The growing discussions of Heidegger's opus postumum, Schwartze Hefte, require adequate considerations of the issue. These discussions can no more be considered by separating Heidegger's political ...and philosophical thought, as was the case until now, because the content they provide is almost unambiguous. The concept of 'decision' is actualized almost universally, hence the decisionism here accounts for the negative unity of all investigating categories. We postulate that this resulted from abandoning the critical attitude and the subsequent dialectological discussion of the original ontological concepts, as well as its hermeneutical consequences. The absurdity of turning a blind eye to the glorification of Neo-Nazi inclinations should not be a part of philosophy.
The currently used immunohistochemical approach in determining the estrogen receptor (ER) positivity of breast cancers (BCs) is inherently subjective and additionally limited by its semi-quantitative ...nature. The application of software in the analysis of digitized slide images may overcome some of these limitations. However, the utilization of such an approach requires that the entire staining procedure is standardized.
We aimed to establish a procedure for the photometric and morphometric analysis of BC immunohistochemical parameters that can possibly be used for a diagnostic purpose that is in line with the current semi-quantitative scoring system.
Semi-quantitative analysis of ER-stained tissue sections was performed following the Allred scoring system guidelines. The quantitative analysis was performed in ImageJ software after color deconvolution. The quantitative analysis of 66 cases of invasive lobular BC included: Percent of ER-positive cells, average nuclear coloration intensity, and the quantitative ER score. The percent of ER-positive tumor cells was counted using a standard grid overlay, while optical density (0.0-1.0) was measured within each nucleus at the grid points.
A statistical analysis revealed a significant positive correlation (
= 0.886,
< 0.001) between the subjective semi-quantitative and quantitative ER scores, with a large effect size (
= 3.8215). We observed strong statistically significant correlations between individual parameters of the total ER score, percentage of ER-positive nuclei, and color intensity, obtained by the two independent methods.
Additionally, besides excluding subjectivity, the up to now unreported cases of 3 + 0, 4 + 0, and 5 + 0 Allred scores were detected only by the application of the proposed quantitative approach.
Achievements of ones' working life are significant in marking and rounding off one's own 70th anniversary of life. This paper present the basic avenues of interpretation of the concept of time in ...Husserl, Heidegger, and Fink in the historical thinking, taking into consideration the subtle objections presented by Milan Uzelac in his three-part study of the phenomenology of our time as the end of the historical process. His insights are authentic and deliberate by topology.
Protection and promotion of geoheritage has been changing and improving in recent decades, in line with the growing research in this field. Some research papers specifically study geomorphological ...geoheritage and introduce a special term − geomorphosite. Karst geomorphosites present specific objects of geomorphological heritage. On Kučaj and Beljanica mountains there is the largest karst area in Serbia. The purpose of this paper is to select and evaluate the scientific value of karst geomorphosites of Kučaj and Beljanica. More than one hundred karst geomorphosites were analyzed. In order to achieve more adequate coverage and representation, they were grouped into 25 geomorphotypes in three major geomorphological components of the investigated area. The results of this analysis highlighted the most important natural potentials of this area for establishing a karst-based geopark. More than 20 geomorphotypes have a positive recommendation index, which provides a good basis for further geotourism analysis.
THE EU AND INDIA IN THE POLARIZED WORLD Petrović, Aleksandar S; Stevanović, Aleksandra P
Przegląd Geopolityczny,
07/2021, Letnik:
36, Številka:
36
Journal Article
Recenzirano
Odprti dostop
The paper explores basic political relations between the European Union and India which are at theoretical level almost “terra nullius”. The paper starts from the present epochal situation and enters ...the realm of EU–India geopolitics from the perspective of Gandhian moral practice on one side, and challenges presented by the impact of Coronavirus politics on the other. Our question is – on which platform is strategic negotiating between the EU and India possible? Despite their Lisbon summit in 2000 as well as virtual summit in 2020, it is obvious that until today the EU and India could not find a common denominator. Our idea is that the missing link of a better understanding partly lays in the new perspective that may be unexpectedly found from the Balkans’ point of view. Only unprecedented cognizance today may set up the roadmap for the times to come.
One of the biggest problems of environmental protection in Serbia is landfills. It is often a case that the economic interests are predominant in the landfill sitting; thus, most landfills are not ...located according to standards. This study shows that detailed geological data assets combined with geographical modeling represents a reliable way to define and locate the landfill site. Geological evaluation is discussed in detail with regard to bedrock lithology, quaternary geology, geological structure, hydrogeology, surface runoff patterns, and topography. An approach combining geographical modeling and geology is presented for determining the sites suitable for landfill selection with respect to their geologic favorability. As opposed to numerous research papers on this topic, in the methodological procedure, special importance is devoted to the analysis of the geological criteria. In this way, it is significantly easier to determine the landfill area with the best characteristics due to geological structure and lithology which unequivocally and precisely indicates inadequate territories for candidate sites. The multicriteria decision analysis (MCDA) is based on geological criteria upgraded with road (primary, residential, secondary, and tertiary), settlements network, railway, airport, infrastructure, land use, hypsometry aquifer, wetland, and surface water. The score values are divided into four classes, i.e., restricted areas, suitable but avoid, suitable, and most suitable. Combining geographical modeling with geology led to the recognition of two locations to be most favorable for landfill site located in the most suitable area, which represents 25.3% of the study area.
