By applying a parabolic–hyperbolic formulation of the constraints and superposing Kerr–Schild black holes, a simple method is introduced to initialize time evolution of binary systems. As the input ...parameters are essentially the same as those used in the post-Newtonian (PN) setup the proposed method interrelates various physical expressions applied in PN and in fully relativistic formulations. The global ADMcharges are also determined by the input parameters, and no use of boundary conditions in the strong field regime is made.
Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the ...optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring, it has not been explored whether paternal dietary methyl donor intake influences behavioral and cognitive functions in the next generation. Here, we report that elevated paternal dietary methyl donor intake in a mouse model, transiently applied prior to mating, resulted in offspring animals (methyl donor-rich diet (MD) F1 mice) with deficits in hippocampus-dependent learning and memory, impaired hippocampal synaptic plasticity and reduced hippocampal theta oscillations. Gene expression analyses revealed altered expression of the methionine adenosyltransferase Mat2a and BK channel subunit Kcnmb2, which was associated with changes in Kcnmb2 promoter methylation in MD F1 mice. Hippocampal overexpression of Kcnmb2 in MD F1 mice ameliorated altered spatial learning and memory, supporting a role of this BK channel subunit in the MD F1 behavioral phenotype. Behavioral and gene expression changes did not extend into the F2 offspring generation. Together, our data indicate that paternal dietary factors influence cognitive and neural functions in the offspring generation.
To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ...ulcerative colitis.
A randomised, double-blind, double-dummy, parallel group, multicentre, international, phase III non-inferiority study.
54 centres in 13 countries.
380 patients with confirmed diagnosis of established or first attack of ulcerative colitis (clinical activity index (CAI)>4 and endoscopic index > or =4 at baseline) were randomised and treated.
8-week treatment with either 3 g OD or 1 g TID mesalazine granules.
Clinical remission (CAI< or =4) at study end.
380 patients were evaluable for efficacy and safety by intention-to-treat (ITT); 345 for per protocol (PP) analysis. In the ITT population, 79.1% in the OD group (n = 191) and 75.7% in the TID group (n = 189) achieved clinical remission (p<0.0001 for non-inferiority). Significantly more patients with proctosigmoiditis achieved clinical remission in the OD group (86%; n = 97) versus the TID group (73%; n = 100; p = 0.0298). About 70% of patients in both treatment groups achieved endoscopic remission, and 35% in the OD group and 41% in the TID group achieved histological remission. About 80% of all patients preferred OD dosing. Similar numbers of adverse events occurred in 55 patients (28.8%) in the OD group and in 61 patients (32.3%) in the TID group, indicating that the two dosing regimens were equally safe and well tolerated.
OD 3 g mesalazine granules are as effective and safe as a TID 1 g schedule. With respect to the best possible adherence of patients to the treatment, OD dosing of mesalazine should be the preferred application mode in active ulcerative colitis.
The importance of pollination and pollinators is easy to underestimate and impossible to overstate, since its importance goes far beyond the crop production and even the maintenance of plant ...populations. Most terrestrial ecosystems ultimately depend on the plant–pollinator interactions formed by million years coevolution. This is essential for both the daily functioning of the ecosystems and the long-term development of biodiversity. At the same time, the loss of biodiversity caused by climate change and human activities will soon lead to an ecological crisis, a catastrophe, which could endanger our life: For example, through the decline and loss of various ecosystem services. Such may be the pollination crisis, resulted from a significant loss of pollinating insects’ diversity and abundance. The discovery of a pollinator Orthoptera species has encouraged researchers in the densely populated region of Indo-Malaysia to explore the potential role of orthopterans as pollinators. Although the flower visitation of some species has been already known, the role of orthopterans in pollination is scarcely revealed. Here, we collected and reviewed the available data in order to point out some factors of their importance and set priorities that may serve as a basis for further investigations regarding ecological, evolutionary and practical points of view.
