Among the characteristic features of Hungary's new political parties, the absence of open competition for leadership positions is striking. Fragmentation, defections and other factors of the ...establishment of parties make their internal structures and procedures difficult to become established. Nevertheless, there appears to be a trend towards a somewhat elitist uniformity, which may reflect external influences. The mechanisms of leadership selection and the role of leaders are likely to be tested as the democratic process unfolds.
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7.
Hungary: the politics of transition Cox, Terry; Furlong, Andy; Ágh, Attila ...
The journal of communist studies and transition politics,
09/1994, Letnik:
10, Številka:
3
Journal Article
Book reviews Goldsworthy, David; Harman, Elizabeth; Higley, John ...
Australian Journal of Political Science,
07/1994, Letnik:
29, Številka:
2
Book Review
Recenzirano
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9.
Book reviews Goldsworthy, David; Harman, Elizabeth; Higley, John ...
Australian Journal of Political Science,
19/7/1/, Letnik:
29, Številka:
2
Book Review
Recenzirano
Australian Politics. Sharon Beder, The Nature of Sustainable Development (Newham, Vic: Scribe Publications, 1993) pp.304 $32.95 ISBN 0 908011 24 5.
Stephen Bell, Australian Manufacturing and the ...State: The polities of industry policy in the post-war era (Melbourne: Cambridge University Press, 1993) pp.276 $29.95 ISBN 0521 44800 X.
Ann Capling and Brian Galligan, Beyond the Protective State: The political economy of Australia's manufacturing industry policy (Melbourne: Cambridge University Press, 1992) pp.272 $29.95 ISBN 0 521 42629 4.
Hugh V. Emy, Remaking Australia: The State, the Market, and Australia's Future (Sydney: Allen & Unwin, 1993) pp.257 $19.95 ISBN 1 86373 450 3.
Murray Goot and Rodney Tiffen (eds), Australia's Gulf War (Melbourne: Melbourne University Press, 1992) pp.304 $24.95 ISBN 0 522 84463 4.
John Halligan and John Power, Political Management in the 1990s (Melbourne: Oxford University Press, 1992) pp.310 $27.95 ISBN 0 19 553428 X.
Race Mathews, Australia's First Fabians: Middle-class Radicals, Labour Activists and the Early Labour Movement (Cambridge: Cambridge University Press, 1993) pp.284 $29.95 ISBN 0 521 44678 3.
Uldis Ozolins, The Polities of Language in Australia (Melbourne: Cambridge University Press, 1993) pp.287 $35.00 ISBN 0 521 44786 0.
Malcolm Saunders, Quiet Dissenter: The life and thought of an Australian pacifist Eleanor May Moore, 1875-1949, Monograph no. 12 (Peace Research Centre, Research School of Pacific Studies, Australian National University, Canberra, 1993), pp.398 $n.p. ISBN 0 7315 1321 5.
R.B. Scotton and C.R. Macdonald, The Making of Medibank (Sydney: School of Health Services Management, University of New South Wales, 1993) pp.320 $35.00 ISBN 0 85832 081 9.
Rodney Smith (ed.), Politics in Australia, 2nd ed. (Sydney: Allen and Unwin, 1993) pp.341 $24.95 ISBN 1 86373 341 8.
Patrick Weller, John Forster and Glyn Davis (eds.), Reforming the Public Service: Lessons from Recent Experience (Melbourne: Macmillan, 1993) pp.258 $29.95 ISBN 0 7329 2390 5.
Comparative and International Politics. Ian Ayres and John Braithwaite, Responsive Regulation: Transcending the Deregulation Debate. Oxford Socio-Legal Studies, general editors Donald R. Harris et al (Oxford: Oxford University Press, 1992) pp.205 $55.00 ISBN 0 19 507070 4.
Robert H. Bates and Anne O. Krueger (eds), Political and Economic Interactions in Economic Policy Reform (Cambridge, Mass.: Blackwell, 1993) pp.481 £55.00 ISBN 1 55786 340 7.
John Baylis and N.J. Rengger (eds), Dilemmas of World Politics. International Issues in a Changing World (Oxford: Clarendon Press, 1992) pp.438 $37.50. ISBN 0 19 827350 9.
