In this paper we compile the analysis of similar to 200 synchrotron flare events from similar to 90 distinct objects/events for which the distance is well established, and hence the peak luminosity ...can be accurately estimated. For each event we measure this peak and compare it to the rise and decay time-scales, as fit by exponential functions, which allows us in turn to estimate a minimum brightness temperature for all the events. The astrophysical objects from which the flares originate vary from flare stars to supermassive black holes in active galactic nuclei, and include both repeating phenomena and single cataclysmic events (such as supernovae and gamma-ray burst afterglows). The measured time-scales vary from minutes to longer than years, and the peak radio luminosities range over 22 orders of magnitude. Despite very different underlying phenomena, including relativistic and non-relativistic regimes, and highly collimated versus isotropic phenomena, we find a broad correlation between peak radio luminosity and rise/decay time-scales, approximately of the form L ... This rather unexpectedly demonstrates that the estimated minimum brightness temperature, when based upon variability time-scales, and with no attempt to correct for relativistic boosting, is a strongly rising function of source luminosity. It furthermore demonstrates that variability time-scales could be used as an early diagnostic of source class in future radio transient surveys. As an illustration of radio transients parameter space, we compare the synchrotron events with coherent bursts at higher brightness temperatures to illustrate which regions of radio transient parameter space have been explored. (ProQuest: ... denotes formulae/symbols omitted.)
Abstract
Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but regulation of lymphatic vessel function and its link to disease remain unclear. Here we show that ...intestinal lymphatic endothelial cells (LECs) have an increasing CD36 expression from lymphatic capillaries (lacteals) to collecting vessels, and that LEC CD36 regulates lymphatic integrity and optimizes lipid transport. Inducible deletion of CD36 in LECs in adult mice (
Cd36
ΔLEC
) increases discontinuity of LEC VE-cadherin junctions in lacteals and collecting vessels.
Cd36
ΔLEC
mice display slower transport of absorbed lipid, more permeable mesenteric lymphatics, accumulation of inflamed visceral fat and impaired glucose disposal.
CD36
silencing in cultured LECs suppresses cell respiration, reduces VEGF-C-mediated VEGFR2/AKT phosphorylation and destabilizes VE-cadherin junctions. Thus, LEC CD36 optimizes lymphatic junctions and integrity of lymphatic lipid transport, and its loss in mice causes lymph leakage, visceral adiposity and glucose intolerance, phenotypes that increase risk of T2D.
ABSTRACT
With the advent of powerful telescopes such as the Square Kilometer Array and the Vera C. Rubin Observatory, we are entering an era of multiwavelength transient astronomy that will lead to a ...dramatic increase in data volume. Machine learning techniques are well suited to address this data challenge and rapidly classify newly detected transients. We present a multiwavelength classification algorithm consisting of three steps: (1) interpolation and augmentation of the data using Gaussian processes; (2) feature extraction using wavelets; and (3) classification with random forests. Augmentation provides improved performance at test time by balancing the classes and adding diversity into the training set. In the first application of machine learning to the classification of real radio transient data, we apply our technique to the Green Bank Interferometer and other radio light curves. We find we are able to accurately classify most of the 11 classes of radio variables and transients after just eight hours of observations, achieving an overall test accuracy of 78 per cent. We fully investigate the impact of the small sample size of 82 publicly available light curves and use data augmentation techniques to mitigate the effect. We also show that on a significantly larger simulated representative training set that the algorithm achieves an overall accuracy of 97 per cent, illustrating that the method is likely to provide excellent performance on future surveys. Finally, we demonstrate the effectiveness of simultaneous multiwavelength observations by showing how incorporating just one optical data point into the analysis improves the accuracy of the worst performing class by 19 per cent.
Abstract
We have shown previously that a broad correlation between the peak radio luminosity and the variability time-scales, approximately L ∝ τ5, exists for variable synchrotron emitting sources ...and that different classes of astrophysical sources occupy different regions of luminosity and time-scale space. Based on those results, we investigate whether the most basic information available for a newly discovered radio variable or transient – their rise and/or decline rate – can be used to set initial constraints on the class of events from which they originate. We have analysed a sample of ≈800 synchrotron flares, selected from light curves of ≈90 sources observed at 5–8 GHz, representing a wide range of astrophysical phenomena, from flare stars to supermassive black holes. Selection of outbursts from the noisy radio light curves has been done automatically in order to ensure reproducibility of results. The distribution of rise/decline rates for the selected flares is modelled as a Gaussian probability distribution for each class of object, and further convolved with estimated areal density of that class in order to correct for the strong bias in our sample. We show in this way that comparing the measured variability time-scale of a radio transient/variable of unknown origin can provide an early, albeit approximate, classification of the object, and could form part of a suite of measurements used to provide early categorization of such events. Finally, we also discuss the effect scintillating sources will have on our ability to classify events based on their variability time-scales.
