Abstract
Giant radio galaxies (GRGs) are one of the largest astrophysical sources in the Universe with an overall projected linear size of ∼0.7 Mpc or more. The last six decades of radio astronomy ...research has led to the detection of thousands of radio galaxies. However, only ∼300 of them can be classified as GRGs. The reasons behind their large size and rarity are unknown. We carried out a systematic search for these radio giants and found a large sample of GRGs. In this paper, we report the discovery of 25 GRGs from the National Radio Astronomy Observatory Very Large Array Sky Survey, in the red-shift range z ∼ 0.07 to 0.67. Their physical sizes range from ∼0.8 Mpc to ∼4 Mpc. Eight of these GRGs have sizes ≥2 Mpc, which is a rarity. Here, for the first time, we investigate the mid-infrared (IR) properties of the optical hosts of the GRGs and classify them securely into various active galactic nuclei types using the WISE mid-IR colours. Using radio and IR data, four of the hosts of the GRGs were observed to be radio-loud quasars that extend up to 2 Mpc in radio size. These GRGs missed detection in earlier searches possibly because of their highly diffuse nature, low surface brightness and lack of optical data. The new GRGs are a significant addition to the existing sample. They will contribute to a better understanding of the physical properties of radio giants.
Abstract
Claudin-low breast cancers are aggressive tumors defined by the low expression of key components of cellular junctions, associated with mesenchymal and stemness features. Although they are ...generally considered as the most primitive breast malignancies, their histogenesis remains elusive. Here we show that this molecular subtype of breast cancers exhibits a significant diversity, comprising three main subgroups that emerge from unique evolutionary processes. Genetic, gene methylation and gene expression analyses reveal that two of the subgroups relate, respectively, to luminal breast cancers and basal-like breast cancers through the activation of an EMT process over the course of tumor progression. The third subgroup is closely related to normal human mammary stem cells. This unique subgroup of breast cancers shows a paucity of genomic aberrations and a low frequency of
TP53
mutations, supporting the emerging notion that the intrinsic properties of the cell-of-origin constitute a major determinant of the genetic history of tumorigenesis.
Several studies have linked the E3 ubiquitin ligase TRIP12 (Thyroid hormone Receptor Interacting Protein 12) to the cell cycle. However, the regulation and the implication of this protein during the ...cell cycle are largely unknown. In this study, we show that TRIP12 expression is regulated during the cell cycle, which correlates with its nuclear localization. We identify an euchromatin-binding function of TRIP12 mediated by a N-terminal intrinsically disordered region. We demonstrate the functional implication of TRIP12 in the mitotic entry by controlling the duration of DNA replication that is independent from its catalytic activity. We also show the requirement of TRIP12 in the mitotic progression and chromosome stability. Altogether, our findings show that TRIP12 is as a new chromatin-associated protein with several implications in the cell cycle progression and in the maintenance of genome integrity.
Brightest cluster galaxies (BCGs) are excellent laboratories for the study of galaxy evolution in dense Mpc-scale environments. We used the IRAM-30 m to observe, in CO(1→0), CO(2→1), CO(3→2), or ...CO(4→3), 18 BCGs at
z
∼ 0.2 − 0.9 drawn from the Cluster Lensing And Supernova survey with
Hubble
(CLASH) survey. Our sample includes RX1532, which is our primary target as it is among the BCGs with the highest star formation rate (SFR ≳100
M
⊙
yr
−1
) in the CLASH sample. We unambiguously detected both CO(1→0) and CO(3→2) in RX1532, yielding a large reservoir of molecular gas,
M
H
2
= (8.7 ± 1.1)×10
10
M
⊙
, and a high level of excitation,
r
31
= 0.75 ± 0.12. A morphological analysis of the
Hubble
Space Telescope I-band image of RX1532 reveals the presence of clumpy substructures both within and outside the half-light radius
r
e
= (11.6 ± 0.3) kpc, similarly to those found independently both in ultraviolet and in H
α
in previous works. We tentatively detected CO(1→0) or CO(2→1) in four other BCGs, with molecular gas reservoirs in the range of
M
H
2
= 2 × 10
10 − 11
M
⊙
. For the remaining 13 BCGs, we set robust upper limits of
M
H
2
/
M
⋆
≲ 0.1, which are among the lowest molecular-gas-to-stellar-mass ratios found for distant ellipticals and BCGs. In comparison with distant cluster galaxies observed in CO, our study shows that RX1532 (
M
H
2
/
M
⋆
= 0.40 ± 0.05) belongs to the rare population of star-forming and gas-rich BCGs in the distant universe. By using the available X-ray based estimates of the central intra-cluster medium entropy, we show that the detection of large reservoirs of molecular gas
M
H
2
≳ 10
10
M
⊙
in distant BCGs is possible when the two conditions are met: (i) high SFR and (ii) low central entropy, which favors the condensation and the inflow of gas onto the BCGs themselves, similarly to what has been previously found for some local BCGs.
The objective of this study was to assess the effectiveness of a Patient Navigation Intervention targeting deprived patients for Colo-Rectal Cancer (CRC) screening participation.