Coral Bell, Dependent Ally: A Study In Australian Foreign Policy (Canberra: Allen & Unwin in association with Department of International Relations, RSPacS, ANU) pp.205 $24.95 ISBN 1 86373 400 7.
Frank Castles (ed.), The Comparative History of Public Policy (Cambridge: Polity Press, 1989) pp.340 $39.95 ISBN 0 7456 1069 2.
J. Patrick Dobel, Compromise and Political Action: Political Morality in Liberal and Democratic Life (Savage, MD: Rowman & Littlefield, 1990) pp.215 $n.p. ISBN 0 84767604 8.
Michael Gleeson, Toni Allan, Michael Wilkins, An Act of Corruption: Nick Greiner's years in Power and His Unorthodox Demise (Sydney: ABC, 1992) pp.234 $n.p. ISBN 07333 02637 7.
Peter de Leon, Thinking About Political Corruption (Armonk, N.Y.: M.E. Sharpe, 1993) pp.241 $US16.50 ISBN 0 87332 839 6.
Michael Button, Policing and Punishment in China: From Patriarchy to 'the People' (Cambridge: Cambridge University Press, 1992) pp.354 $75.00 ISBN 0 521 40097 X.
David J. Elkins, Manipulation and Consent: How Voters and Leaders Manage Complexity (Vancouver: UBC Press, 1993) pp.248 $Can65.00 ISBN 0 7748 0424 6.
Kofi Buenor Hadjor, The Penguin Dictionary of Third World Terms (Harmondsworth: Penguin Books, 1992) pp. 305 $16.95 ISBN 0 14 051293 4.
Richard Heffernan and Mike Marqusee, Defeat from the Jaws of Victory: Inside Kinnock's Labour Party (London and New York: Verso, 1992) pp.344 $37.95 ISBN 0 86091 561 1.
James C. Hslung (ed.), Asia Pacific in the New World Politics (Boulder and London: Lynne Rienner, 1993) pp.265 $US18.95 ISBN 1 55587 355 3.
George F. Kennan, The Other Balkan Wars: A 1913 Carnegie Endowment Inquiry in Retrospect with a New Introduction and Reflections on the Present (New York: Carnegie Endowment for International Peace, 1993) pp.418 $US15.95 ISBN 0 87078 032 9.
Walter Laqueur, Europe in Our Time: History 1945-92 (London: Penguin, 1993) pp.617 $19.95 ISBN 0 14 013969 9.
Andrew MacIntyre and Kanishka Jayasuriya (eds), The Dynamics of Economic Policy Reform in South-East Asia and the South-West Pacific (Singapore: Oxford University Press, 1992) pp.256 $55.95 ISBN 0 19 588584 8.
Stephen McBride, Not Working: State. Unemployment, and Neo-Conservatism in Canada (Toronto: University of Toronto Press, 1992) pp.259 $Can19.95 ISBN 0 8020 5998 8.
Barrett L. McCormick, Political Reform in Post-Mao China (Berkeley: University of California Press, 1990) pp.222 $n.p ISBN 0 520 06765 7.
T.B. Millar and James Walter (eds), Asian-Pacific Security After the Cold War, 2nd ed., (Canberra: Allen & Unwin/Department of International Relations, Australian National University, 1993) pp.142 $n.p. ISBN 1 86373 398 1.
James W. Morley (ed.) Driven by Growth: Political Change in the Asia-Pacific Region (Armonk N.Y.: M.E. Sharpe, 1993) pp.346 $US55.00 ISBN 1 56324 013 0.
Daniel Patrick Moynihan, Pandaemonium: Ethnicity in International Politics (Oxford: Oxford University Press, 1993) pp.221 $54.95 ISBN 0 19 827787 3.
B. Guy Peters and Anthony Barker (eds), Advising West European Governments (Edinburgh: University of Edinburgh Press, 1993) pp.228 $£30.00 ISBN 0 7486 0357 3.
Anthony Barker and B. Guy. Peters (eds), The Politics of Expert Advice (Edinburgh: University of Edinburgh Press, 1993) pp.129 $£25.00 ISBN 0 7486 0349 2.
