The preparation of multifunctionalized luminophores with full‐color emission based on an identical core skeleton is a significative but challenging research topic. In this work, eight ...donor‐donor‐acceptor (D‐D‐A)‐type luminogens based on a central carbazole core bearing a C6 hydrocarbon chain were designed by using different kinds of donor and acceptor units on the left and right, and synthesized in good yields. These D‐D‐A carbazole derivatives display deep‐blue, sky‐blue, cyan, green, yellow‐green, yellow, orange and red fluorescence in the solid state, achieving full‐color emission covering the whole visible light range under UV light illumination. Notably, the dicyano‐functionalized triphenylamine‐containing carbazole derivative exhibits rare aggregation‐induced near‐infrared emission and red‐to‐near‐infrared mechano‐fluorochromism with high contrast beyond 100 nm. Furthermore, the red‐emissive luminogen can serve as a potential candidate for cell imaging and photodynamic therapy (PDT). This work not only provides reference for the construction of full‐color emissive systems but also opens a new avenue to the preparation of multifunctionalized luminophores capable of simultaneous application in near‐Infrared mechanical‐force sensors and PDT fields.
A riot of color: We have developed eight D‐D‐A type carbazole derivatives capable of exhibiting full‐color solid‐state emission. Notably, this is the first time that a dicyano‐functionalized triphenylamine‐modified carbazole derivative has not only displayed noteworthy aggregation‐induced near‐infrared emission, but also achieved the rare red‐to‐near‐infrared mechano‐fluorochromism with high contrast beyond 100 nm. Furthermore, the red‐emissive luminophore has potential applications in cell imaging and photodynamic therapy.
Efficacy and safety of chemotherapeutic drugs constitute two major criteria in tumor chemotherapy. Nanomedicines with tumor‐targeted properties hold great promise for improving the efficacy and ...safety. To design targeted nanomedicines, the pathological characteristics of tumors are extensively and deeply excavated. Here, the rationale, principles, and advantages of exploiting these pathological characteristics to develop targeted nanoplatforms for tumor chemotherapy are discussed. Homotypic targeting with the ability of self‐recognition to source tumors is reviewed individually. In the meanwhile, the limitations and perspective of these targeted nanomedicines are also discussed.
Nanomedicines with tumor‐targeted properties hold great potential for improved efficacy and safety of tumor chemotherapy. This review summarizes the recent advances in exploiting tumor‐associated pathological features to elaborate tumor targeting nanomedicines. Homotypic targeting strategies are also discussed due to the self‐recognition to source tumors.
Surface modification of nanomaterials is essential for their biomedical applications owing to their passive immune clearance and damage to reticuloendothelial systems. Recently, a cell ...membrane‐coating technology has been proposed as an ideal approach to modify nanomaterials owing to its facile functionalized process and good biocompatibility for improving performances of synthetic nanomaterials. Here, recent advances of cell membrane‐coated nanomaterials are reviewed based on the main biological functions of the cell membrane in living cells. An overview of the cell membrane is introduced to understand its functions and potential applications. Then, the applications of cell membrane‐coated nanomaterials based on the functions of the cell membrane are summarized, including physical barrier with selective permeability and cellular communication via information transmission and reception processes. Finally, perspectives of biomedical applications and challenges about cell membrane‐coated nanomaterials are discussed.
Recent advances of cell membrane‐coated nanomaterials are summarized here based on the main biological functions of the cell membrane, including physical barrier and cellular communication. Perspectives of biomedical applications and challenges of cell membrane‐coated nanomaterials are also discussed.
The clinical outcomes of conventional mono-chemotherapy of cancers are usually far from satisfactory due to some issues such as tumor heterogeneity and resistance to chemotherapeutic drugs. With the ...increasing knowledge of molecular signal pathways and pathological mechanisms involved in the initiation and progression of cancers, collaborative strategies have been elaborated to optimize therapeutic outcomes. This review surveys the most recent advances in combination therapy including combination chemotherapy, chemotherapy plus gene therapy, chemotherapy plus phototherapy, as well as chemotherapy plus immunotherapy. Additionally, chemotherapy-involved multiple therapy that merges various therapeutic modalities is also presented. We try to elicit the rationales of applying these combinational formulations for cancer chemotherapy, which might provide new guidelines for high-performance cancer treatments.
Combinational therapy, including combination chemotherapy, chemotherapy plus gene therapy, chemotherapy plus phototherapy, chemotherapy plus immunotherapy, as well as chemotherapy-involved multiple therapy, are confirmed to be the robust choices for high-performance cancer chemotherapy due to their abilities of conquering tumor heterogeneity and complexity, reversing multidrug resistance (MDR), and decreasing unwanted side effects, etc. Display omitted
Residual dipolar coupling (RDC), a robust anisotropic NMR parameter for structural elucidation of organic molecules, is only accessible in an anisotropic environment. Herein, we introduce a novel ...alignment medium based on the molecular self‐assembly of oligopeptide amphiphile (OPA). This medium is compatible with different intermediate and polar solvent systems, such as CD3OD, D6DMSO, and D2O. The preparation of the OPA‐based medium is simple and rapid, while only very weak background signals were observed from OPAs. Furthermore, we show that the purity of OPA has only a minor influence on the quality of the RDC data. These advantages allow RDC measurements of organic molecules with different polarities and solubilities with high efficiency and accuracy.
