Positron emission tomography is one of the most mature techniques for monitoring the particles range in hadron therapy, aiming to reduce treatment uncertainties and therefore the extent of safety ...margins in the treatment plan. In-beam PET monitoring has been already performed using inter-spill and post-irradiation data, i.e. while the particle beam is off or paused. The full beam acquisition procedure is commonly discarded because the particle spills abruptly increase the random coincidence rates and therefore the image noise. This is because random coincidences cannot be separated by annihilation photons originating from radioactive decays and cannot be corrected with standard random coincidence techniques due to the time correlation of the beam-induced background with the ion beam microstructure. The aim of this paper is to provide a new method to recover in-spill data to improve the images obtained with full-beam PET acquisitions. This is done by estimating the temporal microstructure of the beam and thus selecting input PET events that are less likely to be random ones. The PET detector we used was the one developed within the INSIDE project and tested at the CNAO synchrotron-based facility. The data were taken on a PMMA phantom irradiated with 72 MeV proton pencil beams. The obtained results confirm the possibility of improving the acquired PET data without any external signal coming from the synchrotron or ad hoc detectors.
Abstract
The design of smaller and less costly gantries for carbon ion particle therapy represents a major challenge to the diffusion of this treatment. Here we present the work done on the linear ...beam optics of possible gantry layouts, differing for geometry, momentum acceptance, and magnet technology, which share the use of combined function superconducting magnets with a bending field of 4 T. We performed parallel– to–point and point–to–point optics matching at different magnification factors to provide two different beam sizes at the isocenter. Moreover, we considered the orbit distortion generated by magnet errors and we introduced beam position monitors and correctors. The study, together with considerations on the criteria for comparison, is the basis for the design of a novel and compact gantry for hadrontherapy.
Abstract
The yearly energy requirements of room temperature (RT) and superconducting (SC) magnet options of a new hadron therapy (HT) facility are compared. Special reference is made to the layouts ...considered for the proposed SEEIIST facility. Benchmarking with the RT CNAO HT centre in Pavia (Italy) was carried out. The energy comparison is centred on the different synchrotron solutions, assuming the same injector and lines in the designs. The beam current is 20 times higher than in present generation facilities: this allows efficient multi-energy extraction (MEE), which shortens the therapy treatment and is needed especially in the SC option, because of the slow magnet ramping time. Hence, power values of the facility in the traditional mode were converted into MEE ones, for a fair comparison between RT and SC magnets. Cryocoolers (c.c.) and a liquefier are also compared, for synchrotron refrigeration. This study shows that a RT facility in MEE mode requires the least average energy, followed by the SC synchrotron solution with a liquefier, while the most energy intensive solution is the SC one with c.c.
Abstract
The Heavy Ion Therapy Research Integration plus (HITRIplus) is an European project that aims to integrate and propel research and technologies related to cancer treatment with heavy ion ...beams. Among the ambitious goals of the project, a specific work package includes the design of a gantry for carbon ions, based on superconducting magnets. The first milestone to achieve is the choice of the fundamental gantry parameters, namely the beam optics layout, the superconducting magnet technology, and the main user requirements. Starting from a reference 3 T design, the collaboration widely explored dozens of possible gantry configurations at 4 T, aiming to find the best compromise in terms of footprint, capital cost, and required R&D. We present here a summary of these configurations, underlying the initial correlation between the beam optics, the mechanics and the main superconducting dipoles design: the bending field (up to 4 T), combined function features (integrated quadrupoles), magnet aperture (up to 90 mm), and angular length (30° – 45°). The resulting main parameters are then listed, compared, and used to drive the choice of the best gantry layout to be developed in HITRI
plus
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Rotatorlike gantry optics Pavlovič, M.; Pivi, M. T. F.; Strašík, I. ...