Jonas Pontusson, The Limits of Social Democracy: Investment Politics in Sweden (Ithaca and London: Cornell University Press, 1992) pp.261 $US31.35 ISBN 0 8014 2652 9.
Joseph Rothschild, Return to Diversity. A Political History of East Central Europe Since World War II (Oxford: Oxford University Press, 1993) pp.299 $28.95 ISBN 0 19 507382 7.
Michael Waller, The End of the Communist Power Monopoly (Manchester: Manchester University Press, 1993) pp.287 $35.00 ISBN 0 7190 3820 0.
Steven A. Shull, A Kinder, Gentler Racism? The Reagan-Bush Civil Rights Legacy (Armonk: New York: M.E. Sharpe, 1993) pp.256 $US20.00 ISBN 156324 240 0.
Mark Sproule-Jones, Governments at Work: Canadian Parliamentary Federalism and Its Public Policy Effects (Toronto: University of Toronto Press, 1993) pp.291 $n.p. ISBN 0 8020 7355 7.
C. Tilly, Coercion, Capital and European States, AD 990-1992 (Cambridge M.A. and Oxford: Blackwell, 1993) pp.271 $39.95 ISBN 1 55786 368 7.
Chris Ward, Stalin's Russia (London: Edward Arnold, 1993) pp.241 $32.95 ISBN 07131 6530 8.
Christopher Weeramantry, Nauru: Environmental Damage Under International Trusteeship (Melbourne: Oxford University Press, 1992) pp.448 $65.00 ISBN 0 19 553289 9.
Stephen White, Alex Pravda, Zvi Gitelman (eds), Developments in Soviet and Post-Soviet Politics, 2nd ed. (Durham NC: Duke University Press and Basingstoke and London: Macmillan, 1992) pp.347 $US19.95 ISBN 0 8223 12670.
Avner Yaniv (ed.), National Security and Democracy in Israel (An Israel Democracy Institute Policy Study) (London: Lynne Rienner, 1993) pp.257 $n.p. ISBN 1 5587 394 4.
Political Theory and Methodology. Ian Adams, Political Ideology Today (Manchester and New York: Manchester University Press, 1993) pp.369 $27.50 ISBN 0 7190 3347 0.
W.J. Stankiewicz, In Search of a Political Philosophy: Ideologies at the Close of the Twentieth Century (London and New York: Routledge, 1993) pp.460 $130.00 ISBN 0 415 08874 7.
Frederick Beiser (ed.), The Cambridge Companion to Hegel (Cambridge: Cambridge University Press, 1993) pp.518 $35.00 ISBN 0 521 38711 6.
Larry Diamond and Marc F. Plattner (eds), The Global Resurgence of Democracy (Baltimore and London: John Hopkins University Press, 1993) pp.336 $US29.95 ISBN 0 8018 4564 3.
Robyn Eckersley, Environmentalism and Political Theory: Toward an Ecocentric Approach (London: UCL Press, 1992) pp.274 $29.95 ISBN 1 85728 020 2.
Robert Goodin, Green Political Theory (Cambridge: Polity Press, 1992) pp.240 $39.95 ISBN 0 7456 1027 7.
Murray Forsyth, Maurice Keens-Soper and John Hoffman (eds), The Political Classics: Hamilton to Mill (Oxford: Oxford University Press, 1993) pp.250 $28.95 ISBN 0 19 878026 5.
Donald F. Miller, The Reason of Metaphor. A Study in Politics (New Delhi: Sage Publications, 1992) pp.268 $n.p. ISBN 0 8039 9410 9.
Chantal Mouffe, The Return of the Political (London: Verso, 1993) pp.156 $37.95 ISBN 0 86091 660 X.
Philip Pettit, The Common Mind (New York and London: Oxford University Press, 1993) pp.365 $59.95 ISBN 0 19 507818 7.
Maurice Roche, Rethinking Citizenship: Welfare, Ideology and Change in Modern Society (Cambridge: Polity Press, 1992) pp.280 $39.95 ISBN 0 7456 0307 6.
