An association between anorexia nerviosa (AN) and low bone mass has been demonstrated. Bone loss associated with AN involves hormonal and nutritional impairments, though their exact contribution is ...not clearly established. We compared bone mass in AN patients with women of similar weight with no criteria for AN, and a third group of healthy, normal-weight, age-matched women. The study included forty-eight patients with AN, twenty-two healthy eumenorrhoeic women with low weight (LW group; BMI < 18·5 kg/m2) and twenty healthy women with BMI >18·5 kg/m2 (control group), all of similar age. We measured lean body mass, percentage fat mass, total bone mineral content (BMC) and bone mineral density in lumbar spine (BMD LS) and in total (tBMD). We measured anthropometric parameters, leptin and growth hormone. The control group had greater tBMD and BMD LS than the other groups, with no differences between the AN and LW groups. No differences were found in tBMD, BMD LS and total BMC between the restrictive (n 25) and binge–purge type (n 23) in AN patients. In AN, minimum weight (P = 0·002) and percentage fat mass (P = 0·02) explained BMD LS variation (r2 0·48) and minimum weight (r2 0·42; P = 0·002) for tBMD in stepwise regression analyses. In the LW group, BMI explained BMD LS (r2 0·72; P = 0·01) and tBMD (r2 0·57; P = 0·04). We concluded that patients with AN had similar BMD to healthy thin women. Anthropometric parameters could contribute more significantly than oestrogen deficiency in the achievement of peak bone mass in AN patients.
Environmental temperature has been described to affect plasma glucose levels after oral glucose tolerance testing (OGTT).
We evaluated the relationship between seasons and environmental temperature ...and gestational diabetes mellitus (GDM) diagnosis and treatment.
We analyzed data from 2374 women retrospectively. GDM was diagnosed in 473 patients by a 100-g OGTT. OGTT results and needing of insulin therapy were evaluated in relation to seasons and environmental temperature (mean temperature and temperature change) the day of the OGTT and the preceding 14 and 28 days.
We found significant seasonal differences in the percentage of GDM: 24.4% in summer vs. 15.6% in autumn (p < 0.01). The odds ratio (OR) for being diagnosed with GDM was 1.78 in summer relative to autumn, after controlling for age. A higher mean temperature the day of the OGTT and the preceding 14 and 28 days increased the risk of being diagnosed with GDM the months in which temperature was rising (March–August) but not the months in which temperature was decreasing (September–February). We observed a negative correlation between temperature and fasting glucose and a positive correlation with post-load glucose. Neither the season nor the environmental temperature affected the risk of requiring insulin therapy.
There is a higher prevalence of GDM diagnosis at warmer seasons and at rising temperatures the 2–4 weeks prior to the OGTT. The impact of temperature is different between fasting and post-load glucose.
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•Higher prevalence of gestational diabetes mellitus in warmer seasons.•Preceding 14 and 28 days mean temperature as independent predictors of being diagnosed with gestational diabetes mellitus.•Environmental temperature is inversely correlated with fasting glucose and directly with post-load glucose.•Environmental temperature is not associated with the risk of requiring insulin therapy.
El tratamiento de los derechos humanos en el cine constituye un tema bastante recurrente dentro de los llamados Estudios de Derecho y Cine. La naturaleza fundamental de estos derechos en nuestros ...ordenamientos jurídicos y su importancia política cardinal en las democracias actuales, son razones que explican, en buena medida, la circunstancia anterior. Sin embargo, a pesar de todo, hasta ahora no había sido objeto de un tratamiento monográfico, sistemático y exhaustivo en el contexto específico de nuestro cine, el cine español. El presente volumen pretende cubrir esta laguna desde varios presupuestos y enfoques: por un lado, desde un punto de vista histórico, haciendo un repaso panorámico del cine español, prácticamente desde las primeras noticias filmográficas de estos derechos en nuestras películas, hasta nuestros días; por otro lado, mediante el examen y análisis de filmes, cineastas, géneros y tendencias específicas de nuestra cinematografía, en relación con ellos.
Con este fin, se han convocado aquí a buena parte de los más importantes representantes de Derecho y Cine, en lengua española, tanto de España como de Iberoamérica.Texto del la editorial
Comparar los resultados de tiroglobulina obtenidos ante estimulación con tirotropina recombinante humana (rhTSH) con fines diagnósticos y tras privación hormonal previa a la terapia con
131I.
Se ...evaluó a 31 pacientes en seguimiento por cáncer diferenciado de tiroides (CDT) a los que se indicó dosis terapéutica de
131I. Fueron sometidos de forma consecutiva a ambos protocolos de estimulación, y el tratamiento con radioyodo distó 1-2 meses del procedimiento diagnóstico con rhTSH. Se realizaron determinaciones analíticas de TSH, tiroglobulina (Tg) y anticuerpos anti-Tg por métodos inmunométricos.
Las medianas de Tg obtenidas tras rhTSH y privación fueron de 1,10 y 1,80
ng/ml, respectivamente. Analizados como positivos o negativos, dichos valores mostraron un índice kappa de concordancia de 0,633. Los casos discordantes mostraron una mayor elevación de Tg en estímulo con rhTSH (3 casos) y sólo en 1 caso se obtuvo un resultado negativo con estimulación con rhTSH que luego se positivizó en la dosis ablativa.
El estímulo con rhTSH consigue elevaciones diagnósticas de TSH en todos los casos aplicados. Los valores de Tg obtenidos con ambos estímulos muestran un grado de concordancia elevado.
To compare the results of thyroglobulin (Tg) determination after diagnostic recombinant human thyroid-stimulating hormone (rhTSH) stimulation and after hormone withdrawal prior to
131I therapy.
Thirty-one patients followed-up for differentiated thyroid cancer were evaluated. In all patients
131I therapy was indicated. All patients underwent both stimulation methods, with an interval of 1-2 months between diagnostic rhTSH administration and radioiodine therapy. Laboratory determinations of TSH, Tg and Tg antibodies were carried out by immunometric methods.
Median Tg values obtained after rhTSH stimulation and hormone withdrawal were 1.10 and 1.80
ng/ml, respectively. Considered as positive or negative, these values showed a
kappa value of 0.633. Discordant cases showed greater elevation after rhTSH stimulation (3 patients). Only one patient showed a negative result after rhTSH stimulation, which was then positive after the ablative dose.
Stimulus with rhTSH achieved diagnostic elevations of TSH in all patients. Tg levels after both stimulation methods showed a high degree of agreement.
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