We study the processes e + e - → γ ISR J / ψ , where J / ψ → π + π - π 0 , J / ψ → K + K - π 0 , and J / ψ → K$0\atop{S}$ K ± π ∓ using a data sample of 519 fb - 1 recorded with the BABAR detector ...operating at the SLAC PEP-II asymmetric-energy e + e - collider at center-of-mass energies at and near the Υ ( n S ) ( n = 2 , 3 , 4 ) resonances.
Based on the full BABAR data sample of 466.5 million $B\bar{B}$ pairs, we present measurements of the electron spectrum from semileptonic B meson decays. We fit the inclusive electron spectrum to ...distinguish Cabibbo-Kobayashi-Maskawa (CKM) suppressed B → Xueν decays from the CKM-favored B → Xceν decays, and from various other backgrounds, and determine the total semileptonic branching fraction B (B → Xeν) = ( 10.34 ± 0.04stat ± 0.2 6syst)%, averaged over B± and B0 mesons. We determine the spectrum and branching fraction for charmless B → Xueν decays and extract the CKM element | Vub| , by relying on four different QCD calculations based on the heavy quark expansion. While experimentally, the electron momentum region above 2.1 GeV / c is favored, because the background is relatively low, the uncertainties for the theoretical predictions are largest in the region near the kinematic endpoint. Detailed studies to assess the impact of these four predictions on the measurements of the electron spectrum, the branching fraction, and the extraction of the CKM matrix element |Vub| are presented, with the lower limit on the electron momentum varied from 0.8 GeV / c to the kinematic endpoint. We determine |Vub| using each of these different calculations and find, |Vub| = ( 3.794 ± 0.107exp $+ 0.292\atop{ - 0.219 SF}$ $+ 0.078 \atop{- 0.068 theory}$ ) × 10- 3 (De Fazio and Neubert), (4.563 ± 0.126exp $+ 0.230\atop {- 0.208 SF}$ $+ 0.162\atop{- 0.163 theory}$ ) ×10-3 (Bosch, Lange, Neubert, and Paz), (3.959 ± 0.104exp $+ 0.164\atop{- 0.154 SF}$ $+ 0.042\atop{ - 0.079 theory}$ ) × 10-3 (Gambino, Giordano, Ossola, and Uraltsev), (3.848 ± 0.108exp $+ 0.084\atop{ - 0.070 theory}$) × 10-3 (dressed gluon exponentiation), where the stated uncertainties refer to the experimental uncertainties of the partial branching fraction measurement, the shape function parameters, and the theoretical calculations.
We present a search for f(J)(2220) production in radiative J/ψ→γf(J)(2220) decays using 460 fb⁻¹ of data collected with the BABAR detector at the SLAC PEP-II e(+)e⁻ collider. The f(J)(2220) is ...searched for in the decays to K(+)K⁻ and K(S)⁰K(S)⁰. No evidence of this resonance is observed, and 90% confidence level upper limits on the product of the branching fractions for J/ψ→γf(J)(2220) and f(J)(2220)→K(+)K⁻(K(S)⁰K(S)⁰) as a function of spin and helicity are set at the level of 10⁻⁵, below the central values reported by the Mark III experiment.
We study the processes e+e−→γISRJ/ψ, where J/ψ→π+π−π0, J/ψ→K+K−π0, and J/ψ→KS0K±π∓ using a data sample of 519 fb−1 recorded with the BABAR detector operating at the SLAC PEP-II asymmetric-energy e+e− ...collider at center-of-mass energies at and near the Υ(nS) (n=2,3,4) resonances. We measure the ratio of branching fractions R1=B(J/ψ→K+K−π0)B(J/ψ→π+π−π0) and R2=B(J/ψ→KS0K±π∓)B(J/ψ→π+π−π0). We perform Dalitz plot analyses of the three J/ψ decay modes and measure fractions for resonances contributing to the decays. We also analyze the J/ψ→π+π−π0 decay using the Veneziano model. We observe structures compatible with the presence of ρ(1450) in all three J/ψ decay modes and measure the relative branching fraction: R(ρ(1450))=B(ρ(1450)→K+K−)B(ρ(1450)→π+π−)=0.307±0.084(stat)±0.082(sys).
