Bayesian optimization has become a widely used tool in the optimization and machine learning communities. It is suitable to problems as simulation/optimization and/or with an objective function ...computationally expensive to evaluate. Bayesian optimization is based on a surrogate probabilistic model of the objective whose mean and variance are sequentially updated using the observations and an “acquisition” function based on the model, which sets the next observation at the most “promising” point. The most used surrogate model is the Gaussian Process which is the basis of well-known Kriging algorithms. In this paper, the authors consider the pump scheduling optimization problem in a Water Distribution Network with both ON/OFF and variable speed pumps. In a global optimization model, accounting for time patterns of demand and energy price allows significant cost savings. Nonlinearities, and binary decisions in the case of ON/OFF pumps, make pump scheduling optimization computationally challenging, even for small Water Distribution Networks. The well-known EPANET simulator is used to compute the energy cost associated to a pump schedule and to verify that hydraulic constraints are not violated and demand is met. Two Bayesian Optimization approaches are proposed in this paper, where the surrogate model is based on a Gaussian Process and a Random Forest, respectively. Both approaches are tested with different acquisition functions on a set of test functions, a benchmark Water Distribution Network from the literature and a large-scale real-life Water Distribution Network in Milan, Italy.
The utility of neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) as prognostic markers in Feline Leukemia Virus (FeLV) and Feline ...Immunodeficiency Virus (FIV) infections has not yet been investigated. The aim of this study was to investigate these leukocyte ratios in retrovirus-positive cats and to evaluate their prognostic value for survival. This retrospective case-control study included 142 cats, 75 FIV-Antibodies (Ab)-positive, 52 FeLV-Antigen (Ag)-positive, and 15 FIV-Ab+FeLV-Ag-positive, and a control population of 142 retrovirus-negative age-, sex-, and lifestyle-matched cats. Signalment, complete blood count at the time of serological testing, and outcome were recorded. Leukocyte ratios were compared within the same case-control population, among the three retrovirus-seropositive populations, and were related to survival time. No significant difference was found in NLR, MLR, or PLR between FIV-Ab-positive and FIV-Ab+FeLV-Ag-positive cats and their cross-matched controls. In the FeLV-Ag-positive population, MLR was significantly lower than in the control population (0.05 and 0.14, respectively, P=0.0008). No ratio discriminated among the three infectious states. No ratio was significantly different between survivors and non-survivors in the population of FIV-Ab-positive cats. MLR at diagnosis was significantly higher in FeLV-Ag-positive cats that died 1–3 years after diagnosis than in FeLV-Ag-positive cats still alive at 3 years (P=0.0284). None of the three ratios could predict retroviruses-positive cats that would survive to the end of the study. Overall the results indicate that NLR, MLR, and PLR are not significantly different among retrovirus statuses evaluated and had a very limited prognostic value for the survival time in retrovirus-positive cats.
•The utility of leukocyte ratios as prognostic markers in FeLV and FIV infections has not yet been investigated.•Monocyte-lymphocyte ratio (MLR) was significantly lower in FeLV-Ag-positive cats than in the negative cross-matched cats.•None of the leukocyte ratios could predict retroviruses-seropositive cats that would survive to the end of the study.•MLR at diagnosis was significantly higher in FeLV-Ag-positive cats that died 1-3 years after diagnosis.
This paper presents a new scalable algorithm for discovering closed frequent itemsets, a lossless and condensed representation of all the frequent itemsets that can be mined from a transactional ...database. Our algorithm exploits a divide-and-conquer approach and a bitwise vertical representation of the database and adopts a particular visit and partitioning strategy of the search space based on an original theoretical framework, which formalizes the problem of closed itemsets mining in detail. The algorithm adopts several optimizations aimed to save both space and time in computing itemset closures and their supports. In particular, since one of the main problems in this type of algorithms is the multiple generation of the same closed itemset, we propose a new effective and memory-efficient pruning technique, which, unlike other previous proposals, does not require the whole set of closed patterns mined so far to be kept in the main memory. This technique also permits each visited partition of the search space to be mined independently in any order and, thus, also in parallel. The tests conducted on many publicly available data sets show that our algorithm is scalable and outperforms other state-of-the-art algorithms like CLOSET+ and FP-CLOSE, in some cases by more than one order of magnitude. More importantly, the performance improvements become more and more significant as the support threshold is decreased.
Display omitted
•Sustainability evaluation of a vertical closed-loop GSHP system is performed.•A newly developed modelling suite is validated for low enthalpy simulations.•Effects of main subsurface ...and design parameters are studied.•Interference is amplified by strong heterogeneity of Po Plain alluvial deposits.•Homogeneous model assumption underrates the magnitude of thermal imbalance issues.
