The Mg-suite represents an enigmatic episode of lunar highlands magmatism that presumably represents the first stage of crustal building following primordial differentiation. This review examines the ...mineralogy, geochemistry, petrology, chronology, and the planetary-scale distribution of this suite of highlands plutonic rocks, presents models for their origin, examines petrogenetic relationships to other highlands rocks, and explores the link between this style of magmatism and early stages of lunar differentiation. Of the models considered for the origin of the parent magmas for the Mg-suite, the data best fit a process in which hot (solidus temperature at ≥2 GPa = 1600 to 1800 °C) and less dense (ρ ∼3100 kg/m3) early lunar magma ocean cumulates rise to the base of the crust during cumulate pile overturn. Some decompressional melting would occur, but placing a hot cumulate horizon adjacent to the plagioclase-rich primordial crust and KREEP-rich lithologies (at temperatures of <1300 °C) would result in the hybridization of these divergent primordial lithologies, producing Mg-suite parent magmas. As urKREEP (primeval KREEP) is not the "petrologic driver" of this style of magmatism, outside of the Procellarum KREEP Terrane (PKT), Mg-suite magmas are not required to have a KREEP signature. Evaluation of the chronology of this episode of highlands evolution indicates that Mg-suite magmatism was initiated soon after primordial differentiation (<10 m.y.). Alternatively, the thermal event associated with the mantle overturn may have disrupted the chronometers utilized to date the primordial crust. Petrogenetic relationships between the Mg-suite and other highlands suites (e.g., alkali-suite and magnesian anorthositic granulites) are consistent with both fractional crystallization processes and melting of distinctly different hybrid sources.
Heme, iron protoporphyrin IX, is one of life’s most central molecules. Hence, availability of the enzymatic machinery necessary for its synthesis is crucial for every cell. Consequently, inborn ...errors of porphyrin metabolism that compromise normal synthesis, namely the family of porphyrias, undermine normal cellular metabolism given that heme has functions in catalytic centers, signal transduction and functional regulation and its synthesis is fully integrated into the center of intermediary metabolism. Very often, diagnosis of porphyrias is difficult and therefore delayed. Therapy can be as complicated. Over the last 50 years, several strategies have been developed: because of its integration with other parts of intermediary metabolism, the infusion of glucose (glucose effect) was one of the first attempts to counterbalance the dysregulation of porphyrin synthesis in porphyrias. Since heme synthesis is impaired, infusional replacement of heme was the next important therapeutic step. Recently, siRNA technology has been introduced in order to downregulate 5-ALA-synthase 1, which contributes to the patho-physiology of these diseases. Moreover, other novel therapies using enzyme protein replacement, mRNA techniques or proteostasis regulators are being developed.
The lunar surface is ancient and well-preserved, recording Solar System history and planetary evolution processes. Ancient basin-scale impacts excavated lunar mantle rocks, which are still expected ...to be present on the surface. Sampling these rocks would provide insight into fundamental planetary processes, including differentiation and magmatic evolution. There is contention among lunar scientists as to what lithologies make up the upper lunar mantle, and where they may have been exposed on the surface. We review dynamical models of lunar differentiation in the context of recent experiments and spacecraft data, assessing candidate lithologies, their distribution, and implications for lunar evolution.
•LRO is mapping the moon for the next generation of explorers.•LRO observes contemporary surface changes including new LRO-era impact craters.•LRO has delivered more than 600Tbytes of data to the ...Planetary Data System.
Since entering lunar orbit on June 23, 2009 the Lunar Reconnaissance Orbiter (LRO) has made comprehensive measurements of the Moon and its environment. The seven LRO instruments use a variety of primarily remote sensing techniques to obtain a unique set of observations. These measurements provide new information regarding the physical properties of the lunar surface, the lunar environment, and the location of volatiles and other resources. Scientific interpretation of these observations improves our understanding of the geologic history of the Moon, its current state, and what its history can tell us about the evolution of the Solar System. Scientific results from LRO observations overturned existing paradigms and deepened our appreciation of the complex nature of our nearest neighbor. This paper summarizes the capabilities, measurements, and some of the science and exploration results of the first six years of the LRO mission.
While the Earth and Moon are generally similar in composition, a notable difference between the two is the apparent depletion in moderately volatile elements in lunar samples. This is often ...attributed to the formation process of the Moon, and it demonstrates the importance of these elements as evolutionary tracers. Here we show that paleo space weather may have driven the loss of a significant portion of moderate volatiles, such as sodium and potassium, from the surface of the Moon. The remaining sodium and potassium in the regolith is dependent on the primordial rotation state of the Sun. Notably, given the joint constraints shown in the observed degree of depletion of sodium and potassium in lunar samples and the evolution of activity of solar analogs over time, the Sun is highly likely to have been a slow rotator. Because the young Sun's activity was important in affecting the evolution of planetary surfaces, atmospheres, and habitability in the early Solar System, this is an important constraint on the solar activity environment at that time. Finally, as solar activity was strongest in the first billion years of the Solar System, when the Moon was most heavily bombarded by impactors, evolution of the Sun's activity may also be recorded in lunar crust and would be an important well-preserved and relatively accessible record of past Solar System processes.
