Imaging the dome of Santa Maria del Fiore using cosmic rays Guardincerri, E; Bacon, J D; Barros, N ...
Philosophical transactions - Royal Society. Mathematical, Physical and engineering sciences/Philosophical transactions - Royal Society. Mathematical, physical and engineering sciences,
12/2018, Letnik:
377, Številka:
2137
Journal Article
Recenzirano
Odprti dostop
The dome of Santa Maria del Fiore, Florence Cathedral, was built between 1420 and 1436 by architect Filippo Brunelleschi and it is now cracking under its own weight. Engineering efforts are under way ...to model the dome's structure and reinforce it against further deterioration. According to some scholars, Brunelleschi might have built reinforcement structures into the dome itself; however, the only known reinforcement is a wood chain 7.75 m above the springing of the Cupola. Multiple scattering muon radiography is a non-destructive imaging method that can be used to image the interior of the dome's wall and therefore ascertain the layout and status of any iron substructure in it. A demonstration measurement was performed at the Los Alamos National Laboratory on a mock-up wall to show the feasibility of the work proposed, and a lightweight and modular imaging system is currently under construction. We will discuss here the results of the demonstration measurement and the potential of the proposed technique, describe the imaging system under construction and outline the plans for the measurement.This article is part of the Theo Murphy meeting issue 'Cosmic-ray muography'.
Imaging the dome of Santa Maria del Fiore using cosmic rays Guardincerri, E.; Bacon, J. D.; Barros, N. ...
Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences,
01/2019, Letnik:
377, Številka:
2137
Journal Article
Recenzirano
The dome of Santa Maria del Fiore, Florence Cathedral, was built between 1420 and 1436 by architect Filippo Brunelleschi and it is now cracking under its own weight. Engineering efforts are under way ...to model the dome’s structure and reinforce it against further deterioration. According to some scholars, Brunelleschi might have built reinforcement structures into the dome itself; however, the only known reinforcement is a wood chain 7.75 m above the springing of the Cupola. Multiple scattering muon radiography is a non-destructive imaging method that can be used to image the interior of the dome’s wall and therefore ascertain the layout and status of any iron substructure in it. A demonstration measurementwas performed at the Los Alamos National Laboratory on a mock-up wall to show the feasibility of the work proposed, and a lightweight and modular imaging system is currently under construction. We will discuss here the results of the demonstration measurement and the potential of the proposed technique, describe the imaging system under construction and outline the plans for the measurement.
This article is part of the Theo Murphy meeting issue ‘Cosmic-ray muography’.
Cardiovascular diseases (CVDs) pose a significant global health threat, with familial hypercholesterolemia (FH) being a key genetic contributor. The apolipoprotein E (APOE) gene plays a vital role in ...lipid metabolism, and its variants are associated with CVD risk. This study explores prevalent APOE variants (p.R163C, p.R176C, p.R246C and p.V254E) using genetic and structural analyses. The research, initiated by identifying high-frequency APOE variants through the ABraOM database, utilizes homology modeling and molecular dynamics (MD) simulations to understand the structural consequences. The major lipid-binding region, a critical domain for lipid metabolism, was a focal point. Structural dynamics, including principal component analyses and domain movement analyses, highlighted distinct patterns in APOE variants compared to the wild type (WT). Results revealed significant differences in the structural behavior of variants, particularly in the Major lipid-binding region. The identification of an 'elbow' structure with two states (Elbow I and Elbow II) provided insights into conformational changes. Notably, variants exhibited unique patterns in hydrogen bonding (hb) and hydrophobic interactions, indicating potential functional consequences. The study further associated APOE variants with clinical outcomes, including cognitive impairment and cholesterol levels. Specific variants demonstrated correlations with cognitive decline and variations in lipid profiles, emphasizing their relevance to cardiovascular and neurobiological health. In conclusion, this integrated approach enhances our understanding of APOE variants, shedding light on their role in lipid metabolism and cardiovascular health. The identified structural 'elbows' and their association with clinical outcomes offer a nuanced perspective, guiding future research toward targeted interventions for diseases linked to lipid metabolism and neurobiology.Communicated by Ramaswamy H. Sarma.