In this study the effects on the thermal field of a medium scale GSHP system located in Alessandria (Italy) and installed in highly heterogeneous alluvials are considered. The system was monitored over a year and data showed a progressive loss of efficiency. Simulation results obtained from a 3D numerical model show that the analyzed GSHP system has an inadequate design even for a short/medium period operation. A strong probe interference phenomenon was observed, due to the particular layout of the probe field and to the high energy request for building conditioning. The efficiency loss is also amplified by the presence of alluvial deposits with poor thermal properties. Adopting a homogeneous distribution of the thermal properties of the subsurface results in an underestimation of the thermal alteration of 25% while the increase of probe distance by 55% produces a reduction of thermal alteration of 45%. In this case study the homogeneous subsurface assumption leads to excessive simplification of the observed strong heterogeneity and it underrates thermal impact on the soil, especially in layers with poor thermal properties.
•The effect of storage on selected hematologic and biochemical parameters for feline whole blood units were reported.•Statistically significant increases in hemolysis and erythrocyte morphologic ...change become evident from 21 days storage.•Mean percentage hemolysis was <1% up to 21 days of storage.•Statistically significant changes in biochemical parameters (glucose, potassium, and sodium) commenced from 7 days storage.•In vivo studies are needed to verify the clinical relevance of changes in feline blood during storage.
Despite the increasing availability of feline blood, which is collected and stored for transfusion purposes, few studies have assessed the effect of storage on feline whole blood (WB) units. The purpose of this study was to investigate selected hematologic and biochemical changes during storage of feline WB units and to determine when they occurred. Data from a quality control program for WB units was used in this study. Twelve feline WB units, collected using an open system, were sampled every 7 days from the point of collection to the end of storage at 35 days (D0, D7, D14, D21, D28, and D35). Measurements at each time point were: (1) hematologic parameters; (2) percentage hemolysis; (3) morphologic index scored at 0–3, based on echinocyte transformation of the erythrocytes; and (4) selected biochemical parameters. Aerobic and anaerobic culture was performed at D0 and D35. Results were compared statistically to D0 (statistical significance set at <0.01).
Storage did not result in statistically significant changes in measured hematological parameters. There were statistically significant increases in percentage hemolysis and morphologic index, starting from D21 (P=0.000 and P=0.004, respectively). Glucose decreased significantly from D21 (P=0.003); potassium increased significantly from D7 (P=0.001); and sodium increased significantly, starting from D28 (P=0.009). Bacteria were not isolated. Blood in feline WB units collected using an open system underwent some significant storage changes that were time-dependent. As these changes could affect the quality and the utility of stored WB used in feline transfusion medicine, further study is required to determine their clinical importance.
Recommender systems represent one of the most successful applications of machine learning in B2C online services, to help the users in their choices in many web services. Recommender system aims to ...predict the user preferences from a huge amount of data, basically the past behaviour of the user, using an efficient prediction algorithm. One of the most used is the matrix-factorization algorithm. Like many machine learning algorithms, its effectiveness goes through the tuning of its hyper-parameters, and the associated optimization problem also called hyper-parameter optimization. This represents a noisy time-consuming black-box optimization problem. The related objective function maps any possible hyper-parameter configuration to a numeric score quantifying the algorithm performance. In this work, we show how Bayesian optimization can help the tuning of three hyper-parameters: the number of latent factors, the regularization parameter, and the learning rate. Numerical results are obtained on a benchmark problem and show that Bayesian optimization obtains a better result than the default setting of the hyper-parameters and the random search.
We present a paleoenvironmental reconstruction for the mountain fringe between the South-Eastern Alps and the Northern Dinarides (NE-Italy/W-Slovenia) during the Last Glacial Maximum. We focused on a ...new sedimentary and paleoecological archive spanning the LGM acme, located in an aggrading, permanently flooded and ponded plain, dammed by an active fluvioglacial megafan. The ecosystem reconstruction, based on two high resolution pollen records, is supported by a rich plant macrofossil flora and constrained by a robust radiocarbon chronology between 26 and 22calka BP. We show evidence for persistence of boreal trees and of different open boreal forest types throughout the LGM at the south-eastern mountain fringe of the Alps and the Northern Dinarides. Fire frequency is responsible for high, oscillating forest openness. The paleobotanical record is discussed in the light of the ecogeographic diversity of the region. A belt formed by Swiss stone pine, larch and dwarf mountain pine on limestone bedrock, and accompanied by Spruce in the floodplain, extended uphill, while proximal outwash plain supported Scots pine and dwarf mountain pine. These differences arise from groundwater regimes rather than from local climate variability. A steep moisture gradient from the semiarid pedoclimatic regime prevailing in the Adriatic alluvial plain to the forested mountain fringe is related to the orographic rainout triggered by southern air circulation. Mesophytic broad-leaved forest trees did not withstand the LGM temperature extremes in zonal ecosystems at the Alpine–Dinaric fringe; however, the fossil evidence suggests a number of microrefugia in karstic and thermal spring habitats of the northern Adriatic.