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Background: Approaches to therapy in pediatric and adult cHL have differed historically. Brentuximab vedotin (BV) is efficacious in pediatric patients (pts) with high-risk cHL when combined with ...chemotherapy and response based involved site radiation therapy (RT) ( Castellino. NEJM 2022). Inhibition of the PD-1 pathway, central to the pathogenesis of cHL, is safe and effective in children with relapsed HL but has not been evaluated in the frontline setting. Led by SWOG, the National Clinical Trials Network (NCTN) conducted the randomized, phase 3 trial S1826 to evaluate nivolumab (N)-AVD vs BV-AVD in pts ages ≥12 years (y) with newly diagnosed Stage 3-4 cHL.
Methods: Eligible pts were randomized 1:1 to either 6 cycles of N-AVD or BV-AVD. At randomization enrollment was stratified by age, International Prognostic Score (IPS), and intent to use RT. Treating site of pts 12-17y, the subject of this subgroup analysis, declared intent to use RT for residual metabolically active lesions on the end of treatment PET per protocol. Recipients of BV-AVD were required to receive G-CSF prophylaxis vs optional with N-AVD. Dexrazoxane was permitted, but not mandated. Response and disease progression was assessed by investigators using the 2014 Lugano Classification. The primary endpoint was PFS; secondary endpoints included overall survival (OS), event-free survival (EFS), and safety.
Results: Of 976 eligible pts enrolled (from 7/9/2019 to 10/5/2022): 24.3% (n=237) were 12-17 y and randomized to N-AVD (n=120) or BV-AVD (n=117). Median age was 15.6 y (range, 12-17.9 y), 50% of pts were male, 69% were white, 15% were black, and 18% were Hispanic. 27% had an IPS score 4-7. At the 2nd interim analysis (50% of total PFS events) the SWOG Data and Safety Monitoring Committee recommended reporting the primary results as the primary PFS endpoint crossed the protocol-specified conservative statistical boundary for the full trial. In the pediatric cohort, 6 PFS events were observed after N-AVD compared to 12 events after BV-AVD. At a median follow-up of 12.1 months, the PFS was compared between arms HR 0.48, 95% CI 0.18-1.28, stratified one-sided logrank p=0.067) in the pediatric cohort; 1 y PFS: N-AVD, 94%, BV-AVD, 88% (Fig.1). There have been no deaths in this age group. Overall use of RT was 0.8% (2/237) and 79% of pediatric pts received dexrazoxane. The rate of grade (gr) ≥ 3 hematologic adverse events (AE) was 45% after N-AVD compared to 41% after BV-AVD, with 3% gr ≥ 3 febrile neutropenia and 1% with sepsis after either regimen, despite differences in GCSF use (59.2% N, 93.2% BV). Overall rates of immune related AEs (irAEs) (any gr) were low: pneumonitis (3.0% N vs 1% BV), and colitis (0% N vs 1% BV). Rash (any gr) was more common in BV-AVD (2% N vs 14% BV).
Hypo/hyperthyroidism (any gr) was higher after N-AVD (2% N vs 0% BV). Rates of transaminitis were similar (ALT elevation: 42% N vs 54% BV). While sensory peripheral neuropathy was more frequent after BV-AVD (sensory: 18% N vs 29% BV; motor: 8% N vs 5% BV), only 1% was > grade 3. Discontinuation of N vs BV therapy occurred in 8.3% vs 2.6% of pediatric pts respectively, compared to 7.9% vs 21.1% of adults.
Conclusions: In early follow-up, N-AVD and BV-AVD are well tolerated and associated with low rates of irAEs in pts ages 12-17 y. With 12.1 mos median follow-up the PFS benefit observed for N-AVD in pediatric pts mirrors that observed in the overall study. RT usage is lower, and cumulative doxorubicin dose is higher than historical pediatric cHL trials. The difference in rate of discontinuation between study arms and by age group needs further evaluation. Longer follow-up is needed to better define the roles of N-AVD and Bv-AVD for AS cHL. S1826 is a model NCTN trial, providing earlier access to novel agents and harmonization of treatment for adolescents and young adults with AS cHL.
Funding: NIH/NCI/NCTN grants U10CA180888 and U10CA180819, U10CA180820, U10CA180821, U10CA180863, U10 CA180886; and Bristol-Myers Squibb. Bv provided by Seagen (Canada Only). Clinical Trial NCT03907488.