A cluster randomized ...controlled trial was conducted in 5 districts. Peer Lay Patient Navigators were recruited to operate in deprived areas. Eligible participants had to be between 50 and 74 years old, live in these deprived areas and receive an invitation to the nationally organized Colo-Rectal Cancer (CRC) screening during the study period. The theory-driven navigation intervention was deployed for 18 months. A population Health Intervention Research assessment method was used to assess effectiveness and context interaction. The primary criterion was screening participation at 12 months.
Twenty-four thousand two hundred eighty-one individuals were included inside 40 clusters. The increase in participation in the intervention group was estimated at 23%, (ORa = 1.23, CI95% 1.07-1.41, p = 0.003). For the subgroup of individuals who participated, the time delay to participating was reduced by 26% (ORa = 0.74, CI95% 0.57-0.96, p = 0.021). Main factors modulating the effect of the intervention were: closeness of navigator profiles to the targeted population, navigators' abilities to adapt their modus operandi, and facilitating attachment structure.
The ColoNav Intervention succeeded in demonstrating its effectiveness, for CRC screening. Patient Navigation should be disseminate with broader health promotion goals in order to achieve equity in health care.
clinicaltrials.gov NCT02369757 24/02/2015.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Summary
Interscalene brachial plexus block provides analgesia for shoulder surgery but is associated with hemidiaphragmatic paralysis. Before considering a combined suprascapular and axillary nerve ...block as an alternative to interscalene brachial plexus block, evaluation of the incidence of diaphragmatic dysfunction according to the approach to the suprascapular nerve is necessary. We randomly allocated 84 patients undergoing arthroscopic shoulder surgery to an anterior or a posterior approach to the suprascapular nerve block combined with an axillary nerve block using 10 ml ropivacaine 0.375% for each nerve. The primary outcome was the incidence of hemidiaphragmatic paralysis diagnosed by ultrasound. Secondary outcomes included: characterisation of the hemidiaphragmatic paralysis over time; numeric rating scale pain scores; oral morphine equivalent consumption; and patient satisfaction. The incidence of hemidiaphragmatic paralysis was 40% (n = 17) vs. 2% (n = 1) in the anterior and posterior groups, respectively (p < 0.001). In one third of patients with hemidiaphragmatic paralysis, it persisted beyond the eighth hour. The median (interquartile range range) oral morphine equivalent consumption was significantly higher in the posterior approach when compared with the anterior approach, whether in the recovery area (20 5–31 (0–60) mg vs. 7.5 0–14 (0–52) mg, respectively; p = 0.004) or during the first 24 h (82 61–127 (12–360) mg vs. 58 30–86 (0–160) mg, respectively; p = 0.01). Patient satisfaction was comparable between groups (p = 0.6). Compared with the anterior approach, diaphragmatic function is best preserved with the posterior needle approach to the suprascapular nerve block.
Abstract
This study uses H
i
image data from the Widefield ASKAP L-band Legacy All-sky Blind surveY (WALLABY) pilot survey with the Australian Square Kilometre Array Pathfinder (ASKAP) telescope, ...covering the Hydra cluster out to 2.5
r
200
. We present the projected phase–space distribution of H
i
-detected galaxies in Hydra, and identify that nearly two-thirds of the galaxies within
1.25
r
200
may be in the early stages of ram pressure stripping. More than half of these may be only weakly stripped, with the ratio of strippable H
i
(i.e., where the galactic restoring force is lower than the ram pressure in the disk) mass fraction (over total H
i
mass) distributed uniformly below 90%. Consequently, the H
i
mass is expected to decrease by only a few 0.1 dex after the currently strippable portion of H
i
in these systems has been stripped. A more detailed look at the subset of galaxies that are spatially resolved by WALLABY observations shows that, while it typically takes less than 200 Myr for ram pressure stripping to remove the currently strippable portion of H
i
, it may take more than 600 Myr to significantly change the total H
i
mass. Our results provide new clues to understanding the different rates of H
i
depletion and star formation quenching in cluster galaxies.
The conventional diagnostic and prognostic biomarkers (i.e. Clark Level (CL), Breslow Index (BI) or immunohistochemical markers 2) seem insufficient to distinguish precisely primary epidermis-limited ...neoplasms from aggressive or advanced/metastatic melanomas, and to assess the outcome for individual patients. ...additional relevant biomarkers are needed to predict the individual risk of metastasis and monitor disease progression. ...we identified several Tspan8 transcriptional regulators whose deregulation leads to Tspan8 expression 3, 5, 6, which could help to design new therapeutic strategies targeting Tspan8. Tspan8 protein expression in human primary melanomas was correlated with a higher propensity to give rise to distant metastases and an increased risk of death To evaluate the impact of Tspan8 expression at the protein level, we performed Tspan8 immunohistochemical staining analysis in a cohort of 100 primary melanoma samples: 73% of primary melanomas were positive for Tspan8 protein expression (sup. Tspan8 protein seemed more frequently expressed in the thinnest melanomas from patients dead during the 5-year period after diagnosis (92.3% of samples). ...the thinnest primary melanomas seemed to express the highest levels of Tspan8 protein (immunointensity score 4 exclusively in < 1 mm samples), especially in patients’ dead 5-years after diagnosis (60% of immunointensity scores 3–4; Fig. 2c).
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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