Abstract
Background: Aggressive behavior and negative symptoms are two features of schizophrenia that may have a hormonal basis. Aim: The aim of this study was to compare testosterone level with ...clinical features of schizophrenia, focusing on negative symptoms and aggressive behavior. Methods: The study population consisted of 120 male schizophrenic patients (ages 18-40) classified into non-aggressive (n = 60) and aggressive (n = 60) groups. Depending on the type of aggression that was manifested prior to admission, the aggressive group was divided into violent (n = 32) and suicidal (n = 28) subgroups. Psychopathological severity, violence and suicidality were assessed using the Positive and Negative Syndrome Scale (PANSS), Overt Aggression Scale and Columbia Suicide Severity Rating Scale, respectively. Total serum testosterone level was determined on the same morning that symptoms were assessed. Results: In the non-aggressive group, testosterone level was negatively correlated with the score on the negative subscale of PANSS (P = 0.04) and depression (P = 0.013), and positively correlated with excitement (P = 0.027), hostility (P = 0.02) and impulsive behavior (P = 0.008). In the aggressive group, testosterone level had non-significant correlation with these parameters, and with violent or suicidal behavior. Conclusions: The results confirmed that non-aggressive male schizophrenic patients with lower levels of testosterone had a greater severity of negative symptoms. In aggressive patients, there was no correlation between testosterone and clinical features of the disorder or the degree or type of aggression. These findings indicate that therapeutic strategies targeting testosterone could be useful in the treatment of negative symptoms of schizophrenia.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Delusion of Pregnancy – Case Series of Seven Patients Sisek-Šprem, Mirna; Barić, Vesna; Herceg, Miroslav ...
International journal of medical and pharmaceutical case reports,
01/2015, Letnik:
3, Številka:
3
Journal Article
It is a well known fact that mentally ill patients, especially those with schizophrenia, have a higher incidence of somatic diseases than the general population and finally a significantly shorter ...life expectancy. In this paper a comparison is made between schizophrenia and somatic comorbidity before the era of antipsychotics and after, with consideration to the prevalent morbidity during each of these periods. In the period before antipsychotics acute infectious diseases and TBC were the prevalent comorbid diseases. High comorbidity rates were due not only to epidemics but also poor treatment success, deficient health habits and poor personal hygiene. In the period after the discovery of antipsychotics significant changes in morbidity occurred with the prevalence of chronic degenerative diseases, primarily diabetes, hypertension and dyslipidemia. Studies show that new generation antipsychotics partly generate the occurrence of metabolic disorders, which makes it necessary to consider the choice of antipsychotic depending on the assessed risk in every individual case.
Folic acid and folates have an important role in prevention of neural tube defect that appears in the first weeks of pregnancy, when women are still not aware of their pregnancy, especially when ...pregnancy is not planned. Since ensuring sufficient quantities of folates and folic acid in this period is essential, dietary habits of childbearing age women are very important. In line with that the intake of folates and folic acid in nutrition of women age group 20-30 years is examined, as well as the frequency of consumption of foodstuffs rich in vitamins and folic acid supplements. Values of folates in serum are presented, dependent on their nutritional habits. Obtained results indicate that in spite of inadequate intake of folates and folic acid from foodstuffs, clinical deficit is not recorded, which is the result of frequent consumption of dietary supplements. In accordance with these dietary habits, differences in the folates status of examinees were observed.