The 'Check Strategy' Light Pizzico, Bill
Drug Store News,
05/2019, Letnik:
41, Številka:
5
Trade Publication Article
Drug chains can grab a larger share of the food service business, but it requires effort At one time or another, every person who owns a car has had the dreaded "check engine light" come on. The past ...decade has turned on "check strategy" lights in market segments from supermarkets to convenience stores, each with channel problems, ranging from product assortment, inventory, logistics management and customer profiling. Drug store food service, in particular, also will be a challenge to your marketing department, your merchandising group, your communications strategy and, above all, your boardroom.
A Review of University Maker Spaces Barrett, Thomas William; Matthew Cole Pizzico; Levy, Bryan ...
Association for Engineering Education - Engineering Library Division Papers,
06/2015
Conference Proceeding
Odprti dostop
Maker Spaces and Pedagogy: A Review of University Maker SpacesThe Engineer of 2020 recognizes that creativity, invention, and innovation are indispensablequalities for engineering. 1 Engineers need ...opportunities to begin to develop these critical skillsduring their education. These skills are not inherent and fixed, but rather can be fostered.Unfortunately with limited resources and time, adding innovation-fostering experiences toalready over-packed curriculums seems to be an insurmountable challenge.Well-designed maker spaces have the potential to enhance students’ deep learning of engineeringby supplementing the traditional curriculum with non-linear, open-ended, student-driven projectsthat require hands-on designing, prototyping, modeling, and testing. Many universities are in theprocess of building and expanding their student design spaces. These spaces go well beyond thetraditional machine shop by integrating typical machine tools with a wider variety of rapidprototyping and low-tech building approaches while simultaneously providing meeting space forstudent design teams to foster supportive cultures. Some research has begun on maker spacesoutside the university, 2 but studies have yet to determine the impacts and best practicesassociated with university maker spaces. We believe that university maker spaces will increasestudent retention as well as improve students’ engineering innovation skills, confidence and deeptechnical knowledge of engineering.This paper will present a review of university maker spaces compiling operational models (e.g.,student-run, lab technician-run, faculty-run), pedagogical integration (e.g., capstone requiringuse of Maker Spaces), and administrative details (e.g., budgeting, safety, and oversight). Basedon this review of university maker spaces, a discussion will describe common trends, advancesand innovations, and perceived benefits to the university community. The goal of this paper is tocreate a baseline of current state-of-the-art with respect to university maker spaces. 1 National Academy of Engineering, 2002, The Engineer of 2020: Visions of Engineering in the New Century. 2 Lande, M., Jordan, S.S., and Nelson, J., 2013, Defining Makers Making: Emergent Practice and EmergentMeanings. ASEE Annual Conference & Exposition, Atlanta, GA.
The right kind of chef Pizzico, Bill
The Progressive grocer,
10/1997, Letnik:
76, Številka:
10
Journal Article
Supermarket operators need to make sure that their prepared-food menu offerings match the customers' needs, take full advantage of the chefs' sell-through disciplines, and still meet rigorous ...profitability profiles.
A smorgasbord of ideas Pizzico, Bill
The Progressive grocer,
09/1997, Letnik:
76, Številka:
9
Journal Article
Retail Culinary, a new section of Progressive Grocer magazine, will address all supermarket departments involving meal marketing. A variety of issues will be explored, ranging from retailer and ...vendor relations, to changing consumer demographics and buying patterns, menu development, the impact of technology, meal preparation and marketing.
By not fully understanding consumers, the perimeter departments in supermarkets are looking only at short-term gains, often sacrificing the chance to drive real profits over the long run. Where ...retailers are making mistakes when they try to look at consumer data is that they are only looking at buying behavior from their own stores. This data is skewed because consumers can only buy at your store the products that you have offered them. The only way that same-store sales will eventually rise is by understanding who is actually paying the bills.
PDF
