Context.
The Extreme Ultraviolet Imager (EUI) is part of the remote sensing instrument package of the ESA/NASA Solar Orbiter mission that will explore the inner heliosphere and observe the Sun from ...vantage points close to the Sun and out of the ecliptic. Solar Orbiter will advance the “connection science” between solar activity and the heliosphere.
Aims.
With EUI we aim to improve our understanding of the structure and dynamics of the solar atmosphere, globally as well as at high resolution, and from high solar latitude perspectives.
Methods.
The EUI consists of three telescopes, the Full Sun Imager and two High Resolution Imagers, which are optimised to image in Lyman-
α
and EUV (17.4 nm, 30.4 nm) to provide a coverage from chromosphere up to corona. The EUI is designed to cope with the strong constraints imposed by the Solar Orbiter mission characteristics. Limited telemetry availability is compensated by state-of-the-art image compression, onboard image processing, and event selection. The imposed power limitations and potentially harsh radiation environment necessitate the use of novel CMOS sensors. As the unobstructed field of view of the telescopes needs to protrude through the spacecraft’s heat shield, the apertures have been kept as small as possible, without compromising optical performance. This led to a systematic effort to optimise the throughput of every optical element and the reduction of noise levels in the sensor.
Results.
In this paper we review the design of the two elements of the EUI instrument: the Optical Bench System and the Common Electronic Box. Particular attention is also given to the onboard software, the intended operations, the ground software, and the foreseen data products.
Conclusions.
The EUI will bring unique science opportunities thanks to its specific design, its viewpoint, and to the planned synergies with the other Solar Orbiter instruments. In particular, we highlight science opportunities brought by the out-of-ecliptic vantage point of the solar poles, the high-resolution imaging of the high chromosphere and corona, and the connection to the outer corona as observed by coronagraphs.
Summary
Chronic wounds have a debilitating effect on the quality of life of many individuals, and the large economic impact on health system budgets warrants greater attention in policy making and ...condition management than is currently evident. The aim of this narrative review is to summarize the nature and extent of the chronic wound problem that confronts health systems across the world. The first section is used to highlight the underlying epidemiology relating to chronic wounds, while the second explores the economic costs associated with them and the relative efficiency of measures designed to manage them.
CoV2019 has evolved to be much more dangerous than CoV2003. Experiments suggest that structural rearrangements dramatically enhance CoV2019 activity. We identify a new first stage of infection that ...precedes structural rearrangements by using biomolecular evolutionary theory to identify sequence differences enhancing viral attachment rates. We find a small cluster of mutations which show that CoV-2 has a new feature that promotes much stronger viral attachment and enhances contagiousness. The extremely dangerous dynamics of human coronavirus infection is a dramatic example of evolutionary approach of self-organized networks to criticality. It may favor a very successful vaccine. The identified mutations can be used to test the present theory experimentally.
•CoV2019 has evolved to be much more dangerous than CoV2003.•We use a new thermodynamic method of sequence analysis to explain many differences.•Thermodynamic scaling exploits self-organized criticality in protein amino acid sequences,•Scaling identifies critical wave lengths in Coronavirus evolution, not identifiable by BLAST.•We discover a new feature that enhances contagiousness in the absence of symptoms.
We present first results of the H2O Southern Galactic Plane Survey (HOPS), using the Mopra Radio Telescope with a broad-band backend and a beam size of about 2 arcmin. We have observed 100 deg2 of ...the southern Galactic plane at 12 mm (19.5-27.5 GHz), including spectral line emission from H2O masers, multiple metastable transitions of ammonia, cyanoacetylene, methanol and radio recombination lines. In this paper, we report on the characteristics of the survey and H2O maser emission. We find 540 H2O masers, of which 334 are new detections. The strongest maser is 3933 Jy and the weakest is 0.7 Jy, with 62 masers over 100 Jy. In 14 maser sites, the spread in the velocity of the H2O maser emission exceeds 100 km s−1. In one region, the H2O maser velocities are separated by 351.3 km s−1. The rms noise levels are typically between 1 and 2 Jy, with 95 per cent of the survey under 2 Jy. We estimate completeness limits of 98 per cent at around 8.4 Jy and 50 per cent at around 5.5 Jy. We estimate that there are between 800 and 1500 H2O masers in the Galaxy that are detectable in a survey with similar completeness limits to HOPS. We report possible masers in NH3 (11,9) and (8,6) emission towards G19.61−0.23 and in the NH3 (3,3) line towards G23.33−0.30.