We study the processes e+e−→KS0KL0π0γ, KS0KL0ηγ, and KS0KL0π0π0γ, where the photon is radiated from the initial state, providing cross section measurements for the hadronic final states over a ...continuum of center-of-mass energies. The results are based on 469 fb−1 of data collected at or near the Υ(4S) resonance with the BABAR detector at SLAC. We present the first measurements of the e+e−→KS0KL0π0, KS0KL0η, and KS0KL0π0π0 cross sections up to a center-of-mass energy of 4 GeV and study their intermediate resonance structures. We observe J/ψ decays to all of these final states for the first time, present measurements of their J/ψ branching fractions, and search for ψ(2S) decays.
The management of individual patients requiring anthracyclines remains challenging because uncertainty persists on predictors of cardiotoxicity. We aimed to perform a systematic review and ...meta-analysis on incidence and predictors of anthracycline chemotherapy in patients with cancer. Databases were searched for pertinent studies. Meta-analytic pooling with random-effects methods was performed for incidence estimates, while relying on descriptive statistics for prevalence and strength of association of predictors. From 16,054 retrieved citations, 18 studies reporting on 49,017 patients with cancer were included, with 22,815 treated with anthracyclines. After a median follow-up of 9 years, clinically overt cardiotoxicity occurred in 6% (95% confidence interval 3% to 9%), whereas subclinical cardiotoxicity developed in 18% (95% confidence interval 12% to 24%). Appraisal of independent risk factors of cardiotoxicity showed that cumulative anthracycline dose was most consistently reported as an accurate and robust predictor of cardiotoxicity, with an acceptable prognostic role also for chest radiotherapy, African-American ethnicity, very young or very old age, diabetes, hypertension, very high or very low body weight, or severe co-morbidities. In conclusion, despite ongoing refinements in chemotherapy regimens, anthracyclines still pose a significant risk of cardiotoxicity, especially in those requiring a high cumulative dose or chest radiotherapy.
Using the eight time dependences e − Γ t ( 1 + C i cos Δ m t + S i sin Δ m t ) for the decays Υ ( 4 S ) → B 0 ¯ B 0 → f j f k , with the decay into a flavor-specific state f j = ℓ ± X before or after ...the decay into a C P eigenstate f k = c ¯ c K S , L , as measured by the BABAR experiment, we determine the three C P T -sensitive parameters Re ( z ) and Im ( z ) in B 0 − ¯ B 0 mixing and | ¯ A / A | in B 0 → c ¯ c K 0 decays. We find Im ( z ) = 0.010 ± 0.030 ± 0.013 , Re ( z ) = − 0.065 ± 0.028 ± 0.014 , and | ¯ A / A | = 0.999 ± 0.023 ± 0.017 , in agreement with C P T symmetry.
Cell-free gene expression (CFE) systems from crude cellular extracts have attracted much attention for biomanufacturing and synthetic biology. However, activating membrane-dependent functionality of ...cell-derived vesicles in bacterial CFE systems has been limited. Here, we address this limitation by characterizing native membrane vesicles in Escherichia coli-based CFE extracts and describing methods to enrich vesicles with heterologous, membrane-bound machinery. As a model, we focus on bacterial glycoengineering. We first use multiple, orthogonal techniques to characterize vesicles and show how extract processing methods can be used to increase concentrations of membrane vesicles in CFE systems. Then, we show that extracts enriched in vesicle number also display enhanced concentrations of heterologous membrane protein cargo. Finally, we apply our methods to enrich membrane-bound oligosaccharyltransferases and lipid-linked oligosaccharides for improving cell-free N-linked and O-linked glycoprotein synthesis. We anticipate that these methods will facilitate on-demand glycoprotein production and enable new CFE systems with membrane-associated activities.
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