Resilience to host inflammation and other perturbations is a fundamental property of gut microbial communities, yet the underlying mechanisms are not well understood. We have found that human gut ...microbes from all dominant phyla are resistant to high levels of inflammation-associated antimicrobial peptides (AMPs) and have identified a mechanism for lipopolysaccharide (LPS) modification in the phylum Bacteroidetes that increases AMP resistance by four orders of magnitude. Bacteroides thetaiotaomicron mutants that fail to remove a single phosphate group from their LPS were displaced from the microbiota during inflammation triggered by pathogen infection. These findings establish a mechanism that determines the stability of prominent members of a healthy microbiota during perturbation.
The Last Glacial Termination Denton, G. H.; Anderson, R. F.; Toggweiler, J. R. ...
Science (American Association for the Advancement of Science),
06/2010, Letnik:
328, Številka:
5986
Journal Article
Recenzirano
A major puzzle of paleoclimatology is why, after a long interval of cooling climate, each late Quaternary ice age ended with a relatively short warming leg called a termination. We here offer a ...comprehensive hypothesis of how Earth emerged from the last global ice age. A prerequisite was the growth of very large Northern Hemisphere ice sheets, whose subsequent collapse created stadial conditions that disrupted global patterns of ocean and atmospheric circulation. The Southern Hemisphere westerlies shifted poleward during each northern stadial, producing pulses of ocean upwelling and warming that together accounted for much of the termination in the Southern Ocean and Antarctica. Rising atmospheric CO₂ during southern upwelling pulses augmented warming during the last termination in both polar hemispheres.
Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from the ...Great Barrier Reef, and show that it is remarkably similar to other animal genomes in content, structure and organization. Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes. This diverse 'toolkit' of genes correlates with critical aspects of all metazoan body plans, and comprises cell cycle control and growth, development, somatic- and germ-cell specification, cell adhesion, innate immunity and allorecognition. Notably, many of the genes associated with the emergence of animals are also implicated in cancer, which arises from defects in basic processes associated with metazoan multicellularity.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
High‐resolution tree ring reconstructions from the Himalaya provide essential context for assessing impacts of future climate change on regional water reserves and downstream agriculture. Here we ...evaluate a small network of tree ring chronologies from Bhutan to produce a 638 year summer temperature reconstruction, from 1376–2013 (Common Era) C.E. Relative to the 1950–2013 C.E. average summer temperature three prominent cold periods stand out, two in the midfifteenth century, and one in the late seventeenth century. The warmest period began in the first decade of the 21st century coinciding with the timing of general glacier recession in the eastern Himalaya that continues to the present. The Bhutan temperature reconstruction exhibits a significant correlation to known volcanic eruptions (p = 97%) and anomalously cold periods appear to align with solar irradiance minima in the fifteenth, late seventeenth, and early nineteenth centuries, implying a link between solar variability and decadal‐scale temperature variability.
Key Points
First multicentennial temperature reconstruction from Bhutan
Temperature variations suggest influence of solar and volcanic forcing
Scare temperature data from the region makes reconstructions difficult
High-resolution tree ring reconstructions from the Himalaya provide essential context for assessing impacts of future climate change on regional water reserves and downstream agriculture. Here we ...evaluate a small network of tree ring chronologies from Bhutan to produce a 638 year summer temperature reconstruction, from 1376-2013 (Common Era)C.E. Relative to the 1950-2013C.E. average summer temperature three prominent cold periods stand out, two in the midfifteenth century, and one in the late seventeenth century. The warmest period began in the first decade of the 21st century coinciding with the timing of general glacier recession in the eastern Himalaya that continues to the present. The Bhutan temperature reconstruction exhibits a significant correlation to known volcanic eruptions (p=97%) and anomalously cold periods appear to align with solar irradiance minima in the fifteenth, late seventeenth, and early nineteenth centuries, implying a link between solar variability and decadal-scale temperature variability.
Remote seismic observations of a glacial lake outburst flood highlight potential for improving early warning systems.