•Paleoenvironmental reconstruction at Alps–Dinarides fringe during the Last Glacial Maximum•Relationships between regional geological frame, sedimentary environments, and forest history•Persistence of trees and of different types of open boreal forest throughout the LGM
REASONS FOR PERFORMING STUDY: This is the first study comparing stemness features of equine mesenchymal progenitor cells derived from amniotic membrane and bone marrow. OBJECTIVES: To investigate an ...alternative and noninvasive stromal cell source for equine tissue engineering. STUDY DESIGN: In vitro experimental study of the characteristics of equine mesenchymal progenitor cells derived from amnion and bone marrow. METHODS: Cells isolated from amniotic membrane and bone marrow were analysed for proliferation (growth curve, doubling time, colony forming unit). Immunocytochemical detection of pluripotency markers and gene expression of stromal cell markers were also performed and these cells were studied for multilineage plasticity. RESULTS: Amniotic stromal cells (AMSCs) and bone marrow mesenchymal cells (BM‐MSCs) both exhibited mature stromal cell‐specific gene expression and immunocytochemical properties, but showed substantial differences in their proliferative and differentiation potential. The mean doubling time for AMSCs was significantly lower (P<0.05) than that observed for BM‐MSCs (1.17 ± 0.15 vs. 3.27 ± 0.19 days, respectively). Compared to AMSCs, BM‐MSCs also demonstrated a significantly (P<0.05) lower clonogenic capability (one fibroblast‐like colony forming unit from a mean of 590.15 cells seeded for BM‐MSCs vs. 242.73 cells seeded for AMSCs). BM‐MSCs did not differentiate into glial cells, and the osteogenic differentiation process was longer than for AMSCs. CONCLUSIONS AND POTENTIAL RELEVANCE: The amniotic membrane could be a valuable source of MSCs to be used both for allogenic and/or autologous therapies. The noninvasive nature and low cost of collection, the rapid proliferation along with a greater differentiation potential and the ‘off the shelf’ preparation potential could make AMCs useful for cell therapy.
•Information on prevalence of dog erythrocyte antigens (DEAs) is important in selection of blood donors.•Corso dogs fulfil common requirements for blood donors: large size, good-tempered, easy to ...handle during blood collection.•There is a high prevalence of DEA 1 and DEA 7-negative dogs in the Corso breed.•The presence of suspected naturally occurring anti-DEA 7 antibodies may be implicated in delayed transfusion reactions.
We sought to determine the prevalence of dog erythrocyte antigen (DEA) 1, 4 and 7 and naturally occurring anti-DEA7 antibodies in Italian Corso dogs. In addition, we correlated DEAs with different epidemiologic variables, compared the prevalence of DEAs against other canine populations and assessed the risk of sensitisation and transfusion reactions (TRs) following unmatched transfusion. Blood samples from 100 Corso dogs were evaluated for DEA 1, 4, 7 and naturally occurring anti-DEA 7 antibodies.
Seventy-one percent of samples were DEA 1-negative, 100% tested DEA 4-positive, and 95% tested DEA 7-negative. Suspected anti-DEA7 antibodies were found in 32% dogs. The DEA 1 and 7-negative phenotypes were significantly more common than in most canine populations. When a previously tested Italian canine population was considered as blood donors for Corso dogs, the risk of DEA 1 sensitisation using DEA 1 untyped blood was 29%, and of acute haemolytic TRs after a second untyped DEA 1-incompatible transfusion was 8%. The potential for delayed TRs between DEA 7-negative Corso dogs with suspected naturally occurring anti-DEA 7 antibodies receiving untyped DEA 7-positive blood was 11%. Conversely, when Corso dogs were blood donors for the same population, the risk of DEA 1 sensitisation was 17% and the risk of an acute haemolytic TR after a second DEA 1-incompatible blood transfusion was 3%. Corso dogs can be suitable blood donors. Additional studies are needed to clarify whether the high prevalence of naturally occurring anti-DEA 7 antibodies in this breed could increase their risk of delayed TRs when they are blood recipients.
The combination of genetic and local search heuristics has been shown to be an effective approach to solving the traveling salesman problem (TSP). This paper describes a new hybrid algorithm that ...exploits a compact genetic algorithm in order to generate high-quality tours, which are then refined by means of the Lin-Kernighan (LK) local search. The local optima found by the LK local search are in turn exploited by the evolutionary part of the algorithm in order to improve the quality of its simulated population. The results of several experiments conducted on different TSP instances with up to 13,509 cities show the efficacy of the symbiosis between the two heuristics.
PDF