Hat‐trick: An alignment medium compatible with multiple solvents (D6DMSO, CD3OD, D2O) is fabricated by molecular self‐assembly. The facile fabrication of the three‐in‐one system combined with its negligible background signals and without strict purity requirements enables efficient and accurate RDC measurements of organic molecules with different polarities and solubilities.
Invited for the cover of this issue are Zhao Chen at Jiangxi Science and Technology Normal University and Yue Sun at Tiangong University. For this cover picture, yellow ball containing character “D” ...represents donor, green ball containing character “A” represents acceptor. The image depicts eight donor–donor–acceptor‐type carbazole derivatives that display full‐color emission, and a luminogen that shows red to near‐infrared mechano‐fluorochromism and a photodynamic therapy effect. Read the full text of the article at 10.1002/chem.202203797.
Herein, we have developed a solvent-tailored ordered self-assembly strategy to create anisotropic nanomaterials. A trace amount of water has been found to be a predominant factor to direct peptide ...self-assembly into an anisotropic meso-matrix in DMSO. The obtained meso-matrix was applied to measure the anisotropic RDC parameter of organic molecules for structural elucidation.
We developed a solvent-tailored ordered self-assembly strategy to create an anisotropic meso-matrix, which displays great potential to align organic molecules for structural elucidation
via
anisotropic NMR parameters.
Temozolomide (TMZ) is an oral DNA-alkylating drug used in colorectal cancer (CRC) chemotherapy. In this work, we proposed a safe and biomimetic platform for macrophages-targeted delivery of TMZ and ...O6-benzylguanine (O6-BG). TMZ was loaded in poly (D, l-lactide-coglycolide) (PLGA) nanoparticles, followed by sequential coating with O6-BG-grafted chitosan (BG-CS) layers and yeast shell walls (YSW) via layer-by-layer assembly (LBL) process, forming TMZ@P-BG/YSW biohybrids. Due to the yeast cell membrane-camouflage, TMZ@P-BG/YSW particles exhibited significantly enhanced colloidal stability as well as low premature drug leakage in simulated gastrointestinal conditions. In vitro drug release profiles of TMZ@P-BG/YSW particles revealed noticeable higher TMZ release in simulated tumor acidic environment within 72 h. Meanwhile, O6-BG could down-regulate MGMT expression in CT26 colon carcinoma cells, ultimately facilitating TMZ-induced tumor cell death. After oral delivery of yeast cell membrane-camouflaged particles containing fluorescent tracer (Cy5), TMZ@P-BG/YSW and bare YSW displayed high retention time of 12 h in the colon and small intestine (ileum). Correspondingly, oral gavage administration of TMZ@P-BG/YSW particles afforded favorable tumor-specific retention and superior tumor growth inhibition. Overall, TMZ@P-BG/YSW is validated to be a safe, targetable and effective formulation, paving a new avenue towards highly effective and precise treatment of malignancies.
PLGA-based bioinspired platform for tumor-specific retention and enhanced colorectal cancer therapy. Display omitted
Residual Dipolar Coupling (RDC), acquired relying on weakly alignment media, is highly valuable for the structural elucidation of organic molecules. Arising from the striking features of no ...background signals and low critical concentrations, two-dimensional (2D) liquid crystals (LCs) show the clear advantages of acting as alignment media to measure RDCs. So far, creating multisolvent compatible 2D LC media through a simple and versatile method is still formidably challenging. Herein, we report the rapid creation of aligned media based on the Ti3C2Tx MXene, which self-aligned in multiple co-solvents including CH3OH-H2O, DMSO-H2O, DMF-H2O, and acetone-H2O. We demonstrated the applicability of these aligned media for the RDC measurement of small organic molecules with different polarities and solubilities. Notably, Ti3C2Tx MXene LCs without chemical modification enabled RDC measurements on aromatic molecules. The straightforward preparation of Ti3C2Tx media and its compatibility with multiple solvents will push RDC measurement as a routine methodology for structural elucidation. It may also facilitate the investigation of solvation effects on conformational dynamics.
A novel aligned nanofiber matrix was obtained from the self-assembly of an oligopeptide amphiphile. The alignment properties can be applied to measure residual dipolar couplings (RDCs) for the ...structural elucidation of molecules by liquid-state NMR.
An aligned nanofiber matrix is obtained from the self-assembly of an oligopeptide amphiphile, which can capture the residual dipolar couplings of biomolecules.