Background/Aim. Taking into consideration the justified popularity of total arterial revascularization, the saphenous vein graft (SVG) is still one of the most utilized conduits in coronary artery ...bypass grafting (CABG). One of the determining factors of this conduit?s durability is its endothelial integrity at the time of surgery. The aim of the study was to investigate the effect of different storage solutions on SVG endothelial integrity in patients with diabetes mellitus (DM) type 2 (T2DM) and non-T2DM patients undergoing CABG. The solutions under evaluation were heparinized saline solution (0.9% NaCl), heparinized autologous whole blood, Bretschneider (histidine-tryptophan-ketoglutarate ? HTK) solution, and fresh frozen plasma (FFP) solution. Methods. Forty patients were included in this study and were divided into two groups: group A with 23 T2DM patients and group B with 17 non-T2DM patients. The effects of these solutions were examined by immunohistochemical staining with anti-CD34 antibodies and morphometric comparison in histologic samples of T2DM patients undergoing CABG between July 2021 and September 2022 with samples provided by non-T2DM patients. Results. In this study, the FFP solution showed the most prominent positive effect on the preservation of SVG endothelial integrity, with an average cell integrity preservation of 92.2%. HTK solution was found to be the least effective, with an endothelial cell preservation integrity of 26.77%. There was no marked statistically significant difference in results from groups A and B. There was a noticeable contrast in preserving SVG endothelial integrity between the two patient groups, T2DM and non-T2DM patients, although it was not statistically significant. Conclusion. The storage solution with the most beneficial effect on SVG endothelial integrity preservation was the FFP solution when harvested via the conventional open method in CABG.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
One of the most challenging technical implementations of today is self-driving vehicles. An important segment of self-driving is the ability of the computer to “see/detect” objects of interest at a ...distance which enables safe vehicle operation. An algorithm for the detection of railway infrastructure objects, namely, track and signals, is proposed in this paper to enable detection of signals which are relevant for the track the train is moving along. The algorithm integrates traditional computer vision (CV) algorithms, including Canny edge detection, Hough transform, and You Only Look Once (YOLO) algorithm, based on convolutional neural networks (CNNs). Each of the concepts (CV and CNNs) deals with a different object of detection which together form a unique system that aims to detect both the rails and the relevant signals. This approach ensures that the artificial intelligence (AI) system is “aware” of which route the signal belongs to. The reliability of the proposed algorithm in detection of a relevant signal, verified by the performed tests, is up to 99.7%. The metric method used for validation was intersection over union (IoU). The obtained value of IoU applied on the entire validation dataset exceeds 0.7. Calculated values of average precision and recall were 0.89 and 0.76, respectively. The algorithm created in this way solves the problem of detection of relevant signals along the train route, especially in multitrack scenarios such as stations and yards.
: In patients with colorectal cancer (CRC), heterogeneous expression of Mismatch repair (MMR) proteins can manifest itself in several different forms and is not such a rare phenomenon. Therefore, it ...is very important to recognize the nuclear expression of MMR proteins of different MMR status in order to avoid false positive or false negative results. The aim of this study was to determine the frequency and distribution of heterogeneous expression of MMR proteins in patients with stages II and III of the disease as well as its association with clinical, demographic and pathological characteristics of CRC in relation to proficient and deficient expression of MMR proteins.
: The study included 104 cases of colorectal cancer obtained from surgical colectomy material in stages II and III of the disease.
From a total of 104 patients with colorectal cancer, immunohistochemical analysis of the expression of all four MMR proteins showed that heterogeneous expression of MMR proteins (as well as deficient immunoreactivity of tumor cells) was present in 12 cases, while proficient expression of MMR proteins was detected in 80 tumors.
: Our study showed that the only independent predictors of the loss of MMR protein expression were younger patient age and right-sided anatomical location of the tumor. The study also established the existence of heterogeneous expression of MMR proteins in a non-negligible percentage of CRCs (11.5%), where heterogeneous nuclear expression of MMR proteins was described in several different forms.
The aim of this study was to analyze the expression of extracellular matrix (ECM) proteins in human endoneurium during aging. We harvested 15 cadaveric sural nerves, distributed in 3 age groups (I: ...25-44, II: 45-64, III: 65-86 years old). Histological sections were stained immunohistochemically for the presence of collagen type I, type IV and laminin, and the ImageJ processing program was used in morphometrical analysis to determine the percentages of these endoneurial proteins. In two younger groups, the endoneurial matrix of the sural nerve was composed from about equal proportions of these proteins, which may be considered a favorable microenvironment for the regeneration of nerve fibers. Linear regression analysis showed a significant increase in endoneurial collagen type IV with age, while collagen type I and laminin significantly decreased during the aging process. In cases older than 65 years, remodeling of the endoneurial matrix was observed to be significantly higher for the presence of collagen type IV, and lower for the expression of collagen type I and laminin. This age-related imbalance of ECM proteins could represent a disadvantageous microenvironment for nerve fiber regeneration in older adults. Our findings contribute to the development of therapeutic approaches for peripheral nerve regeneration.
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