Traditional and extensively used agricultural lands maintain and protect high levels of biological diversity. This diversity is in decline due to land use intensification and abandonment. Natural and ...semi-natural grasslands of the Carpathian lowlands have become endangered over the 19th century. However, some remains of former wetlands have survived land use change in the Bereg Region (North-eastern Hungary and Eastern Ukraine). We surveyed Orthopterans as sensitive indicators of habitat structure and microclimate in grasslands. We identified three different Orthoptera assemblages and their character species. Although rare and especially valuable species were not found in the studied sites, the species rich remains of wetlands still protected relics of former wildlife of wetlands. Understanding the quantitative character of the assemblages, ratios of life forms and particularly co-occurrences of their character species (
Chorthippus dorsatus, Leptophyes albovittata, Tettigonia viridissima
and
Ruspolia nitidula
) and use of Grasshopper Conservation Indexes (GCI) can help to identify remaining good quality patches with highest conservation value and monitoring.
Implications for insect conservation
The focused management of these habitats with reconsideration of the traditional water management can be effective practice for wetland management and Orthoptera conservation.
We make use of the black hole holograph construction of Rácz (2014 Class. Quantum Grav. 31 035006) to analyse the existence of Killing spinors in the domain of dependence of the horizons of distorted ...black holes. In particular, we provide conditions on the bifurcation sphere ensuring the existence of a Killing spinor. These conditions can be understood as restrictions on the curvature of the bifurcation sphere and ensure the existence of an axial Killing vector on the 2-surface. We obtain the most general 2D metric on the bifurcation sphere for which these curvature conditions are satisfied. Remarkably, these conditions are found to be so restrictive that, in the considered particular case, the free data on the bifurcation surface (determining a distorted black hole spacetime) is completely determined by them. In addition, we formulate further conditions on the bifurcation sphere ensuring that the Killing vector associated to the Killing spinor is Hermitian. Once the existence of a Hermitian Killing vector is guaranteed, one can use a characterisation of the Kerr spacetime due to Mars to identify the particular subfamily of 2-metrics giving rise to a member of the Kerr family in the black hole holograph construction. Our analysis sheds light on the role of asymptotic flatness and curvature conditions on the bifurcation sphere in the context of the problem of uniqueness of stationary black holes. The Petrov type of the considered distorted black hole spacetimes is also determined.
The biodiversity conservation needs recent high-quality data and efficient methods for prioritizing species and sites for conservation. Here we prioritized Orthoptera habitats of the Aggtelek ...National Park, based on revised and actualized distribution data of 69 Orthoptera species living at 98 sites. The simple ranking and complementary areas methods were used with species richness (S), rarity weighted species richness (SR), and number of rare species (SQ). Additionally, the Grasshopper Conservation Indexes (GCI” and GCIn”) combining European and local rarity and dispersal capacity of the species were also tested. Contrary to simple ranking the complementary areas method represented the whole fauna and significant part of the species-site data records. All the used indices performed similar except the standardized GCIn” which is highly affected by the differences in study intensity of sites. High-priority areas of the Aggtelek National Park were designated in the plateau above Jósvafő and Aggtelek villages and in the small, isolated hill near Jósvafő (Szőlő-hegy) covered with remained mosaic of former vineyards, orchards and hayfields. The combined use of the efficient indices provides additional ranking that allows the best selection of hotspots to support efficient use of limited resources in nature conservation.
Aliment Pharmacol Ther 2011; 33: 313–322
Summary
Background Comparative data regarding different regimens of oral mesalazine (mesalamine) for maintaining remission in ulcerative colitis are limited.
...Aim To evaluate whether 3.0 g mesalazine once‐daily (OD) is superior to the standard treatment of 0.5 g mesalazine three times daily (t.d.s.) and to prove the therapeutic equivalence of OD vs. t.d.s. dosing of total 1.5 g mesalazine for remission maintenance in patients with ulcerative colitis.