Uvod: Osobe s demencijom osjetljivije su na razvoj različitih komplikacija/neželjenih događaja u odnosu na osobe iste dobne skupine bez demencije. Češće se zaprimaju u bolnicu, gdje imaju veću ...prevalenciju komplikacija i povećanu smrtnost. Cilj: ispitati učestalost hitnih premještaja bolesnika s demencijom zbog tjelesnih komplikacija iz Klinike za psihijatriju Vrapče na somatske odjele drugih bolnica. Metode: U ovom retrospektivnom istraživanju analizirali smo podatke bolesnika s demencijom koji su liječeni od 1. siječnja do 31. kolovoza 2019. godine na Odjelu psihogerijatrije u Klinici za psihijatriju Vrapče s naglaskom na vrijeme trajanja hospitalizacije i razloge otpusta koji su doveli do premještaja s Odjela. Rezultati: Od siječnja do kraja kolovoza 2019. godine na Odjel psihogerijatrije u Klinici zaprimljeno je ukupno 256 bolesnika (67,97 % žena i 32,03 % muškaraca). Prosječna dob žena bila je 80,5, a muškaraca 76,4 godina. Premješteno na somatski odjel (bolnicu) bilo je 28 % bolesnika (40,24 % muškaraca, 23 % žena), a od toga 39 % u prvih sedam dana od dolaska u bolnicu. Pneumonija je bila vodeća somatska dijagnoza kod 19 % premještenih. Prosječno trajanje hospitalizacije među svim ispitanicima bilo je kod muškaraca 33,08 dana, a kod žena 36,47 dana. U istom je razdoblju na Odjelu preminulo 10,93 % bolesnika (12,2 % muškaraca i 10,34 % žena), od toga 25 % unutar pet dana od dolaska u bolnicu. Zbog neujednačenosti pisanja redoslijeda otpusnih dijagnoza, za detaljniju analizu razloga premještaja, bit će potrebno podrobnije ispitivanje. Zaključak: Najteža tjelesna pogoršanja i smrtni ishodi javljali su se u prvih tjedan dana od dolaska u bolnicu. Rezultati ukazuju na nužnost somatske obrade i liječenja bolesnika s demencijom prije nego budu hospitalizirani na psihijatrijskom odjelu.
Vodeći čimbenici rizika za agresivno ponašanje bolesnika sa shizofrenijom su antisocijalne osobine ličnosti, pozitivni
simptomi u kliničkoj slici te ovisnost ili zlouporaba psihoaktivnih tvari. S ...ciljem analiziranja utjecaja i povezanosti
kliničke slike i pojedinih simptoma shizofrenije na agresivno ponašanje uspoređivali smo skupinu agresivnih (N=60) i
neagresivnih (N=60) muškaraca sa shizofrenijom. S obzirom da se u literaturi raspravlja o mogućoj zajedničkoj osnovi
hetero- i autoagresivnosti, agresivni su ispitanici razdvojeni na heteroagresivnu (N=32) i suicidalnu skupinu (N=28).
Prisutnost i intenzitet pojedinih simptoma shizofrenije ocijenili smo PANSS-om, stupanj heteroagresivnosti OAS (Overt
Aggression Scale), a suicidalnosti C-SSRS (Columbia-Suicide Severity Rating Scale) i InterSePT (International Suicide
Prevention Trial) ljestvicama. U heteroagresivnoj skupini značajno je viši ukupni PANSS te njegova pozitivna i opća
podljestvica. Stupanj heteroagresivnosti u pozitivnoj je korelaciji s ukupnim PANSS-om i impulzivnošću, a u negativnoj
korelaciji s depresivnošću i imperativnim halucinacijama. Stupanj suicidalnosti u pozitivnoj je korelaciji s depresivnošću
i imperativnim halucinacijama, a u negativnoj s ukupnim PANSS-om, stupnjem heteroagresivnosti i impulzivnošću. Jedini
je značajni prediktor izrazitog agresivnog ponašanja viši rezultat pozitivne podljestvice PANSS-a.
Ovi rezultati upućuju na nužnost prepoznavanja pozitivnih simptoma shizofrenije kao značajnog čimbenika za pojavu
agresivnosti s ciljem što ranijeg terapijskog djelovanja i sprečavanja agresivnih incidenata.
Cilj: Cilj ovog rada je podići svijest o tome kako koštice trešnje mogu uzrokovati opstrukciju crijeva kod pacijenata koji boluju od karcinoma debelog crijeva. Prikaz slučaja: Muškarac starosti 68 ...godina javio se u hitnoći s anamnezom konstipacije i boli paraumbilikalno lijevo. Nativni radiogram abdomena u stojećem stavu pokazuje aerolikvidne nivoe tankog i debelog crijeva koji upućuju na ileus te se indicira CT pregled na kojem se potvrdi distenzija vijuga tankog i debelog crijeva s aerolikvidnim nivoima te stenozirajuća neoplazma silaznog kolona. Uzak, nepravilan lumen tumora bio je opstruiran okruglim stranim tijelom. Na CT pregledu okruglo strano tijelo ima hipodenzno ovoidno središte i hiperdenzni pokrov, što po opisu odgovara koštici trešnje. Napravljen je kirurški otvor na trbušnoj stijenci kroz koji je izveden segment crijeva (anus praeter) te je pacijent nakon oporavka otpušten iz bolnice. Dva mjeseca kasnije pacijent je zaprimljen na odjel kirurgije. Nakon učinjene prijeoperacijske obrade pristupilo se planiranom operacijskom zahvatu. Međutim, intraoperacijski je pronađena karcinoza peritoneuma te se odustalo od planiranog radikalnog zahvata. Upućen je na Kliniku za radioterapiju i onkologiju gdje su uvedeni ciklusi kemoterapije. Iduće godine u rujnu pacijent dolazi na aplikaciju 12. ciklusa. Osjećao se dobro te je otpušten kući uz preporuku da nastavi s dosadašnjom terapijom. Zaključak: Ileus izazvan košticom trešnje rijetko je stanje, ali treba biti uključeno u diferencijalnu dijagnozu u pacijenata s rizičnim čimbenicima kao što je zloćudna novotvorina debelog crijeva. Karcinom debelog crijeva ozbiljna je bolest koja zahtijeva pažljivu prehranu i brigu o prohodnosti crijeva.