High platelet counts in essential thrombocythemia (ET) can be effectively lowered by treatment with either anagrelide or hydroxyurea. In 259 previously untreated, high-risk patients with ET, ...diagnosed according to the World Health Organization classification system, the efficacy and tolerability of anagrelide compared with hydroxyurea were investigated in a prospective randomized noninferiority phase 3 study in an a priori–ordered hypothesis. Confirmatory proof of the noninferiority of anagrelide was achieved after 6 months using the primary end point criteria and was further confirmed after an observation time of 12 and 36 months for platelet counts, hemoglobin levels, leukocyte counts (P < .001), and ET-related events (HR, 1.19 95% CI, 0.61-2.30, 1.03 95% CI, 0.57-1.81, and 0.92 95% CI, 0.57-1.46, respectively). During the total observation time of 730 patient-years, there was no significant difference between the anagrelide and hydroxyurea group regarding incidences of major arterial (7 vs 8) and venous (2 vs 6) thrombosis, severe bleeding events (5 vs 2), minor arterial (24 vs 20) and venous (3 vs 3) thrombosis and minor bleeding events (18 vs 15), or rates of discontinuation (adverse events 12 vs 15 or lack of response 5 vs 2). Disease transformation into myelofibrosis or secondary leukemia was not reported. Anagrelide as a selective platelet-lowering agent is not inferior compared with hydroxyurea in the prevention of thrombotic complications in patients with ET diagnosed according to the World Health Organization system. This trial was registered at http://www.clinicaltrials.gov as #NCT01065038.
•Noninferiority of anagrelide in comparison with hydroxyurea in WHO-essential thrombocythemia, a phase 3 trial
Basin‐forming impacts expose material from deep within the interior of the Moon. Given the number of lunar basins, one would expect to find samples of the lunar mantle among those returned by the ...Apollo or Luna missions or within the lunar meteorite collection. However, only a few candidate mantle samples have been identified. Some remotely detected locations have been postulated to contain mantle‐derived material, but none are mineralogically consistent upon study with multiple techniques. To locate potential remnants of the lunar mantle, we searched for early‐crystallizing minerals using data from the Moon Mineralogy Mapper (M3) and the Diviner Lunar Radiometer (Diviner). While the lunar crust is largely composed of plagioclase, the mantle should contain almost none. M3 spectra were used to identify massifs bearing mafic minerals and Diviner was used to constrain the relative abundance of plagioclase. Of the sites analyzed, only Mons Wolff was found to potentially contain mantle material.
Plain Language Summary
During the Moon's early development, minerals such as olivine and pyroxene would have crystallized first, sinking toward the lunar interior and becoming the primary components of the mantle. After approximately 70–80% of the magma ocean solidified, plagioclase began to crystallize and floated on the iron‐rich residual melt. The lunar highland crust is characterized by an abundance of plagioclase, whereas samples of the mantle should contain very little plagioclase. Considering the size and number of large impact basins on the Moon, one would expect that some of these dug through the lunar crust, exposing lunar mantle. However, very few candidates for mantle material have been identified among the lunar samples on Earth. This study uses near‐infrared data from the Moon Mineralogy Mapper to identify sites on the surface that contain early‐crystallizing minerals (olivine and pyroxene), which are indicative of mantle material. These sites were then analyzed using data from the Diviner Lunar Radiometer, which is able to constrain the abundance of these minerals relative to the amount of plagioclase present. Based on our analysis, the Imbrium Basin contains only one instance of rocks that are mineralogically consistent with being sourced from the mantle.
Key Points
Lunar rocks exhibiting mafic signatures in the near infrared are inconsistent with ultramafic compositions when viewed in the mid‐infrared
Combining data from the Moon Mineralogy Mapper and Diviner Lunar Radiometer enabled bulk and mafic mineralogy to be robustly interpreted
A near‐ and mid‐infrared survey of the inner and outer rings of Imbrium Basin reveals only Mons Wolff as potential exposed mantle
In the near‐infrared from about 2 μm to beyond 3 μm, the light from the Moon is a combination of reflected sunlight and emitted thermal emission. There are multiple complexities in separating the two ...signals, including knowledge of the local solar incidence angle due to topography, phase angle dependencies, emissivity, and instrument calibration. Thermal emission adds to apparent reflectance, and because the emission's contribution increases over the reflected sunlight with increasing wavelength, absorption bands in the lunar reflectance spectra can be modified. In particular, the shape of the 2 μm pyroxene band can be distorted by thermal emission, changing spectrally determined pyroxene composition and abundance. Because of the thermal emission contribution, water and hydroxyl absorptions are reduced in strength, lowering apparent abundances. It is important to quantify and remove the thermal emission for these reasons. We developed a method for deriving the temperature and emissivity from spectra of the lunar surface and removing the thermal emission in the near infrared. The method is fast enough that it can be applied to imaging spectroscopy data on the Moon.
Key Points
Lunar spectra contain enough information to remove the thermal component
Spectra of some locations on the Moon contain water absorptions
Hottest areas are in craters where multiply scattered sunlight adds heat
This paper presents a high-throughput method for Above Ground Estimation of Biomass (AGBE) in rice using multispectral near-infrared (NIR) imagery captured at different scales of the crop. By ...developing an integrated aerial crop monitoring solution using an Unmanned Aerial Vehicle (UAV), our approach calculates 7 vegetation indices that are combined in the form of multivariable regressions depending on the stage of rice growth: vegetative, reproductive or ripening. We model the relationship of these vegetation indices to estimate the biomass of a certain crop area. The methods are calibrated by using a minimum sampling area of 1 linear meter of the crop. Comprehensive experimental tests have been carried out over two different rice varieties under upland and lowland rice production systems. Results show that the proposed approach is able to estimate the biomass of large areas of the crop with an average correlation of 0.76 compared with the traditional manual destructive method. To our knowledge, this is the first work that uses a small sampling area of 1 linear meter to calibrate and validate NIR image-based estimations of biomass in rice crops.
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