Glacial lake outburst floods (GLOFs) are a substantial hazard for downstream ...communities in vulnerable regions, yet unpredictable triggers and remote source locations make GLOF dynamics difficult to measure and quantify. Here, we revisit a destructive GLOF that occurred in Bhutan in 1994 and apply cross-correlation–based seismic analyses to track the evolution of the GLOF remotely (~100 kilometers from the source region). We use the seismic observations along with eyewitness reports and a downstream gauge station to constrain a numerical flood model and then assess geomorphic change and current state of the unstable lakes via satellite imagery. Coherent seismic energy is evident from 1 to 5 hertz beginning approximately 5 hours before the flood impacted Punakha village, which originated at the source lake and advanced down the valley during the GLOF duration. Our analysis highlights potential benefits of using real-time seismic monitoring to improve early warning systems.
We report radiocarbon dates that constrain the timing of the deposition of the late-glacial Puerto Bandera moraine system alongside the western reaches of Lago Argentino adjacent to the Southern ...Patagonian Icefield. Close maximum-limiting radiocarbon ages (
n = 11) for glacier advance into the outer moraines, with a mean value of 11,100 ± 60
14C yrs BP (12,990 ± 80 cal yrs BP), were obtained from wood in deformation (soft) till exposed beneath flow and lodgment till in Bahía del Quemado on the northeast side of Brazo Norte (North Branch) of western Lago Argentino. Other exposures of this basal deformation till in Bahía del Quemado reveal incorporated clasts of peat, along with larger inclusions of deformed glaciofluvial and lacustrine deposits. Radiocarbon dates of wood included in these reworked peat clasts range from 11,450 ± 45
14C yrs BP to 13,450 ± 150
14C yrs BP (13,315 ± 60 to 16,440 ± 340 cal yrs BP). The implication is that, during this interval, glacier fronts were situated inboard of the Puerto Bandera moraines, with the peat clasts and larger proglacial deposits being eroded and then included in the basal till during the Puerto Bandera advance.
Minimum-limiting radiocarbon ages for ice retreat come from basal peat in cores sampled in spillways and depressions generated during abandonment of the Puerto Bandera moraines. Glacier recession and subsequent plant colonization were initiated close behind different frontal sectors of these moraines prior to: 10,750 ± 75
14C yrs BP (12,660 ± 70 cal yrs BP) east of Brazo Rico, 10,550 ± 55
14C yrs BP (12,490 ± 80 cal yrs BP) in Peninsula Avellaneda, and 10,400 ± 50
14C yrs BP (12,280 ± 110 cal yrs BP) in Bahía Catalana. In addition, a radiocarbon date indicates that by 10,350 ± 45
14C yrs BP (12,220 ± 110 cal yrs BP), the Brazo Norte lobe (or former Upsala Glacier) had receded well up the northern branch of Lago Argentino, to a position behind the Herminita moraines. Furthermore, glacier termini had receded to just outboard of the outer Holocene moraines at Lago Frías and Lago Pearson (Anita) prior to 10,400 ± 40
14C yrs BP (12,270 ± 100 cal yrs BP) and 9040 ± 45
14C yrs BP (10,210 ± 50 cal yrs BP), respectively. The most extensive recession registered during the early Holocene was in Agassiz Este Valley, where the Upsala Glacier had pulled back behind the outer Holocene moraine, reaching close to the present-day glacier terminus before 8290 ± 40
14C yrs BP (9300 ± 80 cal yrs BP).
The radiocarbon-dated fluctuations of the Lago Argentino glacier in late-glacial time, given here, are in accord with changes in ocean mixed layer properties, predominately temperature, derived from the isotopic record given here of ODP Core 1233, taken a short distance off shore of the Chilean Lake District. It also matches recently published chronologies of late-glacial moraines in the Southern Alps of New Zealand on the opposite side of the Pacific Ocean from Lago Argentino. Finally, the timing of the late-glacial reversal of the Lago Argentino glacier fits the most recent chronology for the culmination of the Antarctic Cold Reversal (ACR) in the deuterium record of the EPICA Dome C ice core from high on the East Antarctic Plateau. Therefore, we conclude that the climate signature of the ACR was widespread in both the ocean and the atmosphere over at least the southern quarter of the globe.