Physical review. Accelerators and beams,
7/2024, Letnik:
27, Številka:
7
Journal Article
Recenzirano
Odprti dostop
Rotating gantries are commonly used in ion-therapy facilities to assist and support optimizing the dose distribution delivered to the patient. They are installed at the end of the beamlines and ...rotated mechanically in the treatment room. In synchrotron-based facilities, the gantries must be able to transport slowly extracted beams with essentially different emittance patterns in the two transverse planes. Such beams will be referred to as the asymmetric beams. A special device called rotator has been proposed as a possible solution. The worldwide first beamline with the rotator has been recently commissioned. The original rotator concept uses an “external” rotator that is a part (a module) of the beamline the gantry is connected to. In this paper, a novel gantry ion-optical concept integrating the rotator optics into the gantry optics is introduced. The first-order gantry transfer matrix satisfies the so-called sigma-matching ion-optical constraints, and—at the same time—it possesses the format of a rotator transfer matrix. The rotator-matching and the sigma-matching principles are combined in the gantry transfer matrix, which means that the sigma-matching gantry acts simultaneously as a rotator without the need for an extra rotator device. In addition, scattering in the gantry nozzle is used to balance the asymmetric beam emittances in the two transverse planes without an additional scattering foil. In this way, the presented ion-optical concept combines all three known matching techniques—the sigma matching, the rotator matching, and the scattering-foil matching—within the gantry beam transport system. Such a beam transport system provides the best matching result and full angular independence of the beam parameters at the gantry isocenter. It also makes it possible to optimize the beam parameters not only at the gantry isocenter but also at the beam monitors located in the gantry nozzle without increasing the number of gantry quadrupoles. There are two possible versions of such gantry optics: the point-to-point and the parallel-to-point optics. They both are presented in this paper. Theoretical calculations are supported by beam transport simulations performed with the in code. Feasibility of the newly proposed ion-optical concept is demonstrated on the MedAustron proton gantry. However, it can be applied to any rotating gantry at any ion-therapy facility. The presented design is the first rotatorlike gantry ion-optical concept worldwide. Published by the American Physical Society 2024
This paper provides an overview of the worldwide first commissioning of a gantry beamline with a rotator at the MedAustron synchrotron-based proton/ion cancer therapy facility in Wiener Neustadt, ...Austria. The gantry beamline consists of the high energy beam transfer (HEBT) line and the gantry beam transport system. It transports the beam from the synchrotron to the gantry-room isocenter. The HEBT transports the beam from the synchrotron to the gantry entrance, which is the coupling point between the HEBT and the gantry. The rotator is one of the HEBT modules, thus it is an integral part of the gantry beamline. The MedAustron rotator is the worldwide first rotator system used to match slowly extracted asymmetric beams from the synchrotron to the rotating gantry. In this paper, main attention is paid to ion-optical and beam-alignment aspects of the beamline commissioning. A novel orbit-correction and beam-alignment technique has been developed specifically for the beamline with the rotator. While the theoretical concept of the rotator has existed for almost two decades, the MedAustron rotator is the first hardware implementation of this concept all over the world. The presented overview of the beamline commissioning includes a description of the principal technical solutions and main results of the first beam-transport measurements. Since the measured beam size and beam position agree well with theoretical predictions, one can conclude that the proof-of-concept of the rotator-matching has been successfully accomplished.
The need of a fs-scale pulsed, high repetition rate, X-ray source for time-resolved fine analysis of matter (spectroscopy and photon scattering) in the linear response regime is addressed by the ...conceptual design of a facility called MariX (Multi-disciplinary Advanced Research Infrastructure for the generation and application of X-rays) outperforming current X-ray sources for the declared scope. MariX is based on the original design of a two-pass two-way superconducting linear electron accelerator, equipped with an arc compressor, to be operated in CW mode (1 MHz). MariX provides FEL emission in the range 0.2–8 keV with 108 photons per pulse ideally suited for photoelectric effect and inelastic X-ray scattering experiments. The accelerator complex includes an early stage that supports an advanced inverse Compton source of very high-flux hard X-rays of energies up to 180 keV that is well adapted for large area radiological imaging, realizing a broad science programme and serving a multidisciplinary user community, covering fundamental science of matter and application to life sciences, including health at preclinical and clinical level.
In this contribution we discuss the calibration and performance of the TOF-Wall detector of the Fragmentation-Of-Target (FOOT) experiment. A thin carbon target was irradiated with carbon ions of ...several energies ranging from 150 to 400 MeV/u. The charge spectra of the produced fragments were used to calibrate the energy response. The energy resolution for a single bar was about 6%. The time resolution between the two layers ranged from 42 (150 MeV/u) to 62 ps (400 MeV/u).
Nuclear physics processes are an important source of uncertainty in dose calculations in particle therapy and radioprotection in space. Accurate cross section measurements are a crucial ingredient in ...improving the understanding of these processes. The FOOT (FragmentatiOn Of Target) experiment aims at measuring the production cross sections of fragments for energies, beams and targets that are relevant in particle therapy and radioprotection in space. An experimental apparatus composed of several sub-detectors will provide the mass, charge, velocity and energy of fragments produced in nuclear interactions in a thin target. A crucial component of the FOOT apparatus will be the ΔE-TOF detector, designed to identify the charge of the fragments using plastic scintillators to measure the energy deposited and the time of flight with respect to a start counter. In this work, we present a charge reconstruction procedure of produced fragments at particle therapy energies. We validate it by measuring the charges of various fragments at an angle of 3.2°and 8.3°with respect the beam-axis, using a small-scale detector and clinical beams of carbon ions at the CNAO oncology center. Experimental results agree well with FLUKA Monte Carlo simulations.
FOOT (FragmentatiOn On Target) is an applied nuclear physics experiment aimed at measuring the production cross sections of fragments for energies, beams and targets relevant in particle therapy and ...radioprotection in space. The ΔE-TOF detector will measure the energy deposited by the fragments in a wall of plastic scintillators and the time of flight with respect to a start detector. These two quantities allow to determine the charge Z of the fragment. In this work, we summarize the charge identification procedure of a detector prototype with two scintillator modules.
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