Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A.
We present unique case of ...patient with hemophilia B and high titer inhibitors to coagulation FIX, who developed severe renal damage due to thromboembolic event during rFVIIa therapy, associated with unsuspected renovascular anomalies.
Caution is necessary if hematuria B requires administration of rFVIIa. US color doppler renal imaging before and after drug administration should be sufficient as an early warning.
The aim of this study was to provide data on genetic hazards associated with occupational exposure to low doses of ionising radiation in nuclear medicine departments. The DNA damage in peripheral ...blood lymphocytes of medical staff was assessed using the chromosome aberration test. Altogether 120 subjects (60 exposed and 60 controls) participated in the study. The exposed subjects showed significantly higher frequencies of chromosome aberrations than controls. Significant inter-individual differences in DNA damage within the exposed population indicate different genome sensitivity. Age and sex were not confounding factors, while smoking increased DNA damage only in control subjects. This study suggests that chronic exposure to low doses of ionising radiation in nuclear medicine departments causes cytogenetic damage. For this reason, exposed medical personnel should minimise radiation exposure wherever possible. Our results also point to the significance of biological indicators, which provide information about the actual risk for the radiation-exposed individuals.
Successful Early Pyeloplasty in Infants Zupancic, Bozidar; Antabak, Anko; Popovic, Ljiljana ...
Archives of medical research,
03/2002, Letnik:
33, Številka:
2
Journal Article
Recenzirano
Early pyeloplasty for the treatment of congenital ureteropelvic junction obstruction to maximize nephron salvage is justified only if potential hazards of operating on small infants are avoided.
The ...records were analyzed of all infants who underwent pyeloplasty over a 5-year period. Open pyeloplasty was performed if collecting systems had deteriorated or were demonstrated to be obstructed; it was also performed for severe cases of hydronephrosis. Outcome of surgery in the younger infant (patients <2 months of age) was compared with the older infant group (patients >2 months of age). Preoperative evaluation in case of mild or moderate hydronephrosis was directed toward ruling out a non-obstructed collection system and included voiding cystourethrography, and serial ultrasonography and/or dual isotope diuretic renography. Postoperative assessment consisted of serial ultrasonography and/or nuclear imaging to confirm decompression and relief of obstruction.
A total of 24 pyeloplasties were performed on 22 patients in the younger infant group (two bilateral) and 30 were performed on 27 infants in the older infant group (three bilateral). The only significant differences between the groups were as follows: patients in the younger infant group were likely to present
in utero (75%,
p = 2.69), whereas those in the older infant group were more likely to present with a urinary tract infection (48%,
p = 4.12). During follow-up examination, 23 renal units in the younger infant group and 24 in the older infant group were judged to be stable or improved. Four kidneys were not salvaged after pyeloplasty, one in the younger infant group and three in the older infant group.
Good results of pyeloplasties performed in the infants in this series support early correction of ureteropelvic junction obstruction in infants.
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Ionizirajuće zračenje izaziva različita oštećenja u živim stanicama, čija je pojava ovisna o dozi kojoj su stanice izložene, apsorbiranoj dozi, trajanju izloženosti te osjetljivosti tkiva. Osoblje ...profesionalno izloženo zračenju pod povećanim je rizikom od štetnih učinaka ionizirajućeg zračenja samo u slučajevima nepoštivanja propisa sigurnosti pri radu. Dugogodišnja profesionalna izloženost zračenju za posljedicu može imati zloćudne bolesti (rak) i genske mutacije. Unatoč intenzivnim istraživanjima, genetska oštećenja proizašla iz izloženosti osoblja ionizirajućem zračenju još nisu potpuno razjašnjena, a posebice ona proizašla iz izloženosti niskim dozama. Cilj ovog istraživanja bio je proučiti genetska oštećenja nastala pod utjecajem profesionalne izloženosti niskim dozama ionizirajućeg zračenja u osoblja zaposlenog na odjelima nuklearne medicine. Procjena oštećenja DNA u limfocitima periferne krvi izloženoga medicinskog osoblja provedena je s pomoću testa analize kromosomskih aberacija. Istraživanje je obuhvatilo ukupno 120 ispitanika (60 izloženih i 60 kontrolnih). U izloženih ispitanika utvrđena je statistički značajno povišena učestalost kromosomskih aberacija u usporedbi s kontrolnom skupinom. Unutar izložene skupine uočene su i značajne interindividualne razlike u razini oštećenja DNA, koje upućuju na različitu genetsku osjetljivost. Dob i spol ispitanika nisu značajnije utjecali na razinu oštećenja genoma, a navika pušenja utjecala je na porast razine oštećenja DNA samo u ispitanika kontrolne skupine. Na osnovi dobivenih rezultata vidljivo je da kronična profesionalna izloženost niskim dozama ionizirajućeg zračenja na odjelima nuklearne medicine izaziva genotoksična oštećenja u limfocitima periferne krvi medicinskog osoblja. Kako bi se izbjegli potencijalni genotoksični učinci, izloženost medicinskog osoblja, kad god je to moguće, treba smanjiti na najmanju moguću razinu. Dobiveni rezultati također naglašavaju važnost primjene bioloških indikatora koji pružaju niz informacija o stvarnom i trenutačnom riziku za izložene ispitanike koji se ne mogu dobiti iz fizikalne dozimetrije.