The gastric epithelium is often exposed to injurious elements and failure of appropriate healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric function of CD36, a ...protein linked to disease and homeostasis. We used the tamoxifen model of gastric injury in mice null for Cd36 (Cd36
), with Cd36 deletion in parietal cells (PC-Cd36
) or in endothelial cells (EC-Cd36
). CD36 expresses on corpus ECs, on PC basolateral membranes, and in gastrin and ghrelin cells. Stomachs of Cd36
mice have altered gland organization and secretion, more fibronectin, and inflammation. Tissue respiration and mitochondrial efficiency are reduced. Phospholipids increased and triglycerides decreased. Mucosal repair after injury is impaired in Cd36
and EC-Cd36
, not in PC-Cd36
mice, and is due to defect of progenitor differentiation to PCs, not of progenitor proliferation or mature PC dysfunction. Relevance to humans is explored in the Vanderbilt BioVu using PrediXcan that links genetically-determined gene expression to clinical phenotypes, which associates low CD36 mRNA with gastritis, gastric ulcer, and gastro-intestinal hemorrhage. A CD36 variant predicted to disrupt an enhancer site associates (p < 10
) to death from gastro-intestinal hemorrhage in the UK Biobank. The findings support role of CD36 in gastric tissue repair, and its deletion associated with chronic diseases that can predispose to malignancy.
We report on the results of a search for radio transients between 115 and 190 MHz with the LOw-Frequency ARray (LOFAR). Four fields have been monitored with cadences between 15 min and several ...months. A total of 151 images were obtained, giving a total survey area of 2275 deg2. We analysed our data using standard LOFAR tools and searched for radio transients using the LOFAR Transients Pipeline. No credible radio transient candidate has been detected; however, we are able to set upper limits on the surface density of radio transient sources at low radio frequencies. We also show that low-frequency radio surveys are more sensitive to steep-spectrum coherent transient sources than GHz radio surveys. We used two new statistical methods to determine the upper limits on the transient surface density. One is free of assumptions on the flux distribution of the sources, while the other assumes a power-law distribution in flux and sets more stringent constraints on the transient surface density. Both of these methods provide better constraints than the approach used in previous works. The best value for the upper limit we can set for the transient surface density, using the method assuming a power-law flux distribution, is 1.3 × 10−3 deg−2 for transients brighter than 0.3 Jy with a time-scale of 15 min, at a frequency of 150 MHz. We also calculated for the first time upper limits for the transient surface density for transients of different time-scales. We find that the results can differ by orders of magnitude from previously reported, simplified estimates.
LOFAR 150-MHz observations of SS 433 and W 50 Broderick, J W; Fender, R P; Miller-Jones, J C A ...
Monthly Notices of the Royal Astronomical Society,
04/2018, Letnik:
475, Številka:
4
Journal Article
Recenzirano
Odprti dostop
Abstract
We present Low-Frequency Array (LOFAR) high-band data over the frequency range 115–189 MHz for the X-ray binary SS 433, obtained in an observing campaign from 2013 February to 2014 May. Our ...results include a deep, wide-field map, allowing a detailed view of the surrounding supernova remnant W 50 at low radio frequencies, as well as a light curve for SS 433 determined from shorter monitoring runs. The complex morphology of W 50 is in excellent agreement with previously published higher frequency maps; we find additional evidence for a spectral turnover in the eastern wing, potentially due to foreground free–free absorption. Furthermore, SS 433 is tentatively variable at 150 MHz, with both a debiased modulation index of 11 per cent and a χ2 probability of a flat light curve of 8.2 × 10−3. By comparing the LOFAR flux densities with contemporaneous observations carried out at 4800 MHz with the RATAN-600 telescope, we suggest that an observed ∼0.5–1 Jy rise in the 150-MHz flux density may correspond to sustained flaring activity over a period of approximately 6 months at 4800 MHz. However, the increase is too large to be explained with a standard synchrotron bubble model. We also detect a wealth of structure along the nearby Galactic plane, including the most complete detection to date of the radio shell of the candidate supernova remnant G 38.7−1.4. This further demonstrates the potential of supernova remnant studies with the current generation of low-frequency radio telescopes.
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