Introduction: Neurological diseases can be due to direct diseases of the central nervous system (CNS) or peripheral nervous system (PNS) or be a bystander syndrome of systemic diseases. Treatment ...options depend on the cause. Toxic, metabolic and nutritional, and immune-mediated consequences of clinically occult neoplasms produce a spectrum of neurological diseases, recognition of which has therapeutic and prognostic importance.
Patients and Methods: Children, as well as adults who presented to the authors in the last 5 years with neurological diseases and later their diseases could be diagnosed or attributed to neoplasms which were occult, were included for the study.
Observation: 28 patients were seen by the authors in the last 5 years with neurological manifestation and hidden tumor. Maximum incidence was in the age of above 60 years followed by the age group of 21-40 years. The commonest neurological presentation was muscle and nerve in adults and seizure in children.
Discussion: Short duration, rapid progression, severe weight loss, and poor response to treatment given for nontumor associated neurological syndrome are the red flags which point to the diagnosis.
Conclusion: Seizures and psychosis formed the commonest features in children, muscle and nerve in adults. Short duration, rapid progression, and resistance to treatment are the markers for possible underlying neoplasm.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Introduction: The classical surgical treatment of Hirschsprung’s Disease (HD) is by resection of the aganglionic segment of the distal intestine and bringing down the ganglionic segment by Modified ...Duhamel’s procedure or other pull-through operations. The assessment of the postoperative functional outcome and continence scoring systems are important considerations during follow-up of these children. In the present study, a scoring system was used to analyse the postoperative functional outcome of HD as there are very few studies, that have objectively assessed the same. Aim: To assess the functional outcome in children under six years of age, who underwent Modified Duhamel’s procedure for HD. Materials and Methods: This descriptive longitudinal, study was conducted in the Tertiary Teaching Institution at Government Medical College, Thiruvananthapuram, Kerala, India. The duration of the study was one year and nine months, from February 2017 to November 2018. Forty cases of biopsy proven HD, who underwent Modified Duhamel’s procedure were analysed. Postoperative follow-up was done at one, two, and three years after the definitive surgical procedure. Patients were classified as good, fair and poor outcome groups depending based on the Taylor-Duthies-Zachary continence scoring system. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) version 22.0. Pretest comparison of scores and p-value were analysed by Wilcoxon signed-rank test. A p-value <0.05 was considered as statistically significant. Results: The mean age of the study participants was 12.7±4.1 months and age ranges from three to 25 months. Median stool frequency per day after one, two, and three years of surgery, was 6.0, 4.0, and 3.0, respectively. The observed difference in median frequency between one and two year, one and three, and two year and three year was statistically significant (p<0.05). Median continence score to assess the anal sphincter control at one, two and three years after surgery were 2.3, 4.0 and 4.5, respectively. The observed difference in scores over successive years, was statistically significant (p<0.05). Conclusion: The functional outcome in patients, who underwent Duhamel’s procedure was good and the postoperative issues like increased stool frequency, and sphincter control improved over successive years.
Chrysaora cf caliparea, one of the most abundant medusae species in india, seems to be an important predator in the coastal waters of Bay of Bengal. The ability of Chrysaora cf caliparea to feed at ...maximum rate in high prey concentrations implies that this jellyfish can efficiently exploit dense prey patches, at least for a short period. This study presents preliminary information regarding digestion and feeding rate upon copepods in a warm water environment. The ingestion rate of the average-sized medusae Chrysaora cf caliparea is well balanced in nature, which in turn implies that this jellyfish is tuned for optimal utilization of available prey resources. Comparison with earlier research indicates that prey escape speed is one important factor governing which prey will be captured. A full understanding of predation mechanics awaits further investigation of both predator and prey behavior. However, because of the scarcity of long-term quantitative population data most insights have to be made indirectly. Nevertheless, low abun- dance of Chrysaora cf caliparea in the water column during summer （May 2007） and the overall annual abundance seem not to con- siderably affect the zooplankton population, especially copepods. The present work contributes to the knowledge of prey-predator relationship of the forgotten fauna in Indian waters, which is especially crucial for understanding the process of ecological recovery of coastal water environment.
