Adrenoceptors are a large family of seven membrane spanning G-protein coupled receptors involved in many regulatory processes of the heart. Under conditions of mechanical load to heart, i.e., ...pressure overload, an activation of the sympathetic nerve system leads direcdy to stimulation of receptors of this family. Especially α-adrenoceptors are constantly coupled to regulation of protein synthesis and their stimulation leads to an imbalance of protein synthesis and degradation causing myocardial hypertrophy. Moreover, events initially evoked by coactivation of the renin-angiotensin-system, including the activation of cytokines like TGF-β, are able to induce an additional coupling of β2-adrenoceptors to the regulation of protein synthesis, further favouring an imbalance of protein synthesis and degradation. Thus, several adrenoceptors are involved in a complex network of external and internal signals, finally leading to an adaptive response of the heart to mechanical load. The present review summarises our current understanding of these signal transduction pathways and their contribution to myocardial hypertrophy and heart failure.
Primary malignant pericardial mesothelioma is a very rare pericardial tumor of unknown etiology.
A 61-year-old Caucasian woman was admitted to our hospital complaining of exertional dyspnea due to a ...large pericardial effusion. Intrapericardial fluid volume declined after repeated pericardiocentesis, but the patient progressively developed a hemodynamically relevant pericardial constriction. Pericardiectomy revealed a pericardial mesothelioma. Subsequently, four cycles of chemotherapy (dosage according to recently published trials) were administered. The patient remained asymptomatic, and there was no recurrence of the tumor after three years.
Pericardial mesothelioma should be considered and managed appropriately in non-responders to pericardiocentesis, and in patients who develop constrictive pericarditis late in their clinical course.
INTRODUCTIONPrimary malignant pericardial mesothelioma is a very rare pericardial tumor of unknown etiology. CASE PRESENTATIONA 61-year-old Caucasian woman was admitted to our hospital complaining of ...exertional dyspnea due to a large pericardial effusion. Intrapericardial fluid volume declined after repeated pericardiocentesis, but the patient progressively developed a hemodynamically relevant pericardial constriction. Pericardiectomy revealed a pericardial mesothelioma. Subsequently, four cycles of chemotherapy (dosage according to recently published trials) were administered. The patient remained asymptomatic, and there was no recurrence of the tumor after three years. CONCLUSIONPericardial mesothelioma should be considered and managed appropriately in non-responders to pericardiocentesis, and in patients who develop constrictive pericarditis late in their clinical course.
Die deutsche Volkswirtschaft gibt Rätsel auf: Einerseits ist Deutschland Export-(Vize-)Weltmeister, andererseits leidet es unter einer anhaltenden Wachstums- und Beschäftigungsschwäche. Ist das ...Exportwachstum Ausdruck ungebrochener internationaler Wettbewerbsfähigkeit und die Wachstums- und Beschäftigungsschwäche nur ein konjunkturelles Problem, das sich einem Mangel an privater Binnennachfrage verdankt. Oder deutet das Nebeneinander von Wirtschaftskrise und Exportboom auf ein Standortproblem Deutschlands im Allgemeinen und ein Lohnproblem im Besonderen hin?
Die deutsche Volkswirtschaft gibt Rätsel auf: Einerseits ist Deutschland Export-(Vize-)Weltmeister, andererseits leidet es unter einer anhaltenden Wachstums- und Beschäftigungsschwäche. Ist das ...Exportwachstum Ausdruck ungebrochener internationaler Wettbewerbsfähigkeit und die Wachstums- und Beschäftigungsschwäche nur ein konjunkturelles Problem, das sich einem Mangel an privater Binnennachfrage verdankt. Oder deutet das Nebeneinander von Wirtschaftskrise und Exportboom auf ein Standortproblem Deutschlands im Allgemeinen und ein Lohnproblem im Besonderen hin?
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