The past several years have witnessed an explosion of successful ancient human genome-sequencing projects, with genomic-scale ancient DNA data sets now available for more than 1,100 ancient human and ...archaic hominin (for example, Neandertal) individuals. Recent 'evolution in action' analyses have started using these data sets to identify and track the spatiotemporal trajectories of genetic variants associated with human adaptations to novel and changing environments, agricultural lifestyles, and introduced or co-evolving pathogens. Together with evidence of adaptive introgression of genetic variants from archaic hominins to humans and emerging ancient genome data sets for domesticated animals and plants, these studies provide novel insights into human evolution and the evolutionary consequences of human behaviour that go well beyond those that can be obtained from modern genomic data or the fossil and archaeological records alone.
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain. Under the microscope, ...neuronal accumulation of abnormal tau proteins and amyloid plaques are two pathological hallmarks in affected brain regions. Although the detailed mechanism of the pathogenesis of AD is still elusive, a large body of evidence suggests that damaged mitochondria likely play fundamental roles in the pathogenesis of AD. It is believed that a healthy pool of mitochondria not only supports neuronal activity by providing enough energy supply and other related mitochondrial functions to neurons, but also guards neurons by minimizing mitochondrial related oxidative damage. In this regard, exploration of the multitude of mitochondrial mechanisms altered in the pathogenesis of AD constitutes novel promising therapeutic targets for the disease. In this review, we will summarize recent progress that underscores the essential role of mitochondria dysfunction in the pathogenesis of AD and discuss mechanisms underlying mitochondrial dysfunction with a focus on the loss of mitochondrial structural and functional integrity in AD including mitochondrial biogenesis and dynamics, axonal transport, ER-mitochondria interaction, mitophagy and mitochondrial proteostasis.
Ecological memory is central to how ecosystems respond to disturbance and is maintained by two types of legacies -information and material. Species life-history traits represent an adaptive response ...to disturbance and are an information legacy; in contrast, the abiotic and biotic structures (such as seeds or nutrients) produced by single disturbance events are material legacies. Disturbance characteristics that support or maintain these legacies enhance ecological resilience and maintain a "safe operating space" for ecosystem recovery. However, legacies can be lost or diminished as disturbance regimes and environmental conditions change, generating a "resilience debt" that manifests only after the system is disturbed. Strong effects of ecological memory on post-disturbance dynamics imply that contingencies (effects that cannot be predicted with certainty) of individual disturbances, interactions among disturbances, and climate variability combine to affect ecosystem resilience. We illustrate these concepts and introduce a novel ecosystem resilience framework with examples of forest disturbances, primarily from North America. Identifying legacies that support resilience in a particular ecosystem can help scientists and resource managers anticipate when disturbances may trigger abrupt shifts in forest ecosystems, and when forests are likely to be resilient.
Invasive species can cause shifts in vegetation composition and fire regimes by initiating positive vegetation-fire feedbacks. To understand the mechanisms underpinning these shifts, we need to ...determine how invasive species interact with other species when burned in combination and thus how they may influence net flammability in the communities they invade. Previous studies using litter and ground fuels suggest that flammability of a species mixture is nonadditive and is driven largely by the more-flammable species. However, this nonadditivity has not been investigated in the context of plant invasions nor for canopy fuels. Using whole shoots, we measured the flammability of indigenous-invasive species pairs for six New Zealand indigenous and four globally invasive plant species, along with single-species control burns. Our integrated measure of flammability was clearly nonadditive, and the more-flammable species per pairing had the stronger influence on flammability in 83 % of combinations. The degree of nonadditivity was significantly positively correlated with the flammability difference between the species in a pairing. The strength of nonadditivity differed among individual flammability components. Ignitability and combustibility were strongly determined by the more-flammable species per pair, yet both species contributed more equally to consumability and sustainability. Our results suggest mechanisms by which invasive species entrain positive vegetation-fire feedbacks that alter ecosystem flammability, enhancing their invasion. Of the species tested, Hakea sericea and Ulex europaeus are those most likely to increase the flammability of New Zealand ecosystems and should be priorities for management.
Oxidative stress (OS) is one of the major pathomechanisms of Alzheimer’s disease (AD), which is closely associated with other key events in neurodegeneration such as mitochondrial dysfunction, ...inflammation, metal dysregulation, and protein misfolding. Oxidized RNAs are identified in brains of AD patients at the prodromal stage. Indeed, oxidized mRNA, rRNA, and tRNA lead to retarded or aberrant protein synthesis. OS interferes with not only these translational machineries but also regulatory mechanisms of noncoding RNAs, especially microRNAs (miRNAs). MiRNAs can be oxidized, which causes misrecognizing target mRNAs. Moreover, OS affects the expression of multiple miRNAs, and conversely, miRNAs regulate many genes involved in the OS response. Intriguingly, several miRNAs embedded in upstream regulators or downstream targets of OS are involved also in neurodegenerative pathways in AD. Specifically, seven upregulated miRNAs (miR-125b, miR-146a, miR-200c, miR-26b, miR-30e, miR-34a, miR-34c) and three downregulated miRNAs (miR-107, miR-210, miR-485), all of which are associated with OS, are found in vulnerable brain regions of AD at the prodromal stage. Growing evidence suggests that altered miRNAs may serve as targets for developing diagnostic or therapeutic tools for early-stage AD. Focusing on a neuroprotective transcriptional repressor, REST, and the concept of hormesis that are relevant to the OS response may provide clues to help us understand the role of the miRNA system in cellular and organismal adaptive mechanisms to OS.