Aim: The aim of this paper is to raise awareness of how cherry pits can cause bowel obstruction in patients with colon cancer. Case report: A 68-year-old male presented to the emergency department with a history of constipation and left paraumbilical pain. A standing abdominal x-ray revealed air-fluid levels in the small and large bowel suggestive of ileus, and the CT scan confirmed the dilation of the small and large bowel with air-fluid levels and a stenosing neoplasm in the descending colon. The narrow, irregular lumen of the tumor was obstructed by a round foreign body. The CT scan showed a hypodense oval center and hyperdense shell consistent with a cherry pit. A surgical opening was made in the abdominal wall and a segment of the bowel was extracted (anus praeter), and the patient was discharged after recovery. Two months later, the patient was readmitted to the surgical department, and a planned surgery was performed after preoperative evaluation. However, peritoneal carcinomatosis was found intraoperatively, and the planned radical procedure was abandoned. He was referred to the Department of Radiotherapy and Oncology where he received chemotherapy cycles. The following year in September, the patient returned for the 12th cycle application. He felt well and was discharged with the recommendation to continue his current therapy. Conclusion: Bowel obstruction caused by a cherry pit is a rare condition but should be included in the differential diagnosis in patients with risk factors such as colon cancer. Colon cancer is a serious disease that requires careful nutrition and bowel management.
Aim To expand our previous findings by increasing the number of patients in a study characterizing medicinal signaling cells (MSC) of stromal vascular fraction from lipoaspirate (SVF-LA) and from ...microfragmented lipoaspirate (SVF-MLA) applied for the treatment of osteoarthritis (OA). Methods Twenty OA patients, including 8 new patients, acquiring autologous microfragmented adipose tissue were enrolled. In-parallel immunophenotyping of SVF-LA and SVF-MLA was performed. The samples were incubated in a DuraClone SC prototype tube targeting the CD31, CD34, CD45, CD73, CD90, CD105, and CD146 surface markers, stained with the DRAQ7 cell nuclear dye and Live/Dead Yellow Fixable Stain, and analyzed by flow cytometry. Results The population phenotypes in SVF-LA and SVF-MLA samples included CD31.sup.+CD34.sup.+CD73.sup.+ or -CD90.sup.+ or - CD105.sup.+ or -CD146.sup.+ or - endothelial progenitors (EP), CD31.sup.+CD34.sup.-CD73.sup.+ or -CD90.sup.+ or -CD105.sup.-CD146.sup.+ or - mature endothelial cells, CD31.sup.-CD34.sup.-CD73.sub.+ or -CD90.sup.+CD105.sup.-CD146.sup.+ pericytes, CD3V CD34.sup.+CD73.sup.+ or -CD90.sup.+CD105.sup.-CD146.sup.+ transitional pericytes, and CD31.sup.-CD34.sup.+CD73.sup.highCD90.sup.+CD105.sup.-CD146.sup.- supra-adventitial-adipose stromal cells. Compared with the autologous SVF-LA samples, the prevailing cell type in SVF-MLA were EP, which outnumbered leukocytes and supra-adventitial-adipose stromal cells (SA-ASC). The ratio of progenitor cells in SVF-MLA samples differed between female and male patients, showing a higher EP-pericyte and pericyte-SA-ASC ratio in men. Conclusion Our results, hallmarked by EP-enriched anti-inflammatory features and indicating a possible sex-specific impact, contribute to defining the cellular composition of the clinically applied MSC serving as a regenerative cell therapy in OA.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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