reason for the directionality of surface hydrophobicity. The microstructure can realize the transformation of the titanium alloy surface from hydrophilic to hydrophobic. Under the combined effects of the macro and micro composite structure, the surface of the titanium alloy shows obvious directional hydrophobicity.
VoLTE (Voice-over-LTE) is the designated voice solution to the LTE mobile network, and its worldwide deployment is underway. It reshapes call services from the traditional circuit-switched telecom ...telephony to the packet-switched Internet VoIP. In this work, we conduct the first study on VoLTE security before its full rollout. We discover several vulnerabilities in both its control-plane and data-plane functions, which can be exploited to disrupt both data and voice in operational networks. In particular, we find that the adversary can easily gain free data access, shut down continuing data access, or subdue an ongoing call, etc. We validate these proof-of-concept attacks using commodity smartphones (rooted and unrooted) in two Tier-1 US mobile carriers. Our analysis reveals that, the problems stem from both the device and the network. The device OS and chipset fail to prohibit non-VoLTE apps from accessing and injecting packets into VoLTE control and data planes. The network infrastructure also lacks proper access control and runtime check.
Key message
miR319 was identified as a dwarf-inducing gene from Shiokari and its dwarf near isogenic line, and its transgenic rice showed a reduced plant height. This finding reveals the potential ...application of miR319 in future molecular breeding.
It is well known that microRNAs (miRNAs) play important roles in plant physiology, especially in development and stress responses. However, little is known about the role of miRNAs in plant height. In this study, the rice cultivar Shiokari and its dwarf near isogenic line Shiokari-d6 were analysed to identify and characterize plant height-associated miRNAs. This anatomic and morphological investigation revealed that the major cause of the shorter height of Shiokari-d6 is the significantly dis-elongated internodes, particularly the second internode and those underneath it. The results of miRNA microarray profiling and real-time RT-PCR indicated that miR319 is expressed at a significantly higher level in Shiokari-d6 than in Shiokari. Transgenic rice overexpressing miR319 in
Oryza sativa
L. cv. Tainung 67 generated through
Agrobacterium
-mediated transformation had a stable dwarf phenotype regardless of whether the plants were from the T1 or T2 generation. We also found that the internodes of miR319-overexpressing rice are shortened, particularly the third internode and those underneath it. Furthermore, we identified three putative miR319 target genes that were previously uncharacterized with expression levels that were negatively correlated with the expression of miR319. In conclusion, miR319 is the first miRNA proposed to be involved in plant height regulation, and its function may influence the elongation of internodes, which leads to decreased plant height.
X-Ray photoelectron spectroscopy is a powerful tool for identifying the interactions of additives or surface treatments with components in lead halide perovskites. However, with the increasing number ...of studies using XPS, inaccurate or faulty data analysis has been encountered during a literature survey. Herein, we describe the fundamental principle of chemical shifts of Pb atoms in XPS and critically review the commonly seen mistakes in the literature: (i) misinterpretation of the XPS mechanism; (ii) misinterpretations due to disturbed chemical environments; (iii) lack of awareness of the properties of the passivator; iv. misquoted references. We hope that this perspective can help the community avoid the pitfalls in applying the XPS technique and in explaining their experimental results.
X-Ray photoelectron spectroscopy is a powerful tool for identifying the interactions of additives or surface treatments with components in lead halide perovskites.
In this letter, we display InGaN/GaN-based photovoltaic (PV) devices with active layers in absorbing the solar spectrum around blue regions. The GaN/In 0.25 Ga 0.75 N superlattice layers grown by ...metalorganic vapor-phase epitaxy are designed as the absorption layers with the same total thickness. The PV effect is almost absent when the In 0.25 Ga 0.75 N single layer is used as the absorption layer. This could be due to the large leakage current caused by the poor material quality and the relatively small shunt resistance. Devices with superlattice structure illuminated under a one-sun air-mass 1.5-G condition exhibit an open-circuit voltage of around 1.4 V and a short-circuit current density of around 0.8 mA/cm 2 corresponding to a conversion efficiency of around 0.58%.
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