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Kolorektalni karcinom zlocudna je novotvorina incidencija kojega je u stalnom porastu i koja predstavlja globalni javnozdravstveni problem. U vecine bolesnika ova se bolest dijagnosticira nakon 50. ...godine zivota, a rizik od njenog razvoja tijekom zivotnog vijeka iznosi oko 5%. Razvoj preventivnih, dijagnostickih i terapijskih metoda rezultirao je znacajnim smanjenjem smrtnosti i drugih negativnih klinickih ishoda. Upravo zbog ucinkovite metode prevencije i ranog otkrivanja ove bolesti u brojnim drzavama pa tako i u Republici Hrvatskoj organizirani su nacionalni programi probira i pracenja kolorektalnog karcinoma. Medutim, navedeni su programi prvenstveno organizirani za populaciju s uobicajenim, odnosno prosjecnim rizikom obolijevanja od kolorektalnog karcinoma. Visokorizicne skupine obuhvacaju osobe u kojih su endoskopski otkriveni, odnosno uklonjeni polipi debelog crijeva, osobe kirurski lijecene zbog karcinoma debelog crijeva, osobe s pozitivnom obiteljskom anamnezom za kolorektalni karcinom, osobe oboljele od upalnih bolesti crijeva, pojedinci i obitelji s nasljednim poremecajima, odnosno genetskim mutacijama koje visestruko povecavaju rizik za razvoj ove bolesti, osobe oboljele od akromegalije te bolesnici u kojih je ucinjen zahvat ureterosigmoidostomije. Preporuke za otkrivanje i pracenje visokorizicnih skupina cesto nisu jasno definirane, a neke od postojecih se temelje na uglavnom oskudnim znanstvenim dokazima. Opee je prihvaceno misljenje da bi probir u visokorizicnih skupina trebao zapoceti u ranijoj zivotnoj dobi uz krace vremenske intervale izmedu pojedinih pregleda. Osnovna dijagnosticka metoda probira i pracenja u ovih skupina bolesnika je endoskopsko pracenje, odnosno kolonoskopija. Cilj ovoga preglednog rada je prikazati znacajke navedenih rizicnih skupina i dati jasne preporuke za probir. Kljucne rijeci: Oportunisticki probir; Rak debelog i zavrsnog crijeva; Obiteljska medicina
Colorectal cancer is a malignant neoplasm which has an increasing incidence and represents a global public health problem. The majority of patients are diagnosed after the age of 50, and the risk of ...developing it over lifetime is 5%. Development of preventive, diagnostic and treatment methods has resulted in a significant reduction in mortality and other negative clinical outcomes. Precisely because of the efficient method of prevention and early detection of this disease, numerous countries, including Croatia, have organized national colorectal cancer screening and monitoring programs. However, these programs are primarily organized for the population with the usual, i.e. average risk of developing colorectal cancer. High-risk groups include persons with endoscopically detected and removed colon polyps, persons surgically treated for colon cancer, persons with a positive family history of colorectal cancer, persons with inflammatory bowel diseases, individuals and families with hereditary disorders or genetic mutations that increase the risk of this disease several fold, persons with acromegaly, and patients who have undergone ureterosigmoidostomy. Recommendations for the detection and monitoring of high-risk groups are often not defined clearly, and some of the existing ones are based mostly on scarce scientific evidence. It is commonly accepted that screening in high-risk groups should start at an earlier age, with shorter intervals between follow-ups. The basic diagnostic method for screening and monitoring in these patient groups is endoscopic monitoring, or colonoscopy. The aim of this review paper is to present the characteristics of the abovementioned risk groups and provide clear screening recommendations.
Eosinophilic esophagitis is a chronic, Th2-mediated disease characterized by the presence of predominantly eosinophilic inflammation in the esophagus. The disease is mediated by an immune or ...antigenic pathophysiological background, and the definition of the disease requires the presence of clinical symptoms and histological elements of the disease. Over the past ten years, there has been an increase in the incidence and prevalence of EoE, where the prevalence of EoE varies, and in the general population is 0.2–4 / 1000 in asymptomatic patients, while in symptomatic patients it is 5–6%. The prevalence in the general population is considered to be 43 to 52/100000. Pathophysiologically, it is a polygenic disease in which certain cytokines (IL-4, IL-5, IL-13, IL-14 and TGF-β) play a key role by activating eotaxin-3 in the esophageal mucosa. Eotaxin-3 strongly attracts eosinophils into the esophageal mucosa, and thus activated eosinophils lead to the attraction of other inflammatory cells, the release of mediators and the onset of disease. The histological criterion for the diagnosis of EoE is the presence of more than 15 eosinophils present in the visual field of esophageal mucosal biopsies. Clinically, the disease can manifest itself by a spectrum of symptoms, from acute food impaction, dysphagia, epigastric pain and heartburn, and nonspecific symptoms such as incontinence or vomiting also occur in these patients. The basis of treatment of these patients is based on drug therapy, dietary recommendations and endoscopic dilatation. Thea im of these clinical recommendations is to present the pathway of diagnosis and therapy of eosinophilic esophagitis.
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