We report the detection of repeat bursts from the source of FRB 171019, one of the brightest fast radio bursts (FRBs) detected in the Australian Square Kilometre Array Pathfinder (ASKAP) fly's eye ...survey. Two bursts from the source were detected with the Green Bank Telescope in observations centered at 820 MHz. The repetitions are a factor of ∼590 fainter than the ASKAP-discovered burst. All three bursts from this source show no evidence of scattering and have consistent pulse widths. The pulse spectra show modulation that could be evidence for either steep spectra or patchy emission. The two repetitions were the only ones found in an observing campaign for this FRB totaling 1000 hr, which also included ASKAP and the 64 m Parkes radio telescope, over a range of frequencies (720-2000 MHz) at epochs spanning two years. The inferred scaling of repetition rate with fluence of this source agrees with the other repeating source, FRB 121102. The detection of faint pulses from FRB 171019 shows that at least some FRBs selected from bright samples will repeat if follow-up observations are conducted with more sensitive telescopes.
The aims of this study were to examine differences in self-schemas between persons living with HIV/AIDS with and without depressive symptoms, and the degree to which these self-schemas predict ...depressive symptoms in this population. Self-schemas are beliefs about oneself and include self-esteem, HIV symptom management self-efficacy, and self-compassion. Beck's cognitive theory of depression guided the analysis of data from a sample of 1766 PLHIV from the USA and Puerto Rico. Sixty-five percent of the sample reported depressive symptoms. These symptoms were significantly (p ≤ 0.05), negatively correlated with age (r = −0.154), education (r = −0.106), work status (r = −0.132), income adequacy (r = −0.204, self-esteem (r = −0.617), HIV symptom self-efficacy (r = − 0.408), and self-kindness (r = − 0.284); they were significantly, positively correlated with gender (female/transgender) (r = 0.061), white or Hispanic race/ethnicity (r = 0.047) and self-judgment (r = 0.600). Fifty-one percent of the variance (F = 177.530 (df = 1524); p < 0.001) in depressive symptoms was predicted by the combination of age, education, work status, income adequacy, self-esteem, HIV symptom self-efficacy, and self-judgment. The strongest predictor of depressive symptoms was self-judgment. Results lend support to Beck's theory that those with negative self-schemas are more vulnerable to depression and suggest that clinicians should evaluate PLHIV for negative self-schemas. Tailored interventions for the treatment of depressive symptoms in PLHIV should be tested and future studies should evaluate whether alterations in negative self-schemas are the mechanism of action of these interventions and establish causality in the treatment of depressive symptoms in PLHIV.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, OILJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Study participants with HIV-associated sensory polyneuropathy (HIV-SN) had higher plasma triglyceride concentrations, depression, anxiety, catastrophizing scores, and prevalence of insomnia than HIV ...participants without HIV-SN.
HIV-associated sensory neuropathy (HIV-SN) is a frequent complication of HIV infection and a major source of morbidity. A cross-sectional deep profiling study examining HIV-SN was conducted in people living with HIV in a high resource setting using a battery of measures which included the following: parameters of pain and sensory symptoms (7day pain diary, Neuropathic Pain Symptom Inventory NPSI and Brief Pain Inventory BPI), sensory innervation (structured neurological examination, quantitative sensory testing QST and intraepidermal nerve fibre density IENFD), psychological state (Pain Anxiety Symptoms Scale-20 PASS-20, Depression Anxiety and Positive Outlook Scale DAPOS, and Pain Catastrophizing Scale PCS, insomnia (Insomnia Severity Index ISI), and quality of life (Short Form (36) Health Survey SF-36). The diagnostic utility of the Brief Peripheral Neuropathy Screen (BPNS), Utah Early Neuropathy Scale (UENS), and Toronto Clinical Scoring System (TCSS) were evaluated. Thirty-six healthy volunteers and 66 HIV infected participants were recruited. A novel triumvirate case definition for HIV-SN was used that required 2 out of 3 of the following: 2 or more abnormal QST findings, reduced IENFD, and signs of a peripheral neuropathy on a structured neurological examination. Of those with HIV, 42% fulfilled the case definition for HIV-SN (n=28), of whom 75% (n=21) reported pain. The most frequent QST abnormalities in HIV-SN were loss of function in mechanical and vibration detection. Structured clinical examination was superior to QST or IENFD in HIV-SN diagnosis. HIV-SN participants had higher plasma triglyceride, concentrations depression, anxiety and catastrophizing scores, and prevalence of insomnia than HIV participants without HIV-SN.
