Objective of the study is to characterize the case of human plague in the territory of Gorno-Altaisk high-mountain natural focus in 2015 and to analyze the initiated measures, associated with ...localization and elimination of epidemic focus. Materials and methods. Utilized are the data contained in reporting and source (primary) documentation of the FGHI “Altai Plague Control Station”, records of the Rospotrebnadzor Administration in the Republic of Altai, and information collected by the FGHI “Irkutsk Research Anti-Plague Institute”. Results and conclusions. Human infection occurred as a result of gray marmot dressing, which was caught in the Elangash River-Valley, against the background of unfavorable epizootic situation, caused by proliferation of the plague agent of main subspecie in the territory of the focus. Clinical material investigations, performed by means of bacteriological and molecular-genetic methods, showed negative findings. Applying serological method within the system of indirect hemagglutination test (IHAT)/antigen neutralization test (ANT), in blood sera, obtained at the time of hospitalization, low-titred specific antibodies to plague microbe (recognized as post-vaccinal ones) were detected. In blood serum sample, obtained 7 days later, identified were high-titer antibodies, which allowed for confirmation of clinical diagnosis - “bubonic plague”. Due to efficient cooperation between Rospotrebnadzor institutions and medical facilities, as well as municipal authorities it was possible to avoid further development of anthropogenic transmission of plague; to localize and eliminate epidemic outbreak of this dangerous infectious disease in Kosh-Agach Region of the Republic of Altai in the shortest possible time.
This paper provides evaluation of the current publications on ice-accretion forecast and main parameters that influence ice-accretion process considered by the authors. The ice buildup process ...evaluation applies 10 years' statistics obtained by weather stations in Bratolyubovka, Elabuga, Zeya, Bolshoi Shantar and Nickolaevsk. The main parameters applied: air temperature, wind speed and direction, relative humidity, partial pressure, humidity deficit and atmospheric pressure. The weather station data obtaining process is described. The existing statistic data processing techniques and drawbacks thereof are assessed. The weather station statistic data processing is described for different deposit diameters. It is attempted to give a mathematical description of ice-accretion basing on the data. It is concluded that it is feasible to apply smart systems to make the mathematic description of ice-accretion process.
The CORONAS-Photon spacecraft was successfully launched in January 2009. Its scientific payload included the TESIS complex of telescopes and spectrometers, designed to obtain high spectral, temporal ...and spatial resolution solar corona images in soft X-ray to far UV spectral range.
The extracellular matrix (ECM) is highly dynamic as it is constantly deposited, remodeled and degraded to maintain tissue homeostasis. ECM is a major structural component of the tumor ...microenvironment, and cancer development and progression require its extensive reorganization. Cancerized ECM is biochemically different in its composition and is stiffer compared to normal ECM. The abnormal ECM affects cancer progression by directly promoting cell proliferation, survival, migration and differentiation. The restructured extracellular matrix and its degradation fragments (matrikines) also modulate the signaling cascades mediated by the interaction with cell-surface receptors, deregulate the stromal cell behavior and lead to emergence of an oncogenic microenvironment. Here, we summarize the current state of understanding how the composition and structure of ECM changes during cancer progression. We also describe the functional role of key proteins, especially tenascin C and fibronectin, and signaling molecules involved in the formation of the tumor microenvironment, as well as the signaling pathways that they activate in cancer cells.
ATP activity in mouse bone marrow cells was in vitro estimated by expression of phosphatidylserine on the outer membrane surface using FITC-labeled annexin. ATP induced apoptosis in bone marrow ...cells. Purinergic receptor antagonists PPADS and suramin modulated the apoptotic effect of ATP on hemopoietic cells. Acute and subacute administration of doxorubicin, an inductor of oxidative burst, decreased cell sensitivity to ATP and abolished its apoptotic effect.
В статье авторами анализируется правовая природа договора банковского вклада. Исследуются существующие авторские и законодательные подходы к пониманию правовой природы договора банковского вклада. В ...заключение авторы приходят к выводу о самостоятельности правовой природы договора банковского вклада. Говорится, что договор необходимо рассматривать в качестве самостоятельного, публичного гражданско-правового договора, а также договора присоединения, имеющего собственную правовую природу, несмотря на присущие данному договору элементы заемного обязательства.
This paper discusses methods for processing large arrays of statistical data. A conclusion is made that the ant colony optimization algorithm can be used to identify the shortest distances between ...points and determine areas of membership function localization for a smart module. The dependence of the relative humidity on the air temperature is analyzed for the ice accretion diameter of 5 and 6 mm at weather stations of Bratolyubov-ka, Bolshoi Shantar, Yelabuga, Nikolaevsk-on-Amur and Zeya. The dependence of the wind direction on the air temperature is analyzed for the ice accretion diameter of 5 and 6 mm for the mentioned weather stations, as well as the dependence of the relative humidity on the wind direction for the ice accretion diameter of 5 and 6 mm. A conclusion is made about the device to be used as a fuzzy identifier, as well as the probable variation range to be taken for each specific parameter of the ice accretion process.
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