Methods A 1‐year, multicentre, double‐blind, double‐dummy study was undertaken in patients with endoscopically and histologically confirmed ulcerative colitis in remission. Patients were randomised to oral mesalazine 3.0 g OD, 1.5 g OD or 0.5 g t.d.s. The primary efficacy endpoint was the proportion of patients still in clinical remission at the final visit, with clinical relapse being defined as CAI score >4 and an increase of ≥3 from baseline.
Results The primary efficacy endpoint occurred in 162/217 3.0 g OD patients (75%), 129/212 1.5 g OD patients (61%) and 150/218 0.5 g t.d.s. patients (69%) in the intention‐to‐treat population, and in 152/177 (86%), 121/182 (67%) and 144/185 (78%) in the per protocol population respectively; 3.0 g OD was superior to both low‐dose regimens for the primary endpoint (i.e. P < 0.001, 3.0 g OD vs. 1.5 g OD; P = 0.024, 3.0 g OD vs. 0.5 g t.d.s.; superiority test, per protocol population). Safety analysis, including comprehensive renal monitoring, revealed no concern in any treatment group.
Conclusion Mesalazine 3.0 g once daily was the most effective dose for maintenance of remission in ulcerative colitis of the three regimens assessed, with no penalty in terms of safety.
According to the cosmological principle (CP), Universal large-scale structure is homogeneous and isotropic. The observable Universe, however, shows complex structures even on very large scales. The ...recent discoveries of structures significantly exceeding the transition scale of 370 Mpc pose a challenge to the CP. We report here the discovery of the largest regular formation in the observable Universe; a ring with a diameter of 1720 Mpc, displayed by 9 gamma-ray bursts (GRBs), exceeding by a factor of 5 the transition scale to the homogeneous and isotropic distribution. The ring has a major diameter of 43° and a minor diameter of 30° at a distance of 2770 Mpc in the 0.78 < z < 0.86 redshift range, with a probability of 2 × 10−6 of being the result of a random fluctuation in the GRB count rate. Evidence suggests that this feature is the projection of a shell on to the plane of the sky. Voids and string-like formations are common outcomes of large-scale structure. However, these structures have maximum sizes of 150 Mpc, which are an order of magnitude smaller than the observed GRB ring diameter. Evidence in support of the shell interpretation requires that temporal information of the transient GRBs be included in the analysis. This ring-shaped feature is large enough to contradict the CP. The physical mechanism responsible for causing it is unknown.
Statistical properties of Fermi GBM GRBs’ spectra Rácz, István I; Balázs, Lajos G; Horvath, Istvan ...
Monthly Notices of the Royal Astronomical Society,
03/2018, Letnik:
475, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Abstract
Statistical studies of gamma-ray burst (GRB) spectra may result in important information on the physics of GRBs. The Fermi GBM catalogue contains GRB parameters (peak energy, spectral ...indices, and intensity) estimated fitting the gamma-ray spectral energy distribution of the total emission (fluence, flnc), and during the time of the peak flux (pflx). Using contingency tables, we studied the relationship of the models best-fitting pflx and flnc time intervals. Our analysis revealed an ordering of the spectra into a power law – Comptonized – smoothly broken power law – Band series. This result was further supported by a correspondence analysis of the pflx and flnc spectra categorical variables. We performed a linear discriminant analysis (LDA) to find a relationship between categorical (spectral) and model independent physical data. LDA resulted in highly significant physical differences among the spectral types, that is more pronounced in the case of the pflx spectra, than for the flnc spectra. We interpreted this difference as caused by the temporal variation of the spectrum during the outburst. This spectral variability is confirmed by the differences in the low-energy spectral index and peak energy, between the pflx and flnc spectra. We found that the synchrotron radiation is significant in GBM spectra. The mean low-energy spectral index is close to the canonical value of α = −2/3 during the peak flux. However, α is ∼ −0.9 for the spectra of the fluences. We interpret this difference as showing that the effect of cooling is important only for the fluence spectra.
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