The Amazon basin hosts half the planet's remaining moist tropical forests, but they may be threatened in a warming world. Nevertheless, climate model predictions vary from rapid drying to modest ...wetting. Here we report that the catchment of the world's largest river is experiencing a substantial wetting trend since approximately 1990. This intensification of the hydrological cycle is concentrated overwhelmingly in the wet season driving progressively greater differences in Amazon peak and minimum flows. The onset of the trend coincides with the onset of an upward trend in tropical Atlantic sea surface temperatures (SST). This positive longer‐term correlation contrasts with the short‐term, negative response of basin‐wide precipitation to positive anomalies in tropical North Atlantic SST, which are driven by temporary shifts in the intertropical convergence zone position. We propose that the Amazon precipitation changes since 1990 are instead related to increasing atmospheric water vapor import from the warming tropical Atlantic.
Key Points
Intensification of Amazon Hydrological Cycle since 1990
Revealed by both river discharge and precipitation records
In parallel onset of tropical Atlantic warming offering explanation
Cultured meat is an emerging food technology that has the potential to resolve many of the social, environmental and ethical issues surrounding traditional factory farming practices. Recently, ...research has begun to explore consumer attitudes to the product, revealing a number of barriers and demographic predictors. However, our understanding of the psychological mechanisms that underpin attitudes to cultured meat remains limited. In the current study, we draw on an attitude roots model (Hornsey & Fielding, 2017) to explore a range of psychological mechanisms that may underpin attitudes to cultured meat. In terms of negative attitudes and intentions toward cultured meat, the most powerful predictors were food neophobia, political conservatism, and distrust of food scientists. When it comes to absolute opposition to cultured meat - defined by the unconditional belief that it should never be allowed under any circumstances - the strongest predictors were food and hygiene disgust sensitivity subscales, food neophobia, and conspiratorial ideation. A number of presumed mechanisms held no relationships to cultured meat attitudes, including social dominance orientation, speciesism, and naturalness bias. The null results on naturalness bias are of particular interest given recent research identifying concerns about naturalness as a key barrier to consumer acceptance. These results demonstrate the need for a more nuanced understanding of the psychological mechanisms that contribute to cultured meat attitudes and engagement.
In 2005 and 2010 the Amazon basin experienced two strong droughts, driven by shifts in the tropical hydrological regime possibly associated with global climate change, as predicted by some global ...models. Tree mortality increased after the 2005 drought, and regional atmospheric inversion modelling showed basin-wide decreases in CO2 uptake in 2010 compared with 2011 (ref. 5). But the response of tropical forest carbon cycling to these droughts is not fully understood and there has been no detailed multi-site investigation in situ. Here we use several years of data from a network of thirteen 1-ha forest plots spread throughout South America, where each component of net primary production (NPP), autotrophic respiration and heterotrophic respiration is measured separately, to develop a better mechanistic understanding of the impact of the 2010 drought on the Amazon forest. We find that total NPP remained constant throughout the drought. However, towards the end of the drought, autotrophic respiration, especially in roots and stems, declined significantly compared with measurements in 2009 made in the absence of drought, with extended decreases in autotrophic respiration in the three driest plots. In the year after the drought, total NPP remained constant but the allocation of carbon shifted towards canopy NPP and away from fine-root NPP. Both leaf-level and plot-level measurements indicate that severe drought suppresses photosynthesis. Scaling these measurements to the entire Amazon basin with rainfall data, we estimate that drought suppressed Amazon-wide photosynthesis in 2010 by 0.38 petagrams of carbon (0.23-0.53 petagrams of carbon). Overall, we find that during this drought, instead of reducing total NPP, trees prioritized growth by reducing autotrophic respiration that was unrelated to growth. This suggests that trees decrease investment in tissue maintenance and defence, in line with eco-evolutionary theories that trees are competitively disadvantaged in the absence of growth. We propose that weakened maintenance and defence investment may, in turn, cause the increase in post-drought tree mortality observed at our plots.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
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