P7; Chrysaora cf. caliparea, one of the most abundant medusae species in India, seems to be an important predator in the coastal waters of Bay of Bengal. The ability of Chrysaora cf. caliparea to ...feed at maximum rate in high prey concentrations implies that this jellyfish can efficiently exploit dense prey patches, at least for a short period. This study presents preliminary information regarding digestion and feeding rate upon copepods in a warm water environment. The ingestion rate of the average-sized medusae Chrysaora cf. caliparea is well balanced in nature, which in turn implies that this jellyfish is tuned for optimal utilization of available prey resources. Comparison with earlier research indicates that prey escape speed is one important factor governing which prey will be captured. A full understanding of predation mechanics awaits further investigation of both predator and prey behavior. However, because of the scarcity of long-term quantitative population data most insights have to be made indirectly. Nevertheless, low abundance of Chrysaora cf. caliparea in the water column during summer (May 2007) and the overall annual abundance seem not to considerably affect the zooplankton population, especially copepods. The present work contributes to the knowledge of prey-predator relationship of the forgotten fauna in Indian waters, which is especially crucial for understanding the process of ecological recovery of coastal water environment.
The programmed cell death protein (PD-1)/programmed cell death protein ligand (PD-L1) pathway and cytotoxic T lymphocyte antigen are the most important co-stimulatory molecules that play a key role ...in the negative regulation of T cells during carcinogenesis. We aimed to evaluate the immunohistochemical expression of PD-1 and PD-L1 in oral leukoplakia and squamous cell carcinoma compared with normal oral mucosa. Twenty-five cases of oral squamous cell carcinoma, oral leukoplakia and normal oral mucosa tissue specimens were immunohistochemically stained to assess PD-1 and PD-L1 expression. The PD-L1 positivity of subepithelial TAFs (p < 0.001) increased with increasing grades of oral leukoplakia. Pearson's correlation indicated a high positive correlation between the PD-L1 labelling index of epithelial tumour cells and the PD-1 labelling index of tumour infiltrating lymphocytes (p value: 0.005) in OSCC. A high positive correlation was noted between the H-score of PD-L1 positive tumour epithelial cells and the H-score of PD-1 positive tumour infiltrating lymphocytes in OSCC (p value: 0.001). PD-L1 positivity increased in dysplastic epithelial cells from premalignant lesions to malignancy. The sub-epithelial PD-L1 positive TAFs were higher in oral leukoplakia compared to OSCC inferring that PD-L1 positivity in TAFs decreased with malignant transformation. The PD-1 positivity in TILs was higher in oral leukoplakia than in OSCC.
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A unique gold(111) oriented nanoparticles trapped carbon nanofiber-chitosan modified electrocatalyst coated glassy carbon electrode(GCE/CNF-CHIT@Aunano) was prepared by an in-situ ...electrochemical procedure for efficient bifunctional electrocatalytic oxidation and reduction of formaldehyde and hydrogen peroxide in neutral pH solution. In the typical preparation, a microliter quantity of Au3+ solution was drop-casted on GCE/CNF-CHIT surface and potential cycled in pH 7 PBS. The GCE/CNF-CHIT@Aunano showed well-defined electrochemical response of gold nanoparticles of calculated electrochemically active surface area, 0.1347cm2, which is about 3–3000 times higher than that of the surface area of the respective unmodified electrodes such as polycrystalline Au (0.0407cm2), GCE/CNF@Aunano (0.0034cm2) and GCE@Aunano (0.0005cm2). Physicochemical characterizations such as FESEM, EDAX, TEM, XRD, Raman, FTIR and XPS spectroscopic techniques revealed stabilization of 10±5nm sized Au(111) phase oriented nanoparticles by the amino functional group of chitosan in the composite matrix. The detailed electrochemical characterization by cyclic voltammetry(CV), rotating disk electrode (RDE) and in-situ CV-electrochemical quartz crystal microbalance (EQCM; Mw=44±1gmol−1 species was identified) techniques showed direct oxidation of formaldehyde to formate as an intermediate (45gmol−1) without any CO poisoning, unlike the conventional Pt and Au based electrodes. Using a bipotentiostat, selective and simultaneous flow injection analyses of formaldehyde and hydrogen peroxide in a mixture at discreet applied potentials (Eapp=0.5V/0.15V and −0.15V vs Ag/AgCl) were demonstrated. The applicability of the GCE/CNF-CHIT@Aunano was tested by detecting formaldehyde and hydrogen peroxide in a commercial hair dye formulation with about 100% recovery values.
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