Fire positively and negatively affects food webs across all trophic levels and guilds and influences a range of ecological processes that reinforce fire regimes, such as nutrient cycling and soil ...development, plant regeneration and growth, plant community assembly and dynamics, herbivory and predation. Thus we argue that rather than merely describing spatio-temporal patterns of fire regimes, pyrodiversity must be understood in terms of feedbacks between fire regimes, biodiversity and ecological processes. Humans shape pyrodiversity both directly, by manipulating the intensity, severity, frequency and extent of fires, and indirectly, by influencing the abundance and distribution of various trophic guilds through hunting and husbandry of animals, and introduction and cultivation of plant species. Conceptualizing landscape fire as deeply embedded in food webs suggests that the restoration of degraded ecosystems requires the simultaneous careful management of fire regimes and native and invasive plants and animals, and may include introducing new vertebrates to compensate for extinctions that occurred in the recent and more distant past.
This article is part of the themed issue ‘The interaction of fire and mankind’.
Metapopulation persistence depends on connectivity between habitat patches. While emphasis has been placed on the spatial dynamics of connectivity, much less has been placed on its short‐term ...temporal dynamics. In many terrestrial and aquatic ecosystems, however, transient (short‐term) changes in connectivity occur as habitat patches are connected and disconnected due, for example, to climatic or hydrological variability. We evaluated the implications of transient connectivity using a network‐based metapopulation model and a series of scenarios representing temporal changes in connectivity. The transient loss of connectivity can influence metapopulation persistence, and more strongly autocorrelated temporal dynamics affect metapopulation persistence more severely. Given that many ecosystems experience short‐term and temporary loss of habitat connectivity, it is important that these dynamics are adequately represented in metapopulation models; failing to do so may yield overly optimistic‐estimates of metapopulation persistence in fragmented landscapes.
1. In the context of ongoing climatic warming, forest landscapes face increasing risk of conversion to non-forest vegetation through alteration of their fire regimes and their post-fire recovery ...dynamics. However, this pressure could be amplified or dampened, depending on how fire-driven changes to vegetation feed back to alter the extent or behaviour of subsequent fires. 2. Here we develop a mathematical model to formalize understanding of how firevegetation feedbacks and the time to forest recovery following high-severity (i.e. stand-replacing) fire affect the extent and stability of forest cover across landscapes facing altered fire regimes. We evaluate responses to increasing burn rates while varying the direction (negative vs. positive) of fire-vegetation feedbacks under a continuum of values for feedback strength and post-fire recovery time. In doing so, we determine how interactions among these variables produce thresholds and tipping points in landscape responses to changing fire regimes. 3. Where the early-seral vegetation was less fire-prone than older forests, negative feedbacks limited the reductions in forest cover in response to higher fire frequency or slower forest recovery. By contrast, positive feedbacks (more flammable early-seral vegetation) produced a tipping point beyond which increases in burn rates or a slowing of forest recovery drove extensive forest loss. 4. With negative feedbacks, the rates of forest loss and expansion in response to variation in fire frequency were similar. However, where feedbacks were positive, the conversion from predominantly forested to non-forested conditions in response to increasing fire frequency was faster than the re-expansion of forest cover following a return to the initial burn rate. Strengthening the positive feedbacks increased this asymmetry. 5. Synthesis. Our analyses elucidate how fire-vegetation feedbacks and post-fire recovery rates interact to affect the trajectories and rates of landscape response to altered fire regimes. We illustrate the vulnerability of ecosystems with positive fire-vegetation feedbacks to climate change-driven increases in fire activity, especially where post-fire recovery is slow. Although negative feedbacks initially provide resistance to forest loss with increasing burn rates, this resistance is eventually overwhelmed with sufficient increases to burn rates relative to recovery times.
Morphology and phenology influence plant–pollinator network structure, but whether they generate more stable pairwise interactions with higher pollination success remains unknown. Here we evaluate ...the importance of morphological trait matching, phenological overlap and specialisation for the spatio‐temporal stability (measured as variability) of plant–pollinator interactions and for pollination success, while controlling for species' abundance. To this end, we combined a 6‐year plant–pollinator interaction dataset, with information on species traits, phenologies, specialisation, abundance and pollination success, into structural equation models. Interactions among abundant plants and pollinators with well‐matched traits and phenologies formed the stable and functional backbone of the pollination network, whereas poorly matched interactions were variable in time and had lower pollination success. We conclude that phenological overlap could be more useful for predicting changes in species interactions than species abundances, and that non‐random extinction of species with well‐matched traits could decrease the stability of interactions within communities and reduce their functioning.
Morphology and phenology influence plant‐pollinator network structure, but whether they generate more stable pairwise interactions with higher pollination success is unknown. We show that interactions among abundant plants and pollinators with well‐matched traits and phenologies formed the stable and functional backbone of the pollination network, whereas poorly‐matched interactions were variable in time and had lower pollination success.
Estrous synchronization, coupled with natural service, provides the benefit of female cows conceiving early, but there are an increased number of females expressing estrus in a short period of time. ...Thus, considerations need to be made for the bull. Select a protocol that will distribute estrus over a longer period of time and ensure bulls pass a breeding soundness examination. Mature bulls (3 years old or older) have increased efficiency in getting cows pregnant compared with younger bulls; therefore, a ratio of 1 mature bull to 25 cows is a good recommendation within an estrous synchronized herd.
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