► We present a radiocarbon chronology of late-glacial glacier behavior in Patagonia. ► Glacier advance occurred ∼13,000 yrs ago. ► Ice receded to near-present-day margins by ∼12,000 yrs ago. ► South Patagonian glaciers registered Antarctic Cold Reversal.
The genomics era has opened up exciting possibilities in the field of conservation biology by enabling genomic analyses of threatened species that previously were limited to model organisms. ...Next-generation sequencing (NGS) and the collection of genome-wide data allow for more robust studies of the demographic history of populations and adaptive variation associated with fitness and local adaptation. Genomic analyses can also advance management efforts for threatened wild and captive populations by identifying loci contributing to inbreeding depression and disease susceptibility, and predicting fitness consequences of introgression. However, the development of genomic tools in wild species still carries multiple challenges, particularly those associated with computational and sampling constraints. This review provides an overview of the most significant applications of NGS and the implications and limitations of genomic studies in conservation.
Systemic autoimmune responses are associated with certain environmental exposures, including crystalline particles such as silica. Positive antinuclear antibody (ANA) tests have been reported in ...small cohorts exposed to asbestos, but many questions remain regarding the prevalence, pattern, and significance of autoantibodies associated with asbestos exposures. The population in Libby, Montana, provides a unique opportunity for such a study because of both occupational and environmental exposures that have occurred as a result of the mining of asbestos-contaminated vermiculite near the community. As part of a multifaceted assessment of the impact of asbestos exposures on this population, this study explored the possibility of exacerbated autoimmune responses. Age- and sex-matched sets of 50 serum samples from Libby and Missoula, Montana (unexposed), were tested for ANA on HEp-2 cells using indirect immunofluorescence. Data included frequency of positive tests, ANA titers, staining patterns, and scored fluorescence intensity, all against known controls. Serum immunoglobulin A (IgA), rheumatoid factor, and antibodies to extractable nuclear antigen (ENA) were also tested. The Libby samples showed significantly higher frequency of positive ANA and ENA tests, increased mean fluorescence intensity and titers of the ANAs, and higher serum IgA, compared with Missoula samples. In the Libby samples, positive correlations were found between ANA titers and both lung disease severity and extent of exposure. The results support the hypothesis that asbestos exposure is associated with autoimmune responses and suggests that a relationship exists between those responses and asbestos-related disease processes.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Records of past variability afford context for evaluating present-day glacier behavior and for testing hypotheses of climate change. Here, we use 69 radiocarbon dates of wood and other organic ...materials in association with glacial deposits to document the behavior of Ventisqueros Marinelli and Brooks in Cordillera Darwin over the past ∼17,000 years. Recession from the last glacial maximum was early, with most occurring prior to 17,000 yr BP. Any glacial resurgence during the Antarctic Cold Reversal must have terminated within the bounds of Holocene ice fluctuations. By early Holocene time, Ventisquero Marinelli had retreated such that it was no more extensive than it was in AD 1992. We identify several subsequent glacier readvances, but also note long periods of restricted ice extent, particularly in the mid-Holocene. There were times when Holocene glaciers must have been smaller than at present. Our new record from Marinelli shows similarities to other reconstructions of Holocene glacier variation from southern South America, such as at Mt. Sarmiento and the South Patagonian Icefield, suggesting an underlying climate signal. The overall implication is of substantial early Holocene deglaciation followed by repeated advances interspersed with periods of recession when ice extent was smaller than at present. This general pattern of glacier behavior appears to differ from that of New Zealand's Southern Alps and points to the value of a geographic spread of datasets to elucidate the pattern of Southern Hemisphere climate during the Holocene.
•69 14C dates of organic remains document Holocene history of Cordillera Darwin.•Ice was within range of Holocene fluctuations by the Antarctic Cold Reversal.•Advances occurred at ≤6650, ∼≤2430–3800, ∼1300, ∼750, and ∼480 yr BP.•There were long periods of restricted ice in the early and middle Holocene.•Fluctuations of southern South American glaciers differ from those in New Zealand.
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